Minerva endocrinology最新文献_第2页

Associations of cerebrospinal fluid pressure and ocular anatomic parameters with diabetes and diabetic retinopathy. 脑脊液压和眼解剖参数与糖尿病和糖尿病视网膜病变的关系。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 DOI: 10.23736/S2724-6507.23.04078-2

Galina Dimitrova, Ivana Petkovska, Dushan Kemera, Natasha Nedeska Minova, Hasan Taner, Antonela Ljubic, Lidija Lazareska, Etsuo Chihara

引用次数: 0

ACR TI-RADS Score combined with cytopathology classification improves the risk stratification of indeterminate thyroid nodules. ACR TI-RADS评分结合细胞病理学分级可改善不确定甲状腺结节的风险分层。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2023-04-06 DOI: 10.23736/S2724-6507.22.03929-X

Francesco Feroci, Davina Perini, Alessio Giordano, Luca Romoli, Tommaso Guagni, Angela Coppola, Iacopo Giani, Serenella Checchi, Alvaro Petrucci, Antonio Sarno, Stefano Cantafio

{"title":"ACR TI-RADS Score combined with cytopathology classification improves the risk stratification of indeterminate thyroid nodules.","authors":"Francesco Feroci, Davina Perini, Alessio Giordano, Luca Romoli, Tommaso Guagni, Angela Coppola, Iacopo Giani, Serenella Checchi, Alvaro Petrucci, Antonio Sarno, Stefano Cantafio","doi":"10.23736/S2724-6507.22.03929-X","DOIUrl":"10.23736/S2724-6507.22.03929-X","url":null,"abstract":"Background: The aim of this retrospective study was the elaboration of a new diagnostic model that integrate cytological reports (2017 Bethesda System for Reporting Thyroid Cytopathology) with ultrasonographic features (based on ACR TI-RADS score) to achieve a more accurate definition of indeterminate thyroid nodule malignancy risk.Methods: Ninety patients submitted to thyroidectomy were divided in three classes: low malignancy risk (AUS/FLUS with TI-RADS 2/TI-RADS 3 and FN/SFN with TI-RADS 2), intermediate malignancy risk (AUS/FLUS with TI-RADS 4/TI-RADS 5 and FN/SFN with TI-RADS 3/TI-RADS 4), and high malignancy risk (FN/SFN with TI-RADS 5).Results: The surgical approach should be recommended in high-risk patients (81.82% of malignancies), carefully evaluated in intermediate risk (25.42%), whereas a conservative approach can be adopted in low-risk patients (0.00%).Conclusions: The integration of these two multiparametric systems in a Cyto-US score has proven to be a feasible and reliable aid to achieve a more accurate definition of malignancy risk.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"134-143"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Online health information on thyroid nodules: do patients understand them? 关于甲状腺结节的在线健康信息：患者了解它们吗？

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2023-04-06 DOI: 10.23736/S2724-6507.23.03952-0

Emine A Cimbek, Ahmet Cimbek

{"title":"Online health information on thyroid nodules: do patients understand them?","authors":"Emine A Cimbek, Ahmet Cimbek","doi":"10.23736/S2724-6507.23.03952-0","DOIUrl":"10.23736/S2724-6507.23.03952-0","url":null,"abstract":"Background: Given the lack of a previous study assessing understandability and considering there is only one study assessing the readability and quality of online information related to thyroid nodules, we aimed to assess the readability, understandability, and quality of online patient education materials on thyroid nodules.Methods: Materials were identified through an online search performed by inputting the term \"thyroid nodule\" into Google. A total of 150 websites were identified, 59 met the inclusion criteria. Websites were classified as academic and hospital (N.=29), physician and clinic (N.=7), organization (N.=12), and health information websites (N.=11). The readability was evaluated using an online system performing a group of validated readability tests. The Patient Education Materials Assessment Tool (PEMAT) was utilized to assess the understandability. The quality was evaluated through the Journal of the American Medical Association (JAMA) benchmark criteria.Results: Among all websites, the mean reading grade level was 11.25±1.88 (range, 8-16), well above the recommended sixth grade reading level (P<0.001). The mean PEMAT Score was 57.4±14.5% (range, 31-88%). For all groups of types of websites, the understandability score was below 70%. There was no statistical difference between the groups for the average reading grade level or the PEMAT score (P=0.379 and P=0.26, respectively). The average JAMA benchmark score was 1.86±1.38 (range 0-4), health information-based websites scored the highest (P=0.007).Conclusions: Online resources on thyroid nodules are written at grade levels above the recommended reading level. Most resources scored poorly using the PEMAT and varied in quality. Future work should focus on developing understandable, high-quality, and grade-level appropriate materials.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"144-150"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of paraoxonase activity and association with serum advanced glycation end products as reliable markers of oxidative stress in Hashimoto's thyroiditis. 评估桥本氏甲状腺炎患者血清中作为氧化应激可靠标志物的副氧合酶活性及其与血清高级糖化终产物的关联。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2022-10-17 DOI: 10.23736/S2724-6507.22.03931-8

Rosaria M Ruggeri, Maria T Cristani, Francesco Crupi, Maria S Molonia, Nina Burduja, Angela Alibrandi, Alfredo Campennì, Salvatore Cannavò

{"title":"Evaluation of paraoxonase activity and association with serum advanced glycation end products as reliable markers of oxidative stress in Hashimoto's thyroiditis.","authors":"Rosaria M Ruggeri, Maria T Cristani, Francesco Crupi, Maria S Molonia, Nina Burduja, Angela Alibrandi, Alfredo Campennì, Salvatore Cannavò","doi":"10.23736/S2724-6507.22.03931-8","DOIUrl":"10.23736/S2724-6507.22.03931-8","url":null,"abstract":"Background: Oxidative stress has been implicated in the pathogenesis of autoimmune thyroiditis, also referred to as Hashimoto's thyroiditis (HT), and several biomarkers have been measured to evaluate the impact and clinical relevance of oxidative stress in this setting. Recently, advanced glycation end products (AGEs) have been proposed as reliable markers of oxidative stress in HT. In the present study, we investigated the relationship of AGEs with antioxidant paraoxonase (PON-1) activity as potential combined markers of oxidative stress.Methods: We measured the levels of AGEs, and advanced oxidation protein products (AOPPs) and PON-1 activity by spectrophotometric methods, in the serum of 40 HT patients (36 F; mean age 35.4±11.5 year) and 38 age-, sex- and BMI-matched healthy controls. All subjects were euthyroid at recruitment and none was on LT-4 therapy.Results: Serum levels of AGEs were significantly higher (median 378 vs 290 AU/g protein; P<0.001), while PON1 activity was significantly lower (median 165 vs. 201 U/L; P<0.05) in HT patients compared to controls: the two parameters were inversely correlated (P<0.01), clearly indicating a pro-oxidant imbalance in HT patients. At stepwise regression analysis, TPOAb positivity was an independent predictor of both PON-1 activity (P=0.002) and AGEs levels (P=0.000).Conclusions: Increased formation and accumulation of AGEs contribute to enhanced oxidative stress, along with a decrease in PON-1 activity in HT. As a consequence, AGEs levels and alteration in PON 1 may serve as useful markers for monitoring the levels of oxidative stress in this disorder.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"126-133"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33545856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divulging the overlooked condition: diabetic ketoacidosis as an imminent risk with sodium-glucose co-transporter-2 inhibitors treatment in type 2 diabetes mellitus. 揭示被忽视的病情：糖尿病酮症酸中毒是钠-葡萄糖协同转运体-2 抑制剂治疗 2 型糖尿病的一个迫在眉睫的风险。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2024-10-10 DOI: 10.23736/S2724-6507.24.04235-0

Ubaidullah Yousafzai, Afnan Hashmi, Malaika Saqib

引用次数: 0

Effects of melatonin on ovarian function and gene expression of VEGF and IL-8 in autologous transplantation of cryopreserved rat ovarian tissue. 褪黑素对冷冻大鼠卵巢组织自体移植卵巢功能及VEGF、IL-8基因表达的影响。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2025-01-13 DOI: 10.23736/S2724-6507.24.04249-0

Zou Qian, Xia Zhu, Wen Zou, Lan Nie

引用次数: 0

Metyrapone restores nocturnal cortisol profile and impaired post-dexamethasone suppression in mild autonomous cortisol secretion due to bilateral adrenal incidentaloma. 由于双侧肾上腺偶发瘤，美地塞米松抑制轻度自主皮质醇分泌后，美地塞米松恢复夜间皮质醇谱和受损。

IF 2.5

Minerva endocrinology Pub Date : 2025-05-05 DOI: 10.23736/S2724-6507.25.04327-1

Alessia Longo, Vittorio Oteri, Stefania Panebianco, Francesco Galeano, Veronica Vella, Francesco Frasca, Damiano Gullo, Andrea Tumminia

引用次数: 0

The potential implications of ATM mutations for radioactive iodine therapy in thyroid carcinoma. ATM突变对甲状腺癌放射性碘治疗的潜在影响。

IF 2.5

Minerva endocrinology Pub Date : 2025-04-23 DOI: 10.23736/S2724-6507.25.04340-4

Henrique C Alexandrino, Ana S Oliveira, Fernando Rodrigues

引用次数: 0

Hypophophatasia: the importance of knowing in advance. 超前认知的重要性。

IF 2.5

Minerva endocrinology Pub Date : 2025-03-11 DOI: 10.23736/S2724-6507.24.04222-2

Stefano Stagi, Arianna Maiorana, Alessandra Li Pomi, Letteria A Morabito, Matteo Cerutti, Gianpaolo DE Filippo, Domenico Corica, Maria L Brandi, Malgorzata G Wasniewska

{"title":"Hypophophatasia: the importance of knowing in advance.","authors":"Stefano Stagi, Arianna Maiorana, Alessandra Li Pomi, Letteria A Morabito, Matteo Cerutti, Gianpaolo DE Filippo, Domenico Corica, Maria L Brandi, Malgorzata G Wasniewska","doi":"10.23736/S2724-6507.24.04222-2","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04222-2","url":null,"abstract":"Hypophosphatasia (HPP) is a rare and highly variable genetic disorder of metabolism characterized by markedly reduced serum alkaline phosphatase (ALP) activity as a result of defective production of tissue-non-specific alkaline phosphatase (TNSALP). HPP is known to affect fetuses in utero and also neonates, children, and adults. Severity ranges significantly, from lethal to mild and clinical presentations include rickets or osteomalacia, osteoporosis, respiratory failure and seizures. Odontohypophosphatasia has only dental manifestations. Low total ALP in serum is the hallmark of HPP, whereas elevated serum concentrations of pyridoxal-5-phosphate and phosphoethanolamine levels represent sensitive and specific biomarkers for HPP. Several pathognomonic radiographic changes are suggestive of HPP. Recently, asfotase alfa, a bone targeted recombinant TNSALP has been used to treat HPP with significant success, highlighting the importance of early diagnosis and intervention. This review describes our current knowledge of HPP, reporting on the epidemiology, classification, clinical presentation and main diagnostic features of the disease, as well as more recent therapeutic approaches.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative balance in Graves' disease: advanced glycation end products and paraoxonase as potential markers of oxidative stress. 格雷夫斯病的氧化平衡：晚期糖基化终产物和对氧醛酸酶作为氧化应激的潜在标志物

IF 2.5

Minerva endocrinology Pub Date : 2025-03-06 DOI: 10.23736/S2724-6507.25.04363-5

Martina Laganà, Angela Alibrandi, Maria T Cristani, Alfredo Campennì, Salvatore Cannavò, Rosaria M Ruggeri

引用次数: 0