Minerva endocrinology最新文献

{"title":"Relationship between plasma 12,13-diHOME level and nonalcoholic fatty liver disease in patients with type 2 diabetes and obesity.","authors":"Sichao Wang, Weixia Sun, Yiping Cheng, Lei Wang, Shizhan Ma, Fei Jing, Xiujuan Zhang, Xinli Zhou","doi":"10.23736/S2724-6507.21.03424-6","DOIUrl":"10.23736/S2724-6507.21.03424-6","url":null,"abstract":"<p><strong>Background: </strong>12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) was one of the newly found lipokines. The goal of this study was to investigate whether the 12,13-diHOME was associated with related metabolic markers of nonalcoholic fatty liver disease (NAFLD) in a Chinese population with type 2 diabetes (T2DM) and obesity.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 202 subjects with T2DM. Anthropometric parameters, 12,13-diHOME, serum lipids levels, fasting blood-glucose (FBG), serum glycosylated hemoglobin (HbA<inf>1c</inf>), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR), liver and kidney function parameters were collected. NAFLD was diagnosed based on abdominal ultrasonography examination results. A computer-aided ultrasound quantitative method was applied to evaluate the liver fat content (LFC).</p><p><strong>Results: </strong>The number of the patients with fatty liver was 139 (68.81%) and those with non-fatty liver was 63 (31.19%). Subjects with NAFLD had a higher body mass index (BMI), diastolic blood pressure, serum alanine aminotransferase (ALT), triglyceride (TG), HOMA-IR, LFC, P<0.05 for all. But no significant difference was found in plasma 12,13-diHOME level (P=0.967), though its level trend was higher in non-NAFLD group. Plasma 12,13-diHOME was positively correlated with aspartate aminotransferase (AST), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), blood urea nitrogen (BUN), free fatty acid (FFA), C-peptide, FINS and HOMA-IR. It was negatively correlated with height, body weight, glomerular filtration rate (eGFR) and HbA<inf>1c</inf>.</p><p><strong>Conclusions: </strong>Although 12,13-diHOME was correlated with AST, TC, HDL-C, BUN, FFA, C-peptide, FINS, HOMA-IR, eGFR and HbA<inf>1c</inf>, there was no significant difference in 12,13-diHOME level between the two groups. However, more research should be carried on about this newly-found lipokine.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"72-83"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38875152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of the January-March 2025 issue.","authors":"Giovanni Vitale","doi":"10.23736/S2724-6507.25.04364-7","DOIUrl":"https://doi.org/10.23736/S2724-6507.25.04364-7","url":null,"abstract":"","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"50 1","pages":"1-3"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer cell xenografts in zebrafish embryos as an experimental tool in drug screening for adrenocortical carcinoma.","authors":"Mariangela Tamburello, Andrea Abate, Sandra Sigala","doi":"10.23736/S2724-6507.24.04270-2","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04270-2","url":null,"abstract":"<p><p>Despite the widespread use of murine models in in-vivo experiments, the zebrafish (Danio rerio) offers unique advantages that make it a versatile and faster preclinical model for drug screening, particularly for adrenocortical carcinoma (ACC), a rare malignancy with limited preclinical models that reflect patient heterogeneities. Over the past decade, significant progress has been made with models like cell lines, organoids, and murine models, which are crucial for advancing disease understanding and treatment development. However, recent reviews have overlooked zebrafish model for ACC. This mini review aims to fill this gap by detailing the advancements of the zebrafish model in ACC research. Recent studies have utilized zebrafish embryos xenografted with ACC cells as a novel approach to studying drug effects on tumor growth and metastasis, consistent with studies regarding other tumors. Specifically, it was demonstrated the ability of abiraterone acetate, trabectedin and progesterone to significantly reduce the tumor area at non-toxic-concentrations. Interestingly, this model allowed to confirm in vivo that metastasis-derived cells were able to metastasize and that trabectedin and progesterone reduced the rate of embryos with metastasis. One more study showed that metastasis formation was significantly reduced in H295R/TR-SF-1-xenografted embryos after fascin1 knock-out or inhibition with G2-044. Even with some limitations, the zebrafish xenografts offer a suitable and expeditious animal model for the screening of potentially effective drugs, identification of dose toxicity, and determination of the most promising compounds for more advanced preclinical phases, especially in rare diseases with limited therapeutic options such as ACC.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of melatonin on ovarian function and gene expression of VEGF and IL-8 in autologous transplantation of cryopreserved rat ovarian tissue.","authors":"Zou Qian, Xia Zhu, Wen Zou, Lan Nie","doi":"10.23736/S2724-6507.24.04249-0","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04249-0","url":null,"abstract":"","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine neoplasms of the breast: a multicenter retrospective Italian study.","authors":"Roberto Baldelli, Marta Franco, Valerio Renzelli, Riccardo DE Fata, Paolo Visca, Maria C Macciomei, Alessandra Fabi, Valentina Rossi, Antongiulio Faggiano, Laura Rizza, Francesca Rota, Marialuisa Appetecchia, Andrea Vecchione, Andrea Lania, Simone Antonini, Andrea Botticelli, Monica Verrico, Giulia D'Amati, Maria G Pignataro, Bruna Cerbelli, Antonio Bianchi, Anna LA Salvia, Paolo Zuppi, Guido Rindi","doi":"10.23736/S2724-6507.24.04200-3","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04200-3","url":null,"abstract":"<p><strong>Background: </strong>The aim of our retrospective study was to describe the immunophenotypic characteristics of neuroendocrine breast neoplasm (BNEN), a peculiar and rare type of breast carcinoma.</p><p><strong>Methods: </strong>Pathological data from 51 patients affected by BNEN were retrospectively evaluated, and 44 patients were considered eligible (7 patients with incomplete data were excluded). The patients were followed in six different Italian hospitals between 2009 and 2019. The histological samples, collected by biopsies and/or surgery pieces, were analyzed to determine: 1) tumor histology; 2) immunophenotypic pattern; 3) presence of lymphatic infiltration; 4) presence of necrosis.</p><p><strong>Results: </strong>The median age of the patients included in our analysis was 70 years (67.6±13.7 years). As concerns the histological type we identified 7 cases of well-differentiated neuroendocrine carcinomas (16%), 8 cases of poorly differentiated/small cell neuroendocrine carcinoma (18%), 29 cases of breast carcinomas with neuroendocrine differentiation (66%). From the analysis of breast-specific immunophenotype we identified: 24 cases (54%) of Luminal A pattern; 9 cases (20%) of Luminal B pattern; 8 case (18%) of triple negative pattern. The presence of lymphatic infiltration was assessed in 29 samples and it was observed in 13 cases (45%), necrosis was assessed in 29 samples and was absent in 72% of all cases (21 samples). Neuroendocrine markers expression was heterogeneous with a prevalence of synaptophysin (positivity in 95%); chromogranin A was evaluated in 31 samples and it was positive in 58% of cases.</p><p><strong>Conclusions: </strong>in our series BNENs mainly affect a post-menopausal population and luminal A pattern is the most frequent immunophenotype. As expected, lymphatic infiltration is most frequently reported in invasive breast cancer with neuroendocrine differentiation; necrosis is absent in well-differentiated neuroendocrine carcinomas. Synaptophysin and chromogranin A are important markers for the diagnosis of BNEN.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-medium term complications of bariatric surgery: a pilot study.","authors":"Jorge Carriel-Mancilla, Rosario Suárez, Evelyn Frias-Toral, Estefanía Bautista-Valarezo, Trino Andrade Zambrano, Andrés Andrade García, Roberto Muñoz Jaramillo, Mario Ferrín, Jimmy Martin, Almino Cardoso Ramos, Angelo Michele Carella, Ludovica Verde, Giovanna Muscogiuri, Gerardo Sarno","doi":"10.23736/S2724-6507.24.04193-9","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04193-9","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery (BS) stands as a highly effective intervention for severe obesity; however, limited understanding exists regarding its short to medium-term complications. This study aimed to analyze short-medium term complications in patients undergoing BS in an Ecuadorian hospital.</p><p><strong>Methods: </strong>A retrospective cohort study included 1132 patients who underwent BS between October 2021 and April 2022, specifically evaluating those with complications needing hospital readmission. Demographic, clinical, surgical, and therapeutic data were collected. The degree of complications was evaluated using the Clavien-Dindo classification.</p><p><strong>Results: </strong>Out of the 1132 patients, 1.6% experienced early complications requiring hospital readmission within the first six months post-BS. Complications occurred in 7% of patients with revisional surgery, 2% with gastric bypass, and 1.2% with gastric sleeve. The most common complications were stenosis (28%), leaks/fistulas (17%), gallbladder and/or bile duct pathologies (17%), and fever (17%). Management strategies involved conservative treatment (28%), combined endoscopic and surgical approaches (28%), and surgical reintervention alone (33%). According to the Clavien-Dindo classification, 28% presented mild-moderate and 72% serious complications.</p><p><strong>Conclusions: </strong>BS showed a low incidence of early complications that required readmission. However, a substantial proportion (almost 70%) of patients with early complications experienced severe ones, resulting in prolonged hospital stays. These findings emphasize the need for ongoing monitoring and specialized care in the postoperative period, contributing valuable insights to the safety profile of BS in an Ecuadorian context.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of prevalence of diabetic retinopathy in Asia.","authors":"Clyve Y Yaow, Snow Y Lin, Jieling Xiao, Jin H Koh, Jie N Yong, Phoebe W Tay, See T Tan","doi":"10.23736/S2724-6507.21.03585-5","DOIUrl":"10.23736/S2724-6507.21.03585-5","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic retinopathy (DR) is a common microvascular complication of diabetes. This review reports the prevalence of DR in Asia and guides healthcare provision in screening and treatment.</p><p><strong>Evidence acquisition: </strong>Medline was searched for articles describing the prevalence of DR in Asia. Statistical analysis was performed using Freeman-Tukey double arcsine transformation and the DerSimonian and Laird model. The prevalence of DR was estimated according to the following subgroups: Economic status (high, middle, and low income), country, and ethnicity. The risk of bias of the articles was also assessed.</p><p><strong>Evidence synthesis: </strong>A total of 66 studies were included, and out of 2,599,857 patients with diabetes, 201,646 were diagnosed with DR. The overall prevalence of DR, non-proliferative DR (NPDR), proliferative DR (PDR) and maculopathy were recorded at 21.7% (CI: 19.1-24.6%), 19.9% (CI: 17.3-22.8%), 2.3% (CI: 1.6-3.4%) and 4.8% (CI: 3.5-6.7%) respectively. Low-income countries had the lowest prevalence of DR, NPDR, PDR and maculopathy compared to the middle- and high-income countries. Middle-income countries had the highest prevalence of DR (23.9%; CI: 19.4-29.2%), NPDR (21.1%; CI: 17.0-25.9%), moderate NPDR (7.9%; CI: 5.7-11.0%), PDR (3.0%; CI: 1.8-4.9%) and maculopathy (4.7%; CI: 3.0-7.4%), while high-income countries had the highest prevalence of mild (10.3%; CI: 4.2-23.2%) and severe NPDR (3.0%; CI: 1.0-8.4%).</p><p><strong>Conclusions: </strong>One in five people with diabetes have diabetic retinopathy. It is imperative that public healthcare take heeds to heighten the screening program to provide all patients with diabetes equitable access to DR screening and ophthalmology services.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"406-418"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39807987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of diabetes and the human papillomavirus: a nationwide population‑based cohort study.","authors":"Soumya Aleti, Micheal T Ulrich, Sherief Ghozy, Sandeep S Nayak","doi":"10.23736/S2724-6507.21.03539-9","DOIUrl":"10.23736/S2724-6507.21.03539-9","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have investigated the correlation between diabetes and HPV vaccination; however, there is little evidence about the association between viral infection and diabetes. This study aims to investigate the association between diabetes and human papillomavirus infection.</p><p><strong>Methods: </strong>Using the USA National Health and Nutrition Examination Survey (2015-2016), records of 571 diabetic and 4170 non‑diabetic patients were extracted. Comparative analyses were used to evaluate differences in the HPV testing results between the two groups. Multivariate logistic regression analyses were used to evaluate independent risk factors for diabetes among all subjects.</p><p><strong>Results: </strong>Positive tests were detected in 6.7% of the oral HPV, 19.5% of the Cobas^® HPV swab (high-risk group), 40.9% of the Roche^® HPV linear array (vaginal swab), and 43.8% of the Roche^® HPV linear array (penile swab). The results of multivariate regression analysis, after adjusting for age, gender, race, marital status, and presence of comorbidities, showed no statistically significant association between positive or negative HPV testing and presence of diabetes mellitus, with an exception for the penile swab using Roche^® HPV linear array (P=0.020).</p><p><strong>Conclusions: </strong>This retrospective database study of HPV infection and diabetes showed no significant association between patients with HPV and those with diabetes.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"366-371"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39913326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights of the October-December 2024 issue.","authors":"Giovanni Vitale","doi":"10.23736/S2724-6507.24.04316-1","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04316-1","url":null,"abstract":"","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"49 4","pages":"351-352"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shift work and body composition: a systematic review and meta-analysis.","authors":"Piumika Sooriyaarachchi, Ranil Jayawardena, Toby Pavey, Neil King","doi":"10.23736/S2724-6507.21.03534-X","DOIUrl":"10.23736/S2724-6507.21.03534-X","url":null,"abstract":"<p><strong>Introduction: </strong>There has been a dramatic increase in the practice of shift work throughout the world. It is known to associate with several adverse health outcomes including increased adiposity. The present study aims to systematically evaluate the literature to find the associations between exposure to shift work and body composition.</p><p><strong>Evidence acquisition: </strong>Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed^®, Web of Science^® and Scopus^® for studies published before 31^st March 2020. Studies which compared the outcome related to the body composition of shift workers and regular day workers were included. A meta-analysis was performed on body fat percentage (BF%).</p><p><strong>Evidence synthesis: </strong>Initial database searching indicated 2311 potentially eligible articles, of which seven studies satisfying the inclusion criteria were selected. The number of participants ranged between 17 to 7318, and the age range of the subjects was between 20-65 years. The studies reported diverse shift schedules including rotating shifts, night, evening shifts, alternate shifts, and regular shifts. Four out of seven studies revealed a higher BF% in shift workers when compared to the non-shift group. The pooled mean difference for BF% between shift workers and regular workers was 1.77% (95% CI: 0.18, 3.35; P=0.03; I²=52%, P>0.12).</p><p><strong>Conclusions: </strong>The meta-analysis of the review showed a significant increase in BF% of shift workers when compared to the non-shift group. However, individual studies showed considerable heterogeneity. Therefore in order to further clarify the underlying mechanisms, more and better quality studies on this field are necessary.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"448-456"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39038910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}