Association of skin autofluorescence and carotid intima-media thickness in acromegaly patients.

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Meliha M Uygur, Mehmet Yaşar, Süreyya Ö Uygur, Dilek D Yazici, Dilek G Yavuz
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引用次数: 0

Abstract

Background: The Pituitary Tumors Centers of Excellence (PTCOE) concept was established to provide a multimodal approach with careful management of comorbidities. Acromegaly, one of the main concerns of PTCOE per se, leads to increased mortality rates of which cardiovascular disease is an important cause. Increased skin autofluorescence (SAF) was shown to be associated with carotid intima-media thickness (CIMT), a well-established marker of atherosclerosis, and consequently cardiovascular complications. This study aimed to evaluate SAF and CIMT in association with anthropometric, clinical, and biochemical parameters in acromegaly patients and healthy controls.

Methods: The study group included 138 acromegaly patients and 127 healthy controls from the Department of Endocrinology and Metabolism Disease, Marmara University Medical School. Growth hormone, insulin-like growth factor I, lipids, glucose, insulin levels were assessed. Advanced glycation end products (AGEs) were measured by the auto-fluorescence reader. CIMT was measured from the common carotid artery wall on B-mode ultrasound.

Results: CIMT and SAF levels were significantly higher in the acromegaly group than the control group. There was a positive correlation between SAF and CIMT both in the total cohort and acromegaly patients. The presence of acromegaly, age, and SAF were the determining factors of CIMT in the whole study cohort.

Conclusions: Our study is the first to examine the relationship between SAF and CIMT in acromegaly patients. We found higher CIMT and enhanced SAF in the acromegaly group compared to the control group with a significant positive correlation in between. The presence of acromegaly was related to increased SAF levels and CIMT. SAF was associated with CIMT in acromegaly patients. Implementation of CIMT and SAF evaluation in this clinical setting may improve cardiovascular complications, particularly in the PTCOE.

肢端肥大症患者皮肤自身荧光与颈动脉内膜-中膜厚度的关系。
背景:垂体肿瘤卓越中心(PTCOE)概念的建立是为了提供一种多模式的方法,并仔细管理合并症。肢端肥大症是PTCOE本身的主要问题之一,它导致死亡率增加,其中心血管疾病是一个重要原因。增加的皮肤自身荧光(SAF)被证明与颈动脉内膜-中膜厚度(CIMT)有关,这是一种公认的动脉粥样硬化和心血管并发症的标志。本研究旨在评估肢端肥大症患者和健康对照者的SAF和CIMT与人体测量学、临床和生化参数的关系。方法:研究对象为马尔马拉大学医学院内分泌与代谢疾病科138例肢端肥大症患者和127例健康对照。评估生长激素、胰岛素样生长因子I、血脂、葡萄糖、胰岛素水平。用自动荧光仪测定晚期糖基化终产物(AGEs)。在b超上从颈总动脉壁测量CIMT。结果:肢端肥大症组CIMT和SAF水平明显高于对照组。在整个队列和肢端肥大症患者中,SAF和CIMT均呈正相关。肢端肥大症、年龄和SAF的存在是整个研究队列中CIMT的决定因素。结论:本研究首次探讨了肢端肥大症患者的SAF和CIMT之间的关系。我们发现与对照组相比,肢端肥大症组的CIMT和SAF升高,两者之间存在显著的正相关。肢端肥大症的存在与SAF水平和CIMT升高有关。肢端肥大症患者的SAF与CIMT相关。在这种临床环境中实施CIMT和SAF评估可能会改善心血管并发症,特别是在PTCOE中。
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CiteScore
4.60
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146
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