Minerva endocrinology最新文献_第3页

Online health information on thyroid nodules: do patients understand them? 关于甲状腺结节的在线健康信息：患者了解它们吗？

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2023-04-06 DOI: 10.23736/S2724-6507.23.03952-0

Emine A Cimbek, Ahmet Cimbek

{"title":"Online health information on thyroid nodules: do patients understand them?","authors":"Emine A Cimbek, Ahmet Cimbek","doi":"10.23736/S2724-6507.23.03952-0","DOIUrl":"10.23736/S2724-6507.23.03952-0","url":null,"abstract":"Background: Given the lack of a previous study assessing understandability and considering there is only one study assessing the readability and quality of online information related to thyroid nodules, we aimed to assess the readability, understandability, and quality of online patient education materials on thyroid nodules.Methods: Materials were identified through an online search performed by inputting the term \"thyroid nodule\" into Google. A total of 150 websites were identified, 59 met the inclusion criteria. Websites were classified as academic and hospital (N.=29), physician and clinic (N.=7), organization (N.=12), and health information websites (N.=11). The readability was evaluated using an online system performing a group of validated readability tests. The Patient Education Materials Assessment Tool (PEMAT) was utilized to assess the understandability. The quality was evaluated through the Journal of the American Medical Association (JAMA) benchmark criteria.Results: Among all websites, the mean reading grade level was 11.25±1.88 (range, 8-16), well above the recommended sixth grade reading level (P<0.001). The mean PEMAT Score was 57.4±14.5% (range, 31-88%). For all groups of types of websites, the understandability score was below 70%. There was no statistical difference between the groups for the average reading grade level or the PEMAT score (P=0.379 and P=0.26, respectively). The average JAMA benchmark score was 1.86±1.38 (range 0-4), health information-based websites scored the highest (P=0.007).Conclusions: Online resources on thyroid nodules are written at grade levels above the recommended reading level. Most resources scored poorly using the PEMAT and varied in quality. Future work should focus on developing understandable, high-quality, and grade-level appropriate materials.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"144-150"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of paraoxonase activity and association with serum advanced glycation end products as reliable markers of oxidative stress in Hashimoto's thyroiditis. 评估桥本氏甲状腺炎患者血清中作为氧化应激可靠标志物的副氧合酶活性及其与血清高级糖化终产物的关联。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2022-10-17 DOI: 10.23736/S2724-6507.22.03931-8

Rosaria M Ruggeri, Maria T Cristani, Francesco Crupi, Maria S Molonia, Nina Burduja, Angela Alibrandi, Alfredo Campennì, Salvatore Cannavò

{"title":"Evaluation of paraoxonase activity and association with serum advanced glycation end products as reliable markers of oxidative stress in Hashimoto's thyroiditis.","authors":"Rosaria M Ruggeri, Maria T Cristani, Francesco Crupi, Maria S Molonia, Nina Burduja, Angela Alibrandi, Alfredo Campennì, Salvatore Cannavò","doi":"10.23736/S2724-6507.22.03931-8","DOIUrl":"10.23736/S2724-6507.22.03931-8","url":null,"abstract":"Background: Oxidative stress has been implicated in the pathogenesis of autoimmune thyroiditis, also referred to as Hashimoto's thyroiditis (HT), and several biomarkers have been measured to evaluate the impact and clinical relevance of oxidative stress in this setting. Recently, advanced glycation end products (AGEs) have been proposed as reliable markers of oxidative stress in HT. In the present study, we investigated the relationship of AGEs with antioxidant paraoxonase (PON-1) activity as potential combined markers of oxidative stress.Methods: We measured the levels of AGEs, and advanced oxidation protein products (AOPPs) and PON-1 activity by spectrophotometric methods, in the serum of 40 HT patients (36 F; mean age 35.4±11.5 year) and 38 age-, sex- and BMI-matched healthy controls. All subjects were euthyroid at recruitment and none was on LT-4 therapy.Results: Serum levels of AGEs were significantly higher (median 378 vs 290 AU/g protein; P<0.001), while PON1 activity was significantly lower (median 165 vs. 201 U/L; P<0.05) in HT patients compared to controls: the two parameters were inversely correlated (P<0.01), clearly indicating a pro-oxidant imbalance in HT patients. At stepwise regression analysis, TPOAb positivity was an independent predictor of both PON-1 activity (P=0.002) and AGEs levels (P=0.000).Conclusions: Increased formation and accumulation of AGEs contribute to enhanced oxidative stress, along with a decrease in PON-1 activity in HT. As a consequence, AGEs levels and alteration in PON 1 may serve as useful markers for monitoring the levels of oxidative stress in this disorder.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"126-133"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33545856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divulging the overlooked condition: diabetic ketoacidosis as an imminent risk with sodium-glucose co-transporter-2 inhibitors treatment in type 2 diabetes mellitus. 揭示被忽视的病情：糖尿病酮症酸中毒是钠-葡萄糖协同转运体-2 抑制剂治疗 2 型糖尿病的一个迫在眉睫的风险。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2024-10-10 DOI: 10.23736/S2724-6507.24.04235-0

Ubaidullah Yousafzai, Afnan Hashmi, Malaika Saqib

引用次数: 0

Effects of melatonin on ovarian function and gene expression of VEGF and IL-8 in autologous transplantation of cryopreserved rat ovarian tissue. 褪黑素对冷冻大鼠卵巢组织自体移植卵巢功能及VEGF、IL-8基因表达的影响。

IF 2.5

Minerva endocrinology Pub Date : 2025-06-01 Epub Date: 2025-01-13 DOI: 10.23736/S2724-6507.24.04249-0

Zou Qian, Xia Zhu, Wen Zou, Lan Nie

引用次数: 0

Metyrapone restores nocturnal cortisol profile and impaired post-dexamethasone suppression in mild autonomous cortisol secretion due to bilateral adrenal incidentaloma. 由于双侧肾上腺偶发瘤，美地塞米松抑制轻度自主皮质醇分泌后，美地塞米松恢复夜间皮质醇谱和受损。

IF 2.5

Minerva endocrinology Pub Date : 2025-05-05 DOI: 10.23736/S2724-6507.25.04327-1

Alessia Longo, Vittorio Oteri, Stefania Panebianco, Francesco Galeano, Veronica Vella, Francesco Frasca, Damiano Gullo, Andrea Tumminia

引用次数: 0

The potential implications of ATM mutations for radioactive iodine therapy in thyroid carcinoma. ATM突变对甲状腺癌放射性碘治疗的潜在影响。

IF 2.5

Minerva endocrinology Pub Date : 2025-04-23 DOI: 10.23736/S2724-6507.25.04340-4

Henrique C Alexandrino, Ana S Oliveira, Fernando Rodrigues

引用次数: 0

Hypophophatasia: the importance of knowing in advance. 超前认知的重要性。

IF 2.5

Minerva endocrinology Pub Date : 2025-03-11 DOI: 10.23736/S2724-6507.24.04222-2

Stefano Stagi, Arianna Maiorana, Alessandra Li Pomi, Letteria A Morabito, Matteo Cerutti, Gianpaolo DE Filippo, Domenico Corica, Maria L Brandi, Malgorzata G Wasniewska

{"title":"Hypophophatasia: the importance of knowing in advance.","authors":"Stefano Stagi, Arianna Maiorana, Alessandra Li Pomi, Letteria A Morabito, Matteo Cerutti, Gianpaolo DE Filippo, Domenico Corica, Maria L Brandi, Malgorzata G Wasniewska","doi":"10.23736/S2724-6507.24.04222-2","DOIUrl":"https://doi.org/10.23736/S2724-6507.24.04222-2","url":null,"abstract":"Hypophosphatasia (HPP) is a rare and highly variable genetic disorder of metabolism characterized by markedly reduced serum alkaline phosphatase (ALP) activity as a result of defective production of tissue-non-specific alkaline phosphatase (TNSALP). HPP is known to affect fetuses in utero and also neonates, children, and adults. Severity ranges significantly, from lethal to mild and clinical presentations include rickets or osteomalacia, osteoporosis, respiratory failure and seizures. Odontohypophosphatasia has only dental manifestations. Low total ALP in serum is the hallmark of HPP, whereas elevated serum concentrations of pyridoxal-5-phosphate and phosphoethanolamine levels represent sensitive and specific biomarkers for HPP. Several pathognomonic radiographic changes are suggestive of HPP. Recently, asfotase alfa, a bone targeted recombinant TNSALP has been used to treat HPP with significant success, highlighting the importance of early diagnosis and intervention. This review describes our current knowledge of HPP, reporting on the epidemiology, classification, clinical presentation and main diagnostic features of the disease, as well as more recent therapeutic approaches.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative balance in Graves' disease: advanced glycation end products and paraoxonase as potential markers of oxidative stress. 格雷夫斯病的氧化平衡：晚期糖基化终产物和对氧醛酸酶作为氧化应激的潜在标志物

IF 2.5

Minerva endocrinology Pub Date : 2025-03-06 DOI: 10.23736/S2724-6507.25.04363-5

Martina Laganà, Angela Alibrandi, Maria T Cristani, Alfredo Campennì, Salvatore Cannavò, Rosaria M Ruggeri

引用次数: 0

Association between β-arrestin-2 and filamin-A gene variations with medical treatment response in acromegaly patients. 肢端肥大症患者β停滞素2和丝胺A基因变异与药物治疗反应的关系

IF 2.5

Minerva endocrinology Pub Date : 2025-03-01 Epub Date: 2021-10-20 DOI: 10.23736/S2724-6507.21.03611-3

Ayse S Akdemir, Derya Metin Armagan, Ozge Polat Korkmaz, Hande M Ozkaya, Pinar Kadioglu, Nurperi Gazioglu, Necmettin Tanriover, Ahmet Dirican, Melek Ozturk

{"title":"Association between β-arrestin-2 and filamin-A gene variations with medical treatment response in acromegaly patients.","authors":"Ayse S Akdemir, Derya Metin Armagan, Ozge Polat Korkmaz, Hande M Ozkaya, Pinar Kadioglu, Nurperi Gazioglu, Necmettin Tanriover, Ahmet Dirican, Melek Ozturk","doi":"10.23736/S2724-6507.21.03611-3","DOIUrl":"10.23736/S2724-6507.21.03611-3","url":null,"abstract":"Background: Acromegaly is a disease that occurs as a result of excessive growth hormone caused by pituitary adenomas. Some acromegaly patients show resistance to somatostatin analog (SSA) treatment. Filamin-A (FLNA) and β-arrestins are thought to play a role in the response to SSAs. We aimed to investigate the relationship between FLNA-rs782079491 and β-arrestin-2-rs34230287 single-nucleotide polymorphisms and disease risk, as well as treatment response in patients with acromegaly in the Turkish population.Methods: The genotypes of 110 acromegaly patients and 99 controls were determined by real-time PCR. The genotype distributions were compared with clinical data on the disease.Results: There was no association between the β-arrestin-2 gene polymorphism and the response to SSA treatment in acromegaly patients. For responder patients to SSAs, the β-arrestin-2-rs34230287 CT+TT genotype was associated with higher microadenoma as compared with the CC genotype (P=0.017). The FLNA polymorphism was not observed in the study group.Conclusions: We showed that there was no association between the polymorphic genotypes of FLNA and β-arrestin-2 genes with acromegaly disease and SSAs response in the Turkish population. However, there was a relationship between β-arrestin-2 and some of the clinical characteristics. Furthermore, the CC genotype and the C allele are risk factors associated with tumor growth rate in acromegaly patients.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"32-41"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39533623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can nutraceuticals counteract the detrimental effects of the environment on male fertility? A parallel systematic review and expert opinion. 营养保健品能否抵消环境对男性生育能力的不利影响？系统回顾与专家意见并行。

IF 2.5

Minerva endocrinology Pub Date : 2025-03-01 Epub Date: 2024-09-11 DOI: 10.23736/S2724-6507.24.04218-0

Tommaso Cai, Luca Boeri, Carlos Miacola, Fabrizio Palumbo, Giancarlo Albo, Pasquale Ditonno, Vito Racanelli, Alessandro Palmieri, Truls E Bjerklund Johansen, Antonio Aversa

{"title":"Can nutraceuticals counteract the detrimental effects of the environment on male fertility? A parallel systematic review and expert opinion.","authors":"Tommaso Cai, Luca Boeri, Carlos Miacola, Fabrizio Palumbo, Giancarlo Albo, Pasquale Ditonno, Vito Racanelli, Alessandro Palmieri, Truls E Bjerklund Johansen, Antonio Aversa","doi":"10.23736/S2724-6507.24.04218-0","DOIUrl":"10.23736/S2724-6507.24.04218-0","url":null,"abstract":"Introduction: Male fertility relies on a complex physiology that may be negatively influenced by lifestyle, diet, and environment. The beneficial effect of nutraceuticals on male fertility is a debated claim. The aim of this study was to assess if the positive effect of nutraceuticals can counteract the negative effects of the environment on male fertility.Evidence acquisition: PubMed®/MEDLINE®, Embase and Cochrane Database were searched (September-October 2023), along with crosschecking of references and search for ongoing studies of the effects of the environment and nutraceuticals on male fertility, in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).Evidence synthesis: Several environmental factors such as microplastic and other endocrine-disrupting chemicals and climate changes may affect the sperm quality in terms of reduction of sperm count number, mobility and altered morphology and thereby reduce male fertility. On the other hand, new evidence demonstrates that a balanced diet rich in antioxidants and essential nutrients, together with minimized exposure to environmental toxins, may improve male fertility and reproductive health. Several nutraceutical compounds proved a protective role against negative environmental effects on male fertility.Conclusions: Available evidence confirms that the environment may negatively impact male fertility, and this impact is estimated to rise in the forthcoming years. On the other hand, new data indicate that nutraceuticals may have a protective role against the negative impact of environmental factors on male fertility. The need for future studies to monitor and explore these aspects of men's health cannot be underestimated.","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":"84-96"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0