Minerva endocrinology最新文献

{"title":"Evaluation of thyroid disease and thyroid malignancy in acromegalic patients.","authors":"Yılmaz Cankurtaran,&nbsp;Güzide G Örük,&nbsp;Büşra Tozduman","doi":"10.23736/S2724-6507.21.03363-7","DOIUrl":"https://doi.org/10.23736/S2724-6507.21.03363-7","url":null,"abstract":"<p><strong>Background: </strong>Differences in epidemiological data from different geographical regions have made the prevalence of thyroid disease and thyroid cancer controversial. No previous study has investigated whether thyroid disease and thyroid cancer prevalence are higher in acromegalic patients than in the general population in Türkiye. The aim of this study is to determine the prevalence of thyroid disease and thyroid cancer in acromegaly and to compare it with the control group.</p><p><strong>Methods: </strong>A total of 129 acromegalic patients (78 female, 51 male) and 247 control group patients (151 female, 96 male) were included in the study. Pituitary size, growth hormone (GH) and insulin-like growth factor (IGF)-1 levels in all patients with acromegaly and thyroid function tests, thyroid receptor autoantibody (TRAb), thyroid scintigraphy, thyroid ultrasonography (US), fine-needle aspiration cytology (FNAC) and histopathology findings after thyroidectomy were recorded.</p><p><strong>Results: </strong>Thyroid lesions were present in 93 patients (72.1%) with acromegaly. While diffuse goiter (14.7%) and multinodular goiter (MNG) (47.3%) were significantly higher, Graves' disease (4.5%) was significantly lower in the acromegaly group compared to control group. The presence of thyroid lesions and thyroid nodules was significantly higher in patients with acromegaly (odds ratio 2.766; 95% CI 2.112-4.469, P<0.001 and OR 1.955; 95% CI 1.206-3.170, P=0.007). According to gender, the prevalence of thyroid lesions, MNG and thyroid cancer was significantly higher in female patients than in the control group. Thyroid cancer prevalence was found in 7% of acromegalic patients and the prevalence of thyroid cancer in the control group was 4.5%.</p><p><strong>Conclusions: </strong>It remains controversial whether the risk of thyroid cancer is increased or not in patients with acromegaly. In this study, there is no significant difference in thyroid cancer between acromegaly and control group, but thyroid lesions are significantly more common in acromegaly. Also, more research is required to determine if thyroid lesions are more prevalent in females with acromegaly.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"130-139"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9824496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anandamide is associated with waist-to-hip ratio but not with Body Mass Index in women with polycystic ovary syndrome.","authors":"Plamena Kabakchieva,&nbsp;Antoaneta Gateva,&nbsp;Tsvetelina Velikova,&nbsp;Tsvetoslav Georgiev,&nbsp;Zdravko Kamenov","doi":"10.23736/S2724-6507.21.03336-4","DOIUrl":"https://doi.org/10.23736/S2724-6507.21.03336-4","url":null,"abstract":"<p><strong>Background: </strong>The endocannabinoid system is involved in the regulation of energy balance and ovarian function and may be implicated in the pathogenesis of polycystic ovary syndrome (PCOS). The purpose of the present study is to determine anandamide (AEA) levels in PCOS patients and controls and to analyze its association with metabolic and hormonal disturbances in women with PCOS.</p><p><strong>Methods: </strong>The study included 88 women - 58 patients with PCOS (25.9±5.2 years) and 30 healthy controls (27.6±5.2 years). Further, patients were divided into two subgroups according to their waist-to-hip ratio (WHR): android type PCOS (WHR≥0.85; N.=26) and gynoid type PCOS (WHR<0.85; N.=32). Detailed anthropometric measurements, hormonal and biochemical tests and pelvic ultrasound were obtained between the 3rd and 5th day of a menstrual cycle. AEA was examined by ELISA kits.</p><p><strong>Results: </strong>Patients with PCOS and healthy controls did not differ in anthropometric, metabolic parameters, AEA, and sex hormone-binding globulin (SHBG) levels. The PCOS group had increased total testosterone, FAI, DHEAS, androstenedione, and 17-OH-progesterone levels (P<0.001) and elevated LH/FSH ratio (P=0.023). A negative correlation between AEA levels was found with glycaemia at 120 minutes (r=-0.304, P=0.020) and WHR (r=-0.266, P=0.044). In the subanalysis of patients, the gynoid type group had significantly higher levels of AEA than the android type PCOS (5.4 [2.3;8.8] vs. 2.5 [1.8;5.1]; P=0.020).</p><p><strong>Conclusions: </strong>AEA did not differ between healthy women and patients, but a significant difference in its levels was found in PCOS patients divided according to their body constitution type.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"150-159"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9841698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-dynamic and multiphase CT protocols for parathyroid glands imaging: a review of technical parameters, radiation dose and diagnostic accuracy.","authors":"Christos P Dimitroukas,&nbsp;Vasileios I Metaxas,&nbsp;Fotios O Efthymiou,&nbsp;Petros E Zampakis,&nbsp;George S Panayiotakis,&nbsp;Christina P Kalogeropoulou","doi":"10.23736/S2724-6507.22.03833-7","DOIUrl":"https://doi.org/10.23736/S2724-6507.22.03833-7","url":null,"abstract":"<p><strong>Introduction: </strong>Our purpose was to review the scientific literature and collect information regarding clinical and technical parameters of different single- or multiphase CT protocols, their diagnostic performance and patient dose during parathyroid imaging.</p><p><strong>Evidence acquisition: </strong>PubMed and Scopus databases were searched for studies investigating the diagnostic performance of CT in detecting parathyroid lesions and the corresponding patients' dose. The following information was retrieved for each article: CT system, number, combination and time interval between phases, scanning length, sensitivity, specificity, accuracy, positive and negative predictive values, contrast enhancement in Hounsfield Units (HUs), technical and exposure parameters, and dose indices. Fifty studies published during the last sixteen years (2005-2021) were reviewed.</p><p><strong>Evidence synthesis: </strong>A large discrepancy in the number and combination of phases, as well as clinical and technical parameters of the CT protocols was indicated. The variations in patients' doses are mainly due to scanners' technology, number and combination of phases, the extent of scanning length, technical parameters (tube voltage, tube current modulation, pitch, reconstruction algorithms), and patient-related parameters. Technical parameters are not always adjusted appropriately to the clinical question or patient size. These variations indicate a large potential to optimize dose during parathyroid imaging without compromising diagnostic performance. The potential is to decrease the number of phases or use low tube voltage protocols, tube current modulation, iterative reconstruction, and reduce the scanning length during some phases.</p><p><strong>Conclusions: </strong>The reporting results could inform researchers about the current status of CT parathyroid imaging and guide their future efforts to optimize both patients' dose and corresponding image quality.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"230-246"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9481694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced ability of Cordova formula for estimation of LDL cholesterol in distinguishing patient requiring lipid lowering treatment.","authors":"Sojit Tomo,&nbsp;Shrimanjunath Sankanagoudar,&nbsp;Ravindra Kg Shukla","doi":"10.23736/S2724-6507.22.03697-1","DOIUrl":"https://doi.org/10.23736/S2724-6507.22.03697-1","url":null,"abstract":"","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"247-250"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9926453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatitis and pancreatic cancer in patients with type 2 diabetes treated with glucagon-like peptide-1 receptor agonists: an updated meta-analysis of randomized controlled trials.","authors":"Besmir Nreu, Ilaria Dicembrini, Federico Tinti, Edoardo Mannucci, Matteo Monami","doi":"10.23736/S2724-6507.20.03219-8","DOIUrl":"10.23736/S2724-6507.20.03219-8","url":null,"abstract":"<p><strong>Introduction: </strong>An association between glucagon-like peptide-1 receptor agonists (GLP1-RA) and risk of pancreatitis and pancreatic cancer has been suggested. Since its first description, several new trials (including three cardiovascular outcome trials) have been published, substantially increasing the available data set. This suggests the need for an update of the previous meta-analysis.</p><p><strong>Evidence acquisition: </strong>A Medline search for GLP-1 receptor agonists (exenatide, liraglutide, lixisenatide, albiglutide, dulaglutide, or semaglutide) was performed, collecting all randomized clinical trials, with duration ≥52 weeks, enrolling patients with type 2 diabetes, and comparing a GLP-1 receptor agonist with placebo or any other non-GLP-1 receptor agonist drug. The endpoints were pancreatitis, pancreatic cancer reported as serious adverse events. Mantel-Haenszel Odds Ratio (MH-OR) with 95% confidence interval (95% CI) was calculated for all outcomes defined above, on an intention-to-treat basis.</p><p><strong>Evidence synthesis: </strong>A total of 43 trials fulfilling inclusion criteria (all reporting data on pancreatitis and pancreatic cancer) was identified. GLP-1 RA showed no association with pancreatitis (MH-OR 1.24 [0.94, 1.64]; P=0.13) and pancreatic cancer (MH-OR 1.28 [0.87, 1.89]; P=0.20).</p><p><strong>Conclusions: </strong>No clear evidence of risk for pancreatitis was observed, whereas data on pancreatic cancer are too scarce to draw any conclusion.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"206-213"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New perspectives in management of diabetes in long-term care facilities.","authors":"Lorenzo Sampietro,&nbsp;Monica Cirone,&nbsp;Luca Lione,&nbsp;Davide Gonella,&nbsp;Gianni Testino,&nbsp;Luigi C Bottaro,&nbsp;Enrico Torre","doi":"10.23736/S2724-6507.23.03994-5","DOIUrl":"https://doi.org/10.23736/S2724-6507.23.03994-5","url":null,"abstract":"","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"127-129"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9971910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of plasma carboxyhemoglobin level on gonadal hormone levels.","authors":"Burak Demirci,&nbsp;Abuzer Coskun","doi":"10.23736/S2724-6507.22.03770-8","DOIUrl":"https://doi.org/10.23736/S2724-6507.22.03770-8","url":null,"abstract":"<p><strong>Background: </strong>In emergency departments, carbon monoxide (CO) is a common cause of toxic poisoning. We aimed to determine the relationship between plasma carboxyhemoglobin (COHb) levels and late post-treatment gonadal hormone changes in CO poisoning.</p><p><strong>Methods: </strong>The study included 237 patients older than 18 who presented to the Emergency Department due to CO intoxication between January 2008 and December 2016. Patients with a COHb level of less than 30% were classified as having mild-to-moderate disease, while those with a COHb level of more than 30% were classified as having severe disease.</p><p><strong>Results: </strong>Of 41 (17%) patients with gonadal hormone change (GHC), 19 (46.3%) were females. In cases with GHC, the exposure time was 5.76±1.64 hours (P=0.001). COHb level was 50.46±4.43% in the severe group (P=0.001), while hormone levels were normal in women and men before CO poisoning. GHC within one month and two years after poisoning was significantly higher (P=0.001). There were 138 (58.2%) patients in the mild-to-moderate group, and 99 (41.8%) patients in the severe group. Of the gonadal hormones, LH2 (luteinizing hormone) was 13.54±3.40 mIU/mL, FSH2 (follicle-stimulating hormone) 16.69±4.35 mIU/mL, PRL2 (prolactin) 16.23±4.73 ng/mL, and TTN2 (testosterone) 644.06±120.40 (P=0.001). In addition, COHb was found to be 42.68±8.42% (P=0.001). In univariate and multivariate Cox regression analysis, gender, LH1, LH2, PRL2, TTN2 and COHb values were found to be prognostic signs in terms of endocrine gonadal hormone change (P<0.05). In the correlation of COHb level with GHC, positive moderate-strong correlation was found between LH2, FSH2, PRL2, TTN2 (P=0.001).</p><p><strong>Conclusions: </strong>In patients admitted to the emergency services due to CO poisoning, elevated COHb may help predict the risk for late gonadal hormone levels.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":"48 2","pages":"140-149"},"PeriodicalIF":4.1,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9472511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenoma weight: the only predictive factor for multiple gland disease in primary hyperparathyroidism.","authors":"Kirsten Lindner,&nbsp;Jochen Kussmann,&nbsp;Volker Fendrich,&nbsp;K Alexander Iwen,&nbsp;Alexandra Zahn","doi":"10.23736/S2724-6507.23.03883-6","DOIUrl":"https://doi.org/10.23736/S2724-6507.23.03883-6","url":null,"abstract":"<p><strong>Background: </strong>Predicting a multiple gland disease (MGD) in primary hyperparathyroidism (pHPT) remains challenging. This study aimed to evaluate predictive factors for MGD.</p><p><strong>Methods: </strong>A retrospective chart review was performed of 1211 patients with histologically confirmed parathyroid adenoma or hyperplasia between 2007-2016. Localization diagnostics, laboratory parameters, and the weight of the resected parathyroid glands were evaluated concerning their predictive value of a multiple-gland disease.</p><p><strong>Results: </strong>A number of 1111 (91.7%) had a single-gland disease (SGD), and 100 (8.3%) a multiple-gland disease (MGD). US and MIBI scans were comparable for either negative or positive adenoma localization and suspected MGD. While the PTH level was similar, the calcium level was higher in SGD (2.8 mmol/L versus 2.76 mmol/L, P=0.034). MGD had a significantly lower gland weight (0.78 g versus 0.31 g; P<0.001). A gland weight of 0.418 grams was a predictive factor for MGD with a sensitivity of 72% and a specificity of 66%.</p><p><strong>Conclusions: </strong>Only the weight of the resected parathyroid adenoma was meaningful in predicting MGD. A cut-off value of 0.418 g can differentiate SGD from MGD.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9607472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACR TI-RADS Score combined with cytopathology classification improves the risk stratification of indeterminate thyroid nodules.","authors":"Francesco Feroci,&nbsp;Davina Perini,&nbsp;Alessio Giordano,&nbsp;Luca Romoli,&nbsp;Tommaso Guagni,&nbsp;Angela Coppola,&nbsp;Iacopo Giani,&nbsp;Serenella Checchi,&nbsp;Alvaro Petrucci,&nbsp;Antonio Sarno,&nbsp;Stefano Cantafio","doi":"10.23736/S2724-6507.22.03929-X","DOIUrl":"https://doi.org/10.23736/S2724-6507.22.03929-X","url":null,"abstract":"<p><strong>Background: </strong>The aim of this retrospective study was the elaboration of a new diagnostic model that integrate cytological reports (2017 Bethesda System for Reporting Thyroid Cytopathology) with ultrasonographic features (based on ACR TI-RADS score) to achieve a more accurate definition of indeterminate thyroid nodule malignancy risk.</p><p><strong>Methods: </strong>Ninety patients submitted to thyroidectomy were divided in three classes: low malignancy risk (AUS/FLUS with TI-RADS 2/TI-RADS 3 and FN/SFN with TI-RADS 2), intermediate malignancy risk (AUS/FLUS with TI-RADS 4/TI-RADS 5 and FN/SFN with TI-RADS 3/TI-RADS 4), and high malignancy risk (FN/SFN with TI-RADS 5).</p><p><strong>Results: </strong>The surgical approach should be recommended in high-risk patients (81.82% of malignancies), carefully evaluated in intermediate risk (25.42%), whereas a conservative approach can be adopted in low-risk patients (0.00%).</p><p><strong>Conclusions: </strong>The integration of these two multiparametric systems in a Cyto-US score has proven to be a feasible and reliable aid to achieve a more accurate definition of malignancy risk.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online health information on thyroid nodules: do patients understand them?","authors":"Emine A Cimbek,&nbsp;Ahmet Cimbek","doi":"10.23736/S2724-6507.23.03952-0","DOIUrl":"https://doi.org/10.23736/S2724-6507.23.03952-0","url":null,"abstract":"<p><strong>Background: </strong>Given the lack of a previous study assessing understandability and considering there is only one study assessing the readability and quality of online information related to thyroid nodules, we aimed to assess the readability, understandability, and quality of online patient education materials on thyroid nodules.</p><p><strong>Methods: </strong>Materials were identified through an online search performed by inputting the term \"thyroid nodule\" into Google. A total of 150 websites were identified, 59 met the inclusion criteria. Websites were classified as academic and hospital (N.=29), physician and clinic (N.=7), organization (N.=12), and health information websites (N.=11). The readability was evaluated using an online system performing a group of validated readability tests. The Patient Education Materials Assessment Tool (PEMAT) was utilized to assess the understandability. The quality was evaluated through the Journal of the American Medical Association (JAMA) benchmark criteria.</p><p><strong>Results: </strong>Among all websites, the mean reading grade level was 11.25±1.88 (range, 8-16), well above the recommended sixth grade reading level (P<0.001). The mean PEMAT Score was 57.4±14.5% (range, 31-88%). For all groups of types of websites, the understandability score was below 70%. There was no statistical difference between the groups for the average reading grade level or the PEMAT score (P=0.379 and P=0.26, respectively). The average JAMA benchmark score was 1.86±1.38 (range 0-4), health information-based websites scored the highest (P=0.007).</p><p><strong>Conclusions: </strong>Online resources on thyroid nodules are written at grade levels above the recommended reading level. Most resources scored poorly using the PEMAT and varied in quality. Future work should focus on developing understandable, high-quality, and grade-level appropriate materials.</p>","PeriodicalId":18690,"journal":{"name":"Minerva endocrinology","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}