Low sirtuin-1 levels are associated with gestational diabetes mellitus.

BACKGROUND This study aims to determine whether sirtuin 1 (SIRT1), which has a regulatory role in glucose and lipid metabolism with its deacetylase activity, has a decisive role in predicting gestational diabetes (GDM). METHODS This study was performed at the antenatal outpatient clinic of Ankara City Hospital between January 2021 and May 2021. A total of 525 women with low-risk pregnancy underwent the 75 g oral glucose tolerance test (OGTT) between 24th-28th weeks of pregnancy during the study period. Fasting serum SIRT 1 levels of patients diagnosed with GDM according to OGTT results were compared some of those without GDM. RESULTS Of the 525 pregnant women who underwent 75 g OGTT, 50 (9.6%) were diagnosed with GDM. The data of pregnant women with GDM were compared with age and body mass index matched 122 controls. While serum SIRT1 levels were 22.0 (19.9-24.3) ng/mL in the GDM group, it was 34.7 (28.8-54.6) ng/ml in the control group (p<0.001). ROC curve analysis showed that a threshold level for serum SIRT1 equal to or greater than 27.3 ng/ml may predict GDM with a sensitivity of 86% and specificity of 80%. CONCLUSIONS Second-trimester low serum SIRT1 levels are associated with GDM. It may be a diagnostic marker for GDM.