来伐替尼对来自一家三级癌症中心的一系列晚期分化良好甲状腺癌的有效性和安全性以及文献综述。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM
Inês L Damásio, Ana Figueiredo, Joana Maciel, Mariana Horta, Tiago N Silva, Joana Simões-Pereira, Sara Donato, Valeriano Leite
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引用次数: 0

摘要

背景:晚期分化型甲状腺癌(DTC)的治疗仍是一项挑战,因为25%-50%的局部浸润性或远处转移性疾病患者对放射性碘(RAI)治疗产生难治性。在这种情况下,酪氨酸激酶抑制剂(TKI)的应用越来越广泛。SELECT试验表明,与安慰剂相比,多激酶抑制剂来伐替尼可显著改善无进展生存期(PFS)。我们的目的是报告来伐替尼在晚期DTC患者中的有效性和安全性:方法:回顾性研究了自2016年1月至2022年1月在一家三级中心随访的25例晚期DTC患者:患者接受来伐替尼治疗的平均日剂量为16.9毫克,平均治疗时间为9.1个月。估计PFS中位数为31.3个月。一名患者获得完全应答。客观反应率(ORR)为40%,疾病控制率为84%。靶病灶最长直径总和从基线到最低点的平均变化率为-36.9%。乐伐替尼延长了86.7%患者的肿瘤体积倍增时间。有趣的是,我们发现使用较低剂量(16.9 毫克)来伐替尼治疗的患者,其肿瘤体积增加了一倍。结论:我们的研究结果证实了来伐替尼的有效性:我们的研究结果证实了来伐替尼治疗晚期DTC患者的有效性,并支持根据患者的表现状态和合并症调整来伐替尼剂量的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness and safety of lenvatinib in a series of advanced well-differentiated thyroid carcinomas from a single tertiary cancer center and literature review.

Background: Treatment of advanced differentiated thyroid carcinoma (DTC) remains a challenge as 25-50% of patients with locally invasive or distant metastatic disease become refractory to radioiodine (RAI) therapy. Tyrosine kinase inhibitors (TKI) are increasingly used in this setting. The SELECT trial demonstrated that lenvatinib, a multikinase inhibitor, significantly improved progression free survival (PFS) compared to placebo. Our aim was to report the effectiveness and safety of lenvatinib in our series of patients with advanced DTC.

Methods: A total of 25 patients with advanced DTC followed at a single tertiary center from January of 2016 to January of 2022 were retrospectively reviewed.

Results: Patients were treated with a mean daily dose of lenvatinib of 16.9 mg for a mean of 9.1 months. Median estimated PFS was 31.3 months. One patient achieved complete response. The objective response rate (ORR) was 40% and the disease control rate was 84%. The mean change in summed longest diameter of target lesions from baseline to nadir was -36.9%. Lenvatinib prolonged the tumor volume doubling time in 86.7% patients. Interestingly, we found that patients treated with a lower dose of lenvatinib (<16.9 mg daily) had a significantly higher PFS and ORR than patients treated with higher dosages (>16.9 mg). Adverse events were frequently reported.

Conclusions: Our results confirm the effectiveness of lenvatinib in the management of patients with advanced DTC and support the need to adjust the dosage of lenvatinib to patient´s performance status and comorbidities.

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CiteScore
4.60
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