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Molecular & Cellular Toxicology最新文献

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Sulfasalazine induces ferroptosis by regulating the PIAS3/JAK1/STAT3 pathway to prevent brain metastases of hepatocellular carcinoma 磺胺氮嗪通过调控PIAS3/JAK1/STAT3通路诱导铁下垂，预防肝癌脑转移
4区 医学
Molecular & Cellular Toxicology Pub Date : 2026-01-22 DOI: 10.1007/s13273-026-00604-y
W. L. Li, Peng Wang, ZhiYuan Zhang
{"title":"Sulfasalazine induces ferroptosis by regulating the PIAS3/JAK1/STAT3 pathway to prevent brain metastases of hepatocellular carcinoma","authors":"W. L. Li, Peng Wang, ZhiYuan Zhang","doi":"10.1007/s13273-026-00604-y","DOIUrl":"https://doi.org/10.1007/s13273-026-00604-y","url":null,"abstract":"Sulfasalazine (SAS) has a certain inhibitory effect on cancer, but its therapeutic effect on intracranial metastasis of hepatocellular carcinoma (HCC) remains unclear. The purpose of this study was to explore whether SAS has a beneficial effect on intracranial metastasis of HCC and reveal its potential molecular mechanism. HCC cells were treated with SAS, and PIAS3/JAK1/STAT3 was regulated by siRNA, pcDNA 3.1 overexpression vector, and JAK inhibitors. The regulatory effects of SAS on the PIAS3/JAK1/STAT3 axis were evaluated by loss- and gain-of-function and rescue experiments. Cancer cells were evaluated by C11-BODIPY probe, MDA detection, iron ion detection, and LPO detection. Proliferation was assessed by clonal formation assay, apoptosis by flow cytometry, invasion and migration by Transwell assay, and EMT-associated protein expression by western blot. The ability of cancer cells to metastasize was evaluated by blood–brain barrier model and xenografted mouse model. SAS effectively hampered HCC cell proliferation, invasion, and migration and EMT process, induced apoptosis and ferroptosis of HCC cells, and prevented brain metastases (BMS) of HCC cells. SAS inhibited JAK1/STAT3 pathway activation in HCC cells by upregulating PIAS3. JAK1 inhibitor enhanced the impact of SAS on HCC, while PIAS3 had the opposite action. SAS blocks JAK1/STAT3 pathway by upregulating PIAS3, thereby inducing ferroptosis and inhibiting BMS in HCC. Combined administration of SAS and JAK inhibitors may be a potential strategy for HCC with brain metastases.","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salidroside attenuates myocardial fibrosis through hindering oxidative stress and inflammation via SIRT1/EZH2 signaling pathway 红柳苷通过SIRT1/EZH2信号通路抑制氧化应激和炎症，减轻心肌纤维化
4区 医学
Molecular & Cellular Toxicology Pub Date : 2026-01-20 DOI: 10.1007/s13273-026-00603-z
Wenxue Jin, Xiulan Qiao
{"title":"Salidroside attenuates myocardial fibrosis through hindering oxidative stress and inflammation via SIRT1/EZH2 signaling pathway","authors":"Wenxue Jin, Xiulan Qiao","doi":"10.1007/s13273-026-00603-z","DOIUrl":"https://doi.org/10.1007/s13273-026-00603-z","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Puerarin’s role in modulating ferroptosis resistance and immune escape in NSCLC via cGAS-STING pathway 葛根素通过cGAS-STING通路调节非小细胞肺癌铁凋亡抵抗和免疫逃逸的作用
4区 医学
Molecular & Cellular Toxicology Pub Date : 2026-01-07 DOI: 10.1007/s13273-025-00597-0
ShaoCong Cao, Shuyan Yu, JianRong Lu, QiaoLing Wang, Liang Tong, Yan Zou, Zhengru Tang, Tao Peng
{"title":"Puerarin’s role in modulating ferroptosis resistance and immune escape in NSCLC via cGAS-STING pathway","authors":"ShaoCong Cao, Shuyan Yu, JianRong Lu, QiaoLing Wang, Liang Tong, Yan Zou, Zhengru Tang, Tao Peng","doi":"10.1007/s13273-025-00597-0","DOIUrl":"https://doi.org/10.1007/s13273-025-00597-0","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"475-486"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-37 attenuates HEI-OC1 cell senescence by modulating the NF-κB pathway IL-37通过调节NF-κB通路减缓HEI-OC1细胞衰老
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-12-29 DOI: 10.1007/s13273-025-00596-1
Luan Xu, Beibei Xu, Liya Ding, Shumin Li, Xiaopei Wu, Guanghui Wang, Yuefeng Han
{"title":"IL-37 attenuates HEI-OC1 cell senescence by modulating the NF-κB pathway","authors":"Luan Xu, Beibei Xu, Liya Ding, Shumin Li, Xiaopei Wu, Guanghui Wang, Yuefeng Han","doi":"10.1007/s13273-025-00596-1","DOIUrl":"https://doi.org/10.1007/s13273-025-00596-1","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"465-474"},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition 藏红花素通过抑制TLR4/NF-κB和NLRP3途径抑制前列腺癌进展
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-12-10 DOI: 10.1007/s13273-025-00594-3
Alice Yu, Mingqiang Li
{"title":"Crocin suppresses prostate cancer progression via TLR4/NF-κB and NLRP3 pathway inhibition","authors":"Alice Yu, Mingqiang Li","doi":"10.1007/s13273-025-00594-3","DOIUrl":"https://doi.org/10.1007/s13273-025-00594-3","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"449-463"},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tongyu Qiangjing Decoction ameliorates spermatogenesis in varicocele rats via inhibition of the NLRP3/Caspase-1/GSDMD pathway and prevention of Sertoli cell pyroptosis 通育强精汤通过抑制NLRP3/Caspase-1/GSDMD通路和预防支持细胞焦亡，改善精索静脉曲张大鼠精子发生
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-12-08 DOI: 10.1007/s13273-025-00593-4
Bin Cai, Hui Feng, Xiaotao Hou, Hongle Zhao
{"title":"Tongyu Qiangjing Decoction ameliorates spermatogenesis in varicocele rats via inhibition of the NLRP3/Caspase-1/GSDMD pathway and prevention of Sertoli cell pyroptosis","authors":"Bin Cai, Hui Feng, Xiaotao Hou, Hongle Zhao","doi":"10.1007/s13273-025-00593-4","DOIUrl":"https://doi.org/10.1007/s13273-025-00593-4","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"433-447"},"PeriodicalIF":0.0,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myricetin alleviates myocardial infarction-induced cardiac fibrosis in mice by upregulating SIRT1 to inhibit TGF-β1/Smad2/3 signaling 杨梅素通过上调SIRT1抑制TGF-β1/Smad2/3信号通路，减轻小鼠心肌梗死诱导的心肌纤维化
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-12-02 DOI: 10.1007/s13273-025-00592-5
Xiaojv Xiong, Rui Dai, Guangji Wang, Xin Guo, Qin He, Jijun Liu, Gang Chen, Pan Lu, Shuang Li, Denghai Liu, Jinhua Liu, Manhua Chen
{"title":"Myricetin alleviates myocardial infarction-induced cardiac fibrosis in mice by upregulating SIRT1 to inhibit TGF-β1/Smad2/3 signaling","authors":"Xiaojv Xiong, Rui Dai, Guangji Wang, Xin Guo, Qin He, Jijun Liu, Gang Chen, Pan Lu, Shuang Li, Denghai Liu, Jinhua Liu, Manhua Chen","doi":"10.1007/s13273-025-00592-5","DOIUrl":"https://doi.org/10.1007/s13273-025-00592-5","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"417-431"},"PeriodicalIF":0.0,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaempferitrin inhibits the malignant progression of glioma by inactivating the USP8/CXCR2 axis 山柰素通过灭活USP8/CXCR2轴抑制胶质瘤的恶性进展
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-11-26 DOI: 10.1007/s13273-025-00590-7
Yu Tan, Yongfeng Shen, Xin Guo, JianHong Huo, Xin Zhao, Shi Zeng
{"title":"Kaempferitrin inhibits the malignant progression of glioma by inactivating the USP8/CXCR2 axis","authors":"Yu Tan, Yongfeng Shen, Xin Guo, JianHong Huo, Xin Zhao, Shi Zeng","doi":"10.1007/s13273-025-00590-7","DOIUrl":"https://doi.org/10.1007/s13273-025-00590-7","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"403-415"},"PeriodicalIF":0.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOXS1 promotes cancer cachexia-induced muscle atrophy by down-regulating PIK3IP1 to activate the PI3K/AKT signaling FOXS1通过下调PIK3IP1激活PI3K/AKT信号通路，促进癌症恶病质诱导的肌肉萎缩
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-11-06 DOI: 10.1007/s13273-025-00584-5
AnLong Yao, GuangKe Li, XuDong Gu, LiLi Cao, Peng Zheng
{"title":"FOXS1 promotes cancer cachexia-induced muscle atrophy by down-regulating PIK3IP1 to activate the PI3K/AKT signaling","authors":"AnLong Yao, GuangKe Li, XuDong Gu, LiLi Cao, Peng Zheng","doi":"10.1007/s13273-025-00584-5","DOIUrl":"https://doi.org/10.1007/s13273-025-00584-5","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"351-361"},"PeriodicalIF":0.0,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tenuigenin exerts neuroprotective effects by activating the Nrf2/HO-1 pathway to perform antioxidant activity and inhibit neuronal ferroptosis, preventing epilepsy in immature mice Tenuigenin通过激活Nrf2/HO-1通路发挥神经保护作用，发挥抗氧化作用，抑制神经元铁下沉，预防未成熟小鼠癫痫
4区 医学
Molecular & Cellular Toxicology Pub Date : 2025-11-04 DOI: 10.1007/s13273-025-00586-3
Qinyun Zhang, Lili Huang, Linling Zhou, Wenfeng Fang, Jie Xu, Siyuan Ma, Chun Ge, Lili Sun, Chen Bu, Weijiang Wu
{"title":"Tenuigenin exerts neuroprotective effects by activating the Nrf2/HO-1 pathway to perform antioxidant activity and inhibit neuronal ferroptosis, preventing epilepsy in immature mice","authors":"Qinyun Zhang, Lili Huang, Linling Zhou, Wenfeng Fang, Jie Xu, Siyuan Ma, Chun Ge, Lili Sun, Chen Bu, Weijiang Wu","doi":"10.1007/s13273-025-00586-3","DOIUrl":"https://doi.org/10.1007/s13273-025-00586-3","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"22 2","pages":"375-390"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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