Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases.

IF 1.1 4区 医学 Q4 TOXICOLOGY
Molecular & Cellular Toxicology Pub Date : 2025-01-01 Epub Date: 2025-02-27 DOI:10.1007/s13273-025-00521-6
Garam An, Jisoo Song, Wei Ying, Whasun Lim
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引用次数: 0

Abstract

Background: Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because the liver is the primary organ for xenobiotic metabolism, the impact of environmental stressors on liver homeostasis and MASLD has garnered significant interest over the past few decades. The concept of metabolism-disrupting chemicals (MDCs) has been introduced to underscore the importance of environmental factors in metabolic homeostasis. Recent epidemiological and biological studies suggest a causal link between exposure to MDCs and prevalence and progression of MASLD.

Objective: This review aims to introduce the emerging concept of MDCs and their representative toxic mechanisms. In particular, this review focuses on broadening the understanding of their impacts on MASLD or metabolic dysfunction-associated steatohepatitis (MASH) progression.

Result: Recent research has highlighted the environmental contaminants, such as heavy metals, microplastics, and pesticides, have the potential to influence hepatic metabolism and aggravate MASLD/MASH progression. These MDCs not only directly affect lipid metabolism in hepatocytes but also affect other cell types, such as immune cells and stellate cells, as well as the gut-liver axis.

Conclusion: Collectively, these findings contribute to establishing a well-defined adverse outcome pathway and identify novel therapeutic options for liver diseases associated with pollutants.

代谢破坏化学物质对脂肪肝疾病进展的危险影响综述
背景:鉴于全球肥胖的增加,代谢功能障碍相关的脂肪变性肝病(MASLD)是一个主要的健康问题。由于肝脏是外源代谢的主要器官,在过去的几十年里,环境应激源对肝脏稳态和MASLD的影响已经引起了人们的极大兴趣。代谢干扰化学物质(MDCs)的概念已经被引入,以强调环境因素在代谢稳态中的重要性。最近的流行病学和生物学研究表明,接触MDCs与MASLD的流行和进展之间存在因果关系。目的:本文旨在介绍新兴的MDCs概念及其具有代表性的毒性机制。特别是,这篇综述的重点是扩大对它们对MASLD或代谢功能障碍相关脂肪性肝炎(MASH)进展的影响的理解。结果:最近的研究表明,重金属、微塑料、农药等环境污染物有可能影响肝脏代谢,加剧MASLD/MASH的进展。这些MDCs不仅直接影响肝细胞的脂质代谢,而且还影响其他细胞类型,如免疫细胞和星状细胞,以及肠-肝轴。结论:总的来说,这些发现有助于建立一个明确的不良后果途径,并确定与污染物相关的肝脏疾病的新治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.50
自引率
17.60%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Molecular & Cellular Toxicology publishes original research and reviews in all areas of the complex interaction between the cell´s genome (the sum of all genes within the chromosome), chemicals in the environment, and disease. Acceptable manuscripts are the ones that deal with some topics of environmental contaminants, including those that lie in the domains of analytical chemistry, biochemistry, pharmacology and toxicology with the aspects of molecular and cellular levels. Emphasis will be placed on toxic effects observed at relevant genomics and proteomics, which have direct impact on drug development, environment health, food safety, preventive medicine, and forensic medicine. The journal is committed to rapid peer review to ensure the publication of highest quality original research and timely news and review articles.
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