Journal of Bone and Mineral Research最新文献

{"title":"Editorial on \"Different Lrp5-HBM mutations induce magnitude- and surface-selective effects that are not explained by receptor trafficking\".","authors":"Mark L Johnson","doi":"10.1093/jbmr/zjag058","DOIUrl":"10.1093/jbmr/zjag058","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"913-914"},"PeriodicalIF":6.5,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture Risk Prediction in Patients Receiving Dialysis.","authors":"Andrea C J Cowan, Yuguang Kang, Stephanie N Dixon, Nivethika Jeyakumar, Jessica M Sontrop, Kristin K Clemens, Amit X Garg","doi":"10.1093/jbmr/zjag123","DOIUrl":"https://doi.org/10.1093/jbmr/zjag123","url":null,"abstract":"<p><p>Patients receiving dialysis face a 5-fold higher risk of skeletal fractures compared to the general population, along with increased mortality and a longer hospital stay after a fracture. However, fracture risk varies among patients, and reliable methods to assess risk are limited. Using linked healthcare databases, we conducted a population-based cohort study of adults aged 40-90 years receiving maintenance dialysis with an available parathyroid hormone (PTH) value in Ontario, Canada (2010-2017). Patients were followed for 3 years or until death, first major fracture, or provincial emigration. Using Fine and Gray subdistribution hazards models accounting for the competing risk of death, we developed a fracture prediction tool (Dial-Frac) that included demographic, comorbidity, and laboratory information. Models were compared using measures of discrimination, calibration, and model fit and were internally validated using 10-fold cross-validation. The cohort included 11,599 patients receiving dialysis. Mean age was 66 years; 39% were female, and 12% had a previous fracture. Over 3 years, 839 patients (7.2%) experienced a fracture (44% of which occurred in the first year); hip fracture was most common (299/839). The final prediction model included age, sex, previous fracture, previous kidney transplant, proton pump inhibitor use, and PTH and serum albumin concentrations. The time dependent area under the receiver operating curve for fracture at 1 and 3 years were 0.79 and 0.71, respectively, indicating good discrimination. We developed Dial-Frac, an easy-to-implement equation that predicts fracture risk in patients receiving maintenance dialysis. It predicts risk at 1 and 3 years without requiring bone density measurements or additional tests, helping to identify high-risk patients for further screening, preventive interventions and clinical trial participation. Next steps include external validation.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of anti-RANKL, zoledronate or combination therapy in a mouse model of fibrous dysplasia: a preclinical study-Editorial.","authors":"Elena Tsourdi","doi":"10.1093/jbmr/zjag121","DOIUrl":"10.1093/jbmr/zjag121","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large scale proteomic analyses of HR-pQCT-derived bone loss at the radius and tibia in older men.","authors":"Eric Orwoll, Jack Wiedrick, Charles Ginsberg, Nancy E Lane, Lisa Langsetmo, Nicola Napoli, Andrew J Burghardt, Jodi Lapidus, Osteoporotic Fractures In Men MrOS Study Research Group","doi":"10.1093/jbmr/zjag120","DOIUrl":"https://doi.org/10.1093/jbmr/zjag120","url":null,"abstract":"<p><p>Although bone loss progresses rapidly in older adults, its biological drivers are poorly understood, and effective biomarkers are not available. We used large-scale discovery proteomics to identify serum proteins associated with bone loss, and to develop predictive signatures, in older men (mean age 84 yr). Rates of distal radial and tibial bone loss were assessed with high-resolution peripheral quantitative computed tomography (HR-pQCT) over ~6 yr, and ~ 7 K serum proteins were measured with aptamer-based assays (SomaLogic). Using stringent statistical criteria, 22 proteins were found to be associated with incident bone loss. Higher levels of FSH were most consistently and robustly linked to greater loss. Several other biological pathways were associated with change in bone, including inflammation and endocrine influences. Protein associations with radial and tibial loss were broadly similar, but with distinct patterns. A 22-protein signature was strongly related to bone loss and was considerably more predictive of change than other bone remodeling markers. These data are among the first to examine the serum proteins associated with longitudinal bone loss, and they implicate several underlying biological processes that might be related. The distinct protein patterns associated with loss at radial and tibial sites suggest the nature of those events may be site specific. Serum protein signatures may provide value in predicting those with more rapid bone loss.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The impact of segmentation approach on HR-pQCT microarchitectural and biomechanical metrics depends on bone structure.","authors":"","doi":"10.1093/jbmr/zjag116","DOIUrl":"10.1093/jbmr/zjag116","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Time-lapse HR-pQCT reliably assesses and monitors local bone turnover in patients with chronic kidney disease.","authors":"","doi":"10.1093/jbmr/zjag115","DOIUrl":"https://doi.org/10.1093/jbmr/zjag115","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage.","authors":"David Achudhan, Jacob Orme, Ritika Sharma, Aqsa Komel, Khubaib Gul Khan, Thomas A White, Nathan K LeBrasseur, Sundeep Khosla, Sean S Park, Robert J Pignolo, Abhishek Chandra","doi":"10.1093/jbmr/zjag122","DOIUrl":"10.1093/jbmr/zjag122","url":null,"abstract":"<p><p>Cellular senescence has been implicated in the pathophysiology of radiotherapy-associated bone loss. Based on our previous work, clearance of senescent cells using genetic and pharmacological tools alleviates the anomalies associated with radiation-associated bone deterioration. The pro-inflammatory senescence associated secretome referred to as senescence associated secretory phenotype (SASP), is a hallmark of cellular senescence. The modulation of SASP by senomorphic drugs, potentially can suppress the pro-inflammatory secretome of senescent cells, irrespective of the underlying senescence mechanism. In this study we tested a senomorphic drug, ruxolitinib, a Janus kinase inhibitor (JAKi), during acute and chronic radiotherapy related effects on the bone. Our clinical data indicate an early increase in several pro-inflammatory SASP proteins following radiotherapy of spinal metastasis in prostate cancer patients. Longitudinal assessment of SASP-related genes confirmed this acute elevation in several SASP markers in systemic circulation following irradiation of male mouse femurs. In studies done in male mice, following three preclinical radiotherapy regimens of 30Gy (5 x 6Gy), 60Gy (5 x 12Gy) and a single dose of 24Gy, suppression of SASP by JAKi was efficacious in suppressing radiation-induced bone damage. In comparison and as shown before, the senolytic combination of D+Q was also able to alleviate radiation-associated bone loss. Early and intermittent suppression of SASP using JAK inhibitors in male mice alleviated chronic bone deterioration, diminished telomere dysfunction, lowered senescence and SASP marker expression and reduced bone-marrow adiposity. Overall, our study shows that early targeting of SASP proteins could be a potential therapeutic to prevent radiotherapy-related chronic bone loss and risk of fractures.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One axis, two skeletal fates - PD-L1 blockade spares bone where PD-1 blockade does not. Editorial on Searcy et al. \"Programmed cell death ligand 1 (PD-L1) inhibition in tumor-naïve mice is bone-sparing throughout the lifespan\".","authors":"Hanna Taipaleenmäki","doi":"10.1093/jbmr/zjag118","DOIUrl":"10.1093/jbmr/zjag118","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Microarchitecture and Mechanical Competence Are Associated with Fracture Across Race and Sex in Older Adults.","authors":"Ragyie Rawal, Sanchita Agarwal, Carmen Germosen, Isabella Rosillo, Ivelisse Colon, Jordan Barry, Mildense Del Orbe, Mariana Bucovsky, Lynette X Lopez, Elizabeth Shane, X Edward Guo, Marcella Walker","doi":"10.1093/jbmr/zjag119","DOIUrl":"https://doi.org/10.1093/jbmr/zjag119","url":null,"abstract":"<p><p>Studies evaluating skeletal differences by fracture status used predominantly White female cohorts with limited data in other races and men. Using high-resolution peripheral quantitative CT and microfinite element analysis, we compared skeletal health by fracture status and assessed the effect of socioeconomic (SE) factors and effect modification by race and sex in a population-based study in New York City. Participants with historical fractures (Fx) included adult fractures (18+ yrs; no digits, skull, face). Of 935 (age 76.1±6.3 yrs, 71% female, 27.7% Black, 29.7% White, 41.3% Mixed), 32% had 444 fractures. Results were adjusted for age, BMI, sex, race, ethnicity, past osteoporosis treatment, and oral glucocorticoid use. At the distal radius, the Fx group had worse trabecular (Tb) and cortical (Ct) parameters with 9.7-10.3% lower failure load (FL) and stiffness (p<0.001). At the distal tibia, results were similar with 5.9% lower FL and stiffness in the Fx group (p<0.001). Adjusting for SE factors, Tb and Ct parameters remained worse in the Fx group with lower FL and stiffness. Stiffness and FL varied by race and sex but were lower in Fx vs. NoFx groups within each race and sex. Race and sex did not modify the relationship between stiffness or FL and fracture status. In the whole cohort, higher stiffness (ORRadius 0.732, [95%CI: 0.563, 0.931], p=0.014; ORTibia 0.866, [95%CI: 0.783, 0.954], p=0.004) and FL (ORRadius 0.597, [95%CI: 0.404, 0.893], p=0.011; ORTibia 0.778, [95%CI: 0.681, 0.888], p<0.001) at the distal radius and tibia were associated with lower odds of incident fracture. Hispanic ethnicity was associated with lower odds of incident fracture independent of radial stiffness (OR 0.289, [95%CI: 0.081, 0.845], p=0.038) and FL (OR 0.286, [95%CI: 0.080, 0.842], p=0.038). In conclusion, in this multiethnic cohort, stiffness and FL were independently associated with prevalent and incident fractures, regardless of race or sex.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental History of Hip Fracture is Associated with Trabecular Deterioration.","authors":"Sanchita Agarwal, Ragyie Rawal, Carmen Germosen, Mariana Bucovsky, Ivelisse Colon, Mildense Del Orbe, Lynette X Lopez, X Edward Guo, Marcella Walker","doi":"10.1093/jbmr/zjag111","DOIUrl":"https://doi.org/10.1093/jbmr/zjag111","url":null,"abstract":"<p><p>Parental history of hip fracture is an independent risk factor for fragility fracture, yet the skeletal traits underlying this risk remain poorly defined. We examined whether parental hip fracture is associated with differences in bone microarchitecture and estimated bone strength in a large, ethnically diverse cohort of older adults (n = 950; mean age 76.1 ± 6.2 yr; 71% female; 55.8% Hispanic) using high resolution peripheral quantitative computed tomography (HR-pQCT) with individual trabecula segmentation (ITS) and finite element-based analysis. Ten percent (n = 95) reported a parental hip fracture. Femoral neck aBMD was 3.8% lower in those with versus without parental history (p = .04). At the radius, the parental hip fracture group had lower adjusted trabecular rod bone volume fraction (10.6%), plate and rod number, axial BV/TV (12.2%) and plate connectivity (9.5%; all p < .05). At the tibia, parental hip fracture history was associated with lower adjusted trabecular density (8.8%), trabecular thickness (2.4%), plate and axial BV/TV (14%-15%, all p < .05), and 4%-5% lower estimated stiffness and failure load, differences that persisted after adjustment for aBMD. Patterns were similar regardless of race/ethnicity and whether parental hip fracture was maternal or paternal. Similar patterns were observed in a subset who were matched by propensity score. Individuals with a parental history of hip fracture exhibited significant microarchitectural deterioration, especially in trabecular structure at weight-bearing sites, and reduced estimated bone strength independent of areal BMD. These findings suggest that inherited deficits in trabecular morphology may contribute to familial fracture susceptibility and underscore the utility of HR-pQCT in identifying heritable skeletal fragility beyond DXA indices.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":6.5,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148596924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}