Melanoma Research最新文献_第4页

Real-world recurrence-free and distant metastasis-free survival in early-stage melanoma: concordance with KEYNOTE-716 trial estimates. 早期黑色素瘤的真实世界无复发和无远处转移生存：与KEYNOTE-716试验估计相符。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-06-24 DOI: 10.1097/CMR.0000000000001101

Carole R Berini, Jessica K Paulus, Malcolm Charles, Zhaohui Su, Paul Conkling, Shan Jiang, Kaushal D Desai

{"title":"Real-world recurrence-free and distant metastasis-free survival in early-stage melanoma: concordance with KEYNOTE-716 trial estimates.","authors":"Carole R Berini, Jessica K Paulus, Malcolm Charles, Zhaohui Su, Paul Conkling, Shan Jiang, Kaushal D Desai","doi":"10.1097/CMR.0000000000001101","DOIUrl":"10.1097/CMR.0000000000001101","url":null,"abstract":"Real-world evidence is increasingly used to support treatment effectiveness in oncology research, but endpoint validation in early stage melanoma is limited. This study evaluated the concordance between real-world recurrence-free survival (rwRFS) and distant metastasis-free survival (rwDMFS) with KEYNOTE-716 trial control arm estimates. This was a retrospective observational cohort study using electronic health record data from US community oncology practices within The US Oncology Network. Eligible patients were diagnosed with stage IIB-IIC cutaneous melanoma between 1 January 2018 and 5 December 2023 and had not initiated adjuvant therapy 12 weeks postresection with clear margins. Trial eligibility criteria were applied to define a real-world cohort aligned with that of KEYNOTE-716. Available baseline characteristics were balanced between the two populations using a matching-adjusted indirect comparison. Hazard ratios, confidence intervals (CIs), and P -values were calculated for rwRFS and rwDMFS with the KEYNOTE-716 control arm as the reference. After applying eligibility criteria, 75 patients were included in the real-world cohort. Adjusted hazard ratios for rwRFS and rwDMFS were: 1.17 (95% CI: 0.71-1.94; P = 0.527) and 0.83 (95% CI: 0.51-1.37; P = 0.462), respectively. Sensitivity analyses that censored real-world patients at the time of immunotherapy treatment gave adjusted hazard ratios of 0.98 (95% CI: 0.59-1.64; P = 0.938) for rwRFS, and 0.70 (95% CI: 0.41-1.17; P = 0.171) for rwDMFS. rwRFS and rwDMFS were concordant with estimates from the KEYNOTE-716 control arm. Results of real-world endpoints can reliably reflect clinical trial outcomes when key study design elements are aligned. These findings increase confidence in the validity of real-world outcomes for early stage melanoma.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"296-306"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-evaluating melanoma treatment: a comparative look at herpes simplex virus and coxsackievirus oncolytic therapies in advanced melanoma: a meta-analysis of clinical trials. 重新评估黑色素瘤治疗：单纯疱疹病毒和柯萨奇病毒溶瘤治疗晚期黑色素瘤的比较研究：临床试验的荟萃分析

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-05-14 DOI: 10.1097/CMR.0000000000001105

Hasan Aziz, Hannah Pirzada, Ashfaq Ahmad, Javed Iqbal, Arej Iltaf, Moazzam Akhtar, Nawazish Ali, Asraf Hussain

{"title":"Re-evaluating melanoma treatment: a comparative look at herpes simplex virus and coxsackievirus oncolytic therapies in advanced melanoma: a meta-analysis of clinical trials.","authors":"Hasan Aziz, Hannah Pirzada, Ashfaq Ahmad, Javed Iqbal, Arej Iltaf, Moazzam Akhtar, Nawazish Ali, Asraf Hussain","doi":"10.1097/CMR.0000000000001105","DOIUrl":"10.1097/CMR.0000000000001105","url":null,"abstract":"Advanced melanoma, a highly lethal skin cancer, causes most skin cancer-related deaths. Oncolytic monotherapy or alongside immune checkpoint inhibitors (ICIs) is emerging as a promising treatment. Evaluating the therapeutic benefit and toxicity profile of different oncolytic viruses is essential to identify the most effective option. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-based meta-analysis was conducted to assess and contrast the therapeutic effectiveness and tolerability of herpes simplex virus (HSV) and coxsackievirus (CSV) therapies, both alone or alongside ICIs. Searches were performed in PubMed, Scopus, and clinicaltrials.gov . We extracted data on tumor objective response rates (ORRs) and the occurrence of serious (grade 3 or higher) treatment-related adverse events. Risk of bias was assessed using the ROBINS tools. Twenty trials comprising 1509 patients were included. CSV therapy demonstrated an ORR of 35%, falling between HSV monotherapy (31%) and HSV-ICI combination therapy (45%). CSV therapies, even in combination, were associated with fewer incidents of severe adverse events (17%) compared with HSV-ICI treatment (24%). HSV monotherapy also had similar fewer incidents of serious adverse events (16%). Among ICIs pembrolizumab showed the most favorable outcomes. HSV-ICI therapy showed the highest ORR but with more incidences of serious adverse events, while CSV therapy, even in combinations, offered a good safety-efficacy balance. HSV monotherapy or CSV may be favored when minimizing toxicity is a priority, even if it comes at the cost of some reduced response rate. However, combining CSV with ICIs may surpass talimogene laherparepvec monotherapy in efficacy because of the reduced likelihood of tumor resistance.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"239-250"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of fully regressive melanoma in the absence of metastasis. 一例罕见的完全退行性黑色素瘤，无转移。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-06-02 DOI: 10.1097/CMR.0000000000001111

Antonios Kyriakopoulos, Vasilios Kyriakopoulos, Christina Vourlakou, Stavros Balasis, Efthimios Paronis, Helen John Gogas

{"title":"A rare case of fully regressive melanoma in the absence of metastasis.","authors":"Antonios Kyriakopoulos, Vasilios Kyriakopoulos, Christina Vourlakou, Stavros Balasis, Efthimios Paronis, Helen John Gogas","doi":"10.1097/CMR.0000000000001111","DOIUrl":"10.1097/CMR.0000000000001111","url":null,"abstract":"Fully regressive melanoma is an exceedingly rare phenomenon characterized by the complete histopathologic disappearance of malignant melanocytes, replaced by fibrosis, melanophages, and lymphocytic infiltrates, without identifiable residual tumor cells. We report the case of a 71-year-old female who presented with a pigmented lesion of the right auricle, which was incidentally noted by her daughter. Clinical examination revealed a darkly pigmented, asymmetrical macule with retention of hair follicles, raising suspicion for a benign melanocytic nevus. Excisional biopsy revealed complete regression of a superficial spreading melanoma without measurable Breslow thickness or vertical growth phase. Immunohistochemical studies demonstrated positivity for melanocytic markers and a low proliferative index, while imaging with PET/computed tomography and MRI revealed no evidence of regional or distant metastasis. Given the absence of high-risk features, sentinel lymph node biopsy was not performed, and the patient underwent wide local excision with no residual malignancy identified. She remains disease-free under close clinical follow-up. This case highlights the diagnostic and management challenges associated with fully regressive melanoma and emphasizes the need for heightened clinical suspicion and individualized treatment strategies. Further research is required to better understand the prognostic significance and optimal follow-up protocols for this rare melanoma subtype.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"334-338"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors to consider in a primary care setting when using convolutional neural network tools for melanoma diagnostics: a retrospective analysis of images and patient characteristics. 当使用卷积神经网络工具进行黑色素瘤诊断时，在初级保健环境中要考虑的因素：对图像和患者特征的回顾性分析。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-06-24 DOI: 10.1097/CMR.0000000000001110

My Söderholm, Anna Moberg, Magnus Falk

{"title":"Factors to consider in a primary care setting when using convolutional neural network tools for melanoma diagnostics: a retrospective analysis of images and patient characteristics.","authors":"My Söderholm, Anna Moberg, Magnus Falk","doi":"10.1097/CMR.0000000000001110","DOIUrl":"10.1097/CMR.0000000000001110","url":null,"abstract":"Primary care physicians typically perform the initial assessment of skin lesions. Artificial intelligence tools, using techniques such as convolutional neural networks, are under development and have shown promise for evaluating dermoscopic images for the detection of skin cancer. These tools could possibly support physicians. This study investigated possible factors that might affect the specificity of an artificial intelligence tool, associated with the patient, lesion, or dermoscopic characteristics, which clinicians could potentially avoid, or for which the tool could be optimized. A total of 228 dermoscopic images from a prospective clinical trial in primary care were retrospectively examined by a resident general practitioner using conventional dermoscopy algorithms to describe the lesion characteristics. All lesions falsely classified as melanomas suspected by the artificial intelligence tool in the trial were compared with the true negative lesions with regard to lesion and patient characteristics. Elevated lesions were more often correctly classified as benign compared with macular lesions [odds ratio (OR) = 16, 95% confidence interval (CI) = 2.0-120, P = 0.008]. The tool was more likely to falsely suspect melanoma if the ruler in the dermoscopic image was located over the lesion (OR = 2.0, 95% CI = 1.1-3.4, P = 0.017). This indicates that elevated lesions can be reliably assessed when using this type of tool, while the presence of a ruler might need attention in the optimization of artificial intelligence tools for melanoma assessment.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"344-348"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148265435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy and risk of melanoma: a matched retrospective cohort study. 妊娠与黑色素瘤风险：一项匹配的回顾性队列研究。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-06-24 DOI: 10.1097/CMR.0000000000001109

Brandon R Block, Jaanvi Mehta, Camille M Powers, Jonathan Ungar, Seher Banu Farabi Atak, Nicholas Gulati

{"title":"Pregnancy and risk of melanoma: a matched retrospective cohort study.","authors":"Brandon R Block, Jaanvi Mehta, Camille M Powers, Jonathan Ungar, Seher Banu Farabi Atak, Nicholas Gulati","doi":"10.1097/CMR.0000000000001109","DOIUrl":"10.1097/CMR.0000000000001109","url":null,"abstract":"Pregnancy-associated melanoma has long been debated, with hypotheses that gestational immune tolerance and elevated sex hormones may promote melanocytic transformation; however, large-scale, real-world evidence remains limited and conflicting. Using the TriNetX Global Collaborative Network, we conducted a retrospective cohort study of pregnant patients with documented first and third trimester encounters versus reproductive-age nonpregnant females with an encounter for contraceptive management and equivalent follow-up. Cohorts were 1:1 propensity-score matched on demographics, comorbidities relevant to immune function and cancer risk, and proxies for sun exposure and dermatologic surveillance. Incident invasive melanoma and melanoma in situ (MIS), stratified by anatomic site, were evaluated over a 21-month observation window corresponding to the duration of pregnancy plus 1 year postpartum. A sensitivity analysis restricted the pregnant cohort to patients with prior estrogen-based therapy exposure. In the primary analysis ( n = 854 193 per cohort), pregnancy was not associated with increased risk of invasive melanoma [hazard ratio: 0.92, 95% confidence interval (CI): 0.78-1.07) or MIS (hazard ratio: 1.01, 95% CI: 0.82-1.24), and no significant differences emerged at head and neck, trunk, or extremity subsites. In the sensitivity analysis ( n = 128 716 per cohort), findings were consistent, with no observed association with invasive melanoma (hazard ratio: 1.06, 95% CI: 0.76-1.49) or MIS (hazard ratio: 1.05, 95% CI: 0.67-1.65). Our results argue against pregnancy as an independent melanoma risk factor and point toward a baseline risk inherent to reproductive-age females.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"349-352"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CTLA-4 and TNFRSF1B genetic variants in clinicopathological aspects and outcome of cutaneous melanoma. CTLA-4和TNFRSF1B基因变异在皮肤黑色素瘤的临床病理和预后中的作用

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-06-24 DOI: 10.1097/CMR.0000000000001108

Juliana Carron, Ana Maria Castro Ferreira, Bruna Fernandes Carvalho, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima

{"title":"CTLA-4 and TNFRSF1B genetic variants in clinicopathological aspects and outcome of cutaneous melanoma.","authors":"Juliana Carron, Ana Maria Castro Ferreira, Bruna Fernandes Carvalho, Gustavo Jacob Lourenço, Carmen Silvia Passos Lima","doi":"10.1097/CMR.0000000000001108","DOIUrl":"10.1097/CMR.0000000000001108","url":null,"abstract":"Cutaneous melanoma is the most aggressive form of skin cancer, influenced by environmental and genetic factors, particularly immune-related genes like cytotoxic T-lymphocyte-associated protein 4 ( CTLA-4 ) and TNFRSF1B . We investigated the association of inherited single nucleotide variants in CTLA-4 (rs11571316, rs62182595, rs11571315, and rs4553808) and TNFRSF1B (rs3397, rs1061622, rs1061624, and rs1061628) with clinicopathological aspects and survival of 428 cutaneous melanoma patients. Carriers of CTLA-4 rs4553808 AG/GG plus TNFRSF1B rs3397 TC/CC genotypes were younger at diagnosis. The CTLA-4 rs4553808 AA plus TNFRSF1B rs1061624 GG genotypes were more common in male than female patients. CTLA-4 rs4553808 AA or rs62182595 GG plus TNFRSF1B rs1061624 GG were more frequent among patients with tumors on the head, neck, and trunk. Patients older than 54 years with CTLA-4 rs11571316 GG and TNFRSF1B rs3397 TT had a 3.04-times greater chance of progression to death because of tumor effects. Patients with head, neck, and trunk cutaneous melanoma carrying CTLA-4 rs4553808 AG/GG and TNFRSF1B rs1061624 GA/AA had a 2.30-times greater chance of recurrence, progression, or tumor-related death. Patients with head, neck, and trunk cutaneous melanoma carrying CTLA-4 rs4553808 AG/GG and TNFRSF1B rs1061624 GA/AA, and CTLA-4 rs62182595 GA/AA and TNFRSF1B rs1061624 GA/AA genotypes had a 2.97- and 2.75-times greater chance of progression to death because of tumor effects, respectively. These findings suggest immune modulation linked to these single nucleotide variants may facilitate cutaneous melanoma progression and highlight the potential for immunotherapeutic strategies in genetically predisposed patients.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"263-273"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148016378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

E26 transformation-specific translocation variant 4 participates in melanoma progression and immune evasion by mediating the CD47molecule/signal regulatory protein α pathway. E26转化特异性易位变异4通过介导cd47分子/信号调节蛋白α途径参与黑色素瘤的进展和免疫逃避。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-04-27 DOI: 10.1097/CMR.0000000000001099

Xuetao Lu, Meng Chen, Huayu Fan, Shuangshuang Gao, Jinguang Chen

{"title":"E26 transformation-specific translocation variant 4 participates in melanoma progression and immune evasion by mediating the CD47molecule/signal regulatory protein α pathway.","authors":"Xuetao Lu, Meng Chen, Huayu Fan, Shuangshuang Gao, Jinguang Chen","doi":"10.1097/CMR.0000000000001099","DOIUrl":"10.1097/CMR.0000000000001099","url":null,"abstract":"Melanoma is an aggressive form of skin cancer with few effective treatments available at advanced stages. E26 transformation-specific translocation variant 4 (ETV4) is implicated in tumor progression in several malignancies. However, its role in melanoma and immune evasion remains poorly defined. The objective of this study was to investigate the expression and function of ETV4 in melanoma. ETV4 expression in melanoma tissues and cells was assessed by bioinformatics, quantitative PCR, Western blotting, and immunohistochemistry. Melanoma cell lines with ETV4 overexpression or knockdown were assessed for colony formation, wound healing, and Transwell migration/invasion. The regulatory relationship between ETV4 and integrin-associated protein (CD47) was investigated via dual-luciferase reporter assays and chromatin immunoprecipitation. Macrophage-mediated phagocytic activity was assessed using flow cytometry. ETV4 was markedly upregulated in melanoma tissues and cells, correlating with poor patient survival. Overexpression of ETV4 facilitates melanoma cell proliferation, migration, and invasion. Mechanistically, ETV4 directly bound to the CD47 promoter, transcriptionally activating its expression. ETV4 overexpression enhanced the phosphorylation of Src homology region 2 domain-containing phosphatase-1 and suppressed macrophage phagocytosis, suggesting activation of the CD47/signal regulatory protein α immune checkpoint pathway. Notably, knockdown of CD47 reversed the immunosuppressive effects induced by ETV4 overexpression, restoring macrophage phagocytic activity. ETV4 promotes melanoma progression and immune evasion by upregulating CD47 and activating the CD47/signal regulatory protein α signaling axis. Targeting the ETV4/CD47 pathway may represent a promising therapeutic option to enhance antitumor immunity in melanoma.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"251-262"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variability in synoptic reporting and inclusion of essential histopathologic elements in cutaneous melanoma biopsy pathology reports. 在皮肤黑色素瘤活检病理报告中，天气报告和基本组织病理因素的可变性。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-06-24 DOI: 10.1097/CMR.0000000000001106

Amelia Grace Stapleton Van Doren, Hemali Shah, Ruthia Chen, Dia Shah, Samantha King, Lucie Joerg, Ekaterina Sazon, Francisco Alicandri, Aasim Jaffri, Aimi Toyama Rothrock, Lindy Davis

{"title":"Variability in synoptic reporting and inclusion of essential histopathologic elements in cutaneous melanoma biopsy pathology reports.","authors":"Amelia Grace Stapleton Van Doren, Hemali Shah, Ruthia Chen, Dia Shah, Samantha King, Lucie Joerg, Ekaterina Sazon, Francisco Alicandri, Aasim Jaffri, Aimi Toyama Rothrock, Lindy Davis","doi":"10.1097/CMR.0000000000001106","DOIUrl":"10.1097/CMR.0000000000001106","url":null,"abstract":"Complete, accurate melanoma pathology reports are essential for effective communication between pathologists and treating physicians. The College of American Pathologists (CAP) recommends synoptic reporting for melanoma biopsy pathology reports, while an American Academy of Dermatology (AAD) work group recommended inclusion of essential elements. We aimed to assess completeness of biopsy pathology reports according to the CAP guidelines and AAD recommendations. Biopsy reports of patients referred for invasive melanoma treatment to our academic center from 2017 to 2022 were retrospectively reviewed. Sixty-two percent of reports included all core elements outlined within the CAP guidelines, while 54% of reports included all AAD recommendations. Frequently omitted elements included margin status as well as neurotropism. Breslow depth and ulceration were included in 99% of reports. Report completeness was significantly associated with laboratory type, with the highest rates observed at academic centers and the lowest at third-party laboratories. Variability in melanoma biopsy pathology reporting remains common. Incomplete documentation, including deep margin status, may introduce uncertainty in pathologic T stage interpretation from a surgical management perspective. Wider adoption of standardized biopsy templates may improve reporting consistency, while increased awareness of biopsy report interpretation and application may reduce ambiguity and improve communication between pathologists and clinicians.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"307-313"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sentinel lymph node detection in melanoma: indocyanine green fluorescence compared with conventional mapping techniques. 黑色素瘤前哨淋巴结检测：吲哚菁绿荧光与传统作图技术的比较。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-08-01 Epub Date: 2026-05-11 DOI: 10.1097/CMR.0000000000001104

Yu Zhang, Sahar Borna, Rajendra Saw-Martinez

{"title":"Sentinel lymph node detection in melanoma: indocyanine green fluorescence compared with conventional mapping techniques.","authors":"Yu Zhang, Sahar Borna, Rajendra Saw-Martinez","doi":"10.1097/CMR.0000000000001104","DOIUrl":"10.1097/CMR.0000000000001104","url":null,"abstract":"Accurate sentinel lymph node (SLN) mapping is essential for staging melanoma and guiding adjuvant therapy. Conventional mapping uses technetium-99m (Tc-99m) radiocolloid ± blue dye. Near-infrared fluorescence with indocyanine green (ICG) offers real-time, radiation-free visualization but varies in transcutaneous performance. This review synthesizes contemporary evidence comparing ICG to Tc-99m and blue dye for SLN detection in melanoma, highlighting anatomic, technical, and safety considerations relevant to surgical workflow. Narrative review of prospective series, head-to-head studies, and recent systematic reviews/meta-analyses evaluating SLN identification rates, node-level detection, transcutaneous vs. intraoperative fluorescence, false-negative considerations, and adverse events, with special attention to head/neck melanoma and dual-tracer strategies. ICG achieves high patient-level SLN identification (≈79-100%), comparable to Tc-99m (≈86-100%) and consistently superior to blue dye alone. Dual-tracer approaches (ICG + Tc-99m or ICG + blue dye) frequently report near-universal detection and practical reductions in missed nodes. Transcutaneous fluorescence through intact skin is variable, limited by near-infrared penetration and BMI, whereas intraoperative fluorescence after a small incision is highly reliable and expedites dissection. Head/neck basins particularly benefit from real-time fluorescence to delineate complex channels and confirm first-echelon nodes. ICG demonstrates an excellent safety profile with rare hypersensitivity, avoids radiation exposure, and integrates smoothly with gamma-probe guidance. Adoption barriers include heterogeneous dosing/timing, equipment cost, and lack of standardized reporting. ICG fluorescence is a robust adjunct to standard SLN mapping, offering intraoperative \"visual GPS\" especially valuable in head/neck melanoma. Current evidence supports ICG as a complement for radiocolloid mapping.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"339-343"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the causal association between liver condition and melanoma: evidence from the National Health and Nutrition Examination Survey and Mendelian randomization. 调查肝脏状况和黑色素瘤之间的因果关系：来自国家健康和营养检查调查和孟德尔随机化的证据。

IF 1.8 4区医学

Melanoma Research Pub Date : 2026-07-29 DOI: 10.1097/CMR.0000000000001125

Bendian Song, Shitong Guo, Qiuchen Li, Zhiyu Li, Jianhai Bi

{"title":"Investigating the causal association between liver condition and melanoma: evidence from the National Health and Nutrition Examination Survey and Mendelian randomization.","authors":"Bendian Song, Shitong Guo, Qiuchen Li, Zhiyu Li, Jianhai Bi","doi":"10.1097/CMR.0000000000001125","DOIUrl":"https://doi.org/10.1097/CMR.0000000000001125","url":null,"abstract":"This study aimed to investigate the association between liver condition and the risk of melanoma. We first conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004, involving 7144 participants (49 melanoma cases). The association was examined using multivariable logistic regression (three models), smooth curve fitting, and stratified analysis. To infer causality, a Mendelian randomization analysis was then performed using five algorithms, with sensitivity analyses and a Steiger test to validate the findings. In the NHANES analysis, liver condition was significantly associated with an increased risk of melanoma across all models [model 3: odds ratio (OR) = 4.31, 95% confidence interval (CI): 1.47-12.7]. The Mendelian randomization analysis using the inverse variance weighted method confirmed a positive causal relationship, identifying liver condition as a risk factor for melanoma (OR = 1.173, 95% CI: 1.051-1.310). Sensitivity analyses indicated no heterogeneity or horizontal pleiotropy, and the Steiger test supported the direction of causality. This study suggests a causal association between liver condition and melanoma, offering new insights for the prevention and treatment of melanoma.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0