Melanoma Research最新文献_第4页

The association between dermatologist density and melanoma prognosis using melanoma mortality-incidence ratio. 利用黑色素瘤死亡率-发病率比值分析皮肤科医生密度与黑色素瘤预后之间的关系。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1097/CMR.0000000000001004

Joshua Burshtein, Milaan Shah, Danny Zakria, Darrell Rigel

引用次数: 0

Treatment outcomes following partial shave biopsy of atypical and malignant melanocytic tumors in pediatric patients. 对儿科非典型和恶性黑色素细胞肿瘤进行部分刮片活检后的治疗效果。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI: 10.1097/CMR.0000000000001002

Akshaya Arjunan, Mary Wardrop, Marcus M Malek, Alexander J Davit, Michael R Sargen, John M Kirkwood, Kathryn Demanelis, Brittani K N Seynnaeve

{"title":"Treatment outcomes following partial shave biopsy of atypical and malignant melanocytic tumors in pediatric patients.","authors":"Akshaya Arjunan, Mary Wardrop, Marcus M Malek, Alexander J Davit, Michael R Sargen, John M Kirkwood, Kathryn Demanelis, Brittani K N Seynnaeve","doi":"10.1097/CMR.0000000000001002","DOIUrl":"10.1097/CMR.0000000000001002","url":null,"abstract":"Pediatric melanoma is the most common skin cancer in children and treatment relies on accurate staging. The American Academy of Dermatology recommends excisional biopsy for suspicious skin lesions, however, partial shave biopsies are often performed, the impact of which is unknown in pediatric and adolescent/young adult (AYA) patients. The aim of this retrospective case series study was to evaluate the impact of the diagnostic biopsy method on staging, treatment, and treatment-related outcomes in pediatric/AYA patients with melanoma. Among 103 pediatric/AYA patients with atypical cutaneous melanocytic lesions, the most common biopsy method was partial shave (68/103, 66.0%) followed by punch (20/103, 19.4%), excisional (14/103, 13.6%), and incisional nonshave (1/103, 1%). Over half of all biopsies yielded a positive deep margin, reflecting compromised microstaging (56/103, 55.4%), the majority occurred following partial shave (52/56, 92.9%) compared with other techniques ( P < 0.001). All 11 patients with wider surgical target margins of wide local excision and 8/9 patients with sentinel lymph node biopsy performed due to positive deep margin, underwent a partial shave biopsy ( P = 0.05 and 0.32, respectively). Almost half of all patients who underwent partial shave biopsy had a clinically suspected abnormal melanocytic tumor prior to biopsy (31/68, 45.6%; P = 0.03). Of 56 patients who had compromised microstaging, 17 (30.4%) had a diagnosis of melanoma ( P = 0.17). Pediatric/AYA patients frequently undergo partial shave biopsy, which is associated with more invasive definitive surgical treatment due to compromised microstaging. These results may help optimize care of patients with cutaneous melanocytic tumors.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"544-548"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of prognostic nomogram in pediatric melanoma: a population-based study. 儿科黑色素瘤预后提名图的开发与验证：一项基于人群的研究。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1097/CMR.0000000000000993

Saichun Zhang, Zixiang Liu, Dongsheng Zhu

{"title":"Development and validation of prognostic nomogram in pediatric melanoma: a population-based study.","authors":"Saichun Zhang, Zixiang Liu, Dongsheng Zhu","doi":"10.1097/CMR.0000000000000993","DOIUrl":"10.1097/CMR.0000000000000993","url":null,"abstract":"The aim of the study is to use the Surveillance, Epidemiology, and End Results (SEER) database to develop a useful clinical nomogram that uses prognosis prediction for pediatric melanoma patients. We obtained clinical information on pediatric melanoma patients from the SEER database between 2000 and 2018. Each patient was split into a training cohort or a validation cohort at random. Results between various subgroups were compared using Kaplan-Meier analyses. We created a nomogram to calculate the probability of survival for pediatric patients with melanoma. The performance of nomograms was assessed using calibration and discrimination. To assess the clinical use of this newly created model, decision curve analysis was also performed. In this study, a total of 890 eligible patients were chosen at random and allocated to 70% of training cohorts ( n = 623) and 30% of validation cohorts ( n = 267). After applying the chosen various components to create a nomogram, validated indexes showed that the nomogram had a strong capacity for discrimination. The training set's and validation set's C-index values were 0.817 and 0.832, respectively. The calibration plots demonstrated a strong correlation between the observation and the forecast. The model has a good clinical net benefit for pediatric melanoma patients, according to the clinical decision curve. In conclusion, we created an effective survival prediction model for pediatric melanoma. This nomogram is accurate and useful for clinical decision-making. Still, more external confirmation is required.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"497-503"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma. 肛门直肠黑色素瘤：关于一种侵袭性黑色素瘤的现有文献的系统回顾。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI: 10.1097/CMR.0000000000001003

Giovanni Paolino, Antonio Podo Brunetti, Carolina De Rosa, Carmen Cantisani, Franco Rongioletti, Andrea Carugno, Nicola Zerbinati, Mario Valenti, Domenico Mascagni, Giulio Tosti, Santo Raffaele Mercuri, Riccardo Pampena

{"title":"Anorectal melanoma: systematic review of the current literature of an aggressive type of melanoma.","authors":"Giovanni Paolino, Antonio Podo Brunetti, Carolina De Rosa, Carmen Cantisani, Franco Rongioletti, Andrea Carugno, Nicola Zerbinati, Mario Valenti, Domenico Mascagni, Giulio Tosti, Santo Raffaele Mercuri, Riccardo Pampena","doi":"10.1097/CMR.0000000000001003","DOIUrl":"10.1097/CMR.0000000000001003","url":null,"abstract":"Anorectal melanoma (ARM) is a rare malignancy often associated with a poor prognosis due to its late diagnosis and aggressive biological behavior. This review aims to comprehensively investigate ARM's diagnosis, management, and treatment, emphasizing its clinical characteristics, laboratory findings, and implications for patient prognosis. A systematic literature search was conducted in PubMed, Embase, and Cochrane CENTRAL databases from inception to 1 July 2024. This review synthesizes existing literature to provide a comprehensive understanding of this rare primary malignancy. A total of 110 articles reporting on 166 patients were included. Gender data were available for 131 cases, comprising 67 females (51.1%) and 64 males (48.9%). The median age was 66 years. The overall median time to diagnosis was 4 months for anal melanoma, 3 months for rectal melanoma, and 4 months for anorectal junction melanoma. The clinical presentation was nodular in 98.2% of cases. Pre-diagnosis symptoms included bleeding in 84.9% of cases, mucous elimination (6%), pain (68.7%), tenesmus (16.9%), and changes in bowel movements (28.5%). Overall survival (OS) was reported in 82 cases, with a median OS of 11 months: 11 months for anal melanoma, 7 months for rectal melanoma, and 12 months for anorectal junction melanoma. ARM is a rare and aggressive melanoma subtype often diagnosed at an advanced stage, leading to a poor prognosis. A female predominance was observed, consistent with other mucosal melanomas. Anal melanoma exhibited better progression-free survival, and OS compared to rectal and anorectal junction melanoma.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"487-496"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total body skin examination visits by dermatology providers in the 2011-2016 National Ambulatory Medical Care Survey. 2011-2016 年全国流动医疗护理调查中皮肤科医疗服务提供者的全身皮肤检查访问量。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1097/CMR.0000000000000995

Brandon Smith, Joe K Tung, Annie I Chen, Cassandra Mohr, Malgorzata K Nowakowska, Mackenzie R Wehner, Laura K Ferris

引用次数: 0

Synchronous double primary vulvar melanoma: a not so rare possibility. A clinical and dermoscopic case study. 同步双原发性外阴黑色素瘤：一种并不罕见的可能性。临床和皮肤镜病例研究。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-06-24 DOI: 10.1097/CMR.0000000000000989

Vincenzo De Giorgi, Giovanni Cecchi, Gabriella Perillo, Biancamaria Zuccaro, Piero Covarelli

{"title":"Synchronous double primary vulvar melanoma: a not so rare possibility. A clinical and dermoscopic case study.","authors":"Vincenzo De Giorgi, Giovanni Cecchi, Gabriella Perillo, Biancamaria Zuccaro, Piero Covarelli","doi":"10.1097/CMR.0000000000000989","DOIUrl":"10.1097/CMR.0000000000000989","url":null,"abstract":"Vulvar melanoma is considered rare, but it is the second most frequent vulvar neoplasm; 2% of melanomas in women arise in the vulvar area. It is important to highlight how the characteristics of vulvar melanoma differentiate it from classic cutaneous melanoma. Vulvar melanoma has different risk factors and clinical and dermoscopic characteristics; moreover, it has a higher recurrence rate and a greater likelihood of multifocality. Here, we present a case of a 44-year-old patient with two primary vulvar melanomas located on opposite sides of her vulva. The lesions were both flat, but they had distinct clinical and dermoscopic appearances. Melanoma of the genital tract is likely the result of a multifocal disorder of the melanocytes within the mucosa that inhabit the perineal squamous epithelium. The risk factors of vulvar melanoma differ from those of classical cutaneous melanomas. Vulvar melanoma occurs in an area shielded from ultraviolet radiation; the primary risk factors include chronic inflammatory disease, genetic susceptibility, irritant agents and viral infections. This case study reveals how a close examination of the genital area is important and how dermoscopy can aid in the differential diagnosis of vulvar lesions. Inspections of the genital area should be particularly thorough if a melanoma is detected there, given the higher risk of multifocality in that part of the body.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"540-543"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric melanoma incidence and survival: a fifteen-year nationwide retrospective cohort study in Korea. 小儿黑色素瘤的发病率和存活率：韩国一项为期十五年的全国性回顾性队列研究（2004-2019 年）。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI: 10.1097/CMR.0000000000001000

Isaac Kim, Jisu Oh, Siyeoung Yoon, Man-Yong Han, Jaiwoo Chung, Younghoon Jung, Hyun-Il Lee, Soonchul Lee

{"title":"Pediatric melanoma incidence and survival: a fifteen-year nationwide retrospective cohort study in Korea.","authors":"Isaac Kim, Jisu Oh, Siyeoung Yoon, Man-Yong Han, Jaiwoo Chung, Younghoon Jung, Hyun-Il Lee, Soonchul Lee","doi":"10.1097/CMR.0000000000001000","DOIUrl":"10.1097/CMR.0000000000001000","url":null,"abstract":"The aim of this study was to explore the epidemiology of cutaneous malignant melanoma (CMM) and the associated risk factors influencing its occurrence and survival among Koreans aged <20 years. In this retrospective cohort investigation, we identified cases of incident melanoma diagnosed in Korean patients aged 0-19 years between 2004 and 2019, utilizing the National Health Insurance database. We assessed annual fluctuations in age-adjusted incidence rates and examined 5-year survival rates based on various factors, including sex, age, income level, sun-exposed sites, and the Charlson Comorbidity Index. Of 1160 patients, 51.4% were male and 48.6% were female. The mean age of the patients was 11 years, mostly belonging to the top 25% high-income group. The head and neck regions were the most frequently affected sites. The overall age-adjusted incidence rate of melanoma was 0.22 per 100,000 persons. This rate witnessed a decline of 4.5% annually from 2004 to 2012, followed by a subsequent increase of 12.6% annually from 2012 to 2019. Notably, patients with CMM in low-sun-exposed sites exhibited poorer survival rates compared with those in high-sun-exposed areas ( P < 0.05). The incidence of melanomas in children and adolescents in Korea has shown a rising trend since 2012. Further research is needed to investigate the etiology and risk factors in pediatric patients.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"528-534"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world evidence on efficacy and toxicity of targeted therapy in older melanoma patients treated in a tertiary-hospital setting. 在三甲医院接受治疗的老年黑色素瘤患者接受靶向治疗的疗效和毒性的真实证据。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-08-30 DOI: 10.1097/CMR.0000000000000997

Ronen Stoff, Svetomir N Markovic, Robert R McWilliams, Lisa A Kottschade, Heather N Montane, Anastasios Dimou, Arkadiusz Z Dudek, Winston Tan, Roxana S Dronca, Mahesh Seetharam, Ruqin Chen, Matthew S Block

{"title":"Real-world evidence on efficacy and toxicity of targeted therapy in older melanoma patients treated in a tertiary-hospital setting.","authors":"Ronen Stoff, Svetomir N Markovic, Robert R McWilliams, Lisa A Kottschade, Heather N Montane, Anastasios Dimou, Arkadiusz Z Dudek, Winston Tan, Roxana S Dronca, Mahesh Seetharam, Ruqin Chen, Matthew S Block","doi":"10.1097/CMR.0000000000000997","DOIUrl":"10.1097/CMR.0000000000000997","url":null,"abstract":"Melanoma is the deadliest form of skin cancer. The median age at diagnosis is 66. While most patients are treated with immunotherapy, the use of targeted therapy is a valid alternative for patients whose tumors harbor a BRAF or c-KIT driver mutation. These agents, while effective, come with a variety of side effects which limit their use, especially in older patients. We sought to assess the efficacy and toxicity of these agents in older melanoma patients. Melanoma patients over 65 treated with BRAF/MEK or c-KIT inhibitors were retrospectively identified, and their data were analyzed for treatment efficacy and toxicity. All data were compared using the Chi-square test for categorical comparisons and the Kruskal-Wallis method for median comparisons. One hundred and sixteen patients were identified. One hundred and six patients were treated with BRAF/MEK inhibitors. The assessed response rate (RR) was 83% and was comparable across different subgroups, including advanced line patients and those with a more aggressive disease. The median progression free survival (PFS) was 7.9 months, and the median overall survival (OS) was 15.7 months. Twenty-seven percent experienced grade 3-4 toxicity leading to a 24% treatment discontinuation rate. Another 10 patients were treated with the c-KIT inhibitor imatinib, for whom the assessed RR was 55%. The median PFS was 4.3 months, and the median OS was 22.6 months. Forty percent needed dose reductions, yet none had to stop treatment due to adverse effects. The use of targeted therapy in older patients is effective yet challenging due to toxicity. Deploying mitigation strategies can help maximizing their usefulness.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"510-518"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes and patterns of recurrence in patients with thin melanoma and a negative sentinel lymph node biopsy: a single-center experience. 薄型黑色素瘤前哨淋巴结活检阴性患者的长期疗效和复发模式：单中心经验。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-06-14 DOI: 10.1097/CMR.0000000000000986

Maayan Shemer, Michal Shimonovitz, Rozalin Furer, Adam Abu-Abeid, Danit Dayan, Schlomo Schneebaum, Mor Miodovnik, Eran Nizri

{"title":"Long-term outcomes and patterns of recurrence in patients with thin melanoma and a negative sentinel lymph node biopsy: a single-center experience.","authors":"Maayan Shemer, Michal Shimonovitz, Rozalin Furer, Adam Abu-Abeid, Danit Dayan, Schlomo Schneebaum, Mor Miodovnik, Eran Nizri","doi":"10.1097/CMR.0000000000000986","DOIUrl":"10.1097/CMR.0000000000000986","url":null,"abstract":"The majority of patients diagnosed with melanoma have thin melanomas (≤1 mm). Data on the rate and pattern of recurrence after a negative sentinel lymph node biopsy (SLNB) are sparse. We retrospectively searched our institutional database and retrieved the records of patients with thin melanomas who underwent an SLNB with negative results. We analyzed patterns of recurrence, time to recurrence, and mode of diagnosis. Thirteen of the 198 patients with thin melanomas and negative SLNB results had tumor recurrence (6.5%): two local in transit (15.4%), three regional (21.3%), and eight distant (61.5%). Distant recurrences tended to occur later than local or regional ones [median disease-free survival = 50 months (95% confidence interval: 36.1-63.9) vs. 34 and 15 months (95% confidence interval: 5.4-24.6), P = 0.005, respectively]. The percentage of patients with tumor thickness ≥0.8 mm was higher among those who sustained recurrence (84.6 vs. 64.9% for no recurrence, P = 0.04). The majority of patients with recurrence were not being followed up when diagnosed (69%), and they are presented because of clinical symptoms. Patients with recurrence had lower survival compared with those without recurrence (median: 118 months vs. ongoing survival, P < 0.001, respectively). Melanoma recurrence in patients with thin melanomas and negative SLNBs is rare, tends to be distant, and negatively affects prognosis. Recurrence tends to occur in patients with melanoma thickness ≥0.8 mm. Further studies are needed to identify patients with high recurrence risk and determine optimal follow-up protocols.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"535-539"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcutaneous sentinel lymph node detection in skin melanoma with near-infrared fluorescence imaging using indocyanine green. 利用吲哚菁绿的近红外荧光成像技术经皮检测皮肤黑色素瘤的前哨淋巴结。

IF 1.5 4区医学

Melanoma Research Pub Date : 2024-12-01 Epub Date: 2024-08-02 DOI: 10.1097/CMR.0000000000000994

Bo E Zweedijk, Antonius W Schurink, Thijs van Dalen, Tessa M van Ginhoven, Cornelis Verhoef, Bernd Kremer, Denise E Hilling, Stijn Keereweer, Dirk J Grünhagen

{"title":"Transcutaneous sentinel lymph node detection in skin melanoma with near-infrared fluorescence imaging using indocyanine green.","authors":"Bo E Zweedijk, Antonius W Schurink, Thijs van Dalen, Tessa M van Ginhoven, Cornelis Verhoef, Bernd Kremer, Denise E Hilling, Stijn Keereweer, Dirk J Grünhagen","doi":"10.1097/CMR.0000000000000994","DOIUrl":"10.1097/CMR.0000000000000994","url":null,"abstract":"The aim of the study is to assess whether indocyanine green (ICG) fluorescence can replace technetium in the preoperative detection of sentinel lymph nodes (SLN) from cutaneous melanoma. The current golden standard for SLN detection is the radioisotope technetium. A promising alternative is fluorescence imaging (FLI) using ICG. In this study, we enrolled patients undergoing sentinel lymph node biopsy (SLNB) for skin melanoma at the Erasmus Medical Center between November 2022 and July 2023. The SLNB procedure was performed as a standard of care. After general anesthesia, ICG was injected intradermally around the primary tumor site. Both the patient and the surgeon were not blinded for the location of the SLN. FLI was performed before incision, in vivo after incision, and ex vivo. Fluorescent SLNs were confirmed using the gamma probe in all cases. Thirty-two patients were included in this study, and a total of 39 SLNs were harvested. The transcutaneous detection rate of ICG was 21.9%. The combined ex vivo ICG fluorescence and technetium uptake was 94.9%. One SLN contained only ICG (2.6%) and one SLN contained only technetium-uptake (2.6%). FLI using ICG resulted in a relatively low transcutaneous detection, which means that exclusive use of this technique in its present form is not feasible. However, we did find a high accumulation of ICG in the SLN, indicating the potential of ICG in combination with other imaging techniques.","PeriodicalId":18550,"journal":{"name":"Melanoma Research","volume":" ","pages":"504-509"},"PeriodicalIF":1.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0