Mini reviews in medicinal chemistry最新文献_第8页

Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy. 靶向抑制 PI3K/Akt/mTOR 信号轴：肉瘤治疗的潜力。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575270904231129062137

Atif Khurshid Wani, Reena Singh, Nahid Akhtar, Ajit Prakash, Eugenie Nepovimova, Patrik Oleksak, Zofia Chrienova, Suliman Alomar, Chirag Chopra, Kamil Kuca

{"title":"Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy.","authors":"Atif Khurshid Wani, Reena Singh, Nahid Akhtar, Ajit Prakash, Eugenie Nepovimova, Patrik Oleksak, Zofia Chrienova, Suliman Alomar, Chirag Chopra, Kamil Kuca","doi":"10.2174/0113895575270904231129062137","DOIUrl":"10.2174/0113895575270904231129062137","url":null,"abstract":"Sarcoma is a heterogeneous group of malignancies often resistant to conventional chemotherapy and radiation therapy. The phosphatidylinositol-3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway has emerged as a critical cancer target due to its central role in regulating key cellular processes such as cell growth, proliferation, survival, and metabolism. Dysregulation of this pathway has been implicated in the development and progression of bone sarcomas (BS) and soft tissue sarcomas (STS). PI3K/Akt/mTOR inhibitors have shown promising preclinical and clinical activity in various cancers. These agents can inhibit the activation of PI3K, Akt, and mTOR, thereby reducing the downstream signaling events that promote tumor growth and survival. In addition, PI3K/Akt/mTOR inhibitors have been shown to enhance the efficacy of other anticancer therapies, such as chemotherapy and radiation therapy. The different types of PI3K/Akt/mTOR inhibitors vary in their specificity, potency, and side effect profiles and may be effective depending on the specific sarcoma type and stage. The molecular targeting of PI3K/Akt/mToR pathway using drugs, phytochemicals, nanomaterials (NMs), and microbe-derived molecules as Pan-PI3K inhibitors, selective PI3K inhibitors, and dual PI3K/mTOR inhibitors have been delineated. While there are still challenges to be addressed, the preclinical and clinical evidence suggests that these inhibitors may significantly improve patient outcomes. Further research is needed to understand the potential of these inhibitors as sarcoma therapeutics and to continue developing more selective and effective agents to meet the clinical needs of sarcoma patients.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Fluorescent Probes for G-quadruplex DNAs / RNAs. G-quadruplex DNA / RNA 荧光探针的最新进展。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575301818240510151309

Hongyan Yang, Ping Xu, Fei Pan, Jinhong Gao, Libo Yuan, Kui Lu

引用次数: 0

The Therapeutic Potential and Molecular Mechanisms Underlying the Neuroprotective Effects of Sativex^® - A Cannabis-derived Spray. Sativex® - 一种大麻衍生喷雾剂的治疗潜力及其神经保护作用的分子机制。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575285934240123110158

Sina Motamedy, Bahareh Soltani, Halimeh Kameshki, Asmae Alipour Kermani, Reza Saboori Amleshi, Masoud Nazeri, Mohammad Shabani

引用次数: 0

Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review. 松萝酸衍生物的生物活性和结构-活性关系：综述。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575277085231123165546

Wen-Zhe Nie, Qing-Kun Shen, Zhe-Shan Quan, Hong-Yan Guo, Ya-Mei Li

引用次数: 0

Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer. 靶向溶酶体：对抗癌症化疗抗药性的策略

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575287242240129120002

Ekta Shirbhate, Vaibhav Singh, Aditya Mishra, Varsha Jahoriya, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak

{"title":"Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer.","authors":"Ekta Shirbhate, Vaibhav Singh, Aditya Mishra, Varsha Jahoriya, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak","doi":"10.2174/0113895575287242240129120002","DOIUrl":"10.2174/0113895575287242240129120002","url":null,"abstract":"Chemotherapy is still the major method of treatment for many types of cancer. Curative cancer therapy is hampered significantly by medication resistance. Acidic organelles like lysosomes serve as protagonists in cellular digestion. Lysosomes, however, are gaining popularity due to their speeding involvement in cancer progression and resistance. For instance, weak chemotherapeutic drugs of basic nature permeate through the lysosomal membrane and are retained in lysosomes in their cationic state, while extracellular release of lysosomal enzymes induces cancer, cytosolic escape of lysosomal hydrolases causes apoptosis, and so on. Drug availability at the sites of action is decreased due to lysosomal drug sequestration, which also enhances cancer resistance. This review looks at lysosomal drug sequestration mechanisms and how they affect cancer treatment resistance. Using lysosomes as subcellular targets to combat drug resistance and reverse drug sequestration is another method for overcoming drug resistance that is covered in this article. The present review has identified lysosomal drug sequestration as one of the reasons behind chemoresistance. The article delves deeper into specific aspects of lysosomal sequestration, providing nuanced insights, critical evaluations, or novel interpretations of different approaches that target lysosomes to defect cancer.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of TBK1 Inhibition in Targeted Therapy of Cancer. TBK1 抑制在癌症靶向治疗中的作用

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575271977231115062803

Xueqing Yang, Zongliang Liu

{"title":"Role of TBK1 Inhibition in Targeted Therapy of Cancer.","authors":"Xueqing Yang, Zongliang Liu","doi":"10.2174/0113895575271977231115062803","DOIUrl":"10.2174/0113895575271977231115062803","url":null,"abstract":"TANK-binding kinase 1 (TBK1) is a serine/threonine protein that plays a crucial role in various biological processes like immunity, autophagy, cell survival, and proliferation. The level and kinase activity of the TBK1 protein is regulated through post-translational modifications (PTMs). TBK1 mainly mediates the activation of IRF3/7 and NF-κB signaling pathways while also participating in the regulation of cellular activities such as autophagy, mitochondrial metabolism, and cell proliferation. TBK1 regulates immune, metabolic, inflammatory, and tumor occurrence and development within the body through these cellular activities. TBK1 kinase has emerged as a promising therapeutic target for tumor immunity. However, its molecular mechanism of action remains largely unknown. The identification of selective TBK1 small molecule inhibitors can serve as valuable tools for investigating the biological function of TBK1 protein and also as potential drug candidates for tumor immunotherapy. The current research progress indicates that some TBK1 inhibitors (compounds 15,16 and 21) exhibit certain antitumor effects in vitro culture systems. Here, we summarize the mechanism of action of TBK1 in tumors in recent years and the progress of small molecule inhibitors of TBK1.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139681331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Emergence of N. sativa L. as a Green Antifungal Agent. N. sativa L. 作为绿色抗真菌剂的出现。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575282914240217060251

Raghvendra Pandey, Brijesh Pandey, Atul Bhargava

{"title":"The Emergence of N. sativa L. as a Green Antifungal Agent.","authors":"Raghvendra Pandey, Brijesh Pandey, Atul Bhargava","doi":"10.2174/0113895575282914240217060251","DOIUrl":"10.2174/0113895575282914240217060251","url":null,"abstract":"Background: Nigella sativa L. has been widely used in the Unani, Ayurveda, Chinese, and Arabic medicine systems and has a long history of medicinal and folk uses. Several phytoconstituents of the plant are reported to have excellent therapeutic properties. In-vitro and in-vivo studies have revealed that seed oil and thymoquinone have excellent inhibitory efficacy on a wide range of both pathogenic and non-pathogenic fungi.Objective: The present review aims to undertake a comprehensive and systematic evaluation of the antifungal effects of different phytochemical constituents of black cumin.Method: An exhaustive database retrieval was conducted on PubMed, Scopus, ISI Web of Science, SciFinder, Google Scholar, and CABI to collect scientific information about the antifungal activity of N. sativa L. with 1990 to 2023 as a reference range using 'Nigella sativa,' 'Nigella oil,' 'antifungal uses,' 'dermatophytic fungi,' 'candidiasis,' 'anti-aflatoxin,' 'anti-biofilm' and 'biological activity' as the keywords.Results: Black cumin seeds, as well as the extract of aerial parts, were found to exhibit strong antifungal activity against a wide range of fungi. Among the active compounds, thymoquinone exhibited the most potent antifungal effect. Several recent studies proved that black cumin inhibits biofilm formation and growth.Conclusion: The review provides an in-depth analysis of the antifungal activity of black cumin. This work emphasizes the need to expand studies on this plant to exploit its antifungal properties for biomedical applications.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes Pharmacotherapy and its effects on the Skeletal Muscle Energy Metabolism. 糖尿病药物疗法及其对骨骼肌能量代谢的影响。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575299439240216081711

Baowen Yu, Dong Wang, Junming Zhou, Rong Huang, Tingting Cai, Yonghui Hu, Yunting Zhou, Jianhua Ma

引用次数: 0

An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites. 探索芳樟醇及其代谢物抗痛觉生物活性的硅学方法

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI: 10.2174/0113895575261945231122062659

Pablo Rayff da Silva, Natalia Diniz Nunes Pazos, Jéssica Cabral de Andrade, Natália Ferreira de Sousa, Hugo Fernandes Oliveira Pires, Jaislânia Lucena de Figueiredo Lima, Arthur Lins Dias, Mirian Graciela da Silva Stiebbe Salvadori, Adriana Maria Fernandes de Oliveira Golzio, Ricardo Dias de Castro, Marcus T Scotti, Vaishali M Patil, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida, Luciana Scotti

{"title":"An In Silico Approach to Exploring the Antinociceptive Biological Activities of Linalool and its Metabolites.","authors":"Pablo Rayff da Silva, Natalia Diniz Nunes Pazos, Jéssica Cabral de Andrade, Natália Ferreira de Sousa, Hugo Fernandes Oliveira Pires, Jaislânia Lucena de Figueiredo Lima, Arthur Lins Dias, Mirian Graciela da Silva Stiebbe Salvadori, Adriana Maria Fernandes de Oliveira Golzio, Ricardo Dias de Castro, Marcus T Scotti, Vaishali M Patil, Cícero Francisco Bezerra Felipe, Reinaldo Nóbrega de Almeida, Luciana Scotti","doi":"10.2174/0113895575261945231122062659","DOIUrl":"10.2174/0113895575261945231122062659","url":null,"abstract":"Pain is characterized by the unpleasant sensory and emotional sensation associated with actual or potential tissue damage, whereas nociception refers to the mechanism by which noxious stimuli are transmitted from the periphery to the CNS. The main drugs used to treat pain are nonsteroidal anti-inflammatory drugs (NSAIDs) and opioid analgesics, which have side effects that limit their use. Therefore, in the search for new drugs with potential antinociceptive effects, essential oils have been studied, whose constituents (monoterpenes) are emerging as a new therapeutic possibility. Among them, linalool and its metabolites stand out. The present study aims to investigate the antinociceptive potential of linalool and its metabolites through a screening using an in silico approach. Molecular docking was used to evaluate possible interactions with important targets involved in antinociceptive activity, such as α2-adrenergic, GABAergic, muscarinic, opioid, adenosinergic, transient potential, and glutamatergic receptors. The compounds in the investigated series obtained negative energies for all enzymes, representing satisfactory interactions with the targets and highlighting the multi-target potential of the L4 metabolite. Linalool and its metabolites have a high likelihood of modulatory activity against the targets involved in nociception and are potential candidates for future drugs.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers 线粒体蛋白作为原发性和转移性癌症治疗干预的代谢生物标志物和位点

IF 3.8 3区医学

Mini reviews in medicinal chemistry Pub Date : 2023-11-30 DOI: 10.2174/0113895575254320231030051124

Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velazquez, Jorge Luis Vargas-Navarro, Joaquín Alberto Padilla-Flores, Rafael Moreno-Sanchez, Sara Rodríguez-Enríquez

{"title":"Mitochondrial Proteins as Metabolic Biomarkers and Sites for Therapeutic Intervention in Primary and Metastatic Cancers","authors":"Diana Xochiquetzal Robledo-Cadena, Silvia Cecilia Pacheco-Velazquez, Jorge Luis Vargas-Navarro, Joaquín Alberto Padilla-Flores, Rafael Moreno-Sanchez, Sara Rodríguez-Enríquez","doi":"10.2174/0113895575254320231030051124","DOIUrl":"https://doi.org/10.2174/0113895575254320231030051124","url":null,"abstract":": Accelerated aerobic glycolysis is one of the main metabolic alterations in cancer, associated with malignancy and tumor growth. Although glycolysis is one of the most studied properties of tumor cells, recent studies demonstrate that oxidative phosphorylation (OxPhos) is the main ATP provider for the growth and development of cancer. In this last regard, the levels of mRNA and protein of OxPhos enzymes and transporters (including glutaminolysis, acetate and ketone bodies catabolism, free fatty acid β-oxidation, Krebs Cycle, respiratory chain, phosphorylating system- ATP synthase, ATP/ADP translocator, Pi carrier) are altered in tumors and cancer cells in comparison to healthy tissues and organs, and non-cancer cells. Both energy metabolism pathways are tightly regulated by transcriptional factors, oncogenes, and tumor-suppressor genes, all of which dictate their protein levels depending on the micro-environmental conditions and the type of cancer cell, favoring cancer cell adaptation and growth. In the present review paper, variation in the mRNA and protein levels as well as in the enzyme/ transporter activities of the OxPhos machinery is analyzed. An integral omics approach to mitochondrial energy metabolism pathways may allow for identifying their use as suitable, reliable biomarkers for early detection of cancer development and metastasis, and for envisioned novel, alternative therapies.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138538217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0