Mini reviews in medicinal chemistry最新文献_第8页

Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings. 探索绿茶（Camellia sinensis L.）在抗衰老方面的治疗潜力：机制和研究结果的全面回顾。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575331878240924035332

Bhagavathi Sundaram Sivamaruthi, Natarajan Sisubalan, Shucai Wang, Periyanaina Kesika, Chaiyavat Chaiyasut

{"title":"Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings.","authors":"Bhagavathi Sundaram Sivamaruthi, Natarajan Sisubalan, Shucai Wang, Periyanaina Kesika, Chaiyavat Chaiyasut","doi":"10.2174/0113895575331878240924035332","DOIUrl":"10.2174/0113895575331878240924035332","url":null,"abstract":"Green tea (GT) is rich in phyto-active compounds such as epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC), catechin, and tannic acid, which exhibit synergistic effects when combined. Preclinical studies demonstrate that GT and its compounds can reduce reactive oxygen species (ROS), enhance antioxidant capacity, and alleviate aging-related issues such as memory impairments, cognitive decline, and shortened lifespan. Clinical trials corroborate the efficacy of topical GT formulations in improving skin tone, texture, and elasticity and reducing wrinkles. The present manuscript summarizes the recent update on the anti-aging potential of GT and its possible mechanisms. The literature survey suggests that GT consumption is linked to improved cognition, reduced depression levels, and activation of pathways in model organisms like C. elegans. Additionally, tea polyphenols enhance fibroblast mitophagy, boost hippocampal synaptic plasticity in rodents, and mitigate age-related cognitive decline. Moreover, EGCG exhibits anti-aging properties by reducing TNF-induced MMP-1 expression, suppressing ERK signaling, and inhibiting MEK and Src phosphorylation in human dermal fibroblasts. In the context of skin permeation and deposition, optimized transfersomal formulation (TF) incorporating EGCG and hyaluronic acid (HA) demonstrates significantly increased skin permeation and deposition of EGCG compared to plain EGCG. Furthermore, EGCG protects cardiomyocytes via the PPARγ pathway and combats age-related muscle loss through miRNA-486-5p regulation, AKT activation, and FoxO1a-mediated expression of MuRF1 and Atrogin-1. In conclusion, the regular consumption of GT holds promise for promoting physical and mental health, delaying brain and skin aging, and improving overall health by enhancing total antioxidant capacity.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"403-424"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Nature-derived Biopolymers for Oral Applications- A Mini-Review. 天然衍生生物聚合物的口服应用潜力综述。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575359305241218113847

Vijayalakshmi Kumar, Ashok K Sundramoorthy

{"title":"Potential of Nature-derived Biopolymers for Oral Applications- A Mini-Review.","authors":"Vijayalakshmi Kumar, Ashok K Sundramoorthy","doi":"10.2174/0113895575359305241218113847","DOIUrl":"10.2174/0113895575359305241218113847","url":null,"abstract":"In recent years, there has been a growing emphasis on the \"back-to-nature\" movement, which has brought biopolymers derived from natural sources into the spotlight. These biopolymers are gaining attention for their versatile surface-active properties, anti-adhesive capabilities, excellent biocompatibility, non-toxicity, biodegradability, and antimicrobial effectiveness against a wide range of oral microorganisms, including both bacteria and fungi. Researchers have been actively modifying these eco-friendly, nature-based biopolymers to enhance their interaction with surrounding cells and tissues, improving their performance in vivo. This has led to innovative applications in areas such as surface coatings, controlled drug delivery, tissue repair, and dental implant devices. These advancements hold the potential to pave the way for the development of novel drug delivery systems with enhanced therapeutic properties, ultimately supporting the creation of innovative formulations for clinical use. This review aims to provide an up-to-date overview of recent developments, explore potential future directions, and highlight the promising applications of nature-derived biopolymers in oral healthcare.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"529-538"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper Dyshomeostasis and Diabetic Complications: Chelation Strategies for Management. 铜失衡与糖尿病并发症：螯合治疗策略。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575308206240911104945

Jahnavi Subramaniam, Aarya Aditi, Kishore Arumugam, Sathya Sri, Subramaniam Rajesh Bharathidevi, Kunka Mohanram Ramkumar

{"title":"Copper Dyshomeostasis and Diabetic Complications: Chelation Strategies for Management.","authors":"Jahnavi Subramaniam, Aarya Aditi, Kishore Arumugam, Sathya Sri, Subramaniam Rajesh Bharathidevi, Kunka Mohanram Ramkumar","doi":"10.2174/0113895575308206240911104945","DOIUrl":"10.2174/0113895575308206240911104945","url":null,"abstract":"Cuproptosis, an emerging concept in the field of diabetes research, presents a novel and promising perspective for the effective management of diabetes mellitus and its associated complications. Diabetes, characterized by chronic hyperglycemia, poses a substantial global health burden, with an increasing prevalence worldwide. Despite significant progress in our understanding of this complex metabolic disorder, optimal therapeutic strategies still remain elusive. The advent of cuproptosis, a term coined to describe copper-induced cellular cell death and its pivotal role in diabetes pathogenesis, opens new avenues for innovative interventions. Copper, an indispensable trace element, plays a pivotal role in a myriad of vital biological processes, encompassing energy production, bolstering antioxidant defenses, and altered cellular signaling. However, in the context of diabetes, this copper homeostasis is perturbed, driven by a combination of genetic predisposition, dietary patterns, and environmental factors. Excessive copper levels act as catalysts for oxidative stress, sparking intricate intracellular signaling cascades that further exacerbate metabolic dysfunction. In this review, we aim to explore the interrelationship between copper and diabetes comprehensively, shedding light on the intricate mechanisms underpinning cuproptosis. By unraveling the roles of copper transporters, copper-dependent enzymes, and cuproptotic signaling pathways, we seek to elucidate potential therapeutic strategies that harness the power of copper modulation in diabetes management. This insight sets the stage for a targeted approach to challenge the complex hurdles posed by diabetes, potentially transforming our therapeutic strategies in the ongoing fight against this pervasive global health concern.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"277-292"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of Biomaterials for Chronic Wounds. 生物材料对慢性伤口的影响。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575314580241121080256

Virginia-Silviana Barbu Becherescu, Madalina-Diana Gaboreanu, Ioana Cristina Marinas, Andra-Maria Paun, Ileana Paula Ionel, Speranta Avram

{"title":"Implications of Biomaterials for Chronic Wounds.","authors":"Virginia-Silviana Barbu Becherescu, Madalina-Diana Gaboreanu, Ioana Cristina Marinas, Andra-Maria Paun, Ileana Paula Ionel, Speranta Avram","doi":"10.2174/0113895575314580241121080256","DOIUrl":"10.2174/0113895575314580241121080256","url":null,"abstract":"The use of biomaterials in treating and managing chronic wounds represents a significant challenge in global healthcare due to the complex nature of these wounds, which are slow to heal and can lead to complications such as frequent infections and diminished quality of life for patients. Chronic wounds, which can arise from conditions like diabetes, poor circulation, and pressure sores, pose distinct challenges in wound care, necessitating the development of specialized dressings. The pathophysiology of chronic wounds is thoroughly examined in this article, with particular attention paid to the cellular and molecular defects at work and the therapeutic guidelines. It also identifies key issues in the field, such as biocompatibility, cost-effectiveness, immune reactions, and regulatory obstacles, while suggesting future research focuses on improving biocompatibility, integrating drug delivery systems, and exploring cellular treatments. Ethical implications, such as patient safety, informed consent, and equitable access to technology, are also discussed. Finally, this review highlights the transformative potential of biomaterials in chronic wound management, urging for continued research and clinical integration to fully harness their capabilities in improving patient care.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"463-479"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Development History, Structural Composition, and Functions of Influenza Viruses and the Progress of Influenza Virus Inhibitors in Clinics and Clinical Trials. 流感病毒的发展历史、结构组成和功能以及流感病毒抑制剂在临床和临床试验中的进展。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575316416240724043949

Jianping Yong, Shaoji Lu, Canzhong Lu, Ruiwen Huang

{"title":"The Development History, Structural Composition, and Functions of Influenza Viruses and the Progress of Influenza Virus Inhibitors in Clinics and Clinical Trials.","authors":"Jianping Yong, Shaoji Lu, Canzhong Lu, Ruiwen Huang","doi":"10.2174/0113895575316416240724043949","DOIUrl":"10.2174/0113895575316416240724043949","url":null,"abstract":"Flu is an acute respiratory disease caused by influenza viruses. The influenza viruses are classified as Alphainfluenzavirus (influenza A virus, IAV), Betainfluenzavirus (influenza B virus, IBV), Gammainfluenzavirus (influenza C virus, ICV), and Deltainfluenzavirus (influenza D virus, IDV) according to the antigenicity of nucleoproteins (NPs) and matrix (M) proteins in vivo. It is estimated that the seasonal influenza epidemics will cause about 3-5 million cases of serious illness and 290,000-650,000 deaths in the world every year, while influenza A virus is the leading cause of infection and death. Neuraminidase (NA) is one of the most critical targets for the development of anti-influenza virus drugs, and the main drugs clinically applied for the treatment of flu are neuraminidase inhibitors. However, various mutant strains have developed resistance to these inhibitors (For example, the substrains of H274Y in H1N1, H5N1, and E119V in H3N2 have developed resistance to Oseltamivir). Influenza viruses mutate frequently, and new substrains emerge constantly, and the pandemics caused by the new substrains will break out at any time. Therefore, it is urgent to develop new and wide-spectrum influenza virus inhibitors for overcoming the emerging influenza pandemic. Here, we focus on describing the progress of influenza virus inhibitors in clinics and clinical trials to provide a comprehensive reference for the researchers.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"196-207"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment. 药物再利用：揭示癌症治疗中代谢重编程的途径。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575339660250106093738

Shristy Chaudhary, Abhilash Rana, Seema Bhatnagar

{"title":"Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment.","authors":"Shristy Chaudhary, Abhilash Rana, Seema Bhatnagar","doi":"10.2174/0113895575339660250106093738","DOIUrl":"10.2174/0113895575339660250106093738","url":null,"abstract":"Metabolic reprogramming is a hallmark of cancer. Distinct and unusual metabolic aberrations occur during tumor development that lead to the growth and development of tumors. Oncogenic signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells i.e., glucose, lipid, and amino acid metabolism. Therefore, identifying and targeting the metabolic nodes of cancer cells can be a promising intervention and therapeutic strategy for patients with malignancies. The long road of new drug discovery for cancer therapy has necessitated relooking alternative strategies such as drug repurposing. Advanced genomic and proteomic technologies for the assessment of cancer-specific biological pathways have led to the discovery of new drug targets, which provide excellent opportunities for drug repurposing. The development of effective, safe, cheaper, and readily available anticancer agents is the need of the hour, and drug repurposing has the potential to break the current drug shortage bottleneck. This review will accordingly cover various metabolic pathways that are aberrant in cancer, and strategies for targeting metabolic reprogramming by using repurposed drugs.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"601-627"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olaparib: A Chemosensitizer for the Treatment of Glioblastoma. 奥拉帕利治疗胶质母细胞瘤的化疗增敏剂。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575318854241014101928

Naresh Dhanavath, Priya Bisht, Mohini Santosh Jamadade, Krishna Murti, Pranay Wal, Nitesh Kumar

{"title":"Olaparib: A Chemosensitizer for the Treatment of Glioblastoma.","authors":"Naresh Dhanavath, Priya Bisht, Mohini Santosh Jamadade, Krishna Murti, Pranay Wal, Nitesh Kumar","doi":"10.2174/0113895575318854241014101928","DOIUrl":"10.2174/0113895575318854241014101928","url":null,"abstract":"Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor. The current treatment for GBM includes adjuvant chemotherapy with temozolomide (TMZ), radiation therapy, and surgical tumor excision. There is still an issue because 50% of patients with GBM who get TMZ have low survival rates due to TMZ resistance. The activation of several DNA repair mechanisms, such as Base Excision Repair (BER), DNA Mismatch Repair (MMR), and O-6- Methylguanine-DNA Methyltransferase (MGMT), is the main mechanism via which TMZ resistance develops. The zinc-finger DNA-binding enzyme poly (ADP-ribose) polymerase-1 (PARP1), which is activated by binding to DNA breaks, affects the activation of the MGMT, BER, and MMR pathway deficiency, which results in TMZ resistance in GBM. PARP inhibitors have been studied recently as sensitizing medications to increase TMZ potency. The first member of the PARP inhibitor family to be identified was Olaparib. It inhibits PARP1 and PARP2, which causes apoptosis in cancer cells and DNA strand break. Olaparib is currently investigated as a radio- and/or chemo-sensitizer in addition to being used as a single agent because it may increase the cytotoxic effects of other treatments. This review addresses Olaparib and its significance in treating TMZ resistance in GBM.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"374-385"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing of CDK Inhibitors as Host Targeting Antivirals: A Mini- Review. 将 CDK 抑制剂重新用作宿主靶向抗病毒药物：微型综述。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575311618240820103549

Miao Liu, Wei Peng, Xingyue Ji

引用次数: 0

Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment. 用吲哚支架靶向 Bcl-2：治疗癌症的新兴药物设计策略》。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575306176240925094457

Pouria Zarrin, Zeynep Ates-Alagoz

{"title":"Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment.","authors":"Pouria Zarrin, Zeynep Ates-Alagoz","doi":"10.2174/0113895575306176240925094457","DOIUrl":"10.2174/0113895575306176240925094457","url":null,"abstract":"The B-cell lymphoma-2 (Bcl-2) protein family plays a crucial role as a regulator in the process of apoptosis. There is a substantial body of evidence indicating that the upregulation of antiapoptotic Bcl-2 proteins is prevalent in several cancer cell lines and original tumour tissue samples. This phenomenon plays a crucial role in enabling tumour cells to avoid apoptosis, hence facilitating the development of resistant cells against chemotherapy. Therefore, the success rate of chemotherapy for cancer can be enhanced by the down-regulation of anti-apoptotic Bcl-2 proteins. Furthermore, the indole structural design is commonly found in a variety of natural substances and biologically active compounds, particularly those that possess anti-cancer properties. Due to its distinctive physicochemical and biological characteristics, it has been highly regarded as a fundamental framework in the development and production of anti-cancer drugs. As a result, a considerable range of indole derivatives, encompassing both naturally occurring and developed compounds, have been identified as potential candidates for the treatment of cancer. Several of these derivatives have advanced to clinical trials, while others are already being used in clinical settings. This emphasizes the significant role of indole in the field of research and development of anti-cancer therapeutics. This study provides an overview of apoptosis and the structural characteristics of Bcl-2 family proteins, and mainly examines the present stage and recent developments in Bcl-2 inhibitors with an indole scaffold embedded in their structure.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"293-318"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potental of Quinolin-2H-one Hybrids as Anticancer Agents. 喹啉-2H-酮混合物作为抗癌剂的治疗潜力。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575305597240912192037

Naik Soniya, Vasu Soumya, Mamle Desai Shivlingrao, Manickavasagam M, Chellappan Meeramol

{"title":"Therapeutic Potental of Quinolin-2H-one Hybrids as Anticancer Agents.","authors":"Naik Soniya, Vasu Soumya, Mamle Desai Shivlingrao, Manickavasagam M, Chellappan Meeramol","doi":"10.2174/0113895575305597240912192037","DOIUrl":"10.2174/0113895575305597240912192037","url":null,"abstract":"The statistical data related to cancer in recent years has shown a great increase in the number of cases and is likely to further increase in the future. Even after seeking thorough knowledge on the aetiology of cancer and related disorders and attempting to cure it by various methods like gene therapy, T cell therapy, chemotherapy, surgery, hormone therapy, and photodynamic therapy, there has always been disappointment concerning the survival rate. Hence, there is still a great urge for the discovery of novel drugs for the treatment of cancer. Chemotherapy being one of the widely used methods, several drug entities possessing anticancer properties are already in the market but none of them is known to show good efficacy which necessitates researchers to design newer drugs for the treatment of cancer. The urge to synthesize novel anticancer entities directed researchers towards molecular hybridization as one of the novel methods for designing newer drugs. Literature reveals wide research carried out on quinolin-2-one hybrids, possessing anticancer properties through different mechanisms. Tipifarnib and Dovitinib are quinolin-2-one hybrids used to treat cancer, possessing imidazole and benzimidazole heterocyclic rings. Different heterocyclic scaffolds such as pyrone, pyrrole, pyrimidine, pyridine, thiazole, and pyrazole in combination with heterocyclic quinolin-2-one have shown high potential to become lead for newer anticancer agents with better and wider therapeutic properties and lesser side effects. The current review presents information on the different quinolin-2-one hybrids and their effect on different cancer cell lines. It also imparts knowledge of the structural requirements for designing novel anticancer agents.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"386-402"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0