Mini reviews in medicinal chemistry最新文献

Smart Applications of Lanthanide Chelates-based Luminescent Probes in Bio-Imaging.

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-29 DOI: 10.2174/0113895575350677250101060606

Maria Chiara Santangelo, Leonardo Lucchesi, Leonardo Papa, Annachiara Rossi, Gaia Egizzo, Giusy Laura Fratello, Lucilla Favero, Mauro Pineschi, Valeria Di Bussolo, Sebastiano Di Pietro

{"title":"Smart Applications of Lanthanide Chelates-based Luminescent Probes in Bio-Imaging.","authors":"Maria Chiara Santangelo, Leonardo Lucchesi, Leonardo Papa, Annachiara Rossi, Gaia Egizzo, Giusy Laura Fratello, Lucilla Favero, Mauro Pineschi, Valeria Di Bussolo, Sebastiano Di Pietro","doi":"10.2174/0113895575350677250101060606","DOIUrl":"https://doi.org/10.2174/0113895575350677250101060606","url":null,"abstract":"Luminescent Lanthanide (III) (Ln(III)) bioprobes (LLBs) have been extensively used in the last two decades as intracellular molecular probes in bio-imaging for the efficient revelation of analytes, to signal intracellular events (enzymes/protein activity, antigen-antibody interaction), target specific organelles, and determine parameters of particular biophysical interest, to gain important insights on pathologies or diseases. The choice of using a luminescent Ln(III) coordination compound with respect to a common organic fluorophore is intimately connected to how their photophysical sensitization (antenna effect) can be finely tuned and especially triggered to respond (even quantitatively) to a certain biophysical event, condition or analyte. While there are other reviews focused on how to design chromophoric ligands for an efficient sensitization of Ln(III) ions, both in the visible and NIR region, this review is application-driven: it is a small collection of particularly interesting examples where the LLB's emissive information is acquired by imaging the emission intensity and/or the fluorescence lifetime (fluorescence lifetime imaging microscopy, FLIM).","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Application of the Pyrazole Structure in the Structural Modification of Natural Products.

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-23 DOI: 10.2174/0113895575359419241211092252

Fu-Qun Sun, Ya-Lan Wang, Ke Sun, Fei-Xia Yue, Yun-Xia Sun, Jia-Hong Ju, Zhan-Hui Jin, Qing-Kun Shen, Hong-Yan Guo, Mei-Hui Liu, Zhe-Shan Quan

引用次数: 0

Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment. 药物再利用：揭示癌症治疗中代谢重编程的途径。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-17 DOI: 10.2174/0113895575339660250106093738

Shristy Chaudhary, Abhilash Rana, Seema Bhatnagar

{"title":"Drug Repurposing: A Conduit to Unravelling Metabolic Reprogramming for Cancer Treatment.","authors":"Shristy Chaudhary, Abhilash Rana, Seema Bhatnagar","doi":"10.2174/0113895575339660250106093738","DOIUrl":"https://doi.org/10.2174/0113895575339660250106093738","url":null,"abstract":"Metabolic reprogramming is a hallmark of cancer. Distinct and unusual metabolic aberrations occur during tumor development that lead to the growth and development of tumors. Oncogenic signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells i.e., glucose, lipid, and amino acid metabolism. Therefore, identifying and targeting the metabolic nodes of cancer cells can be a promising intervention and therapeutic strategy for patients with malignancies. The long road of new drug discovery for cancer therapy has necessitated relooking alternative strategies such as drug repurposing. Advanced genomic and proteomic technologies for the assessment of cancer-specific biological pathways have led to the discovery of new drug targets, which provide excellent opportunities for drug repurposing. The development of effective, safe, cheaper, and readily available anticancer agents is the need of the hour, and drug repurposing has the potential to break the current drug shortage bottleneck. This review will accordingly cover various metabolic pathways that are aberrant in cancer, and strategies for targeting metabolic reprogramming by using repurposed drugs.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Synthesis of Medicinally Important Heterocycles. 药用重要杂环化合物的可持续合成。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-16 DOI: 10.2174/0113895575341409241201171848

Dripta De Joardar, Rajarshi Sarkar, Dilip K Maiti

{"title":"Sustainable Synthesis of Medicinally Important Heterocycles.","authors":"Dripta De Joardar, Rajarshi Sarkar, Dilip K Maiti","doi":"10.2174/0113895575341409241201171848","DOIUrl":"https://doi.org/10.2174/0113895575341409241201171848","url":null,"abstract":"Sustainable chemistry and nature-friendly protocols are not only luxury but has become essential requirement for the modern society as it progresses towards a more responsible future. To match the current needs of the community, industries and in particular chemical industry is looking for novel and cheap strategies that have less adverse effects on the environment. Heterocyclic compounds are one particular motif, which is prevalent in nature. It is found in a wide range of synthetic and natural compounds, both established and in development as potent therapeutic candidates. According to the US retail market in 2014-2015, heterocyclic moieties constitute the basic skeletons for 80% of marketed pharmaceuticals. However, majority of the synthetic methodologies still uses classical approaches with toxic solvents, stoichiometric reagents, reactions with less atom economy etc. Thus, there is an urgent need for green, sustainable alternatives of the classical reactions. In recent years, an array of diverse approaches and technologies have been discovered by the scientific community to address the issue of eco-friendly manufacture of various pharmaceutically and medicinally important heterocyclic molecules. In this context, the current review will summarize various reported green pathways to the heterocyclic architecture, particularly O, N, and S-heterocyclic compounds. The methods highlighted in this article includes reaction in environment friendly nonconventional media, solvent-free approaches, heterogeneous catalysis, organocatalysis, electrochemical reactions, microwave-mediated reactions, ultrasound-based reactions, enzymatic reactions, biocatalysis, and others.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Application onto the Eyelid Skin: Is it a Feasible Delivery Route of Ophthalmic Drugs? 眼睑皮肤外用：眼科药物的一种可行的给药途径吗？

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-13 DOI: 10.2174/0113895575358373241220043138

Larysa Grygor'yeva, Manuela Colla Carvalheiro, Sandra Simões

{"title":"Topical Application onto the Eyelid Skin: Is it a Feasible Delivery Route of Ophthalmic Drugs?","authors":"Larysa Grygor'yeva, Manuela Colla Carvalheiro, Sandra Simões","doi":"10.2174/0113895575358373241220043138","DOIUrl":"https://doi.org/10.2174/0113895575358373241220043138","url":null,"abstract":"Topical application of ophthalmic drugs remains to be the preferred delivery method. Eye drops lead the pharmaceutical forms due to ease of application. Despite the poor bioavailability of drugs administered topically, especially related to the dilution and excretion by tear fluid, the absence of controlled drug delivery, and the poor compliance within pediatric and senior populations, eye drops and ointments are still the first choices in eye--related disorders management. Only a few studies have explored the eyelid skin as a site for drug application and transdermal delivery as an alternative route of administration of ophthalmic drugs. Such works have validated the delivery of drugs into the ocular tissues through the eyelid barrier. The eyelid represents a differentiated skin barrier concerning the thickness, the structure of the stratum corneum, the vasculature, and the amount of lipids. This work intends to question why the eyelid, being an accessible, non-invasive, comfortable route of administration is not considered a feasible route for ophthalmic drugs. The eyelid structure is presented, and the anatomical and physiological distinctive characteristics are presented. The work also presents the research work on topical drug application to the eyelid skin that has been published so far.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities. 从氨基酸中提取的生物活性磺胺：它们的合成和药理活性。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-13 DOI: 10.2174/0113895575353663241129064820

Melford Chuka Egbujor, Paolo Tucci, Luciano Saso

{"title":"Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities.","authors":"Melford Chuka Egbujor, Paolo Tucci, Luciano Saso","doi":"10.2174/0113895575353663241129064820","DOIUrl":"https://doi.org/10.2174/0113895575353663241129064820","url":null,"abstract":"Currently, the synthesis of bioactive sulfonamides using amino acid as a starting reagent has become an area of research interest in organic chemistry. Over the years, an amine-sulfonyl chloride reaction has been adopted as a common step in traditional sulfonamide synthetic methods. However, recent developments have shown amino acids to be better precursors than amines in the synthesis of sulfonamides. Although amines and amino acids have some structural similarities, using amino acids rather than amines in the synthesis of sulfonamides minimizes several drawbacks. Comparatively, amino acids are preferred to amines as starting reagents in sulfonamide synthesis due to their biological relevance, chirality, stereochemistry, diversity of side chains, orthogonality in functional group manipulation, the potential for peptide and protein synthesis, mild reaction conditions, alignment with green chemistry principles, diverse synthetic applications, easy availability, and economic viability. Amino acids, having the aforementioned properties, offer a versatile platform for the synthesis of sulfonamides with tailored structures. The reaction mechanism of the synthesis of amino acid-derived sulfonamides involves a nucleophilic attack by the amino group on the activated sulfonyl species to produce a sulfonamide functional group. Amino acid-based sulfonamides have numerous pharmacological activities, including antibacterial, antiviral, anticancer, antioxidant, anti-inflammatory, anti-plasmodial, antimalarial, anti-trypanosomal, and insect growth regulatory properties. This review discusses several synthetic processes, emphasizing established ways, cutting- edge techniques, and novel approaches that emphasize the significance of amino acids in the synthesis of sulfonamides. The structure-activity relationship of amino acid-derived sulfonamides and their pharmacological activities are also highlighted.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications. 探索Azine衍生物的多功能性：综合综述合成和生物应用。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-10 DOI: 10.2174/0113895575363243241129100845

Aftab Alam, Fayaz Ur Rahman, Ahmed A Elhenawy, Abid Ali, Manzoor Ahmad, Momin Khan

{"title":"Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications.","authors":"Aftab Alam, Fayaz Ur Rahman, Ahmed A Elhenawy, Abid Ali, Manzoor Ahmad, Momin Khan","doi":"10.2174/0113895575363243241129100845","DOIUrl":"https://doi.org/10.2174/0113895575363243241129100845","url":null,"abstract":"Organic compounds containing azines, di-imines, or bis-Schiff-bases have two azomethine (-CH=N-) functional groups associated with a bridging component. These constituents have attracted attention from a diversity of disciplines, comprising coordination, medicinal, agriculture chemistry, and organic synthesis, because of their comprehensive chemical reactivity and nature. This study determines common synthetic approaches and various biological and pharmacological activities of several substituted bis-Schiff byproducts. The usefulness of bis-Schiff bases in synthetic chemistry and their potential as inhibitors of a number of enzymes have attracted research attention. We have examined different biological activities and common synthetic methods used to make bis- Schiff bases that have been published in the literature. A systematic search of the literature has been performed, and studies fitting the prearranged inclusion standards have been inspected. This review can open up new potentials for upcoming research in this area and advance our information on bis- Schiff bases.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Development in Hydantoins, Thiohydantoins, and Selenohydantoins as Anticancer Agents: Structure-activity Relationship and Design Strategies. 抗癌药物氢酰脲、硫代氢酰脲和硒代氢酰脲的研究进展：构效关系和设计策略。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-10 DOI: 10.2174/0113895575329643241206101210

Ajay Kumar Gupta, Gajendra Singh Thakur, Sanmati Kumar Jain

引用次数: 0

Implications of Biomaterials for Chronic Wounds. 生物材料对慢性伤口的影响。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-07 DOI: 10.2174/0113895575314580241121080256

Virginia-Silviana Barbu Becherescu, Madalina-Diana Gaboreanu, Ioana-Cristina Marinas, Andra-Maria Paun, Ileana Paula Ionel, Speranta Avram

{"title":"Implications of Biomaterials for Chronic Wounds.","authors":"Virginia-Silviana Barbu Becherescu, Madalina-Diana Gaboreanu, Ioana-Cristina Marinas, Andra-Maria Paun, Ileana Paula Ionel, Speranta Avram","doi":"10.2174/0113895575314580241121080256","DOIUrl":"https://doi.org/10.2174/0113895575314580241121080256","url":null,"abstract":"The use of biomaterials in treating and managing chronic wounds represents a significant challenge in global healthcare due to the complex nature of these wounds, which are slow to heal and can lead to complications such as frequent infections and diminished quality of life for patients. Chronic wounds, which can arise from conditions like diabetes, poor circulation, and pressure sores, pose distinct challenges in wound care, necessitating the development of specialized dressings. The pathophysiology of chronic wounds is thoroughly examined in this article, with particular attention paid to the cellular and molecular defects at work and the therapeutic guidelines. It also identifies key issues in the field, such as biocompatibility, cost-effectiveness, immune reactions, and regulatory obstacles, while suggesting future research focuses on improving biocompatibility, integrating drug delivery systems, and exploring cellular treatments. Ethical implications, such as patient safety, informed consent, and equitable access to technology, are also discussed. Finally, this review highlights the transformative potential of biomaterials in chronic wound management, urging for continued research and clinical integration to fully harness their capabilities in improving patient care.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Insights into the Modifications and Bioactivities of Indole-3-Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review. 吲哚-3-甲醛及其衍生物作为药物设计潜在支架的修饰和生物活性的新见解：综述

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-07 DOI: 10.2174/0113895575351704241120060746

Nuhu Abdullahi Mukhtar, Mustapha Suleiman, Helmi Mohammed Al-Maqtari, Kumitaa Theva Das, Ajmal R Bhat, Joazaizulfazli Jamalis

{"title":"New Insights into the Modifications and Bioactivities of Indole-3-Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review.","authors":"Nuhu Abdullahi Mukhtar, Mustapha Suleiman, Helmi Mohammed Al-Maqtari, Kumitaa Theva Das, Ajmal R Bhat, Joazaizulfazli Jamalis","doi":"10.2174/0113895575351704241120060746","DOIUrl":"https://doi.org/10.2174/0113895575351704241120060746","url":null,"abstract":"Indole, a ubiquitous structural motif in bioactive compounds, has played a pivotal role in drug discovery. Among indole derivatives, indole-3-carboxaldehyde (I3A) has emerged as a particularly promising scaffold for the development of therapeutic agents. This review delves into the recent advancements in the chemical modification of I3A and its derivatives, highlighting their potential applications in various therapeutic areas. I3A derivatives have demonstrated a wide range of biological activities, including anti-inflammatory, anti-leishmanial, anti-cancer, anti-bacterial, antifungal, and anti-HIV properties. The structural modifications introduced to the I3A scaffold, such as substitutions on the indole ring (alkylation/arylation/halogenation), variations in the aldehyde group via condensation (Aldol/Claisen/Knoevenagel), and molecular hybridization with other reputable bioactive compounds like coumarins, chalcones, triazoles, and thiophenes, contribute to these activities. Beyond its therapeutic potential, I3A has also found applications as a ligand for Schiff base synthesis, a polymer, and a chromophore. This review provides a comprehensive overview of the latest research on I3A and its derivatives, focusing on the key reactions, modification pathways, reaction conditions, yields, and associated therapeutic activities. By understanding these advancements, researchers can gain valuable insights into the potential applications and future directions for I3A-based drug discovery.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0