{"title":"Emerging Role of Dendrobium Orchid Plants in Diabetes: Phytochemistry Aspects, SAR, and Therapeutic Potential.","authors":"Sanjeev Kumar Sahu, Paranjeet Kaur, Manish Vyas, Divya Chauhan","doi":"10.2174/0113895575402987250917093529","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Dendrobium belongs to one of the most important genera of the Orchidaceae family, which covers the largest category of flowering plants. More recent traditional medicinal studies have revealed that these orchid plants are used worldwide to treat a variety of illnesses, including those related to the complexion, pulmonary, gastrointestinal, reproductive, and circulatory systems, as well as cancers, pain, and inflammation. Several Dendrobium species have been the subject of phytochemistry and pharmacological research to explore their different medicinal aspects.</p><p><strong>Materials and methods: </strong>A comprehensive search through databases (PubMed, Google Scholar, Web of Science, Traditional integrated knowledge resources, local dissertations, and books) was conducted up until November 2024 using key terms such as \"Orchid plants, Type 2 diabetes, phytomedicine, natural products, phytoconstituents, phytochemistry, therapeutic potential, and plantderived antidiabetic agents.\"</p><p><strong>Results: </strong>Its major phytoconstituents belong to the chemical categories of stilbenoid, glycoside, alkaloids, flavonoids, phenanthrenes, anthocyanins, carotenoids, and bibenzyl derivatives, in which the alkaloids and flavonoids play a most significant role for their biological properties. The flavone Cglycoside and flavanols are commonly found, but highly methylated and glycosylated derivatives of flavonoids are absent in orchid leaves.</p><p><strong>Discussion: </strong>The phytochemical composition of Dendrobium, along with its structure-activity relationship of major classes, supports it as a potential source for novel antidiabetic agents through integrating traditional knowledge with medicinal chemistry aspects.</p><p><strong>Conclusion: </strong>A specific Dendrobium orchid plant has a promising role in the effective management of diabetes. In the future, newer, more potent antidiabetic compounds may be isolated and further developed into more effective antidiabetic agents.</p>","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini reviews in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113895575402987250917093529","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Dendrobium belongs to one of the most important genera of the Orchidaceae family, which covers the largest category of flowering plants. More recent traditional medicinal studies have revealed that these orchid plants are used worldwide to treat a variety of illnesses, including those related to the complexion, pulmonary, gastrointestinal, reproductive, and circulatory systems, as well as cancers, pain, and inflammation. Several Dendrobium species have been the subject of phytochemistry and pharmacological research to explore their different medicinal aspects.
Materials and methods: A comprehensive search through databases (PubMed, Google Scholar, Web of Science, Traditional integrated knowledge resources, local dissertations, and books) was conducted up until November 2024 using key terms such as "Orchid plants, Type 2 diabetes, phytomedicine, natural products, phytoconstituents, phytochemistry, therapeutic potential, and plantderived antidiabetic agents."
Results: Its major phytoconstituents belong to the chemical categories of stilbenoid, glycoside, alkaloids, flavonoids, phenanthrenes, anthocyanins, carotenoids, and bibenzyl derivatives, in which the alkaloids and flavonoids play a most significant role for their biological properties. The flavone Cglycoside and flavanols are commonly found, but highly methylated and glycosylated derivatives of flavonoids are absent in orchid leaves.
Discussion: The phytochemical composition of Dendrobium, along with its structure-activity relationship of major classes, supports it as a potential source for novel antidiabetic agents through integrating traditional knowledge with medicinal chemistry aspects.
Conclusion: A specific Dendrobium orchid plant has a promising role in the effective management of diabetes. In the future, newer, more potent antidiabetic compounds may be isolated and further developed into more effective antidiabetic agents.
石斛属是兰科植物中最重要的属之一，是有花植物中最大的一类。最近的传统医学研究表明，这些兰花植物在世界范围内被用于治疗各种疾病，包括与肤色、肺部、胃肠道、生殖和循环系统有关的疾病，以及癌症、疼痛和炎症。一些种类的石斛已成为植物化学和药理学研究的主题，以探索其不同的药用方面。材料和方法：通过数据库（PubMed，谷歌Scholar， Web of Science，传统集成知识资源，本地论文和书籍）进行了全面的搜索，直到2024年11月，使用关键术语，如“兰花植物，2型糖尿病，植物医学，天然产物，植物成分，植物化学，治疗潜力和植物衍生的抗糖尿病药物”。结果：其主要植物成分属于二苯乙烯类、糖苷类、生物碱类、黄酮类、菲类、花青素类、类胡萝卜素类和联苯衍生物等化学类别，其中生物碱类和黄酮类在其生物学特性中起着最重要的作用。在兰花叶中，黄酮苷和黄烷醇是常见的，但黄酮的高度甲基化和糖基化的衍生物是不存在的。讨论：石斛的植物化学成分及其主要类的构效关系，通过将传统知识与药物化学方面相结合，支持其作为新型抗糖尿病药物的潜在来源。结论：一种特殊的石斛兰植物在糖尿病的有效治疗中具有良好的作用。在未来，新的、更有效的抗糖尿病化合物可能会被分离出来，并进一步发展成为更有效的抗糖尿病药物。
期刊介绍：
The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.
Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.
Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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