Mini reviews in medicinal chemistry最新文献_第2页

An Outline on benzimidazole Containing Marketed Drugs with Proton Pump Inhibitor and H₁ Receptor Antagonist Activities. 苯并咪唑类具有质子泵抑制剂和H1受体拮抗剂活性的市售药物概述。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-06 DOI: 10.2174/0113895575329633240928163509

Sumit Tahlan, Sucheta Singh, Kailash C Pandey, Kuldeep Singh

{"title":"An Outline on benzimidazole Containing Marketed Drugs with Proton Pump Inhibitor and H1 Receptor Antagonist Activities.","authors":"Sumit Tahlan, Sucheta Singh, Kailash C Pandey, Kuldeep Singh","doi":"10.2174/0113895575329633240928163509","DOIUrl":"https://doi.org/10.2174/0113895575329633240928163509","url":null,"abstract":"Heterocyclic compounds are increasingly used in medicinal chemistry because they are the main components of many biological processes and materials. Benzimidazole remains the core center of the heterocyclic chemical group, with essential traits such as six-five-member connected rings and two nitrogen atoms at the 1,3 position in a six-membered benzene and five-membered imidazole- fused ring system. Molecules with benzimidazole derivatives serve important functions as therapeutic agents and have shown excellent results in clinical and biological research. In this comprehensive review, we summarize marketed medications that include the benzimidazole moiety. Here, we discuss two topics: PPIs and H1 receptor antagonists. Benzimidazole derivatives are important in all fields because they have the same isostructural pharmacophore as that of naturally occurring active biomolecules. While PPIs and H1 receptor antagonists are generally safe in the short term, accumulating data suggest that their long-term use may pose concerns. This systematic review aimed to assess global PPI use in the general population. This will help researchers, medicinal chemists, and pharmaceutical scientists to create breakthrough benzimidazole-based drugs. This review can help identify novel lead compounds and optimize existing benzimidazole derivatives to improve medicinal efficacy. Benzimidazole has attracted significant interest because of its high bioavailability, stability, and biological efficiency. This page reveals and discusses typical synthesis processes for marketed pharmaceuticals in the benzimidazole class of scaffolds, MOA, and therapeutic uses.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Nature-Derived Biopolymers for Oral Applications- A Review. 天然衍生生物聚合物的口服应用潜力综述。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-02 DOI: 10.2174/0113895575359305241218113847

Vijayalakshmi Kumar, Ashok K Sundramoorthy

{"title":"Potential of Nature-Derived Biopolymers for Oral Applications- A Review.","authors":"Vijayalakshmi Kumar, Ashok K Sundramoorthy","doi":"10.2174/0113895575359305241218113847","DOIUrl":"https://doi.org/10.2174/0113895575359305241218113847","url":null,"abstract":"In recent years, there has been a growing emphasis on the \"back-to-nature\" movement, which has brought biopolymers derived from natural sources into the spotlight. These biopolymers are gaining attention for their versatile surface-active properties, anti-adhesive capabilities, excellent biocompatibility, non-toxicity, biodegradability, and antimicrobial effectiveness against a wide range of oral microorganisms, including both bacteria and fungi. Researchers have been actively modifying these eco-friendly, nature-based biopolymers to enhance their interaction with surrounding cells and tissues, improving their performance in vivo. This has led to innovative applications in areas such as surface coatings, controlled drug delivery, tissue repair, and dental implant devices. These advancements hold the potential to pave the way for the development of novel drug delivery systems with enhanced therapeutic properties, ultimately supporting the creation of innovative formulations for clinical use. This review aims to provide an up-to-date overview of recent developments, explore potential future directions, and highlight the promising applications of nature-derived biopolymers in oral healthcare.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial Metabolites-induced Epigenetic Modifications for Inhibition of Colorectal Cancer: Current Status and Future Perspectives. 微生物代谢物诱导的表观遗传修饰对结直肠癌的抑制作用：现状与未来展望》。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575320344240625080555

Vaibhav Singh, Ekta Shirbhate, Rakesh Kore, Subham Vishwakarma, Shadiya Parveen, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak

{"title":"Microbial Metabolites-induced Epigenetic Modifications for Inhibition of Colorectal Cancer: Current Status and Future Perspectives.","authors":"Vaibhav Singh, Ekta Shirbhate, Rakesh Kore, Subham Vishwakarma, Shadiya Parveen, Ravichandran Veerasamy, Amit K Tiwari, Harish Rajak","doi":"10.2174/0113895575320344240625080555","DOIUrl":"10.2174/0113895575320344240625080555","url":null,"abstract":"Globally, one of the most prevalent cancers is colorectal cancer (CRC). Chemotherapy and surgery are two common conventional CRC therapies that are frequently ineffective and have serious adverse effects. Thus, there is a need for complementary and different therapeutic approaches. The use of microbial metabolites to trigger epigenetic alterations as a way of preventing CRC is one newly emerging field of inquiry. Small chemicals called microbial metabolites, which are made by microbes and capable of altering host cell behaviour, are created. Recent research has demonstrated that these metabolites can lead to epigenetic modifications such as histone modifications, DNA methylation, and non-coding RNA regulation, which can control gene expression and affect cellular behaviour. This review highlights the current knowledge on the epigenetic modification for cancer treatment, immunomodulatory and anti-carcinogenic attributes of microbial metabolites, gut epigenetic targeting system, and the role of dietary fibre and gut microbiota in cancer treatment. It also focuses on short-chain fatty acids, especially butyrates (which are generated by microbes), and their cancer treatment perspective, challenges, and limitations, as well as state-of-the-art research on microbial metabolites-induced epigenetic changes for CRC inhibition. In conclusion, the present work highlights the potential of microbial metabolites-induced epigenetic modifications as a novel therapeutic strategy for CRC suppression and guides future research directions in this dynamic field.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"76-93"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies. Nimbolide：胰腺癌多模式疗法中的潜在植物化学制剂

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575293138240527061556

Mukesh Jogi, Hitakshi Asnani, Sohini Singh, Pramod Kumar

{"title":"Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies.","authors":"Mukesh Jogi, Hitakshi Asnani, Sohini Singh, Pramod Kumar","doi":"10.2174/0113895575293138240527061556","DOIUrl":"10.2174/0113895575293138240527061556","url":null,"abstract":"A significant contributor to cancer-related death, pancreatic cancer (PC) has a terrible prognosis in general that has not altered over many years. Currently, it is extremely difficult to prevent disease or discover it early enough to initiate treatment. PC is a challenging malignancy to treat, and several major impediments significantly impact the effectiveness of its treatment. These obstacles primarily include chemoresistance, drug toxicity, and limited drug bioavailability. Phytochemicals can be used as an alternative to chemotherapeutic drugs, or they can augment the anticancer properties of the chemotherapeutic agents. Nimbolide (NL) is a prominent limonoid compound found in Azadirachta indica, and has garnered substantial attention as a phytochemical with anticancer potential. It has powerful antiproliferative effects on a variety of cancer cell lines and is effective as a chemotherapeutic in preclinical studies. The primary modes of action of NL include suppression of metastasis and angiogenesis, activation of apoptosis, anti-proliferation, and control of enzymes that metabolize carcinogens. Despite numerous pharmacodynamic (PD) investigations, NL is still in the early stages of the drug development process because no comprehensive pharmacokinetic studies or long-term toxicity studies. Preclinical and toxicological assessments should be conducted to establish an appropriate dosage range, ensuring the safety of NL for its application in initial human clinical trials. This review endeavors to provide a comprehensive summary of the current developmental stage of NL along with nanoparticles as a principal candidate for therapeutic purposes in PC.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"27-41"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmaceutical Studies on Piperazine-based Compounds Targeting Serotonin Receptors and Serotonin Reuptake Transporters. 针对羟色胺受体和羟色胺再摄取转运体的哌嗪类化合物的药物研究。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575319878240612070850

Cem Yamali, Merve Nenni, Mehtap Tugrak Sakarya, Hasan Alper Kaplan

{"title":"Pharmaceutical Studies on Piperazine-based Compounds Targeting Serotonin Receptors and Serotonin Reuptake Transporters.","authors":"Cem Yamali, Merve Nenni, Mehtap Tugrak Sakarya, Hasan Alper Kaplan","doi":"10.2174/0113895575319878240612070850","DOIUrl":"10.2174/0113895575319878240612070850","url":null,"abstract":"Depression is a debilitating mental illness that has a significant impact on an individual's psychological, social, and physical life. Multiple factors, such as genetic factors and abnormalities in neurotransmitter levels, contribute to the development of depression. Monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), serotoninnoradrenaline reuptake inhibitors, and atypical and new-generation antidepressants are well-known drug classes. SSRIs are the commonly prescribed antidepressant medications in the clinic. Genetic variations impacting serotonergic activity in people can influence susceptibility to diseases and response to antidepressant therapy. Gene polymorphisms related to 5-hydroxytryptamine (5-HT) signaling and subtypes of 5-HT receptors may play a role in the development of depression and the response to antidepressants. SSRIs binding to 5-HT reuptake transporters help relieve depression symptoms. Research has been conducted to identify a biomarker for detecting depressive disorders to identify new treatment targets and maybe offer novel therapy approaches. The pharmacological potentials of the piperazine-based compounds led researchers to design new piperazine derivatives and to examine their pharmacological activities. Structure-activity relationships indicated that the first aspect is the flexibility in the molecules, where a linker of typically a 2-4 carbon chain joins two aromatic sides, one of which is attached to a piperazine/phenylpiperazine/benzyl piperazine moiety. Newly investigated compounds having a piperazine core show a superior antidepressant effect compared to SSRIs in vitro/in vivo.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"58-75"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Progress of Glutathione Peroxidase 4 Inhibitors in Cancer Therapy. 谷胱甘肽过氧化物酶 4 抑制剂在癌症治疗中的最新进展。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575308546240607073310

Shangde Liu, Jian Wang

引用次数: 0

An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential. 哒嗪酮类似物概述：化学和药理潜力。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575287746240528072330

Youness Boukharsa, Khalid Karrouchi, Houda Attjioui, M'Hammed Ansar

引用次数: 0

Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold. 共享氨基甲酸酯支架的内源性大麻素降解酶的有望抑制剂。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-11-25 DOI: 10.2174/0113895575328120241107061303

Shivani Jaiswal, Senthil Raja Ayyannan

{"title":"Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold.","authors":"Shivani Jaiswal, Senthil Raja Ayyannan","doi":"10.2174/0113895575328120241107061303","DOIUrl":"https://doi.org/10.2174/0113895575328120241107061303","url":null,"abstract":"Carbamate has been extensively used as a scaffold in the recent era of drug discovery and is a common structural motif of many approved drugs. The carbamate moiety's unique amide-ester hybrid (-O-CO-NH-) feature offers the designing of specific drug-target interactions. Despite the discovery of numerous carbamate derivatives that act on the endocannabinoid system (ECS), the development of clinically effective carbamates remains a challenge. In this review, we highlight the therapeutic potential of carbamate inhibitors of endocannabinoid degrading enzymes as a breakthrough in discovering neurotherapeutic drugs. We discuss the design strategies and medicinal chemistry aspects involved in developing carbamate-based molecular architectures that modulate the endocannabinoid signaling pathway by interfering with fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and α/β-Hydrolase domain-containing 6 (ABHD6). Additionally, we highlight the dual activity profile of carbamates against FAAH and MAGL, FAAH and cholinesterase, and FAAH and TRPV1 channels. Furthermore, we illustrate the pharmacophores of O-functionalized carbamates and N-cyclic carbamates that are crucial for FAAH and MAGL inhibitory activities, respectively.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfonated Penta-Galloyl Glucose (SPGG): The Pharmacological Effects of Promiscuous Glycosaminoglycan Small Molecule Mimetic. 磺化五缩水甘油葡萄糖（SPGG）：杂交氨基葡聚糖小分子模拟物的药理作用。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-11-08 DOI: 10.2174/0113895575332248241030033106

Rami A Al-Horani

引用次数: 0

Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative. 全面透视吡唑啉酮衍生物的绿色合成方法、结构活性关系和治疗潜力。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-11-07 DOI: 10.2174/0113895575327555241024111038

Samyak Bajaj, Akanksha Gupta, Priyanshu Nema, Rashmi Rawal, Varsha Kashaw, Sushil Kumar Kashaw

{"title":"Comprehensive Insight into Green Synthesis Approaches, Structural Activity Relationship, and Therapeutic Potential of Pyrazolic Chalcone Derivative.","authors":"Samyak Bajaj, Akanksha Gupta, Priyanshu Nema, Rashmi Rawal, Varsha Kashaw, Sushil Kumar Kashaw","doi":"10.2174/0113895575327555241024111038","DOIUrl":"https://doi.org/10.2174/0113895575327555241024111038","url":null,"abstract":"Pyrazolic chalcone exhibits diverse therapeutic activities, including anti-inflammatory, antioxidant, antimicrobial, antitumor, and anti-diabetic properties. Structural activity relationship (SAR) studies play a crucial role in understanding the molecular aspects governing their biological effects, guiding the rational design of derivatives with enhanced efficacy and reduced side effects. This review provides an overview of pyrazolic chalcone derivatives, emphasizing their synthesis through both conventional and green methods. In comparison, conventional synthesis methods have been widely employed in the past for the production of pyrazolic chalcones, often relying on traditional chemical processes that may involve the use of hazardous reagents and generate significant waste. On the other hand, green synthesis methods, in harmony with the growing emphasis on sustainable practices in drug discovery, offer a more environmentally friendly alternative. Green synthesis typically involves the use of eco-friendly reagents, solvents, and energy-efficient processes, resulting in reduced environmental impact and improved resource efficiency. Overall, pyrazolic chalcone derivatives represent a promising class of compounds with significant potential for therapeutic applications.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0