Mini reviews in medicinal chemistry最新文献_第9页

Innovative Horizons in Drug Design: Exploring the Synthesis and Medicinal Properties of Heterocyclic Schiff Bases. A Review. 药物设计的创新视野：探索杂环席夫碱的合成和药性。复习一下。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575320413250126041041

Yousaf Khan, Hina Sarfraz, Wajid Rehman, Momin Khan, Liaqat Rasheed, Khursheed Ur Rahman

{"title":"Innovative Horizons in Drug Design: Exploring the Synthesis and Medicinal Properties of Heterocyclic Schiff Bases. A Review.","authors":"Yousaf Khan, Hina Sarfraz, Wajid Rehman, Momin Khan, Liaqat Rasheed, Khursheed Ur Rahman","doi":"10.2174/0113895575320413250126041041","DOIUrl":"10.2174/0113895575320413250126041041","url":null,"abstract":"Schiff bases are an important scaffold for designing drug development. They are characterized by having a carbon-nitrogen double bond. This double bond is synthesized by different synthetic schemes by both the aromatic and aliphatic chains. Bases inspired chemists due to their versatile importance in drug discovery and drug development. A large number of drugs are designed through the heterocyclic Schiff base moieties. This review highlighted the importance of Schiff bases concerning their bioactive importance in drug design. Moreover, amide-iminol tautomerism is a significant tool for the high biological importance of Schiff bases due to the presence of the C=N bond. Furthermore, the reported synthesized heterocyclic scaffolds Schiff bases have a wide range of biological importance. Due to this different biological importance, such as antimicrobial, anticonvulsant, analgesic, antioxidant, antimalarial, anti-inflammatory, anticancer, antidiabetic, and antileishmanial properties, the researcher has shown their interest by synthesizing different heterocyclic Schiff bases. In this review article, biologically active heterocyclic Schiff bases were reviewed intensively concerning drug design and drug development.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"727-744"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Small Molecular PET Tracers for Pancreatic Cancer Diagnosis: Preclinical Stage. 小分子PET示踪剂在胰腺癌诊断中的最新进展：临床前阶段。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575375382250408143606

Meijie Pan, Qiusong Chen, Shaobo Yao

引用次数: 0

An Outline on Benzimidazole Containing Marketed Drugs with Proton Pump Inhibitor and H₁ Receptor Antagonist Activities. 苯并咪唑类具有质子泵抑制剂和H1受体拮抗剂活性的市售药物概述。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575329633240928163509

Sumit Tahlan, Sucheta Singh, Kailash C Pandey, Kuldeep Singh

{"title":"An Outline on Benzimidazole Containing Marketed Drugs with Proton Pump Inhibitor and H1 Receptor Antagonist Activities.","authors":"Sumit Tahlan, Sucheta Singh, Kailash C Pandey, Kuldeep Singh","doi":"10.2174/0113895575329633240928163509","DOIUrl":"10.2174/0113895575329633240928163509","url":null,"abstract":"Heterocyclic compounds are increasingly used in medicinal chemistry because they are the main components of many biological processes and materials. Benzimidazole remains the core center of the heterocyclic chemical group, with essential traits such as six-five-member connected rings and two nitrogen atoms at the 1,3 position in a six-membered benzene and five-membered imidazole- fused ring system. Molecules with benzimidazole derivatives serve important functions as therapeutic agents and have shown excellent results in clinical and biological research. In this comprehensive review, we summarize marketed medications that include the benzimidazole moiety. Here, we discuss two topics: PPIs and H1 receptor antagonists. Benzimidazole derivatives are important in all fields because they have the same isostructural pharmacophore as that of naturally occurring active biomolecules. While PPIs and H1 receptor antagonists are generally safe in the short term, accumulating data suggest that their long-term use may pose concerns. This systematic review aimed to assess global PPI use in the general population. This will help researchers, medicinal chemists, and pharmaceutical scientists to create breakthrough benzimidazole-based drugs. This review can help identify novel lead compounds and optimize existing benzimidazole derivatives to improve medicinal efficacy. Benzimidazole has attracted significant interest because of its high bioavailability, stability, and biological efficiency. This page reveals and discusses typical synthesis processes for marketed pharmaceuticals in the benzimidazole class of scaffolds, MOA, and therapeutic uses.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"440-462"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation-driven Oncogenesis: Precision Medicine and Immunotherapeutic Strategies. 炎症驱动的肿瘤发生：精准医学和免疫治疗策略。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575361098250112085145

Almuthanna K Alkaraki, Alaa A A Aljabali, Mohammad A Obeid

{"title":"Inflammation-driven Oncogenesis: Precision Medicine and Immunotherapeutic Strategies.","authors":"Almuthanna K Alkaraki, Alaa A A Aljabali, Mohammad A Obeid","doi":"10.2174/0113895575361098250112085145","DOIUrl":"10.2174/0113895575361098250112085145","url":null,"abstract":"Cancer remains a significant global health burden, placing immense pressure on healthcare systems and putting huge pressure on the healthcare system. There are multiple driving forces, and increasing attention has been gained over the past two decades regarding chronic inflammation, which represents a pivotal factor owing to its ability to establish or maintain an environment that is permissive for tumor initiation, growth, and progression. This review details the interplay between inflammation and cancer by highlighting how chronic inflammation fuels oncogenesis by promoting genetic instability, immune evasion, and a setting rich in pro-tumorigenic signaling. This review explains how various inflammatory mediators, including cytokines and transcription factors, can potentially create tumor microenvironments by drawing on case studies and recent research data. Furthermore, this article provides insights into the molecular mechanisms of Nuclear Factor Kappa B (NF-κB)-regulated pathways and inflammasomes and provides essential molecular links between inflammation and tumorigenesis. Furthermore, novel therapeutic approaches using nanotechnology and immunotherapy are also discussed. Nanotechnology offers precise drug delivery with increased targeting to tumor sites, whereas immunotherapy, including immune checkpoint inhibitors, attempts to restore the functionality of the immune system to recognize and destroy cancer cells. Thus, a combination of these approaches represents a promising new frontier in cancer treatment that addresses both the inflammatory and immune dimensions of oncogenesis. This review highlights the importance of integrating molecular insights into novel therapeutic strategies to address the dual challenges associated with chronic inflammation and cancer. Their development could lead to significant improvements in patient outcomes and reduce global cancer burden.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":"25 9","pages":"653-663"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Development in Hydantoins, Thiohydantoins, and Selenohydantoins as Anticancer Agents: Structure-activity Relationship and Design Strategies. 抗癌药物氢酰脲、硫代氢酰脲和硒代氢酰脲的研究进展：构效关系和设计策略。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575329643241206101210

Ajay Kumar Gupta, Gajendra Singh Thakur, Sanmati Kumar Jain

引用次数: 0

An Overview of Pyridazinone Analogs: Chemical and Pharmacological Potential. 哒嗪酮类似物概述：化学和药理潜力。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575287746240528072330

Youness Boukharsa, Khalid Karrouchi, Houda Attjioui, M'Hammed Ansar

引用次数: 0

New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review. 吲哚-3-甲醛及其衍生物作为药物设计潜在支架的修饰和生物活性的新见解：综述

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575351704241120060746

Nuhu Abdullahi Mukhtar, Mustapha Suleiman, Helmi Mohammed Al-Maqtari, Kumitaa Theva Das, Ajmal R Bhat, Joazaizulfazli Jamalis

{"title":"New Insights into the Modifications and Bioactivities of Indole-3- Carboxaldehyde and its Derivatives as a Potential Scaffold for Drug Design: A Mini-Review.","authors":"Nuhu Abdullahi Mukhtar, Mustapha Suleiman, Helmi Mohammed Al-Maqtari, Kumitaa Theva Das, Ajmal R Bhat, Joazaizulfazli Jamalis","doi":"10.2174/0113895575351704241120060746","DOIUrl":"10.2174/0113895575351704241120060746","url":null,"abstract":"Indole, a ubiquitous structural motif in bioactive compounds, has played a pivotal role in drug discovery. Among indole derivatives, indole-3-carboxaldehyde (I3A) has emerged as a particularly promising scaffold for the development of therapeutic agents. This review delves into the recent advancements in the chemical modification of I3A and its derivatives, highlighting their potential applications in various therapeutic areas. I3A derivatives have demonstrated a wide range of biological activities, including anti-inflammatory, anti-leishmanial, anti-cancer, anti-bacterial, antifungal, and anti-HIV properties. The structural modifications introduced to the I3A scaffold, such as substitutions on the indole ring (alkylation/arylation/halogenation), variations in the aldehyde group via condensation (Aldol/Claisen/Knoevenagel), and molecular hybridization with other reputable bioactive compounds like coumarins, chalcones, triazoles, and thiophenes, contribute to these activities. Beyond its therapeutic potential, I3A has also found applications as a ligand for Schiff base synthesis, a polymer, and a chromophore. This review provides a comprehensive overview of the latest research on I3A and its derivatives, focusing on the key reactions, modification pathways, reaction conditions, yields, and associated therapeutic activities. By understanding these advancements, researchers can gain valuable insights into the potential applications and future directions for I3A-based drug discovery.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"480-503"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors. 实验癌细胞模型的能量代谢行为和对微环境因素的反应与实际人类肿瘤不同

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2025-01-01 DOI: 10.2174/0113895575322436240924101642

Rafael Moreno-Sanchez, Jorge Luis Vargas-Navarro, Joaquin Alberto Padilla-Flores, Diana Xochiquetzal Robledo-Cadena, Juan Carlos Granados-Rivas, Rutt Taba, Anton Terasmaa, Giuseppe Leonardo Auditano, Tuuli Kaambre, Sara Rodriguez-Enriquez

{"title":"Energy Metabolism Behavior and Response to Microenvironmental Factors of the Experimental Cancer Cell Models Differ from that of Actual Human Tumors.","authors":"Rafael Moreno-Sanchez, Jorge Luis Vargas-Navarro, Joaquin Alberto Padilla-Flores, Diana Xochiquetzal Robledo-Cadena, Juan Carlos Granados-Rivas, Rutt Taba, Anton Terasmaa, Giuseppe Leonardo Auditano, Tuuli Kaambre, Sara Rodriguez-Enriquez","doi":"10.2174/0113895575322436240924101642","DOIUrl":"10.2174/0113895575322436240924101642","url":null,"abstract":"Analysis of the biochemical differences in the energy metabolism among bi-dimensional (2D) and tri-dimensional (3D) cultured cancer cell models and actual human tumors was undertaken. In 2D cancer cells, the oxidative phosphorylation (OxPhos) fluxes range is 2.5-19 nmol O2/min/mg cellular protein. Hypoxia drastically decreased OxPhos flux by 2-3 times in 2D models, similar to what occurs in mature multicellular tumor spheroids (MCTS), a representative 3D cancer cell model. However, mitochondrial protein contents and enzyme activities were significantly different between both models. Moreover, glycolytic fluxes were also significantly different between 2D and MCTS. The glycolytic flux range in 2D models is 1-34 nmol lactate/min/mg cellular protein, whereas in MCTS the range of glycolysis fluxes is 60-80 nmol lactate/min/mg cellular. In addition, sensitivity to anticancer canonical and metabolic drugs was greater in MCTS than in 2D. Actual solid human tumor samples show lower (1.6-4.5 times) OxPhos fluxes compared to normoxic 2D cancer cell cultures. These observations indicate that tridimensional organization provides a unique microenvironment affecting tumor physiology, which has not been so far faithfully reproduced by the 2D environment. Thus, the analysis of the resemblances and differences among cancer cell models undertaken in the present study raises caution on the interpretation of results derived from 2D cultured cancer cells when they are extended to clinical settings. It also raises awareness about detecting which biological and environmental factors are missing in 2D and 3D cancer cell models to be able to reproduce the actual human tumor behavior.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":"319-339"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold. 共享氨基甲酸酯支架的内源性大麻素降解酶的有望抑制剂。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-11-25 DOI: 10.2174/0113895575328120241107061303

Shivani Jaiswal, Senthil Raja Ayyannan

{"title":"Promising Inhibitors of Endocannabinoid Degrading Enzymes Sharing a Carbamate Scaffold.","authors":"Shivani Jaiswal, Senthil Raja Ayyannan","doi":"10.2174/0113895575328120241107061303","DOIUrl":"https://doi.org/10.2174/0113895575328120241107061303","url":null,"abstract":"Carbamate has been extensively used as a scaffold in the recent era of drug discovery and is a common structural motif of many approved drugs. The carbamate moiety's unique amide-ester hybrid (-O-CO-NH-) feature offers the designing of specific drug-target interactions. Despite the discovery of numerous carbamate derivatives that act on the endocannabinoid system (ECS), the development of clinically effective carbamates remains a challenge. In this review, we highlight the therapeutic potential of carbamate inhibitors of endocannabinoid degrading enzymes as a breakthrough in discovering neurotherapeutic drugs. We discuss the design strategies and medicinal chemistry aspects involved in developing carbamate-based molecular architectures that modulate the endocannabinoid signaling pathway by interfering with fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL), and α/β-Hydrolase domain-containing 6 (ABHD6). Additionally, we highlight the dual activity profile of carbamates against FAAH and MAGL, FAAH and cholinesterase, and FAAH and TRPV1 channels. Furthermore, we illustrate the pharmacophores of O-functionalized carbamates and N-cyclic carbamates that are crucial for FAAH and MAGL inhibitory activities, respectively.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemicals and Nanotechnology: A Powerful Combination against Breast Cancer. 植物化学物质与纳米技术：抗击乳腺癌的强大组合。

IF 3.3 3区医学

Mini reviews in medicinal chemistry Pub Date : 2024-09-13 DOI: 10.2174/0113895575297312240903055926

Sadat Shafi, Faraha Ahmed, Ayesha Waheed, Syed Sufiyan Ahmad, Sana Khan, Mohammad Ahmed Khan, Faheem Hyder Pottoo, Syed Arman Rabbani, Shailja Singh, Abul Kalam Najmi

{"title":"Phytochemicals and Nanotechnology: A Powerful Combination against Breast Cancer.","authors":"Sadat Shafi, Faraha Ahmed, Ayesha Waheed, Syed Sufiyan Ahmad, Sana Khan, Mohammad Ahmed Khan, Faheem Hyder Pottoo, Syed Arman Rabbani, Shailja Singh, Abul Kalam Najmi","doi":"10.2174/0113895575297312240903055926","DOIUrl":"https://doi.org/10.2174/0113895575297312240903055926","url":null,"abstract":"Considerable advancements have been made in breast cancer therapeutics in the past few decades. However, the advent of chemo-resistance and adverse drug reactions coupled with tumor metastasis and recurrence posed a serious threat to combat this lethal disease. Novel anti-cancer agents, as well as new therapeutic strategies, are needed to complement conventional breast cancer therapies. The quest for developing novel anti-cancer drugs caused an upsurge in exploring and harnessing natural compounds, especially phytochemicals. Various research groups have explored and documented the anti-cancer potential of wide variety of phytochemical groups including flavonoids (curcumin, kaempferol, myricetin, quercetin, naringenin, apigenin, genistein epigallocatechin gallate), stilbenes (resveratrol), carotenoids (crocin, lycopene, lutein), and anthraquinone (Emodin). However, low chemical stability, poor water solubility, and short systemic half-life impede their clinical utility. The implication of nano-technological approaches to decode the pharmacokinetic challenges associated with phytochemical usage, as well as selective drug targeting, have markedly enhanced the pre-clinical anti-cancer activity, thus aiding in their clinical translation. This review documented the recent advances in utilizing phytochemicals for breast cancer prevention and lipidbased nanotechnological approaches for circumventing their pharmacokinetic concerns to enhance their systemic availability, cytotoxicity, and targeted delivery against breast cancer alone as well as in combination with conventional therapeutic agents.","PeriodicalId":18548,"journal":{"name":"Mini reviews in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142290916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0