Medicine Science | International Medical Journal最新文献

{"title":"The ability of HALP score to distinguish between malignant and benign colorectal neoplasms and its prognostic importance in colorectal cancers","authors":"I. Dusunceli, Z. Sargin, U. Celik, F. Sargın","doi":"10.5455/medscience.2023.04.057","DOIUrl":"https://doi.org/10.5455/medscience.2023.04.057","url":null,"abstract":"Systemic inflammation and nutritional status play important roles in the development and progression of various cancers, including colorectal cancer. The prognosis for malignancies can be predicted using the inflammatory marker known as HALP (calculated by hemoglobin, albumin, lymphocytes, and platelets). Furthermore, recent studies have claimed the HALP score to help distinguish between benign and malignant lesions. We aimed to research the diagnostic importance of the HALP score in the differentiation of malignant (colorectal cancer) and benign colorectal neoplasms (colorectal adenomas and hyperplastic polyps) and its prognostic significance in colorectal cancer patients. Patients diagnosed with colorectal cancer, colorectal adenoma, and hyperplastic polyps were evaluated retrospectively between January 2017 and January 2022. The median HALP score in the colorectal cancer group was significantly lower than the other groups (colorectal adenoma and hyperplastic polyps) (p<0.001). There was no statistical difference between the median HALP scores of the colorectal adenoma and hyperplastic groups (p=0.525). ROC analysis found the cut-off value of the HALP score as 41.01 to differentiate colorectal cancer from benign colorectal lesions (sensitivity= 0.73, specitivity=0.62, 95% CI=0.67-0.76, p<0.001). The HALP level below 28.1 was associated with worse overall survival (p=0.046) and was shown to be an independent prognostic factor in the colorectal cancer group. The HALP score can be used to differentiate colorectal cancer from benign colorectal neoplasms and as a prognostic factor in colorectal cancer.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80930156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between emergency department applications and prognoses of geriatric patients","authors":"Ş. Savrun, A. Savrun","doi":"10.5455/medscience.2022.11.234","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.234","url":null,"abstract":"The World Health Organization (WHO) stated that the elderly population constituted 12% of the population of people over 60 years old in 2015. In the coming years, by 2030, 1 out of 6 people in the world will be 60 years or older, and this ratio will increase to 22% in 2050. In addition, it is estimated that the proportion of the elderly population will be 11.0% in 2025, 12.9% in 2030, 16.3% in 2040, 22.6% in 2060 and 25.6% in 2080. The number of admissions to the emergency services of geriatric patients, the hospital treatment process, and even the mortality and morbidity rates increase in elderly patients. In this direction, it was aimed to retrospectively analyze the data of patients over 65 who applied to a tertiary hospital emergency department and determine the factors affecting the mortality of geriatric patients. The presented study is a cross-sectional and retrospective study. All patients over the age of 65 who applied to the emergency department of Ordu University Medical Faculty Training and Research Hospital between 01 July 2022 and 31 2022 were retrospectively analyzed. Demographic features of the cases, the way they applied to the emergency room (112 Emergency Service Ambulance, others: with their own vehicle, by taxi, etc.), the last diagnosis in the emergency department (neurological, cardiovascular, respiratory, metabolic, trauma and others), treatment methods (outpatient, inpatient, intensive care), their motility and the relationship of these data with each other were examined. Between the specified dates, a total of 28459 patients over the age of 18 were admitted to the emergency department. It was determined that 10.16% (n=2894) of these patients consisted of patients over 65 years of age. The relationship between the treatment modalities and mortality according to the way the patients came to the hospital was found to be statistically significant (p<0.005). The relationship between hospitalization, treatment modalities and mortality was statistically significant according to the clinical diagnosis of the cases (p<0.005). In the presented study, it was determined that the mortality of patients who applied to the emergency department due to metabolic problems and who used the ambulance system as a referral tool was high. In fact, the prognosis of geriatric patients who apply to the emergency department for any reason, especially by using the emergency ambulance system, is worse than those who do not use the emergency ambulance system. For this reason, the use of an emergency ambulance system alone affects the prognosis negatively and it is necessary to evaluate such geriatric patients more carefully.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78424778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-related carpal tunnel syndrome; non-invasive early diagnosis and postpartum evaluation","authors":"Aslihan Ozturk, F. Erpala","doi":"10.5455/medscience.2022.12.260","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.260","url":null,"abstract":"The diagnosis of pregnancy-related carpal tunnel syndrome (PRCTS) was made with noninvasive methods and evaluated the effect of PRCTS on quality of life, its treatment and prognosis. Third-trimester pregnant women between the ages of 18-45 and diagnosed with PRCTS were included. For diagnosis; the presence of pain, positive motor and sensory tests, Carpal Tunnel Symptoms Scale-6 (CTS-6), and Boston Carpal Tunnel Questionnaire (BCTQ) were evaluated. The criteria used to determine improvement were the regression of complaints and symptoms based on a VAS score of 0 and a CTS-6 score of less than 5. According to these criteria, patients whose complaints regressed in the postpartum eighth week were called group A, whose complaints regressed in the postpartum sixth month were called group B, and women who still did not meet the criteria were called group C. The study included 102 wrists of 94 women. When the type of delivery, gestational age at birth, gravida, and parity were compared according to the continuity of complaints and symptoms, no differences were found. When the first trimester body mass index (BMI) measurements were compared between groups A and B, it was observed that group B had higher first trimester BMI values; this difference was statistically significant. The mean age was 29.2 years in group A, was 32.6 years in group B and the difference was significant. Conclusions: We recommend that pregnant women over 30 years old with a high BMI should be screened for PRCTS using non-invasive diagnostic tools, CTS-6, and VAS.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78759314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The affecting factors and prevalence rate of sick building syndrome in healthcare workers","authors":"Muge Karadag, Seva Ecin, S. Turkkan, Z. Aytemur, S. Hacievliyagil","doi":"10.5455/medscience.2022.12.272","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.272","url":null,"abstract":"Sick building syndrome (SBS) is defined as symptoms that occur while living or working in a certain building but disappear after moving away from the environment. In this study, we aimed to determine the effects of indoor air pollutants on the health of employees, the prevalence of SBS in healthcare workers at the university hospital, its relationship with environmental and personal factors and the respiratory system. A questionnaire was applied to 951 healthcare workers who agreed to participate in the study. Having at least one general, one mucosal and one skin symptom every week in the last 3 months was accepted as SBS. Temperature, CO and CO2 levels and relative humidity were measured in different areas of the hospital. The prevalence of SBS was 62.1%. There was a statistically significant relationship between SBS and having a chronic disease (p<0.0001), continuous drug use (p=0.005) and the evaluation of the environment as warm (p=0.042). Having a chronic disease (OR=0.426; 95% CI, 0.228–0.797), the environment often being too warm (OR 0.218; 95% CI, 0.084–0.567) or occasionally too bright (OR=0.300; 95% CI, 0.158–0571) and diagnosed by a doctor due to symptoms (OR=3.209; 95% CI, 1.529–6.731) was found to be significant in forward variable selection method and binary logistic regression analysis. In our study, a relationship was found between physical factors such as temperature, humidity and CO2 level of the environment and personal factors such as stress, chronic disease and SBS. SBS can be prevented by control at the source as well as by administrative and engineering interventions among the employees.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79321413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of lymph node metastasis rates in breast cancer molecular subtypes; A retrospective clinical study","authors":"E. Esen, M. Saydam, Sumeyra Guler, K. Yılmaz, M. Turan, P. Demır, M. Gulcelik","doi":"10.5455/medscience.2022.11.233","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.233","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79491365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative predictor laboratory markers for complicated appendicitis: A retrospective analysis of single center experience","authors":"B. Barut, Cengiz Ceylan","doi":"10.5455/medscience.2023.05.077","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.077","url":null,"abstract":"In this study, we aimed to investigate the pre-operative predictive role of the serum white blood cell and platelet counts, C-reactive protein (CRP), bilirubin, amylase, lipase, and sodium levels for complicated appendicitis in patients aged≥18 years. We retrospectively evaluated 574 patients (aged≥18 years) who underwent appendectomy due to acute appendicitis (AA) between March 2018 and March 2022 at our clinic. The patient population was divided into two groups as perioperative complicated and uncomplicated appendicitis and the preoperative predictor role of serum white blood cell counts, platelet counts, CRP, bilirubin, amylase, lipase, and sodium levels were compared for complicated versus uncomplicated appendicitis. In multivariate analyses, age>38 years, the timing of Emergency Department (ED) arrival to admission ≥2 days, CRP ≥3.36 mg/dL, and total bilirubin ≥0.76 mg/dL are independent risk factors for detecting complicated AA. Moreover, in the designed scoring system, the AUC: 0.877 (CI: 0.847-0.907) for perforated AA at scores below or above. Estimation of the complications of AA can help clinicians practically with the scoring system designed because of the determined predictive factors.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78152273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy","authors":"Pinar Akdur, N. Ciledag, B. Savran, Ayse Duran","doi":"10.5455/medscience.2023.06.084","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.084","url":null,"abstract":"In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78642693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-alcoholic fatty liver disease and sleep quality: a single center cross-sectional survey study","authors":"Z. Sargin, Guray Ceylan","doi":"10.5455/medscience.2022.08.203","DOIUrl":"https://doi.org/10.5455/medscience.2022.08.203","url":null,"abstract":"Sleep-wake disorders are probably a part of Nonalcoholic Fatty Liver Disease (NAFLD) etiology. This study aimed to evaluate the relationship between NAFLD and the Pittsburgh Sleep Quality Index (PSQI) components. Sleep quality was assessed by the PSQI, which comprised seven components. Participants diagnosed with hepatic steatosis using ultrasonographic imaging and healthy volunteers were given the questionnaire. The percentage of subjects with poor sleep quality was noticeably higher in the NAFLD patients than in the non-NAFLD control group (OR: 4.58, 95% CI: 2.67-7.85) (p<0.001). Compared to the control group, the NAFLD group reported shorter sleep duration (p=0.044), a longer sleep onset delay (p<0.001), worse subjective sleep quality (p<0.001), a higher percentage of subjects with sleep disturbances (p<0.001), a higher percentage of subjects using hypnotic drugs (p=0.009), and a higher percentage of subjects with daytime dysfunction (p<0.001). When the subjects were split into two groups based on gender, global PSQI sleep quality and subjective sleep quality were significantly worse in both genders with NAFLD than in the non-NAFLD group (p<0.001). The sleep onset delay of the NAFLD group was substantially longer in males (p=0.002) and females (p<0.001) compared to controls. Sleep disturbances were significantly higher in both sexes with NAFLD compared to controls (p<0.001). The rate of those with daytime dysfunction in the NAFLD group was considerably higher in both genders compared to the non-NAFLD group (p=0.001). Only among the male patients in the NAFLD group the prevalence of hypnotic drug use was substantially greater (p=0.033) than in the non-NAFLD group. Poor sleep was associated with NAFLD in both genders.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77975545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of enteral nutrition through feeding stomas or gastric tubes in digestive surgery","authors":"C. Finaritra, A. Rakotondrainibe, F. Rasoaherinomenjanahary, A. Rajaonera, L. Samison","doi":"10.5455/medscience.2022.06.129","DOIUrl":"https://doi.org/10.5455/medscience.2022.06.129","url":null,"abstract":"Ostomy feeding remains a reference approach for enteral nutritional assistance. In Madagascar, the techniques are still conventional surgical procedures due to the lack of adequate endoscopic equipment. This study aims to evaluate the benefits and risks of enteral nutrition with a two-week follow-up. Included patients who had benefited from enteral nutrition by tube feeding using nasogastric, gastrostomy, and jejunostomy tubes over six months in Joseph Ravoahangy Andrianavalona Hospital. Prevalence, age and gender, current body mass index (BMI), weight, nutritional grade, initial pathology, psychological status, comorbidities, type of feeding stoma, and the surgical technique (gastrostomy or jejunostomy) were studied. After 15 days, the effectiveness of enteral nutrition was assessed using BMI, serum albumin, C-Reactive Protein (CRP) level, as well as postoperative complications and quality of life. The patient's outcome on the 15th day has been determined. The Chi-square test analyzed the associations and Mann Whitney test compared the effects of enteral nutrition by ostomy and gastric tube use. Forty-two patients were included, aged 47(17-78). The sex ratio was 0.5. Initially, the body mass index was 17(12-23) kg/m², the serum albumin value 3.4 (2.5-4.7) gr/dl with a median CRP level of 16 (2-74.2) mg/l. Nutritional assistance resulted in a weight variation between baseline and 15th day. Comparing enteral nutrition by ostomy and gastric tube, only variation of C Reactive Protein on the 15th day has a significative difference. Mortality was 33% (gastrostomy), 31% (jejunostomy), 24% (nasogastric tube). Nutritional support and the choice of ostomy or gastric tube for enteral nutrition were not associated with mortality. The effectiveness of nutritional assistance is still questionable in this study if the results are more promising in the literature. The death rate linked to the initial pathology and the general state of the patients is still considerable, hence the interest in decision-making in multidisciplinary consultation meetings.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72664262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Our treatment outcomes in bartholin cysts or abscesses","authors":"Nurcan Yoruk","doi":"10.5455/medscience.2023.04.055","DOIUrl":"https://doi.org/10.5455/medscience.2023.04.055","url":null,"abstract":"The purpose of this study was to examine the outcomes of Bartholin abscess or cyst surgery, silver nitrate therapy, and cyst or abscess excision in terms of recurrence, duration of the procedure, and healing times. The files of 100 patients treated in our hospital for Bartholin cysts or abscesses between March 2022 and December 2022 were reviewed retrospectively. The patients’ demographic characteristics were recorded. Demographic data, the location and size of Bartholin abscesses, complaints at presentation, and cases with recurrence were noted. The patients were divided into three groups according to the treatment applied and were compared with one another, especially in terms of recurrence, operative time, and recovery time. Group 1 consisted of those who underwent drainage due to Bartholin cyst or abscess, Group 2 of those treated with silver nitrate, and Group 3 of those who underwent cyst excision. Recurrence was detected in 12 (40%) of the cases in Group 1. Relapsed cases were treated with silver nitrate. Recurrence was observed in only one patient in the group treated with silver nitrate (Group 2). Bartholin cyst excision was performed on that patient. Mean operation times were 2.80 min in Group 1, 4.40 min in Group 2, and 23 min in Group 3 (p=0.0001). Mean recovery times were 3.37±0.49 days in Group 1, 6.13±0.73 days in Group 2, and 13.70±2.09 days in Group 3 (p=0.0001). A comparison of the patients in all three groups revealed that the recurrence rate was higher in the group receiving abscess drainage. While recurrence was observed in only one patient in the silver nitrate group, no recurrence occurred in the cyst excision group (p<0.001). This study emphasizes that silver nitrate application is a simple practical method that can be performed using local anesthesia, and involving minimal scar tissue, a faster procedure time, and faster recovery.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76246349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}