Medicine Science | International Medical Journal最新文献

{"title":"Short-term comparison of intraarticular administration of IL-1 receptor antagonist and platelet-rich plasma for osteoarthritis treatment","authors":"Y. Guler, E. Kuyucu, A. Kara, Omer Hakyemez, F. Say, A. Bulbul","doi":"10.5455/medscience.2022.12.282","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.282","url":null,"abstract":"Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and chondroitin sulfate, PRP, and IL-1Ra are commonly used. This study aimed to compare the effects of IL-1 receptor antagonist (IL-1Ra) and platelet-rich plasma (PRP) on patients with Kellgren-Lawrence (KG) stage 2-3 knee osteoarthritis in terms of Visual Analog Scale (VAS) and Knee injury and osteoarthritis outcome score (KOOS). Ninety patients with KG stage 2-3 knee primary osteoarthritis were divided into two groups, with one group receiving three intraarticular IL-1Ra injections and the other group receiving three PRP injections. VAS and KOOS scores were recorded at the beginning and after six months to evaluate clinical improvement. Both the IL-1Ra and PRP groups showed statistically significant improvement in all scores, including the VAS and KOOS. After six months, the KOOS score in the IL-1Ra group was significantly higher than the PRP group, while the first-year VAS score after treatment in the IL-1Ra group was significantly lower compared to the PRP group. The mean KOOS scores increased from 44.1 to 87.8 and 46.04 to 84.43 at the end of six months in both groups, while the mean VAS scores decreased from 7.27 to 1.02 and 7.29 to 1.71 in the IL-1Ra and PRP groups, respectively. Administering intra-articular IL-1Ra once a week for three weeks can effectively improve function and reduce pain in patients with Kellgren-Lawrence stage 2-3 osteoarthritis. However, more research is necessary to validate the use of IL-1 receptor antagonists in OA treatment.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79917147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared dissociative identity disorder and defector alter personality: controlled human syndrome and the objectification trap phenomenon as a gaslighting form based on dissociative narcissism from the perspective of dissoanalysis theory and dissoanalytic psychohistory","authors":"E. Ozturk","doi":"10.5455/medscience.2023.04.053","DOIUrl":"https://doi.org/10.5455/medscience.2023.04.053","url":null,"abstract":"In today's age of global dissociation, it has become necessary to deal with the social and clinical aspects of dissociation, which is a \"psychosocial denial experience\" in terms of ideational, emotional, relational, behavioral and sensory aspects. In dysfunctional nations experiencing psychosocial denial, democracy unfortunately functions as the majority's freedom to make wrong decisions. The freedom of the majority to make wrong decisions creates “dissociative and misanthropic masses” and causes “universal violence circulation” and despotism to prevail. Dissoanalysis and “Ozturk’s Pervasive and Reversible Dissociative Fusion Theory” define the universal circulation of violence as a reversible “dissociative violence oscillation” associated with trauma, which spreads from individual to society and from society to individual. The submissive mode associated with the experience of connecting to their oppressors and dictators is contagious; it spreads from traumatized and dysfunctional individuals to dissociated and dysfunctional societies, creating fused interpersonal relationships and both conformist and sadomasochistic masses. The dissoanalytic school defines the phenomenon of dissociation, which is most closely related to chronic, complex and cumulative traumatic experiences, which can transform from the individual to the social dimension and from the social dimension to the individual dimension in the face of oppression, and even be experienced simultaneously in the individual and social dimensions, both in relational and psychosociopolitical contexts. Dissoanalytic psychohistory, which continues its development rapidly in parallel with the principles of dissoanalysis and modern psychotraumatology, has far outstripped the stable and dogmatic schools of psychiatry, psychology, and history with its integrative solution-oriented approaches and effective psychosocial prevention strategies towards the phenomenon of trauma-related dissociation and individual and mass obedience cycles against oppression. In this original article, Ozturk defined the phenomenon of “objectification trap”, “controlled human syndrome” and “shared dissociative identity disorder” as the triple pillar of fused bilateral relations dominated by reversible dominative and submissive modes from the perspective of dissoanalysis theory and dissoanalytic psychohistory.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82721569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the vasorelaxant effect of Sugammadex on the arterial smooth muscle in rats","authors":"Mustafa Karademir, G. Altun, Dilay Karademir","doi":"10.5455/medscience.2023.06.092","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.092","url":null,"abstract":"Although NMBAs (Neuro Muscular Blocking Agents) have been used for a long time, postoperative residual curarization is still a significant problem. Nowadays, an agent named Sugammadex is used for the reversal of curarization. It has been presented as a safer agent than its predecessor, neostigmine. The main purpose of this study is to investigate the effects of Sugammadex on rat thoracic aorta and enlighten the mechanism of action and potential benefits in surgical operations with general anesthesia. Twenty Wistar albino rats were used for the experiments. Thoracic aorta segments have been removed and mounted to the organ bath. Contraction and relaxation responses were presented as a percentage of phenylephrine (3x10-5 M) contraction. After recording contractile responses of Sugammadex (10-8-10-4 M), relaxation responses of Sugammadex (10-8-10-4 M) have been recorded both in the presence and absence of L-NAME (3x10-5 M) (Potent Nitric Oxide Sentase Inhibitor). Finally, relaxation responses of sugammadex-rocuronium have been recorded. Sugammadex caused slightly noticeable and concentration-dependent contraction on isolated thoracic aorta strips. Sugammadex also caused potent and concentration-dependent relaxation on isolated rat thoracic aorta. The relaxation response caused by Sugammadex has been diminished significantly in the presence of L-NAME. Administration of rocuronium with Sugammadex did cause neither relaxation nor any additional contractile effect on isolated rat thoracic aorta strips. Sugammadex is a promising agent in reversing rocuronium-induced neuromuscular block. Although the adverse effects of this agent are not studied in detail, it seems Sugammadex is safer than neostigmine. The side effects of anesthetic agents are one of the main problems of surgical procedures, including neurosurgery, gynecology, and obstetrics. Especially acute hypotension may be fatal in neurosurgery and gynecological operations. Sugammadex should be used carefully in adjusted and individualized doses to avoid hypotension-related adverse effects.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"464 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88892079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxia inducible factors and hypoxia associated factor expression profiles and prognostic significance in renal cell carcinomas","authors":"M. Kıran, N. Sungu, Hayriye Dogan, Arslan Ardicoglu, Fazli Erdogan, B. Gumuskaya","doi":"10.5455/medscience.2023.05.060","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.060","url":null,"abstract":"Hypoxia Inducible Factor-1 alpha and Hypoxia Inducible Factor-2 alpha (HIF-1α and HIF-2α) are crucial in Renal Cell Carcinoma (RCC) formation. Hypoxia Associated Factor (HAF) prompts HIF-1α degradation regardless of oxygen levels, but no such link exists for HIF-2α. This study encompassed 239 cases, where tissue microarray (TMA) sections were exposed to HIF-1α, HIF-2α, and HAF antibodies. Staining intensity and tumor cell percentage determined scores for HIF-1α, HIF-2α, and HAF, with median histoscore establishing \"high\" or \"low\" cutoffs. Among the cases, 64.9% (155 cases) were negative for HIF-1α, 17.6% (42 cases) displayed low, and another 17.6% (42 cases) showed strong HIF-1α expression. HIF-1α expression correlated significantly with histological type and World Health Organization/International Society of Urological Pathology (WHO/ISUP) nuclear grade. Regarding HIF-2α, 15.5% (37 cases) were negative, 23.4% (56 cases) exhibited low, and 61.1% (146 cases) displayed high expression, with larger tumor size in the high HIF-2α group. Among 239 cases, 41.4% (99 cases) were negative for HAF, 36.8% (88 cases) showed low, and 21.8% (52 cases) displayed high HAF scores. HAF expression correlated with WHO/ISUP nuclear grade and metastasis presence. Notably, HIF-2α staining intensity directly correlated with increased HAF intensity (rho=0.146; p=0.024), while HIF-1α intensity decrease corresponded with heightened HAF intensity, showing a statistically significant negative correlation (rho=-0.180; p=0.005). In this rare examination of tumor tissue, a reverse connection between HIF-1α and HAF expression was uncovered, while a linear link emerged between HIF-2α and HAF expression. Overall, this study established that HIF-1α, HIF-2α, and HAF expression are associated with an unfavorable prognosis.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88836381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between emergency department applications and prognoses of geriatric patients","authors":"Ş. Savrun, A. Savrun","doi":"10.5455/medscience.2022.11.234","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.234","url":null,"abstract":"The World Health Organization (WHO) stated that the elderly population constituted 12% of the population of people over 60 years old in 2015. In the coming years, by 2030, 1 out of 6 people in the world will be 60 years or older, and this ratio will increase to 22% in 2050. In addition, it is estimated that the proportion of the elderly population will be 11.0% in 2025, 12.9% in 2030, 16.3% in 2040, 22.6% in 2060 and 25.6% in 2080. The number of admissions to the emergency services of geriatric patients, the hospital treatment process, and even the mortality and morbidity rates increase in elderly patients. In this direction, it was aimed to retrospectively analyze the data of patients over 65 who applied to a tertiary hospital emergency department and determine the factors affecting the mortality of geriatric patients. The presented study is a cross-sectional and retrospective study. All patients over the age of 65 who applied to the emergency department of Ordu University Medical Faculty Training and Research Hospital between 01 July 2022 and 31 2022 were retrospectively analyzed. Demographic features of the cases, the way they applied to the emergency room (112 Emergency Service Ambulance, others: with their own vehicle, by taxi, etc.), the last diagnosis in the emergency department (neurological, cardiovascular, respiratory, metabolic, trauma and others), treatment methods (outpatient, inpatient, intensive care), their motility and the relationship of these data with each other were examined. Between the specified dates, a total of 28459 patients over the age of 18 were admitted to the emergency department. It was determined that 10.16% (n=2894) of these patients consisted of patients over 65 years of age. The relationship between the treatment modalities and mortality according to the way the patients came to the hospital was found to be statistically significant (p<0.005). The relationship between hospitalization, treatment modalities and mortality was statistically significant according to the clinical diagnosis of the cases (p<0.005). In the presented study, it was determined that the mortality of patients who applied to the emergency department due to metabolic problems and who used the ambulance system as a referral tool was high. In fact, the prognosis of geriatric patients who apply to the emergency department for any reason, especially by using the emergency ambulance system, is worse than those who do not use the emergency ambulance system. For this reason, the use of an emergency ambulance system alone affects the prognosis negatively and it is necessary to evaluate such geriatric patients more carefully.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78424778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy","authors":"Pinar Akdur, N. Ciledag, B. Savran, Ayse Duran","doi":"10.5455/medscience.2023.06.084","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.084","url":null,"abstract":"In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78642693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-related carpal tunnel syndrome; non-invasive early diagnosis and postpartum evaluation","authors":"Aslihan Ozturk, F. Erpala","doi":"10.5455/medscience.2022.12.260","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.260","url":null,"abstract":"The diagnosis of pregnancy-related carpal tunnel syndrome (PRCTS) was made with noninvasive methods and evaluated the effect of PRCTS on quality of life, its treatment and prognosis. Third-trimester pregnant women between the ages of 18-45 and diagnosed with PRCTS were included. For diagnosis; the presence of pain, positive motor and sensory tests, Carpal Tunnel Symptoms Scale-6 (CTS-6), and Boston Carpal Tunnel Questionnaire (BCTQ) were evaluated. The criteria used to determine improvement were the regression of complaints and symptoms based on a VAS score of 0 and a CTS-6 score of less than 5. According to these criteria, patients whose complaints regressed in the postpartum eighth week were called group A, whose complaints regressed in the postpartum sixth month were called group B, and women who still did not meet the criteria were called group C. The study included 102 wrists of 94 women. When the type of delivery, gestational age at birth, gravida, and parity were compared according to the continuity of complaints and symptoms, no differences were found. When the first trimester body mass index (BMI) measurements were compared between groups A and B, it was observed that group B had higher first trimester BMI values; this difference was statistically significant. The mean age was 29.2 years in group A, was 32.6 years in group B and the difference was significant. Conclusions: We recommend that pregnant women over 30 years old with a high BMI should be screened for PRCTS using non-invasive diagnostic tools, CTS-6, and VAS.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78759314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The affecting factors and prevalence rate of sick building syndrome in healthcare workers","authors":"Muge Karadag, Seva Ecin, S. Turkkan, Z. Aytemur, S. Hacievliyagil","doi":"10.5455/medscience.2022.12.272","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.272","url":null,"abstract":"Sick building syndrome (SBS) is defined as symptoms that occur while living or working in a certain building but disappear after moving away from the environment. In this study, we aimed to determine the effects of indoor air pollutants on the health of employees, the prevalence of SBS in healthcare workers at the university hospital, its relationship with environmental and personal factors and the respiratory system. A questionnaire was applied to 951 healthcare workers who agreed to participate in the study. Having at least one general, one mucosal and one skin symptom every week in the last 3 months was accepted as SBS. Temperature, CO and CO2 levels and relative humidity were measured in different areas of the hospital. The prevalence of SBS was 62.1%. There was a statistically significant relationship between SBS and having a chronic disease (p<0.0001), continuous drug use (p=0.005) and the evaluation of the environment as warm (p=0.042). Having a chronic disease (OR=0.426; 95% CI, 0.228–0.797), the environment often being too warm (OR 0.218; 95% CI, 0.084–0.567) or occasionally too bright (OR=0.300; 95% CI, 0.158–0571) and diagnosed by a doctor due to symptoms (OR=3.209; 95% CI, 1.529–6.731) was found to be significant in forward variable selection method and binary logistic regression analysis. In our study, a relationship was found between physical factors such as temperature, humidity and CO2 level of the environment and personal factors such as stress, chronic disease and SBS. SBS can be prevented by control at the source as well as by administrative and engineering interventions among the employees.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79321413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of lymph node metastasis rates in breast cancer molecular subtypes; A retrospective clinical study","authors":"E. Esen, M. Saydam, Sumeyra Guler, K. Yılmaz, M. Turan, P. Demır, M. Gulcelik","doi":"10.5455/medscience.2022.11.233","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.233","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79491365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative predictor laboratory markers for complicated appendicitis: A retrospective analysis of single center experience","authors":"B. Barut, Cengiz Ceylan","doi":"10.5455/medscience.2023.05.077","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.077","url":null,"abstract":"In this study, we aimed to investigate the pre-operative predictive role of the serum white blood cell and platelet counts, C-reactive protein (CRP), bilirubin, amylase, lipase, and sodium levels for complicated appendicitis in patients aged≥18 years. We retrospectively evaluated 574 patients (aged≥18 years) who underwent appendectomy due to acute appendicitis (AA) between March 2018 and March 2022 at our clinic. The patient population was divided into two groups as perioperative complicated and uncomplicated appendicitis and the preoperative predictor role of serum white blood cell counts, platelet counts, CRP, bilirubin, amylase, lipase, and sodium levels were compared for complicated versus uncomplicated appendicitis. In multivariate analyses, age>38 years, the timing of Emergency Department (ED) arrival to admission ≥2 days, CRP ≥3.36 mg/dL, and total bilirubin ≥0.76 mg/dL are independent risk factors for detecting complicated AA. Moreover, in the designed scoring system, the AUC: 0.877 (CI: 0.847-0.907) for perforated AA at scores below or above. Estimation of the complications of AA can help clinicians practically with the scoring system designed because of the determined predictive factors.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78152273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}