Medicine Science | International Medical Journal最新文献

{"title":"Examination of the anti-candida activity of vitexin against candida species inducing fungal infection","authors":"Tuba Unver, Merve Dimdik, Rizgar Yilmaz","doi":"10.5455/medscience.2025.06.160","DOIUrl":"https://doi.org/10.5455/medscience.2025.06.160","url":null,"abstract":"Infections caused by Candida species have become a serious problem threatening global health systems today. This situation reveals the need to investigate new antifungal agents that can be alternatives to current treatment approaches, which are safer, more accessible and more effective. In this context, the potential anti-Candida effect of vitexin, a natural compound belonging to the flavonoid family, on different Candida species under in vitro conditions, and experimental methods, reveals the levels of its impact against different Candida species. In this study, vitexin's minimum inhibitory concentration (MIC) values against Candida species were determined using dilution methods. The activity of vitexin against Candida glabrata (ATCC 90030), Candida parapsilosis (ATCC 22019), Candida tropicalis (ATCC 13803), Candida krusei (ATCC 14243), and Candida albicans (ATCC 14053) taken from the American Type Culture Collection (ATCC) was measured. According to broth microdilution results, the MIC value of vitexin was determined as 12 mg/mL against C. glabrata, C. tropicalis, and C. albicans, and 24 mg/mL against C. krusei and C. parapsilosis. According to the results of the agar dilution method, the MIC value was found to be 24 mg/mL for all Candida species. When the results of agar dilution and broth microdilution methods were compared, slight differences were observed in the MIC values of vitexin against Candida species. The data obtained from the study indicate that vitexin may be evaluated as a potential agent for treating various Candida infections. Thus, it is thought that the anti-Candida effect of vitexin can form a scientific basis for more comprehensive preclinical and clinical studies to be conducted in the future.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"14 4","pages":"1187-1187"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.medicinescience.org/download/full_pdf?url=https://manage.medicinescience.org/uploads/articles/DeS22UO1uuHPscibEvwspRbZ7blDmD7znLIUCDX0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study of fumaric acid, called allomaleic acid, as a pharmaceutical antimicrobial compound","authors":"Tuba Ünver","doi":"10.5455/medscience.2024.04.031","DOIUrl":"https://doi.org/10.5455/medscience.2024.04.031","url":null,"abstract":"The emergence of antimicrobial resistance in microorganisms and the adverse effects associated with antibiotic use have necessitated the exploration of new, natural substances for antimicrobial treatments. Fumaric acid, or allomaleic acid, is a natural bioactive compound primarily derived from plant-based products. Fumaric acid has potential analgesic, anti-inflammatory, antioxidant, anti-psoriatic, chemopreventive, immunomodulatory, and neuroprotective properties. So far, studies on the antimicrobial activity of fumaric acid have used a plant ingredient. The antimicrobial activity was attributed to fumaric acid because it was detected in large amounts in herbal products. In this preliminary study, the antibacterial and antifungal properties of pure fumaric acid (99+%) were determined by the microdilution method. As a result of the antimicrobial study, the Minimum Inhibitory Concentration (MIC) values of fumaric acid against Candida tropicalis, Candida krusei, Candida albicans, Candida glabrata, and Candida parapsilosis were 9.375, 37.5, 4.687, 4.687, and 1.172 mg/mL, respectively. Moreover, bacterial cells were found to be approximately one hundred times more sensitive to fumaric acid than Candida cells. The MIC values of fumaric acid against Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes were determined as 150 µg /mL, and against Staphylococcus aureus was 75 µg /mL. These results showed that pure fumaric acid has a potent inhibitory effect against pathogenic or opportunistic microorganisms. Its unique properties and potential as an antimicrobial agent make it a compelling study area. Therefore, the usability of fumaric acid in the pharmacotherapeutic field is promising for future advanced in vivo studies.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"13 2","pages":"383-383"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147896452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of GERD in women of childbearing age in Malatya region","authors":"H. Aladag, M. Aladağ","doi":"10.5455/medscience.2023.01.12","DOIUrl":"https://doi.org/10.5455/medscience.2023.01.12","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is frequently seen not only in our country but also all over the world. GERD not only impairs health and quality of life, but also causes serious financial losses in the working population. In this study, our aim is to determine the frequency of gastroesophageal reflux disease among female healthcare professionals of childbearing age in our region. Questions were asked about demographic data such as weight, age, height, BMI, medical history, and gastroesophageal reflux of female healthcare workers, whose data were generated by us. The answers to the questionnaires were collected and evaluated retrospective. All participants in the study were women. This study was carried out on 1224 female healthcare workers of reproductive age working in Malatya Turgut Özal University training and research hospital. Approximately 1150 of the employees who were distributed questionnaires filled out the questionnaires. The mean age of the female healthcare workers of childbearing age was 30.01±5.38 years, between 19-50. The mean height of the healthcare workers was 1.64±7.8 meters, the average weight was 68.05±13.2 kg, and their body mass index (BMI) was 27.4±3.6 kg/m². The frequency of GERD in the study group was found to be positive in 24%. 38.5% of the healthcare workers had previously gone to the doctor with complaints of pyrosis and/or regurgitation. A significant relationship was found between GERD and stress, fizzy drinks, lying down after meals, and family history of GERD. There was no significant relationship between the smoking and coffee use and age of the participants in the study in terms of the presence of GERD.We think that gastroesophageal reflux symptoms are common due to stress, unbalanced diet, irregular sleep and lifestyle habits due to the COVID pandemic in the last two years due to the fact that the participants in the study were healthcare professionals. Among our healthcare professionals, both pyrosis and other GERD symptoms were found to be higher than some of the previous studies, similar to those in our country. We think that the reason for this is that the extremely stressful work of health workers in the last 2 years has contributed to this. As it is known, health workers have worked very hard in the last 2 years, they did not even use their annual leaves, even those who wanted to retire could not retire. We think that this stress environment may also contribute to GERD symptoms.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"220 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73784374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The beneficial effects of ivabradine against myocardial damage induced by isoproterenol in rats","authors":"S. Polat, Miray Altuntas, M. Gunata, A. Polat, L. Tanrıverdi, A. Yıldız, M. Durhan, N. Vardı, Y. Cigremis, H. Acet, H. Parlakpınar","doi":"10.5455/medscience.2023.03.042","DOIUrl":"https://doi.org/10.5455/medscience.2023.03.042","url":null,"abstract":"We aimed to investigate the potential benefits of two doses of ivabradine (IVA)-an If sodium channel blocker against isoproterenol (ISO)-induced myocardial damage in rats.The rats were randomly divided into 4 groups: Control group (n=8); Saline was administered, ISO group (n=12); 150 mg/kg ISO was administered for 2 days, ISO+IVA (1 mg/kg) group (n=12); 1 mg/kg IVA was administered for 4 days in addition to ISO. ISO+IVA (10 mg/kg) group (n=12): 10 mg/kg IVA was administered for 4 days in addition to ISO. Thereafter, hemodynamic, histopathological, and biochemical studies were performed. In the ISO+IVA (1 mg/kg) and ISO+IVA (10 mg/kg) groups, ISO-induced myocardial changes including an increase in density of granulation tissue and degenerated cardiomyocyte were equally decreased. HR was mildly reduced, and arterial blood pressures were slightly increased in the IVA-treated groups versus the ISO group. In the hearts of IVA-treated groups, malondialdehyde (MDA) levels were significantly reduced and glutathione (GSH) level and catalase (CAT) activity were mildly increased compared to the ISO group. Elevation of GSH and CAT activity were more pronounced in the ISO+IVA (10 mg/kg) group. Our results indicate that both 1 mg/kg and 10 mg/kg doses of IVA are effective against heart damage induced by ISO via its negative chronotropic, anti-oxidant (dose-dependent), anti-inflammatory and anti-degenerative properties.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72581370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sedation-free upper gastrointestinal endoscopy and its cost-effectiveness","authors":"Kubilay Oztutuncu","doi":"10.5455/medscience.2023.06.090","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.090","url":null,"abstract":"This study aimed to determine the success rate of sedation-free upper gastrointestinal (GI) endoscopy and evaluate the cost-effectiveness of this drug-free approach.The study included patients who underwent gastroscopy between February 2020 and December 2022. Demographic information such as age and gender, along with clinical data including whether the procedure was performed with sedation and the patients' tolerance status, were recorded. Statistical analysis revealed no significant difference between the sedation and sedation-free groups in terms of procedural success. Interestingly, a notable cost difference of 43% was observed between the two groups, with the sedation-free group demonstrating higher cost-effectiveness. Despite the nearly 50% higher cost associated with administering sedation, there was no significant disparity in the successful completion of the procedure between the two groups. The findings of this study indicate that sedation-free upper GI endoscopy can achieve comparable success rates to the sedation-assisted approach. Moreover, the cost-effectiveness analysis highlights the economic advantage of the drug-free alternative, given the substantial cost reduction observed in the sedation-free group. This study underscores the feasibility of implementing sedation-free procedures as a cost-effective and successful option for upper GI endoscopy","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79326043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and diagnostic importance of the systemic immune-inflammation index in pediatric head trauma","authors":"K. Şener, A. Çakır, H. Toksul, Halil Olmez, M. Tuğcan, E. Altuğ, R. Guven","doi":"10.5455/medscience.2023.05.061","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.061","url":null,"abstract":"Head trauma is a leading cause of mortality and morbidity in pediatric patients. The trauma itself leads to the activation of a biomolecular cascade of damage. Purinergic receptors and ATP release play an important role in the activation of astroglia, microglia, monocyte-macrophages, neutrophils, and T cells in this process. The systemic immune inflammation index can be easily calculated, cheap, only requires hemogram parameters, and does not include any subjective findings. Therefore, we believe that it could be a prognostic predictor and a diagnostic marker for pediatric head trauma cases. Our study was designed as a retrospective and single-center study. The study was conducted with pediatric patients who presented to the emergency department with isolated head trauma between June 15, 2022, and December 15, 2022. Demographic data, medical history, white blood count, platelet count, neutrophil count, systemic immune inflammation index (SIII), Glasgow Coma Score, and the presence of pathology on brain computed tomography were recorded on the case report form. The study was conducted with 112 cases. In cases with bleeding, the median value of GCS was significantly lower (p<0.001), while WBC, Neutrophil, Platelet, NLR and SIII were significantly higher (p=0.008, p=0.001, p<0.001, p=0.011, and p<0.001, respectively). There was no significant difference between lymphocyte values and bleeding status. We believe that a higher SIII may be associated with persistent pericontusional inflammation in the brain and may be a good marker for predicting intracranial pathology and prognosis of the pathology caused by head trauma.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"368 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84915933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallbladder duplication accompanied by gallstones: A rare congenital anomaly","authors":"M. Goksu, H. Alakus, Mahmut Corapli, B. Turk, F. Daghan","doi":"10.5455/medscience.2022.11.249","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.249","url":null,"abstract":"Gallbladder diseases are among the most common pathologies requiring surgical intervention in general surgery practice. Gallbladder duplication is a rare anomaly of the biliary system. Congenital anomalies and anatomical variations of the gallbladder constitute one of the significant difficulties encountered by surgeons since these variations can cause great uncertainty in defining the anatomical structures of the gallbladder and may lead to significant complications during surgery. Congenital malformations are important predisposing factors for iatrogenic bile duct injuries during cholecystectomy. This case report presents a case of symptomatic gallbladder duplication and a double cystic duct treated with laparoscopic cholecystectomy.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85723824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term outcomes of subtotal colectomy for splenic flexure tumors: a single-center experience","authors":"M. Aslan, Oktay Karakose","doi":"10.5455/medscience.2023.07.102","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.102","url":null,"abstract":"Splenic flexure tumors are a subtype of colon tumors whose treatment is still debated. We aim to evaluate the surgical methods and short-term outcomes of splenic flexure tumors. Fourteen patients with colonic tumors at or near the splenic flexure who underwent subtotal colectomy in the surgical oncology department of Samsun Training and Research Hospital between August 2017 and March 2020 were retrospectively evaluated in terms of postoperative morbidity, mortality, and early oncologic outcomes. Of the fourteen patients evaluated, twelve were urgent and two were elective. Four patients underwent additional organ resection as a curative surgery. The pathology was colonic adenocarcinoma in all patients, and the histotype was mucinous in five patients (35.7%). Lymph node positivity was detected in six patients (42.8%) and metastasis in one patient (7.1%). Postoperatively, two patients (14.2%) developed surgical site infection, and one patient (7.1%) died. Eight (57.1%) patients complained of more frequent defecation, with a mean bowel movement frequency of 3±1.6 times daily. Based on our clinical experience, subtotal colectomy is appropriate for emergency surgical treatment of splenic flexure tumors, whereas left hemicolectomy is appropriate under elective conditions.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80896882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissoanalytic Psychohistory: Dissoanalysis of the Traumatic History of Humanity and the Construction of a New Societal Reality","authors":"E. Ozturk","doi":"10.5455/medscience.2023.02.024","DOIUrl":"https://doi.org/10.5455/medscience.2023.02.024","url":null,"abstract":"In the face of all the limitations and criticisms regarding the recognition of consciousness as a psychosocial \"singularity experience\", the construction of \"Dissoanalysis Theory: Psychocommunal Therapy\" centered on \"multiple consciousness system\", \"multiple reality perception\" and \"multiple memory phenomenon\", that is, a new societal reality, has become an indispensability. Based on trauma and dissociation studies, i.e. modern psychotraumatology paradigms and modalities, the \"Dissoanalysis Theory\", structured by Ozturk with the aim of creating a functional society consisting of empathetic, prudent, just, peaceful, and capable individuals, made it possible for the emergence of \"dissoanalytic psychohistory\" from a psychosocial perspective. Dissoanalytic psychohistory is intervention therapy for psychosocial crises! “Dissoanalytic psychohistory” structured by Ozturk within the framework of the dissoanalytic school is defined as a branch of science that does researches on childhood traumas, psychosocial perceptions of childhood, chronic oppressions, child-rearing styles, dysfunctional families, dysfunctional generations, intergenerational transmission of trauma, intergenerational transfer of psychopathology, psychocommunal dissociation, dominant leaders and mass violence and develops strategies focused on especially preventing childhood traumas and wars. Dissoanalytic psychohistory, emphasizing that the neutralization of dysfunctional generations and the future can be achieved by the administration of \"psychocommunal therapy\" of all nations in the world, is an original psychology theory that consists of a holistic synthesis of modern psychotraumatology and psychohistory paradigms with the study of intergenerational transmission of trauma and intergenerational transfer of psychopathology. Dissoanalytic psychohistory, which is the dissoanalysis of the traumatic history of humanity and the construction of a new societal reality, both analyzes and integrates the dissociative components of societies with absolute reality. Dissoanalytic psychohistory creates development-oriented shifts, “dissociative revolutions”, “integrative psychosocial movements” and “mass predictions” and even functional and healthy new society profiles by raising awareness of masses of human about their actions.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78536446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between thigh and leg circumferences and proprioceptive sense: results of postoperative anterior cruciate ligament reconstruction","authors":"Ahmet Gen, Nizamettin zel","doi":"10.5455/medscience.2023.01.015","DOIUrl":"https://doi.org/10.5455/medscience.2023.01.015","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77454960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}