Medicine Science | International Medical Journal最新文献

{"title":"The association between polypharmacy, anticholinergic burden, comorbidities, and hospital length of stay in geriatric patients","authors":"G. Avcı, B. Kanat, G. Can, H. Yavuzer, D. Erdinçler, A. Doventas","doi":"10.5455/medscience.2023.05.062","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.062","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80365818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research of cystic echinococcus serology in people living in rural areas and dealing with animals with the immunochromatographic method: A small-scale cross-sectional study","authors":"A. Yılmaz, F. Orhan, H. Uslu, Mahmut Ucar","doi":"10.5455/medscience.2023.06.097","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.097","url":null,"abstract":"Cystic echinococcus (CE) is a parasitic disease in humans and animals. Our study was performed with the aim of identifying the serology of hydatic cyst disease caused by the Echinococcus granulosus vector, causing a significant health problem in Eastern Anatolia and specifically in our province, among people living in rural areas and involved in animal husbandry. The population for this study comprised 75 volunteers living in rural regions of Erzurum practicing animal husbandry. Blood samples were stored at -40 °C until the time of the study. A survey form was completed to be able to identify the demographic data of participants and to reveal risk factors in terms of infectious vectors. After thawing blood samples at the time of the study, the immunochromatographic test procedure was implemented. The age distribution in the study group was 18 to 70 years, with a mean age of 46.8±15.97 years. The group comprised a total of 75 people, including 29 women (38.7%) and 46 men (61.3%). Of these 75 people with immunochromatographic screening performed, 72 were negative (96%) and 3 were weakly positive (0.5) (4%). It is notable that 4% CE seropositivity was found among individuals with no complaints. Linked to this seropositivity result, it is considered that creating a comprehensive CE screening program will be beneficial for individuals involved in animal husbandry.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90847847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing COVID-19 RT-PCR results, thorax computed tomography findings, and laboratory results of patients admitted to emergency medicine clinic with clinical symptoms of COVID-19 disease","authors":"Murat Muratoglu, E. Bıyıklı, Idd Athumani, G. Koc, Beyza Kamisli, Furkan Kervancioglu, A. Karakose, Cem Canbeyli, Ejderhan Ulug, Utku Kildokum","doi":"10.5455/medscience.2023.03.047","DOIUrl":"https://doi.org/10.5455/medscience.2023.03.047","url":null,"abstract":"In December 2019, cases of pneumonia of unknown origin were detected in Wuhan, Hubei Province, China. It was later determined that the pathogen SARS-CoV, which causes these cases of pneumonia, has been identified as the new enveloped RNA Betacoronavirus 2, now called severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). In Turkey, the first case was detected on March 10, 2020. This study aimed to evaluate the factors that will enable rapid diagnosis of the disease through comparison of COVID-19 RT PCR results, thorax computed tomography (CT) findings, and laboratory results of patients suspected with COVID-19 who visited Başkent University Ankara Hospital Emergency Medicine Clinic. In our sample of 515 patients (280 female and 235 male patients), infiltration was detected in 113 patients (21.9%) The ratio of females to males increased with age. When the sex distribution of the thoracic CT findings was examined, the incidence of infiltration was higher in male patients. Conversely, no statistically significant dependence was found between the two categories using the chi-squared test. Shortness of breath was observed in 32.7% of patients with positive thoracic CT findings. Other common complaints were chest pain, 12.4%; fever, 10.6%; and weakness, 9.7%, respectively. The other category, which covered unclassified arrival complaints, had the highest percentage in the entire sample. When the thoracic CT distribution of comorbidities was examined (hypertension, 29.2% and diabetes, 25.2%) were more common than the other comorbidities in terms of the presence of infiltration. Thoracic CT results with RT-PCR, which were analyzed using the chi-square test, showed a statistically significant dependence between them. Conversely, COVID-compatible thorax CT findings were detected in 80 of 260 patients who tested negative in the PCR test. No complaints of fever, cough, weakness, shortness of breath, or chest pain associated with COVID were found in 48.6% of patients who were thoracic CT positive. PCR showed a low sensitivity rate. Therefore, thoracic CT is a better choice than PCR for the detection of asymptomatic cases in emergency patients. Because its selectivity rate is high, using PCR as a diagnostic test is more significant.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87586835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of an HPLC-UV method for purity determination of DNA","authors":"Merve Oztug, B. Yalçınkaya","doi":"10.5455/medscience.2023.06.088","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.088","url":null,"abstract":"Determination of the concentration and the purity of DNAs is crucial for measuring the DNA copy number since it will influence further DNA analysis such as digital PCR (dPCR) and next-generation sequencing (NGS). Precise and scientifically validated DNA measurements empower healthcare professionals and authorities to deliver reliable outcomes. DNA agarose gel electrophoresis is commonly used to check DNA purity; however, its resolution is limited. In this study, a quantitative HPLC-UV measurement method to separate DNAs was established as an alternative to both DNA electrophoresis and spectrophotometric techniques. The method was fully validated to separate DNAs ranging between 75 and 20,000 base pairs. DNA mixtures were prepared gravimetrically. Chromatographic separations were conducted on a TSKgel DNA-NPR column with dimensions of 2.5µm, 4.6mm ID x 7.5cm, using a flow rate of 0.75 mL/min. The uncertainty of the method was assessed following the guidelines provided by EURACHEM/CITAC. The method demonstrated linearity for the 200 bp DNA fragment within the range of 0.4 ng to 800 ng DNA, with a high regression coefficient of R²=0.999. The Limit of Detection (LOD) for the 200 bp DNA fragment was determined to be 1 ng, while the Limit of Quantitation (LOQ) was found to be 3 ng. The recovery percentages for the 1%, 5%, and 10% impurities of the 150 bp DNA in 200 bp DNA fragments were measured at 101.8%, 97.4%, and 99.5%, respectively. The method established can be used in the value assignment stages of the reference materials which are required for SI traceable DNA measurements.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88014621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The knowledge levels, sociodemographic characteristics and the reasons for application to the first stage during the COVID-19 pandemic patients who applied to a family medicine clinic in Istanbul","authors":"S. Çakmak","doi":"10.5455/medscience.2023.01.010","DOIUrl":"https://doi.org/10.5455/medscience.2023.01.010","url":null,"abstract":"It is to evaluate whether there is any change in the community's applications to primary care in the Covid-19 pandemic and to evaluate the level of knowledge of patients about Covid-19 in this important process. A total of 331 female and male volunteers between the ages of 18-80 who applied to a family medicine unit on the European side of Istanbul between September 2020 and November 2020 were included in the study. 30 questions in the questionnaire were filled by a single investigator after the patients were informed and their consent was obtained. This study, which we conducted in the early days of the Covid-19 pandemic, showed us that; The most important means of communication in making the pandemic known to the public are TV and social media (87.3%). Thanks to the full closure and other protective measures implemented in the early days of the pandemic, a controlled increase in the number of cases was observed, and the number of people who caught Covid-19 among the people who participated in our survey was quite low (3%) and most of these people were treated at home (62.5%). The epidemic process also affected hospital admissions of people, and it was seen that the number of people who did not apply to the hospital for more than 1 month was the majority (74.9%). One of the remarkable ones among the answers to the Covid-19 information questions; although there is no specific treatment for Covid-19 yet, 209 people (63.1%) say that there is a cure for Covid-19. We think that the preventive treatment (Hydroxychloroquine and Favipiravir) applied by the filiation teams, even if there is no specific treatment, is effective in these discourses. However, although the vaccine studies have not been concluded yet, 34 (10.3%) people stated that the vaccine was available.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87382129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological examination after appendectomy: Neoplastic lesions","authors":"M. Çiftçi, B. Uçaner","doi":"10.5455/medscience.2023.07.109","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.109","url":null,"abstract":"Appendiceal neoplasms include rare tumor formations, whose treatment ranges from an appendectomy, hemicolectomy, and chemotherapeutic agents for benign or malignant lesions. In this study, we aimed to evaluate appendiceal neoplastic lesions according to the literature on histological subgroups. A review was performed on 2.124 patients who had undergone appendectomy between January 2017 and December 2021. Patients were evaluated retrospectively according to their demographic, clinical, radiological, and histopathological characteristics. In the histopathological evaluation of the 23 (1.06%) patients, who were included in the study upon the detection of the appendiceal neoplastic lesion, sessile serrated adenoma was observed in 7 patients, low-grade appendiceal mucinous neoplasm (LAMN) in 6 patients, mucinous adenocarcinoma in 4 patients, signet ring cell mucinous adenocarcinoma in 1 patient, neuroendocrine tumor (NET) in 4 patients, and tubulovillous adenoma in 1 patient. Appendiceal neoplasms are generally asymptomatic; therefore, pathological examination results should be carefully evaluated after appendectomy, and it should be remembered that appendectomy is not always sufficient alone.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89022632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer risk levels among women aged 30-65 and factors affecting compliance with the national cervical cancer screening standards","authors":"Bennur Koca, A. Acikgoz","doi":"10.5455/medscience.2022.07.170","DOIUrl":"https://doi.org/10.5455/medscience.2022.07.170","url":null,"abstract":"Screening programs for early detection of cervical cancer are extremely important for better prognosis and long-term survival. This study was conducted to determine cervical cancer (CC) risk levels among women aged between 30-65 and the factors affecting having an HPV/Pap smear test that complies with national CC screening standards. A total of 1407 women in the 30-65 age group participated in this cross-sectional study. No sample selection procedure was conducted, and 1407 women who voluntarily agreed to participate in the study were included in the study group. Data were collected between January 2019 and March 2020. The questionnaire used in the study consisted of questions about women's sociodemographic characteristics, lifestyles, CC early diagnosis and screening behaviors, and the CC risk calculation model. Pearson chi-square test, chi-square test for trend, and logistic regression analysis were used in the study. The statistical significance level was accepted as p< 0.05. In the study, 58.9% of the women reported that they had a test within one to three years, 67.5% of those who did not have the test stated they did not know that it was necessary, and 46.2% stated that they neglected it. The CC risk level of 83.6% of women was “below average”. The rate of having an HPV/PS test following the national CC screening standards was significantly higher in women who were in the 50-59 age group, smoked, had a childbirth experience, or did not regularly use a condom during sexual intercourse (p<0.05). As the calculated CC risk level increased, testing behaviors decreased statistically significantly (p<0.01). The time of the last screening test was more than five years in those with a calculated CC risk level of ≥average (p<0.01). The CC risk level of the women in the study was below average. There was a significant relationship between HPV/PS testing behavior and age, smoking, having a childbirth experience, and condom use.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75980129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and pulmonary function impact of surgical mask usage in stable COPD patients during the COVID-19 pandemic","authors":"Efraim Guzel, O. Toprak, B. Mete, Ertan Kara, Okan Gurbuz, H. Demirhindi","doi":"10.5455/medscience.2023.07.106","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.106","url":null,"abstract":"There are hesitations about the use of surgical face masks, which are the main tools in protection from the COVID-19 pandemic, one of the biggest disasters of our age, in chronic airway diseases. The purpose of the study was to examine how stable patients with chronic obstructive pulmonary disease (COPD) responded to short-term surgical mask use in terms of in-mask air quality, oxygen saturation, and pulmonary function. Forty-one patients with stable COPD, by clinical presentation and pulmonary function tests (PFTs), were included in a quasi-experimental study. Stable COPD patients' PFTs, in-mask air quality, and pollution measures were collected before and after wearing surgical masks for two hours at rest. The findings of simultaneous tests of peripheral-blood-oxygen saturation were also recorded. The mean age of participants was 67.1 years and 87.8% were male. The pre- and post-mask PFTs parameters for GOLD (A+B) group were FEV1 (ml), FEV1 (%), FVC (ml), FVC (%), FEV1/FVC (%) and DLCO (%) (p=0.067, p=0. 065, p=0.062, p=0.083, p=0.083, p=0.269, p=0.956, respectively), whereas in GOLD (C+D) group (p=0.340, p=0.538, p=0.728, p=0.044, p=0.105, p=0.054, respectively). In post-mask measurements, the respiratory function was not impaired in GOLD-2022 (A-B-C-D) COPD subgroups. Oxygen and carbon-monoxide concentrations in exhaled air and oxygen saturation decreased after surgical mask use. The difference was statistically significant, but the difference was unimportant in terms of clinical implications. Surgical masks don’t appear to have a negative effect on pulmonary function and clinical parameters in stable COPD. This study may help provide evidence-based data to overcome hesitations in use of surgical masks in chronic airway diseases.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76168768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of left atrial ejection force and obesity: A prospective study of middle-aged adults","authors":"Mustafa Kaplangoray, K. Toprak, O. Çiçek, Y. Çekici","doi":"10.5455/medscience.2023.02.026","DOIUrl":"https://doi.org/10.5455/medscience.2023.02.026","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79982455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19-Related life-threatening complications: pneumothorax, pneumo mediastinum and subcutaneous emphysema","authors":"S. Kutlusoy, A. Aydın, E. Koca","doi":"10.5455/medscience.2022.11.236","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.236","url":null,"abstract":"Complications of COVID-19-related pneumothorax, subcutaneous emphysema, and pneumomediastinum are frequently observed in moderate and severe pneumonia cases. The aim of this study is to determine the incidence and potential risk factors of life-threatening complications such as pneumothorax, pneumo-mediastinum, and subcutaneous emphysema that develop in patients received in the tertiary ICUs of our hospital, which serves as a pandemic hospital and to analyze their relationship with mortality. Patients' demographic characteristics, comorbid diseases, length of hospital stay, day and duration of thoracic tube placement, discharge status, and hospitalization laboratory findings were recorded, and the relationship of these parameters with mortality due to pneumothorax, subcutaneous emphysema, and pneumomediastinum were investigated. Of these patients, 33 had pneumothorax, 12 had pneumomediastinum, and 28 had subcutaneous emphysema. Male and female patients were equally represented, and mortality rates were similar. While the rate of pneumothorax in the study patients was 2.21 %, the rate of all life-threatening sequelae such as pneumothorax, pneumomediastinum, and subcutaneous emphysema was 4.7 %, with a high mortality rate (90 %) in 70 patients with these complications. Patients diagnosed with COVID-19 pneumonia should be constantly monitored for life-threatening complications such as pneumothorax, pneumomediastinum, and subcutaneous emphysema during their long-term follow-up.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77151605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}