Medicine Science | International Medical Journal最新文献

{"title":"Prognostic role of C-reactive protein/albumin ratio on cardiovascular mortality in outpatients with heart failure","authors":"Murat Kerkutluoglu","doi":"10.5455/medscience.2023.08.129","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.129","url":null,"abstract":"In light of recent advancements in the field of heart failure management and treatment, it remains crucial to acknowledge that individuals diagnosed with heart failure and presenting with low ejection fraction face a significant risk of adverse outcomes. This high risk is primarily due to impaired pumping function of the heart and concomitant comorbidities. The objective of this study was to assess the prognostic significance of the C-reactive protein/albumin ratio in predicting overall mortality among individuals receiving outpatient care for heart failure. This retrospective, single-center cohort study comprised a total of 218 patients diagnosed with heart failure with low ejection fraction. These patients were diligently monitored as outpatients in a specialized heart failure outpatient clinic. During a median follow-up period of 26 months, the CRP/albumin ratios at the time of the initial hospitalization were assessed in patients who experienced mortality and those who survived. The mean age of the study participants was 56±10 years, 82% were male and 18% were female. The mean C-reactive protein/albumin ratio was 0.12 (0.02-2.1) and the mean left ventricular ejection fraction was 26% (10-40%). It was observed that the predictive accuracy of mortality could be determined by the C-reactive protein/albumin ratio with an optimal threshold value > 0.12. The sensitivity and specificity of this method were 95% and 63%, respectively (AUC: 0.824, 95% CI: 0.740-0.890). In conclusion, the C-reactive protein/albumin ratio can be defined as a prognostic indicator for mortality in outpatients with heart failure.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135652267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of psychological impact levels of the COVID-19 pandemic on people with and without psychiatric disease diagnosis","authors":"Serif Nazli, Muhammet Sevindik, Deniz Ozturan, Fatih Vahapoglu","doi":"10.5455/medscience.2023.08.132","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.132","url":null,"abstract":"This study aimed to investigate the anxiety, depression, and psychological impact levels among people with and without psychiatric disease diagnosis in the quarantine and social isolation periods of the 2019 coronavirus disease (COVID-19) pandemic. This study using the case-control research technique, included 182 cases with psychiatric diagnosis and 183 control participants without a psychiatric diagnosis. The research used the Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Rating Scale (HAM-D), Impact of Event Scale-Revised (IES-R), and a data form inquiring about sociodemographic characteristics. Data were collected from participants during face-to-face psychiatric interviews. The anxiety levels (OR: 6), depression levels (OR: 3.8), and psychological impact levels (OR: 5.8) were identified to be higher in the case group compared to the control group (p<0.05). The HAM-A, HAM-D, and IES-R scores were not affected by age, sex, marital status, education, place of residence, and employment status in the study group. Living alone, receiving treatment, presence of chronic disease, poor income, and COVID (+) relatives affected scores. In this study, those with a psychiatric diagnosis were affected more by the COVID-19 pandemic compared to those without a diagnosis, while among those with a psychiatric diagnosis, those not receiving treatment were more affected than those using treatment.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135698994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of helicobacter pylori positivity and dyspepsia on depression and somatosensory amplification","authors":"Meltem Pusuroglu, Bayram Kizilkaya","doi":"10.5455/medscience.2023.08.147","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.147","url":null,"abstract":"Helicobacter pylori gastritis is an infection frequently observed around the world. In our research, the effect of Helicobacter pylori positivity on depression and somatosensory amplification was investigated. The research included a total of 112 patients with dyspeptic complaints, 52 Helicobacter pylori positive and 60 Helicobacter pylori negative, and a healthy control group of 54 cases without any complaints. Participants completed the Beck Depression Inventory and the Somatosensory Amplification Scale. There was no effect of Helicobacter pylori positivity on depression levels (p=0.116), while Helicobacter pylori positivity had a significant effect on somatosensory amplification (F=6.794; p=0.010; η2=0.40). There were significant effects of dyspeptic complaints on depression levels (F=6.695; p=0.011; η2=0.039) and somatosensory amplification (F=7.554; p=0.007; η2=0.044). It was identified that somatosensory amplification, sex and family history were each statistically significant explanatory variables for depression (p=0.001 β2=0.255; p=0.038 β2=0.150; p=0.002 β2=0.230). There was a 0.269 increase in depression for each 1-unit increase in somatosensory amplification, the female sex increased depression by 2.463 units and positive family history increased it by 4.949 units. Helicobacter pylori positivity was not found to be a significant explanatory variable for depression (p=0.412). While Helicobacter pylori positivity did not have an effect on depression, it was found to be effective in somatosensory amplification. The presence of dyspeptic complaints was effective on both depression and somatosensory amplification. Somatosensory amplification was one of the factors predicting depression in patients with dyspeptic complaints. Somatosensory amplification is an important factor in patients with Helicobacter pylori positivity and dyspeptic complaints. Mental diseases should not be ignored during the monitoring and treatment of this patient group.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new approach to biochemistry: Bibliometric and altmetric analyses in the ketogenic diet","authors":"Busra Yusufoglu, Gokay Vardar, Gozde Kaya, Huseyin Yalcin","doi":"10.5455/medscience.2023.07.108","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.108","url":null,"abstract":"Recently, as doctors and researchers investigate into to the possible benefits of daily diets, ketogenic diets (KD) have started to gain popularity. As the growing up popularity of KD in social media, researchers had the chance to show their academic studies to the public more easily. Therefore, in this study, KD is discussed in terms of the recently popular “altmetric analysis” by scientists. The aim of study is to highlight the role of the ketogenic diet, figure out the mechanism of ketone bodies and the pivotal role of altmetric studies in health sciences. In order to investigate the novel aspects of the top 100 (T100) most cited scientific research paper in academia, 100 most discussed research paper was selected on social media platforms about KD from 1992 to 2019 and it was compared in terms of bibliometrics in web of science and in terms of social media impact in altmetric.com. While the total citations of the top 100 articles ranged from 143–109, altmetric values of T100 are 0–1269. According to the top social media platforms where the articles are mentioned, Twitter, Facebook, and Patent are the most popular social media platforms, respectively. It was not always coherent how altmetric data related to traditional bibliometric analysis. Thus, it might be suggested that bibliometric and altmetric assessments be viewed as complementary to one another. And by far the most important result of this study is that the articles with the highest citation may not receive much attention on social media due to their subject content.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136205093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the stress distributions of the treatment options with 2 implants for 4 missing maxillary incisors with finite element analysis","authors":"Hilal Gumus","doi":"10.5455/medscience.2023.08.126","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.126","url":null,"abstract":"The aim of this study is to evaluate the stress distributions in the bone level, implant and prosthesis parts with three-dimensional (3D) finite element analysis (FEA) in treatment options obtained by using two implants in different positions and different diameters in the four missing maxillary incisors region. Four 3D FEA models were obtained simulating the human maxilla with anterior 4 missing teeth. It is an in vitro study evaluated only by performing FEA with a computer program. Model 1 (M1): 4.3mm diameter implant to 2 central incisors regions, Model 2 (M2): 4.3mm diameter implant to 2 lateral incisors regions, Model 3 (M3): 3.3mm diameter implant to 2 lateral incisors regions and Model 4 (M4): 4.3mm diameter implant to central incisor region, 3.3mm diameter to lateral incisor region. Titanium implants and titanium abutments were used. Four-unit monolithic zirconia cemented fixed partial prostheses were designed on them. An oblique force of 100N was applied to the cingulum of each tooth on the prosthesis at an angle of 45 degrees to the long axis. The data obtained by performing FEA on the stress values in the implants, prosthesis parts and bone were evaluated. Maximum and minimum principal stress in the bone tissue was observed most in model 3 and least in model 1. Von Mises values in the abutment, implant, screw and prosthesis were highest in model 3. According to the obtained stress values, it may be considered the best option to place a standard diameter implant where the central incisors are in the anterior region in order to reduce the stress on the bone. Treatment with a narrow-diameter implant with lateral incisors can be avoided.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135058853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats","authors":"Zeynep Ulutas, Semih Tapsiz, Onural Ozhan, Mehmet Sarihan, Azibe Yildiz, Merve Durhan, Nigar Vardi, Yilmaz Cigremis, Leyla Buyukkorkmaz, Hakan Parlakpinar","doi":"10.5455/medscience.2023.08.179","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.179","url":null,"abstract":"Chronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine. The purpose of the current study was to evaluate the effects of AGM against ISO-induced cardiotoxicity due to the described roles of AGM in cardiovascular disease. Four groups of thirty-two Wistar Albino rats were divided equally as control, ISO, AGM+ISO, and ISO+AGM. ISO was administered intraperitoneally (i.p.) twice at a dose of 150 mg/kg, at 24-hour intervals. Prior to and after ISO injection, 20 mg/kg of AGM was injected i.p. Hemodynamic measurements and serum and tissue biochemical analyses were evaluated at the end of the experiment. The levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) in the tissue were measured. In the ISO group, levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were increased significantly (p<0.05). Co-administration of ISO and AGM significantly reduced CK and LDH levels (p<0.05). MDA levels increased in the ISO-treated group but decreased in the AGM-treated groups (p<0.05). Notably, there was a reduction in the CAT level in the ISO treatment group (p<0.05). CAT was found to be significantly increased (p<0.05) in the groups that received AGM compared to the ISO group. AGM+ISO group had a reduced density of degenerated cardiomyocytes and granulation tissue compared to the ISO group (p<0.05). Although granulation tissue demonstrated a significant reduction in the ISO+AGM group in comparison to the ISO group (p<0.05). In this study, the results indicate that AGM treatment can potentially inhibit ISO-induced myocardial injury and vascular dysfunction by preserving vascular integrity. Notably, the protective effects of AGM on cardiac damage appear to outweigh its therapeutic benefits, as shown by histopathological analysis","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of breast cancer molecular subtypes in axillary lymph node positivity","authors":"M. Aslan, Abdullah Gunes","doi":"10.5455/medscience.2023.03.038","DOIUrl":"https://doi.org/10.5455/medscience.2023.03.038","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75567732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some biochemical tips in the etiopathogenesis of Pectus Excavatum","authors":"B. Harma, T. Kıran, Feyza Inceoğlu","doi":"10.5455/medscience.2023.01.013","DOIUrl":"https://doi.org/10.5455/medscience.2023.01.013","url":null,"abstract":"Pectus excavatum (PE) is the most common deformity among anterior chest wall abnormalities. Although many theories on the pathogenesis of PE have been described, the uncertainty is still going on whether it is a result of developmental, biochemical, or biomechanical reasons or their combination. The aim of this study was to evaluate the biochemical parameters that may cause or be associated with the development of PE between children with PE and their healthy peers. A total of 33 patients' medical records were retrospectively analyzed who followed up because of pectus excavatum between 2019 and 2021. A control group was formed from 32 healthy children from the hospital records with similar age and gender profiles as the patient group. The data from both groups were collected and statistically analyzed in terms of gender, age, and laboratory tests, including hemogram, Vit B12, Parathormone (PTH), Vit.D, Alkaline phosphatase (ALP), and serum Calcium (Ca) and Phosphor (P) levels. Compared to the control group, statistically, significantly higher serum ALP, P, and PTH levels with low Vit.B12 levels were detected. The significant difference in the levels of ALP, PTH, P, and Vit B12, which have an important place in the construction and development of osteochondral structures, may impair the remodeling capacity of the costosternal structure with the contribution of thoracic biomechanics. When PE deformity is noticed, if appropriate medical treatment such as vitamin and mineral supplements and diet regulation is applied to children in the follow-up process, the process can be slowed down, and the deformity can be alleviated.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76240665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of tinnitus, noise sensitivity and anxiety levels in liver transplantation patients in the early and late periods: A cross-sectional study","authors":"D. Cengiz, Busra Kurtcu, Hanifi Korkmaz, S. Çolak, M. Aslan, M. Çiçek, S. Yılmaz","doi":"10.5455/medscience.2023.07.105","DOIUrl":"https://doi.org/10.5455/medscience.2023.07.105","url":null,"abstract":"This study aims to evaluate the perception of anxiety, tinnitus, and noise sensitivity in liver transplant patients according to early and late periods following transplantation. The study included 76 patients with liver transplantation. They were divided into two groups according to the duration of time after transplantation: early (1-3 years) and late (5 years or more). A demographic data form, the Tinnitus Handicap Inventory (THI), Weinstein's Noise Sensitivity Scale (WNSS), and the Beck Anxiety Inventory (BAI) were administered and used for data collection. There was a statistically significant difference between the early and late-period groups in terms of WNSS and THI scores (p<0.05), whereas there was no statistically significant difference in BAI scores (p>0.05). Noise sensitivity and tinnitus perception of the late-period group were statistically higher than those of the early-period group (p<0.05). Correlations between BAI, WNSS, and THI scores of late-stage patients were significant (p<0.05). A multivariate regression model was performed with the WNSS and the THI as dependent variables. According to this analysis, the THI had a statistically significant positive effect on the BAI in the early period (p2=0.003) and WNSS had a statistically significant positive effect on the BAI score in the late period (p2=0.002). Both otologic and psychological effects are observed in patients with liver transplantation. The post-transplant period triggered otologic symptoms more. It is also noteworthy that psychological and otologic symptoms are in correlation. Psychological and otologic evaluations with a multidisciplinary approach should gain importance in the post-transplant period.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"248 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79520020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional peculiarities of specific immunity in inhabitants of different mountain heights of the Kyrgyz Republic","authors":"Nasira Tiumonbaeva, A. Kazybekova, Kaliyman Kasymalieva, K. Soburov","doi":"10.5455/medscience.2023.02.027","DOIUrl":"https://doi.org/10.5455/medscience.2023.02.027","url":null,"abstract":"Kyrgyzstan’s challenging natural conditions and fragile mountain ecosystems can weaken the immune system of individuals residing permanently in high-altitude areas. Our study aimed to explore specific immune protection indicators in healthy populations from the Chui and Naryn regions at varying mountain altitudes. We assessed percentages of CD3+ (T-lymphocytes), CD20+ (B-lymphocytes), CD4+ (T-helper lymphocytes), CD8+ (cytotoxic T-lymphocytes), IRI (immunoregulatory index), CIC (circulating immune complexes), and quantified immunoglobulins of classes A, M, and G. Using immunofluorescent methods and monoclonal antibodies; we determined the percentages of CD3+, CD20+, CD4+, and CD8+. Radial immunodiffusion was used to quantify immunoglobulins of classes A, M, and G, while Falk’s method helped study CIC levels in blood sera. The participant count was based on statistical expert recommendations and G power analysis. The analysis revealed a decrease in the total number of T-lymphocytes (CD3+), primarily due to reduced T-helper and cytotoxic T-lymphocyte subpopulations. However, a significant increase in cytotoxic T-lymphocytes (CD8+) was observed among high-altitude residents. Mountain residents exhibited wide-ranging individual fluctuations for each immunoglobulin class. Our findings suggest varying degrees of immune mechanism disruptions, which maintain natural protection and internal environment constancy at different altitudes, resulting in a mixed type of cellular and humoral immunity suppression. These results emphasize the need for further research in the region and consideration of altitude when implementing disease prevention strategies related to the immune system for the local population.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84385883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}