Medicine & Science in Sports & Exercise最新文献_第3页

Cardiorespiratory Fitness, Polygenic Risk, and Breast Cancer in Postmenopausal Women: A Prospective Cohort Study 绝经后妇女的心肺健康、多基因风险和乳腺癌：一项前瞻性队列研究

Medicine & Science in Sports & Exercise Pub Date : 2026-10-06 DOI: 10.1249/mss.0000000000004164

Kumpei Tanisawa,Daiki Watanabe,Qian Li,Xiayue Fan,Xiaomin Sun

{"title":"Cardiorespiratory Fitness, Polygenic Risk, and Breast Cancer in Postmenopausal Women: A Prospective Cohort Study","authors":"Kumpei Tanisawa,Daiki Watanabe,Qian Li,Xiayue Fan,Xiaomin Sun","doi":"10.1249/mss.0000000000004164","DOIUrl":"https://doi.org/10.1249/mss.0000000000004164","url":null,"abstract":"Purpose: Although cardiorespiratory fitness (CRF) is inversely associated with breast cancer risk, whether CRF modifies the association between breast cancer polygenic risk score (PRS) and incident breast cancer remains unclear. We examined the independent and joint associations of CRF and breast cancer PRS with incident breast cancer in postmenopausal women from the UK Biobank and evaluated multiplicative and additive interactions between CRF and breast cancer PRS. Methods: This prospective cohort study included postmenopausal women from the UK Biobank. CRF was estimated using a submaximal cycle ergometer test, and genetic susceptibility was assessed using a breast cancer PRS. Cox proportional hazards models adjusted for established breast cancer risk factors were used to estimate hazard ratios. Multiplicative and additive interactions between CRF and PRS were evaluated, with additive interaction assessed using the relative excess risk due to interaction (RERI). Results: Among 15,199 postmenopausal women, 547 women developed incident breast cancer during a median follow-up of 10.7 years. Higher CRF was associated with lower risk of incident breast cancer in a dose–response manner, whereas higher PRS was associated with higher risk. Although multiplicative interaction was not significant, additive interaction analyses indicated that higher CRF was associated with attenuation of excess breast cancer risk conferred by high PRS (RERI −0.79, 95% CI −1.47 to −0.10). This attenuation was particularly evident among women aged ≥60 years. Conclusions: Higher CRF was associated with lower breast cancer risk and attenuation of excess breast cancer risk conferred by elevated polygenic risk, particularly among older women. These findings support the potential role of CRF in risk-stratified breast cancer prevention strategies.","PeriodicalId":18500,"journal":{"name":"Medicine & Science in Sports & Exercise","volume":"166 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is a Runner’s Footfall Pattern a Risk Factor for a Running-Related Injury? Using Data from the 4HAIE Cohort Study 跑步者的脚法是造成跑步相关损伤的危险因素吗？使用4HAIE队列研究的数据

Medicine & Science in Sports & Exercise Pub Date : 2026-09-25 DOI: 10.1249/mss.0000000000004155

Joseph Hamill,Jiri Skypala,Jan Plesek,Jan Urbaczka,Lucie Sustkova,Daniel Jandacka

{"title":"Is a Runner’s Footfall Pattern a Risk Factor for a Running-Related Injury? Using Data from the 4HAIE Cohort Study","authors":"Joseph Hamill,Jiri Skypala,Jan Plesek,Jan Urbaczka,Lucie Sustkova,Daniel Jandacka","doi":"10.1249/mss.0000000000004155","DOIUrl":"https://doi.org/10.1249/mss.0000000000004155","url":null,"abstract":"Introduction: In the last several years, a controversy has arisen between which type of footfall pattern, rearfoot versus non-rearfoot, incurs the fewest running-related injuries. Purpose: The primary aims of this paper were to determine if there are differences in the occurrence of running-related injuries between rearfoot and non-rearfoot footfall pattern runners and to determine if there would be differences between rearfoot and non-rearfoot footfall pattern runners in the number of injuries at different anatomical locations. Methods: This study was a secondary analysis of the data collection from Healthy Aging in the Industrial Environment (4HAIE) study. The sub-sample of 1315 participants consisted of 738 runners (307 females/431 males) and parsed into rearfoot (N=591, 248 females/343 males) and non-rearfoot (N=147, 59 females/88 males) groups based on their strike index. The measurement protocol consisted of completing questionnaires and running biomechanics assessments. During the 1-year follow-up the running-related injury onset was derived from the weekly, self-initiated, and decreased activity questionnaires. Results: There was no statistically significant difference between the total percentage of injuries in the two footfall groups (p > 0.05) nor was the percentage of injuries at each anatomical location (p > 0.05) statistically significant. A logistic regression analysis showed no evidence of an association between footfall pattern and injury risk and that the odds of injury was the same in both groups. Conclusions: Therefore, a runner’s footfall pattern neither increases nor decreases the probability of injury.","PeriodicalId":18500,"journal":{"name":"Medicine & Science in Sports & Exercise","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographic, Lifestyle, and Clinical Factors Associated with Accelerometer-Based Physical Activity in Patients with Head and Neck Cancer: A Prospective Cohort Study 人口统计学、生活方式和临床因素与头颈癌患者基于加速度计的身体活动相关：一项前瞻性队列研究

Medicine & Science in Sports & Exercise Pub Date : 2026-09-25 DOI: 10.1249/mss.0000000000004153

Tycho Zuijlen,Brenda Berendsen,Femke Jansen,Femke Lamers,José A. Hardillo,Johannes A. Langendijk,Irma M. Verdonck-de Leeuw,Robert P. Takes,C. René Leemans,Remco de Bree,Laurien M. Buffart,Caroline M. Speksnijder

{"title":"Demographic, Lifestyle, and Clinical Factors Associated with Accelerometer-Based Physical Activity in Patients with Head and Neck Cancer: A Prospective Cohort Study","authors":"Tycho Zuijlen,Brenda Berendsen,Femke Jansen,Femke Lamers,José A. Hardillo,Johannes A. Langendijk,Irma M. Verdonck-de Leeuw,Robert P. Takes,C. René Leemans,Remco de Bree,Laurien M. Buffart,Caroline M. Speksnijder","doi":"10.1249/mss.0000000000004153","DOIUrl":"https://doi.org/10.1249/mss.0000000000004153","url":null,"abstract":"Purpose: This study aimed to objectively assess changes in total physical activity (PA) and moderate-to-vigorous physical activity (MVPA) from head and neck cancer (HNC) diagnosis up to two years post-treatment, and to identify demographic, lifestyle, and clinical factors associated with total PA and MVPA levels and their trajectories. Methods: Data were derived from the prospective NET-QUBIC cohort. PA and MVPA were measured using a waist-worn accelerometer (ActiGraph wGT3X) before treatment and at 6, 12, and 24 months post-treatment. Linear mixed models were used to examine changes in total PA and MVPA and to identify factors associated with these changes. Results: In total, 517 patients were included. Univariable analyses showed higher total PA and MVPA at 24 months compared with baseline. In multivariable analyses, overall time effects were not significant, but alcohol use and sex showed time-dependent associations. Alcohol users were more active at baseline than non-users, whereas activity levels became comparable during follow-up. Females had higher total PA at baseline, but males showed consistently higher total PA and MVPA after treatment. Comorbidities, older age, and smoking were associated with lower total PA and MVPA, while a WHO performance score of one or two was associated with lower total PA. Conclusions: Total PA and MVPA did not significantly change over time after adjustment, although trajectories differed by alcohol use and sex. Comorbidities, older age, smoking, and higher WHO performance score were consistently associated with lower activity levels. These findings may inform risk profiles and support tailored rehabilitation strategies for patients with HNC.","PeriodicalId":18500,"journal":{"name":"Medicine & Science in Sports & Exercise","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practices And Procedures In Clinical Pediatric Exercise Laboratories In North America: A Five-year Follow-up Study 北美临床儿科运动实验室的实践和程序：一项为期五年的随访研究

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001258804.87537.ab

Kelli Teson,Jessica Watson,Adam Powell,Jesse Hansen,William Orr,Danielle Burstein,Suellen Yin,David Williams,David White

引用次数: 0

Acute Effects Of Circuit And Traditional Resistance Exercise On Sclerostin And Osteopontin In Young Adults 循环和传统阻力运动对青年人硬化蛋白和骨桥蛋白的急性影响

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001265328.25530.4d

Madhumitha S. Gayathri,Jose Osorio,Michelle Manochio,Samip Bhattarai,Adam Eckart,Pragya Sharma Ghimire

引用次数: 0

Bed Rest Reduces Muscle Oxidative Capacity And O2Diffusion Sensitivity In Young And Elderly Adults 卧床休息降低年轻人和老年人肌肉氧化能力和o2扩散敏感性

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001265768.96615.e2

Alessio Marciano,Andrea Pilotto,Alessandra Adami,Marco Narici,Rado Pisot,Bostjan Simunic,Roberto Bottinelli,Harry B. Rossiter,Simone Porcelli

引用次数: 0

Hydration And Physical Activity Changes During A Weight Loss Intervention In Adults Aged 50+ Years 50岁以上成人减肥干预期间水合作用和体力活动的变化

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001262444.23852.f5

Jenna R. Warnock,Kristen R. Howard,Theresa Libera,Erica M. Howes,Eleni Laskaridou,Molly Parker,Marrium Mansoor,Shahed Sanuri,Elaina Marinik,Benjamin Katz,Aubrey Knight,Kevin P. Davy,Brenda M. Davy

引用次数: 0

Health Interventions To Improve Dual-task Performance Among Women At Risk For Alzheimer’s Disease 改善阿尔茨海默病风险女性双任务表现的健康干预措施

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001266124.13390.5b

Rebecca Frederichs,Ray Urbina,Megan Jones,Anthony Campitelli,Sally Paulson,Jordan Glenn,Michelle Gray

引用次数: 0

Treadmill Uphill Running Does Not Reliably Simulate Overground Uphill Running In Knee Extensor Activation 在膝伸肌激活中，跑步机上坡跑不能可靠地模拟地上上坡跑

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001265216.43843.48

Hongjiao Duan,Hao Cai,Barry Munkasy,Barry Joyner, Li Li

引用次数: 0

DAILY NOOTROPIC SUPPLEMENTATION IMPROVES SUSTAINED ATTENTION AND FOCUS-HOLD DURATIONS IN WORKING DOGS 每天补充益智药可以提高工作犬的持续注意力和注意力保持时间

Medicine & Science in Sports & Exercise Pub Date : 2026-09-14 DOI: 10.1249/01.mss.0001264292.08638.1d

S. Kyle Travis,Tannisha Duncan,Vanessa Rosete,Will Bohuslavizki

引用次数: 0