Memorias do Instituto Oswaldo Cruz最新文献

{"title":"Relevance of national, regional and global virome projects on pandemics prediction, prevention, and control: a social network analysis of GVP-citing articles.","authors":"Bruna de Paula Fonseca,&nbsp;Carlos Medicis Morel","doi":"10.1590/0074-02760230116","DOIUrl":"10.1590/0074-02760230116","url":null,"abstract":"<p><strong>Background: </strong>The Global Virome Project (GVP) was proposed in 2018 as an evolution of the USAID PREDICT project and was presented as a \"collaborative scientific initiative to discover zoonotic viral threats and stop future pandemics\". The immediate response was mixed, with public health and scientific communities representatives showing skepticism, if not direct opposition.</p><p><strong>Objectives: </strong>The economic, social, and health consequences of the coronavirus disease 2019 (COVID-19) pandemic demonstrated how unprepared the world was in the face of new pandemics. This paper analyses the impact of the GVP on the scientific and public health communities.</p><p><strong>Methods: </strong>Published scientific articles that cited the two 2018 seminal publications proposing the project were analysed using social network analysis methods.</p><p><strong>Findings: </strong>Encompassing the periods before and after the onset of the Covid-19 pandemic, the results indicate that (i) the concepts of the GVP have received more support than opposition in the scientific literature; (ii) its foundations should be updated to address the specific criticisms.</p><p><strong>Main conclusions: </strong>Shifting focus to national virome projects can provide tangible, regional benefits that can positively contribute towards a consensus on achieving a high level of preparedness for the ever-present possibility of the following global viral pandemic.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230116"},"PeriodicalIF":2.8,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur.","authors":"Paloma Rezende Corrêa,&nbsp;Marcos Gustavo Araujo Schwarz,&nbsp;Renata Monteiro Maia,&nbsp;Fátima Maria Figueroa Vergara,&nbsp;Milton Ozório Moraes,&nbsp;Leila Mendonça-Lima","doi":"10.1590/0074-02760230070","DOIUrl":"10.1590/0074-02760230070","url":null,"abstract":"<p><strong>Background: </strong>The Bacille Calmette-Guérin (BCG) vaccine comprises a family of strains with variable protective efficacy against pulmonary tuberculosis (TB) and leprosy, partly due to genetic differences between strains.</p><p><strong>Objectives: </strong>Previous data highlighting differences between the genomes and proteomic profiles of BCG strains Moreau and Pasteur led us to evaluate their behaviour in the macrophage microenvironment, capable of stimulating molecular responses that can impact the protective effect of the vaccine.</p><p><strong>Methods: </strong>Strain infectivity, viability, co-localisation with acidified vesicles, macrophage secretion of IL-1 and MCP-1 and lipid droplet biogenesis were evaluated after infection.</p><p><strong>Findings: </strong>We found that BCG Moreau is internalised more efficiently, with significantly better intracellular survival up to 96 h p.i., whereas more BCG Pasteur bacilli were found co-localised in acidified vesicles up to 6 h p.i. IL-1β and MCP-1 secretion and lipid droplet biogenesis by infected macrophages were more prominent in response to BCG Pasteur.</p><p><strong>Main conclusion: </strong>Overall, our results show that, compared to Pasteur, BCG Moreau has increased fitness and better endurance in the harsh intracellular environment, also regulating anti-microbial responses (lower IL-1b and MCP-1). These findings contribute to the understanding of the physiology of BCG Moreau and Pasteur in response to the intraphagosomal environment in a THP-1 macrophage model.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230070"},"PeriodicalIF":2.8,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49679342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long COVID-19 syndrome associated with Omicron XBB.1.5 infection: a case report.","authors":"Otávio Espíndola, Paola C Resende, Lusiele Guaraldo, Guilherme Amaral Calvet, Trevon L Fuller, Stephanie Lema Suarez Penetra, Heloisa Ferreira Pinto Santos, Anielle Pina-Costa, Michele Fernanda Borges da Silva, Isabella Campos Vargas Moraes, Fernando Medeiros, Jimmy Whitworth, Christopher Smith, Karin Nielsen-Saines, Marilda M Siqueira, Patrícia Brasil","doi":"10.1590/0074-02760230069","DOIUrl":"10.1590/0074-02760230069","url":null,"abstract":"<p><strong>Background: </strong>There is interest in lingering non-specific symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, referred to as Long coronavirus disease 2019 (Long COVID-19). It remains unknown whether the risk of Long COVID-19 is associated with pre-existing comorbidities or initial COVID-19 severity, including infections due to new Omicron lineages which predominated in 2023.</p><p><strong>Objectives: </strong>The aim of this case report was to characterize the clinical features of acute XBB.1.5 infection followed by Long COVID-19.</p><p><strong>Methods: </strong>We followed a 73-year old female resident of Rio de Janeiro with laboratory-confirmed SARS-CoV-2 during acute infection and subsequent months. The SARS-CoV-2 lineage was determined by genome sequencing.</p><p><strong>Findings: </strong>The participant denied comorbidities and had completed a two-dose vaccination schedule followed by two booster doses eight months prior to SARS-CoV-2 infection. Primary infection by viral lineage XBB.1.5. was clinically mild, but the participant subsequently reported persistent fatigue.</p><p><strong>Main conclusions: </strong>This case demonstrates that Long COVID-19 may develop even after mild disease due to SARS-CoV-2 in fully vaccinated and boosted individuals without comorbidities. Continued monitoring of new SARS-CoV-2 lineages and associated clinical outcomes is warranted. Measures to prevent infection should continue to be implemented including development of new vaccines and antivirals effective against novel variants.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230069"},"PeriodicalIF":2.8,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10581372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49679343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid droplets in Zika neuroinfection: Potential targets for intervention?","authors":"Suelen Silva Gomes Dias,&nbsp;Tamires Cunha-Fernandes,&nbsp;Vinicius Cardoso Soares,&nbsp;Cecília Jg de Almeida,&nbsp;Patricia T Bozza","doi":"10.1590/0074-02760230044","DOIUrl":"https://doi.org/10.1590/0074-02760230044","url":null,"abstract":"<p><p>Lipid droplets (LD) are evolutionarily conserved lipid-enriched organelles with a diverse array of cell- and stimulus-regulated proteins. Accumulating evidence demonstrates that intracellular pathogens exploit LD as energy sources, replication sites, and part of the mechanisms of immune evasion. Nevertheless, LD can also favor the host as part of the immune and inflammatory response to pathogens. The functions of LD in the central nervous system have gained great interest due to their presence in various cell types in the brain and for their suggested involvement in neurodevelopment and neurodegenerative diseases. Only recently have the roles of LD in neuroinfections begun to be explored. Recent findings reveal that lipid remodelling and increased LD biogenesis play important roles for Zika virus (ZIKV) replication and pathogenesis in neural cells. Moreover, blocking LD formation by targeting DGAT-1 in vivo inhibited virus replication and inflammation in the brain. Therefore, targeting lipid metabolism and LD biogenesis may represent potential strategies for anti-ZIKV treatment development. Here, we review the progress in understanding LD functions in the central nervous system in the context of the host response to Zika infection.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230044"},"PeriodicalIF":2.8,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10566564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41204764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil.","authors":"Felipe Dutra Rêgo,&nbsp;Eduardo Sérgio da Silva,&nbsp;Valeriana Valadares Lopes,&nbsp;Rafael Gonçalves Teixeira-Neto,&nbsp;Vinícius Silva Belo,&nbsp;Antônio Augusto Fonseca Júnior,&nbsp;Diego Andrade Pereira,&nbsp;Heber Paulino Pena,&nbsp;Márcia Dalastra Laurenti,&nbsp;Gabriela V Araújo,&nbsp;Vânia Lúcia Ribeiro da Matta,&nbsp;Islam Hussein Chouman,&nbsp;Thainá Bergantin Burrin,&nbsp;Carmen M Sandoval,&nbsp;Stella Maria Barrouin-Melo,&nbsp;Flaviane Alves de Pinho,&nbsp;Hélida Monteiro de Andrade,&nbsp;Ramon Vieira Nunes,&nbsp;Célia Maria Ferreira Gontijo,&nbsp;Vanete Thomaz Soccol,&nbsp;Donnamae Klocek,&nbsp;Danyil Grybchuk,&nbsp;Diego Henrique Macedo,&nbsp;Rubens Lima do Monte-Neto,&nbsp;Vyacheslav Yurchenko,&nbsp;Rodrigo Pedro Soares","doi":"10.1590/0074-02760230071","DOIUrl":"https://doi.org/10.1590/0074-02760230071","url":null,"abstract":"<p><strong>Background: </strong>Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania.</p><p><strong>Objectives: </strong>In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions.</p><p><strong>Methods: </strong>A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene.</p><p><strong>Findings: </strong>We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively.</p><p><strong>Main conclusions: </strong>To the best of our knowledge, this is the first detection of LRV2 in the New World.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230071"},"PeriodicalIF":2.8,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41117228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox (Mpox) virus isolation and ultrastructural characterisation from a Brazilian human sample case.","authors":"Milene Dias Miranda, Gabriela Cardoso Caldas, Vivian Neuza Ferreira, Ortrud Monika Barth, Aline de Paula Dias da Silva, Mayara Secco Torres Silva, Beatriz Grinsztejn, Valdiléa Gonçalves Veloso, Thiago Moreno Souza, Edson Elias da Silva, Debora Ferreira Barreto-Vieira","doi":"10.1590/0074-02760230090","DOIUrl":"10.1590/0074-02760230090","url":null,"abstract":"<p><strong>Background: </strong>According to the last 2023 Monkeypox (Mpox) Outbreak Global Map from the Centres for Disease Control and Prevention (CDC), more than 100 countries with no Mpox infection report cases. Brazil stands out in this group and is the second country with the highest number of cases in the last outbreak.</p><p><strong>Objective: </strong>To contribute to knowledge of the virus infection effects in a cellular model, which is important for diagnosis infections not yet included in a provider´s differential diagnosis and for developing viral inhibition strategies.</p><p><strong>Methods: </strong>We describe a virus isolation protocol for a human clinical sample from a patient from Brazil, the viral growth in a cell model through plaque forming units (PFU) assay, reverse transcriptase polymerase chain reaction (RT-PCR) and transmission electron microscopy (TEM).</p><p><strong>Findings: </strong>We follow the viral isolation in Vero cell culture from a Mpox positive clinically diagnosed sample and show the infection effects on cellular structures using a TEM.</p><p><strong>Main conclusions: </strong>Understanding the impact of viral growth on cellular structures and its replication kinetics may offer better strategies for the development of new drugs with antiviral properties.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230090"},"PeriodicalIF":2.8,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10139120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro susceptibility of eighteen clinical isolates of human monkeypox virus to tecovirimat.","authors":"Desiree Dos Santos Nunes, Luiza M Higa, Régis Linhares Oliveira, Lendel Correia da Costa, Larissa Maciel Bomfim, Cássia Cristina Alves Gonçalves, Diana Mariani, Dennis E Hruby, Carolina Moreira Voloch, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Clarissa R Damaso","doi":"10.1590/0074-02760230056","DOIUrl":"10.1590/0074-02760230056","url":null,"abstract":"<p><strong>Background: </strong>In 2022, an outbreak of mpox that started in European countries spread worldwide through human-to-human transmission. Cases have been mostly mild, but severe clinical presentations have been reported. In these cases, tecovirimat has been the drug of choice to treat patients with aggravated disease.</p><p><strong>Objectives: </strong>Here we investigated the tecovirimat susceptibility of 18 clinical isolates of monkeypox virus (MPXV) obtained from different regions of Brazil.</p><p><strong>Methods: </strong>Different concentrations of tecovirimat were added to cell monolayers infected with each MPXV isolate. After 72 hours, cells were fixed and stained for plaque visualization, counting, and measurement. The ortholog of F13L gene from each MPXV isolate was polymerase chain reaction (PCR)-amplified, sequenced, and the predicted protein sequences were analyzed.</p><p><strong>Findings: </strong>The eighteen MPXV isolates generated plaques of different sizes. Although all isolates were highly sensitive to the drug, two showed different response curves and IC50 values. However, the target protein of tecovirimat, F13 (VP37), was 100% conserved in all MPXV isolates and therefore does not explain the difference in sensitivity.</p><p><strong>Main conclusions: </strong>Our results support screening different MPXV isolates for tecovirimat susceptibility as an important tool to better use of the restricted number of tecovirimat doses available in low-income countries to treat patients with mpox.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230056"},"PeriodicalIF":2.8,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and perspectives in research and teaching of host pathogen interaction topics: new post-pandemic times to Brazil and other South American countries.","authors":"Marcel I Ramírez, Rita de Cassia Ruiz, Gessilda de Alcantara Nogueira-Melo, Luiz Claudio Miletti, Mauro Cortez, Melyssa Negri, Giuseppe Palmisano, Jorge González","doi":"10.1590/0074-02760220212","DOIUrl":"10.1590/0074-02760220212","url":null,"abstract":"<p><p>Here is our proposal to improve learning in biomedical sciences for graduate and undergraduate courses with a broad vision integrating disciplines such as molecular cell biology, biochemistry, and biophysics around concepts of pathogen interaction within vertebrate and invertebrate hosts. Our paradigm is based on the possibility offered by the pandemic to have remote activities that give access to students and researchers from different places in Brazil and Latin American countries to discuss science. A multidisciplinary view of host-pathogen interaction allows us to understand better the mechanisms involved in the pathology of diseases, as well as to formulate broad strategies for the diagnosis, treatment, and control of thereof. The approach to integrating heterogeneous groups in science involves the critical analysis of national scientific resource distribution, where only some have the possibilities to conduct competitive scientific research. Solid theoretical training, contact, collaboration with groups of excellence, and training within a multidisciplinary network are our proposals for a permanent platform of scientific strengthening and dissemination for Latin America. Here we will review the concept of host-pathogen interaction, the type of institutions where it is taught and researched, new trends in active teaching methodologies, and the current political context in science.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220212"},"PeriodicalIF":2.5,"publicationDate":"2023-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9892782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERRATUM.","authors":"","doi":"10.1590/0074-02760230003ER","DOIUrl":"https://doi.org/10.1590/0074-02760230003ER","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/0074-02760220202].</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230003er"},"PeriodicalIF":2.8,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10159579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9470414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DC-SIGN receptor is expressed by cells from cutaneous leishmaniasis lesions and differentially binds to Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis promastigotes.","authors":"Carolina de O Mendes-Aguiar, Milene Yoko Kitahara-Oliveira, Ana Cristina Oliveira de Almeida, Marcia Pereira-Oliveira, Manoel Paes de Oliveira Neto, Claude Pirmez, Elizabeth Pereira Sampaio, Adriano Gomes-Silva, Alda Maria Da-Cruz","doi":"10.1590/0074-02760220044","DOIUrl":"10.1590/0074-02760220044","url":null,"abstract":"<p><strong>Background: </strong>Dendritic cells (DCs) specific intercellular adhesion molecule (ICAM)-3-grabbing non integrin receptor (DC-SIGN) binds to subgenera Leishmania promastigotes mediating its interaction with DC and neutrophils, potentially influencing the infection outcome.</p><p><strong>Objectives: </strong>In this work, we investigated whether DC-SIGN receptor is expressed in cells from cutaneous leishmaniasis (CL) lesions as well as the in vitro binding pattern of Leishmania (Viannia) braziliensis (Lb) and L. (L.) amazonensis (La) promastigotes.</p><p><strong>Methods: </strong>DC-SIGN receptor was labeled by immunohistochemistry in cryopreserved CL tissue fragments. In vitro binding assay with CFSE-labeled Lb or La promastigotes and RAJI-transfecting cells expressing DC-SIGN (DC-SIGNPOS) or mock-transfected (DC-SIGNNEG) were monitored by flow cytometry at 2 h, 24 h and 48 h in co-culture.</p><p><strong>Results: </strong>In CL lesion infiltrate, DC-SIGNPOS cells were present in the dermis and near the epidermis. Both Lb and La bind to DC-SIGNPOS cells, while binding to DC-SIGNNEG was low. La showed precocious and higher affinity to DC-SIGNhi population than to DC-SIGNlow, while Lb binding was similar in these populations.</p><p><strong>Conclusion: </strong>Our results demonstrate that DC-SIGN receptor is present in L. braziliensis CL lesions and interact with Lb promastigotes. Moreover, the differences in the binding pattern to Lb and La suggest DC-SIGN can influence in a difference way the intake of the parasites at the first hours after Leishmania infection. These results raise the hypothesis that DC-SIGN receptor could participate in the immunopathogenesis of American tegumentary leishmaniasis accounting for the differences in the outcome of the Leishmania spp. infection.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220044"},"PeriodicalIF":2.5,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}