Memorias do Instituto Oswaldo Cruz最新文献

{"title":"Chikungunya virus infection in the southernmost state of Brazil was characterised by self-limited transmission (2017-2019) and a larger 2021 outbreak.","authors":"Tatiana Schäffer Gregianini, Richard Steiner Salvato, Regina Bones Barcellos, Fernanda Marques Godinho, Amanda Pellenz Ruivo, Viviane Horn de Melo, Júlio Augusto Schroder, Fernanda Letícia Martiny, Erica Bortoli Möllmann, Cátia Favreto, Ludmila Fiorenzano Baethgen, Vithoria Pompermaier Ferreira, Lívia Eidt de Lima, Cláudia Fasolo Piazza, Taís Raquel Marcon Machado, Irina Marieta Becker, Raquel Rocha Ramos, Guilherme Carey Frölich, Alana Fraga Rossetti, Lucas da Cunha Almeida, Tahiana Machado Antunes Rodrigues, Isabella Tabelli Bragança, Aline Alves Scarpellini Campos, Verônica Baú Manzoni, Lais Ceschini Machado, Luisa Maria Inácio da Silva, André Luiz Sá de Oliveira, Marcelo Henrique Santos Paiva, Zenaida Marion Alves Nunes, Paula Rodrigues de Almeida, Meriane Demoliner, Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Vyctoria Malayhka de Abreu Góes Pereira, Fernando Rosado Spilki, Ana Beatriz Gorini da Veiga, Gabriel Luz Wallau","doi":"10.1590/0074-02760220259","DOIUrl":"https://doi.org/10.1590/0074-02760220259","url":null,"abstract":"BACKGROUND Chikungunya is a mosquito-borne virus that has been causing large outbreaks in the Americas since 2014. In Brazil, Asian-Caribbean (AC) and East-Central-South-African (ECSA) genotypes have been detected and lead to large outbreaks in several Brazilian states. In Rio Grande do Sul (RS), the southernmost state of Brazil, the first cases were reported in 2016. OBJECTIVES AND METHODS We employed genome sequencing and epidemiological investigation to characterise the Chikungunya fever (CHIKF) burden in RS between 2017-2021. FINDINGS We detected an increasing CHIKF burden linked to travel associated introductions and communitary transmission of distinct lineages of the ECSA genotype during this period. MAIN CONCLUSIONS Until 2020, CHIKV introductions were most travel associated and transmission was limited. Then, in 2021, the largest outbreak occurred in the state associated with the introduction of a new ECSA lineage. CHIKV outbreaks are likely to occur in the near future due to abundant competent vectors and a susceptible population, exposing more than 11 million inhabitants to an increasing infection risk.","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220259"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10289476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some remarks on peer review and preprints.","authors":"Adeilton Alves Brandão","doi":"10.1590/0074-02760230001","DOIUrl":"https://doi.org/10.1590/0074-02760230001","url":null,"abstract":"","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230001"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10311663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9744082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular diversity of genes related to biological rhythms (period and timeless) and insecticide resistance (Na V and ace-1) in Anopheles darlingi.","authors":"Aline Cordeiro Loureiro,&nbsp;Alejandra Saori Araki,&nbsp;Rafaela Vieira Bruno,&nbsp;José Bento Pereira Lima,&nbsp;Simone Ladeia-Andrade,&nbsp;Liliana Santacoloma,&nbsp;Ademir Jesus Martins","doi":"10.1590/0074-02760220159","DOIUrl":"https://doi.org/10.1590/0074-02760220159","url":null,"abstract":"<p><strong>Background: </strong>Malaria is a public health concern in the Amazonian Region, where Anopheles darlingi is the main vector of Plasmodium spp. Several studies hypothesised the existence of cryptic species in An. darlingi, considering variations in behaviour, morphological and genetic aspects. Determining their overall genetic background for vector competence, insecticide resistance, and other elements is essential to better guide strategies for malaria control.</p><p><strong>Objectives: </strong>This study aimed to evaluate the molecular diversity in genes related to behaviour and insecticide resistance, estimating genetic differentiation in An. darlingi populations from Amazonian localities in Brazil and Pacific Colombian region.</p><p><strong>Methods: </strong>We amplified, cloned and sequenced fragments of genes related to behaviour: timeless (tim) and period (per), and to insecticide resistance: voltage-gated sodium channel (Na V ) and acetylcholinesterase (ace-1) from 516 An. darlingi DNA samples from Manaus, Unini River, Jaú River and Porto Velho - Brazil, and Chocó - Colombia. We discriminated single nucleotide polymorphisms (SNPs), determined haplotypes and evaluate the phylogenetic relationship among the populations.</p><p><strong>Findings: </strong>The genes per, tim and ace-1 were more polymorphic than Na V . The classical kdr and ace-1 R mutations were not observed. Phylogenetic analyses suggested a significant differentiation between An. darlingi populations from Brazil and Colombia, except for the Na V gene. There was a geographic differentiation within Brazilian populations considering per and ace-1.</p><p><strong>Conclusions: </strong>Our results add genetic data to the discussion about polymorphisms at population levels in An. darlingi. The search for insecticide resistance-related mechanisms should be extended to more populations, especially from localities with a vector control failure scenario.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220159"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10337825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9812948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and epidemiological aspects of Delta and Gamma SARS-CoV-2 variant of concern from the western Brazilian Amazon.","authors":"Gabriella Sgorlon,&nbsp;Jackson Alves da Silva Queiroz,&nbsp;Tárcio Peixoto Roca,&nbsp;Ana Maisa Passos da Silva,&nbsp;Nadson Willian Felipe Gasparelo,&nbsp;Karolaine Santos Teixeira,&nbsp;Andreia Souza da Nóbrega Oliveira,&nbsp;Aline Linhares Ferreira de Melo Mendonça,&nbsp;Adriana Cristina Salvador Maia,&nbsp;Soraya Dos Santos Pereira,&nbsp;Flávia Serrano Batista,&nbsp;Juan Miguel Villalobos Salcedo,&nbsp;Rita de Cassia Pontello Rampazzo,&nbsp;Paola Cristina Resende,&nbsp;Marilda Mendonça Siqueira,&nbsp;Felipe Gomes Naveca,&nbsp;Deusilene Vieira","doi":"10.1590/0074-02760220155","DOIUrl":"https://doi.org/10.1590/0074-02760220155","url":null,"abstract":"<p><strong>Background: </strong>The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has become a major concern contributing to increased morbidity and mortality worldwide.</p><p><strong>Objectives: </strong>Here we describe the replacement of the Gamma variant of concern (VOC) with Delta in the western Brazilian Amazon.</p><p><strong>Methods: </strong>In this study, we analysed 540 SARS-CoV-2 positive samples determined by qualitative real-time RT-PCR selected in the state of Rondônia between June and December 2021. The positive cohort was sequenced through next-generation sequencing (NGS) and each sample was quantified using real-time RT-qPCR, the whole genome sequence was obtained, SARS-CoV-2 lineages were classified using the system Pango and the maximum likelihood (ML) method was used to conduct phylogenetic analyses.</p><p><strong>Findings: </strong>A total of 540 high-quality genomes were obtained, where the Delta VOC showed the highest prevalence making up 72%, with strain AY.43 being the most abundant, while the Gamma VOC was present in 28%, where the P.1 strain was the most frequent. In this study population, only 32.96% (178/540) had completed the vaccination schedule.</p><p><strong>Main conclusions: </strong>This study highlighted the presence of Gamma and Delta variants of SARS-CoV-2 in RO. Furthermore, we observed the replacement of the Gamma VOC with the Delta VOC and its lineages.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"117 ","pages":"e220155"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10601761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid: a target of some fungi and an overview.","authors":"Danielly Corrêa-Moreira,&nbsp;Rodolfo Castro,&nbsp;Gisela Lara da Costa,&nbsp;Reginaldo Gonçalves Lima-Neto,&nbsp;Manoel Marques Evangelista Oliveira","doi":"10.1590/0074-02760220251","DOIUrl":"https://doi.org/10.1590/0074-02760220251","url":null,"abstract":"<p><p>Meningitis is a potentially life-threatening infection characterised by the inflammation of the leptomeningeal membranes. The estimated annual prevalence of 8.7 million cases globally and the disease is caused by many different viral, bacterial, and fungal pathogens. Although several genera of fungi are capable of causing infections in the central nervous system (CNS), the most significant number of registered cases have, as causal agents, yeasts of the genus Cryptococcus. The relevance of cryptococcal meningitis has changed in the last decades, mainly due to the increase in the number of people living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and medications that impair the immune responses. In this context, coronavirus disease 19 (COVID-19) has also emerged as a risk factor for invasive fungal infections (IFI), including fungal meningitis (FM), due to severe COVID-19 disease is associated with increased pro-inflammatory cytokines, interleukin (IL)-1, IL-6, and tumour necrosis factor-alpha, reduced CD4-interferon-gamma expression, CD4 and CD8 T cells. The gold standard technique for fungal identification is isolating fungi in the culture of the biological material, including cerebrospinal fluid (CSF). However, this methodology has as its main disadvantage the slow or null growth of some fungal species in culture, which makes it difficult to finalise the diagnosis. In conclusions, this article, in the first place, point that it is necessary to accurately identify the etiological agent in order to assist in the choice of the therapeutic regimen for the patients, including the implementation of actions that promote the reduction of the incidence, lethality, and fungal morbidity, which includes what is healthy in the CNS.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220251"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9174061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy.","authors":"Thalita Mázala-de-Oliveira,&nbsp;Yago Amigo Pinho Jannini de Sá,&nbsp;Vinicius de Frias Carvalho","doi":"10.1590/0074-02760220197","DOIUrl":"https://doi.org/10.1590/0074-02760220197","url":null,"abstract":"<p><p>Diabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e220197"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9174066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giardia lamblia-infected preschoolers present growth delays independent of the assemblage A, B or E.","authors":"Maria Fantinatti,&nbsp;Tiara Cascais-Figueredo,&nbsp;Phelipe Austriaco-Teixeira,&nbsp;Filipe Anibal Carvalho-Costa,&nbsp;Alda Maria Da-Cruz","doi":"10.1590/0074-02760230043","DOIUrl":"https://doi.org/10.1590/0074-02760230043","url":null,"abstract":"<p><strong>Background: </strong>Intestinal parasite Giardia can affect children's physical development mainly stunting even in asymptomatic cases. The protozoa G. lamblia is divided into assemblages A-H. However, it is still unclear whether clinical manifestations and pathogenesis may vary according to the infecting assemblage.</p><p><strong>Objectives: </strong>To investigate whether G. lamblia assemblages influence differently the physical development of preschoolers from a community of Rio de Janeiro, Brazil.</p><p><strong>Methods: </strong>Anthropometric parameters were analysed from children attending a daycare centre and stool samples were obtained for the G. lamblia diagnosis. G. lamblia isolates from positive samples were genotyped. Data were analysed in order to verify whether there is a relationship between G. lamblia infection and the physical development of children according to the assemblage.</p><p><strong>Findings: </strong>Herein we demonstrated that although eutrophic, G. lamblia-infected daycare preschoolers from a low-income community presented growth delay compared to non-infected ones. This effect was observed for the three assemblages (A, B or E) found infecting humans.</p><p><strong>Main conclusion: </strong>G. lamblia causes growth delays on children independent of infecting assemblage (A, B or E).</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230043"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10065352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A short history of innate immunity.","authors":"Yuri Chaves Martins,&nbsp;Flávia Lima Ribeiro-Gomes,&nbsp;Cláudio Tadeu Daniel-Ribeiro","doi":"10.1590/0074-02760230023","DOIUrl":"https://doi.org/10.1590/0074-02760230023","url":null,"abstract":"<p><p>Innate immunity refers to the mechanisms responsible for the first line of defense against pathogens, cancer cells and toxins. The innate immune system is also responsible for the initial activation of the body's specific immune response (adaptive immunity). Innate immunity was studied and further developed in parallel with adaptive immunity beginning in the first half of the 19th century and has been gaining increasing importance to our understanding of health and disease. In the present overview, we describe the main findings and ideas that contributed to the development of innate immunity as a continually expanding branch of modern immunology. We start with the toxicological studies by Von Haller and Magendie, in the late 18th and early 19th centuries, and continue with the discoveries in invertebrate immunity that supported the discovery and characterization of lipopolysaccharide (LPS) and pattern recognition receptors that led to the development of the pattern recognition and danger theory.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"118 ","pages":"e230023"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9511296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stronger control-surveillance systems for vector-borne Chagas disease.","authors":"Rodrigo Gurgel-Gonçalves","doi":"10.1590/0074-02760210130chgsb","DOIUrl":"https://doi.org/10.1590/0074-02760210130chgsb","url":null,"abstract":"The multinational initiatives for the control/surveillance of Chagas launched by disease-endemic countries and the Pan American Health Organization-World Health Organization (PAHO-WHO) contributed to control house-infesting triatomine-bug populations and to reduce disease incidence. However, after 30 years, Chagas disease (CD) transmission persists the Americas. In their recent review, Rojas de Arias et al.(1) highlight the ‘practical impossibility’ of interrupting vector-borne Trypanosoma cruzi transmission, due to the zoonotic nature of most transmission cycles, with well over 100 vector species widely spread across the Americas. Then, Rojas de Arias et al.(1) emphasise the need for stronger surveillance systems to monitor and control CD. Here, I will (1) briefly discuss the prospects for interrupting vector-borne T. cruzi transmission and (2) provide an overview of some innovative approaches that, I believe, can play important roles in the development and operation of stronger control-surveillance systems for vector-borne CD. Disease control needs clear goals, and those goals often heavily depend on the natural history, risk factors, transmission routes and dynamics, pathogenesis, and treatment of the disease. Eradication, elimination, reduction of incidence, reduction of the number of severe cases, and reduction of fatality rates are all possible goals of disease control programs. (2) The most ambitious goal is disease eradication the complete elimination of an infection, with no new cases recorded in the absence of control measures. Eradication is practically impossible for zoonoses such as CD, whose etiological agent can be transmitted by 150+ vector species and infects a wide range of wild vertebrate hosts from the USA to Patagonia.(3) Therefore, the objective of a CD control program cannot be eradication, at least in the Americas. The main goal of the multinational initiatives against CD was the elimination of the strongly synanthropic, non-native populations of a few “primary” vectors mainly Triatoma infestans and Rhodnius prolixus.(4) Elimination of R. prolixus from Mexico and some countries of Central America was certified in 2011 by PAHO/WHO, but R. prolixus-infested houses were detected in rural sites in Mexico after certification.(5) Moreover, a new record of T. infestans in Mexico was recorded after 50 years.(6) In Peru, non-native T. infestans populations were not controlled in Arequipa (see references in Rojas de Arias et al.(1)). In addition, T. infestans residual foci have been detected in Brazil after certification.(7) Overall, these data indicate that elimination of non-native populations of “primary” vectors is feasible, but has many challenges. Elimination may not be the best goal for native vectors of CD.(8,9) There is a high species richness of Triatominae in the Americas.(3) Moreover, it is important to highlight that the response of some native species to vector control with insecticides was not the same as that observe","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"117 ","pages":"e210130chgsb"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9103131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal models and SARS-CoV-2-induced pulmonary and neurological injuries.","authors":"Marcelo Alves Pinto,&nbsp;Alexandre Dos Santos da Silva,&nbsp;Daniela Del Rosario Flores Rodrigues,&nbsp;Rodrigo Müller,&nbsp;Gentil Arthur Lins Bentes Mendonça de Vasconcelos,&nbsp;Patrícia Cristina da Costa Neves,&nbsp;Jaqueline Mendes de Oliveira,&nbsp;Renato Sergio Marchevsky","doi":"10.1590/0074-02760220239","DOIUrl":"https://doi.org/10.1590/0074-02760220239","url":null,"abstract":"<p><p>Laboratory animals are essential mainly for experiments aiming to study pathogenesis and evaluate antivirals and vaccines against emerging human infectious diseases. Preclinical studies of coronavirus disease 19 (COVID-19) pathogenesis have used several animal species as models: transgenic human ACE2 mice (K18 mice), inbred BALB/c or C57BL/6N mice, ferrets, minks, domestic cats and dogs, hamsters, and macaques. However, the choice of an animal model relies on several limitations. Besides the host susceptibility, the researcher's experience with animal model management and the correct interpretation of clinical and laboratory records are crucial to succeed in preclinical translational research. Here, we summarise pathological and clinical findings correlated with virological data and immunological changes observed from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experimental infections using different well-established SARS-CoV-2 animal model species. This essay aims to critically evaluate the current state of animal model translation to clinical data, as described in the human SARS-CoV-2 infection.</p>","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":"117 ","pages":"e220239"},"PeriodicalIF":2.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10601766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}