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Plants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections. 作为治疗阿卡阿米巴感染药物来源的拉米亚西亚科植物。

IF 2.5 4区医学

Memorias do Instituto Oswaldo Cruz Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI: 10.1590/0074-02760240171

Martin Mrva, Lucia Malíková, Mária Garajová

{"title":"Plants of the family Lamiaceae as a source of therapeutic agents against Acanthamoeba infections.","authors":"Martin Mrva, Lucia Malíková, Mária Garajová","doi":"10.1590/0074-02760240171","DOIUrl":"10.1590/0074-02760240171","url":null,"abstract":"Background: Acanthamoebae are causative agents of severe and complicated human infections without a standard effective therapy to date. Therefore, the research is focused on the development of new amoebicidal drugs based on the natural products. Plants of the family Lamiaceae are typical with several phenolic secondary metabolites that make them interesting in medical point of view.Objective: In this review, we concentrate on anti-Acanthamoeba activities of plant extracts, essential oils, and phytochemicals of Lamiaceae in the published literature.Findings: A total of 13 articles in the research field were found. Totally, 16 plant species belonging to family Lamiaceae were studied against trophozoites and cysts of Acanthamoeba in in vitro conditions. Low toxicity of the Lamiaceae plant extracts to tissue cultures enhances their possible potential for clinical use. The research demonstrated promising trophocidal and cysticidal effects against acanthamoebae. Further research is needed with inclusion of more clinical isolates and in vivo studies.Main conclusion: Reviewing the related literature highlights the promising amoebicidal activities of plant extracts, essential oils and bioactive compounds of family Lamiaceae. Identifying the active components could lead to production new effective and well-tolerated drugs for the Acanthamoeba infections treatment.","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the distribution of a rare Colombo-Venezuelan kissing bug, Rhodnius neivai, Lent, 1953, using geographical information system-based analyses. 利用基于地理信息系统的分析，调查一种罕见的科伦坡-委内瑞拉吻蝽 Rhodnius neivai, Lent, 1953 的分布情况。

IF 2.5 4区医学

Memorias do Instituto Oswaldo Cruz Pub Date : 2024-11-11 eCollection Date: 2024-01-01 DOI: 10.1590/0074-02760240106

Guilherme Sanches Corrêa-do-Nascimento, Cleber Galvão, Gustavo Rocha Leite

{"title":"Investigating the distribution of a rare Colombo-Venezuelan kissing bug, Rhodnius neivai, Lent, 1953, using geographical information system-based analyses.","authors":"Guilherme Sanches Corrêa-do-Nascimento, Cleber Galvão, Gustavo Rocha Leite","doi":"10.1590/0074-02760240106","DOIUrl":"10.1590/0074-02760240106","url":null,"abstract":"Background: Rhodnius neivai, a kissing bug found in the dry regions of Colombia and Venezuela, has limited documented occurrences. While it is not deemed a significant vector for Chagas disease, distributional and ecological studies are essential in monitoring species domiciliation and shedding light on the evolutionary aspects of the Rhodniini tribe.Objectives: The study aims to provide a detailed revision of R. neivai distribution and evaluate general spatial data quality for ecological niche modelling (ENM). It will also provide the first published ENM for the species, which may aid species sampling and future analytical improvement.Methods: Registers and other spatial information were gathered by literature review; data georeferencing, preliminary geographical investigations, and model editing were conducted in GIS platforms; ENMs were built using R and explored the uncertainty of parameters and algorithms.Findings: Twenty four unique sites were identified, unearthing 17 previously uncovered records. Data lacks robust spatial and temporal precision; however, ENMs had acceptable validations. The models present some variation in suitability but with objective areas for sampling effort.Main conclusions: Rhodnius neivai distribution is better explained by conditions that characterise dry ecotypes, but further sampling is essential to improve modelling and advance with ecological and evolutive matters.","PeriodicalId":18469,"journal":{"name":"Memorias do Instituto Oswaldo Cruz","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0