Medical Principles and Practice最新文献_第10页

The Effects and Outcomes of the COVID-19 Pandemic on Pregnant Women in Kuwait. COVID-19大流行对科威特孕妇的影响和结果

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-09-14 DOI: 10.1159/000534125

Zahraa Akbar, Eman Al Azmi, Eelaf Husain, Mariam Aldarweesh, Khaled AlMuzayen, Fatemah Alhadhoud, Jehad Al Harmi

{"title":"The Effects and Outcomes of the COVID-19 Pandemic on Pregnant Women in Kuwait.","authors":"Zahraa Akbar, Eman Al Azmi, Eelaf Husain, Mariam Aldarweesh, Khaled AlMuzayen, Fatemah Alhadhoud, Jehad Al Harmi","doi":"10.1159/000534125","DOIUrl":"10.1159/000534125","url":null,"abstract":"Objectives: This retrospective study reports the effects of COVID-19 among hospitalized pregnant women infected with COVID-19 and compares them to a control group.Methods: A multi-center retrospective cohort study, in which data of pregnant women with COVID-19, admitted to five different hospitals in Kuwait, were collected. Two groups were included, the first group were women with COVID-19 who were admitted between March 22, 2020 until December 31, December 2020. The second (control) group included pregnant women without COVID-19, who were admitted between March 1, 2019 and March 21, 2020. Data were collected using a standardized data collection survey, entered using Excel Software and analyzed using Analysis of Variance (ANOVA).Results: We compared 764 patients, with confirmed COVID-19 with 765 uninfected control subjects. The majority of pregnant women were diagnosed with COVID-19 infection during the third trimester. Tachycardia was the most frequent sign at admission and dry cough and fever were the most common presenting symptoms. ICU admission and respiratory failure were significantly higher in the COVID-19 group. Cesarean section (CS) rate was higher in the COVID-19 group, with obstetric and maternal complications being the most common indications in comparison to fetal indications in the control group.Conclusions: This study was conducted to identify the effects of COVID-19 in pregnancy. Most patients were asymptomatic. The rate of normal vaginal delivery was higher in the control group. The main indications for Cesarean section in the COVID-19 group were obstetrical and maternal complications compared to fetal complications in the control group. .","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10590641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thrombin Decrease in Thrombin Generation after Heparin Administration in a Homozygous Type II Heparin Binding Site Antithrombin-Deficient Pregnant Woman. 纯合型II型肝素结合位点抗凝血酶缺乏孕妇服用肝素后凝血酶生成减少。

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-09-13 DOI: 10.1159/000533801

Ivana Malikova, Martina Husakova, Jana Bilkova, Radka Brzezkova, Tomas Kvasnicka

{"title":"Thrombin Decrease in Thrombin Generation after Heparin Administration in a Homozygous Type II Heparin Binding Site Antithrombin-Deficient Pregnant Woman.","authors":"Ivana Malikova, Martina Husakova, Jana Bilkova, Radka Brzezkova, Tomas Kvasnicka","doi":"10.1159/000533801","DOIUrl":"10.1159/000533801","url":null,"abstract":"Objectives: There is a major problem in providing prophylactic treatment in antithrombin (AT)-deficient pregnant women with a homozygous mutation of the heparin binding site (HBS) and AT level of 17 %. The aim of the study was to determine the effectiveness of heparin by monitoring changes in thrombin generation (TG) in vitro so that pregnant women are not exposed to stress in vivo.Methods: We used the chromogenic method for determination of factor Xa (FXa) inhibition for enoxaparine, nadroparine, dalteparine, fondaparinux and unfractionated heparin (UFH) and the Thrombin Generation Assay (TGA).Results: We found that the degree of inhibition is very different when different heparins are compared. Nadroparin reduces TG the most compared to low molecular weight heparins (LMWH).Conclusion: Routine monitoring of anti FXa activity should be supplemented with TG monitoring, where the effect of LMWH does not manifest itself as this could help in estimating thrombophilic risk during pregnancy.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":"1"},"PeriodicalIF":3.2,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Investigation of Platelet Dysfunction Induced by Osmotic Pressure Variations. 渗透压变化致血小板功能障碍的体外研究。

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-09-13 DOI: 10.1159/000533852

Despoina Pantazi, Athina Stratou, Evangelia Dounousi, Anastasios Petrou, Alexandros D Tselepis

{"title":"In Vitro Investigation of Platelet Dysfunction Induced by Osmotic Pressure Variations.","authors":"Despoina Pantazi, Athina Stratou, Evangelia Dounousi, Anastasios Petrou, Alexandros D Tselepis","doi":"10.1159/000533852","DOIUrl":"10.1159/000533852","url":null,"abstract":"Background: Severe variations in osmotic pressure are significant contributors to critical patient morbidity and mortality and might also affect platelet volume. We aimed to investigate possible osmotic-induced changes in mean platelet volume (MPV) and their possible effects on platelet aggregation activity (PLAG). Methods: We induced experimental variations of serum osmolality in blood samples from healthy volunteers (heparinized whole blood [WB]) and isolated platelets (platelet-rich plasma [PRP]) by adding isotonic, hypertonic, and hypotonic solutions of saline/water (pH = 7.2–7.4). PLAG was tested in WB samples with impedance aggregometry (IA) and in PRP samples with light transmission aggregometry (LTA) using three agonists: adenosine diphosphate (ADP, 10 μm), thrombin receptor activating peptide (TRAP-6, 10 μm), and arachidonic acid (500 μm). Osmolality was either calculated using a formula or measured directly. Results: We found almost identical osmolalities in WB and PRP preparations. Osmotic stress did not produce significant changes in MPV. In IA testing, the hypotonic challenge of WB preparations produced significant reductions at 50% (p = 0.056) (95% CI: 11.2–2.4, in Ohms) of ADP and at 31% (p = 0.017) (95% CI: 13.4–8.6, in Ohms) of TRAP-6-induced PLAG, respectively. In PRP, we did not observe any variations in PLAG with LTA. Conclusions: We conclude that in vitro hypotonic stress of WB samples has an inhibitory effect on the PAR-1 (TRAP-6-induced) pathway and on the P2Y12 (ADP-induced) pathway and reflects a distinct in vivo effect of hypoosmotic stress on WB human platelet preparations.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical and Biological Characterization of Mycobacterium Tuberculosis-Specific ESAT6-Like Proteins and their Potentials in the Prevention of Tuberculosis and Asthma. 结核分枝杆菌特异性esat6样蛋白的化学和生物学特性及其在预防结核病和哮喘中的潜力

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-09-13 DOI: 10.1159/000534002

Abu Salim Mustafa

{"title":"Chemical and Biological Characterization of Mycobacterium Tuberculosis-Specific ESAT6-Like Proteins and their Potentials in the Prevention of Tuberculosis and Asthma.","authors":"Abu Salim Mustafa","doi":"10.1159/000534002","DOIUrl":"10.1159/000534002","url":null,"abstract":"Early Secreted Antigenic Target 6 kDa (ESAT6) is a potent immunogenic protein secreted by the bacteria causing tuberculosis, i.e., Mycobacterium tuberculosis. Another highly immunogenic culture filtrate protein whose gene is linked to ESAT6/ESXA is known as CFP10/ESXB. Because of their high immunogenicity and specificity to M. tuberculosis, these proteins have been proposed as a vaccine to prevent tuberculosis and diagnose the active/latent disease. However, the same proteins cannot be used for prevention and diagnosis because immunized but healthy people will also show a positive response and be falsely reported as diseased. Therefore, in this review article, the search was made to identify if any other ESAT6-like proteins exist in the M. tuberculosis genome. The search identified 21 additional ESAT-like proteins, i.e., ESXC to ESXW. Immunological characterization has shown that some of them (especially ESXV) were able to induce immune responses in vitro with cells obtained from tuberculosis patients and healthy donors. When the protein ESXV was tested in different recombinant forms (expressed in Escherichia coli, mycobacterial vectors, and DNA plasmids) and injected in mice, immune responses were induced to multiple epitopes of the protein. Furthermore, immunization of mice with ESXV protected them from infection with M. tuberculosis. The same protein was also able to protect mice against the induction of asthma. These results suggest that ESXV has the potential to protect against two major diseases of the world, i.e., tuberculosis and asthma, and hence may be used as a common vaccine for both diseases.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Subclinical Cardiovascular Disease in Patients with Non-Alcoholic-Fatty Liver Disease: Analysis of the Paracelsus 10.000 Cohort Study. 非酒精性脂肪性肝病患者亚临床心血管疾病的患病率:Paracelsus 10,000队列研究分析

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-09-07 DOI: 10.1159/000533909

Florian Koutny, Elmar Aigner, Christian Datz, Sophie Gensluckner, Andreas Maieron, Andrea Mega, Bernhard Iglseder, Patrick Langthaler, Vanessa Frey, Bernhard Paulweber, Eugen Trinka, Bernhard Wernly

{"title":"Prevalence of Subclinical Cardiovascular Disease in Patients with Non-Alcoholic-Fatty Liver Disease: Analysis of the Paracelsus 10.000 Cohort Study.","authors":"Florian Koutny, Elmar Aigner, Christian Datz, Sophie Gensluckner, Andreas Maieron, Andrea Mega, Bernhard Iglseder, Patrick Langthaler, Vanessa Frey, Bernhard Paulweber, Eugen Trinka, Bernhard Wernly","doi":"10.1159/000533909","DOIUrl":"10.1159/000533909","url":null,"abstract":"Background: In patients with non-alcoholic fatty liver disease (NAFLD) cardiovascular diseases are more often the cause of death than the liver disease itself. However, the prevalence of atherosclerotic manifestations in individuals with NAFLD is still uncertain. This study aimed to explore the association between NAFLD and coronary artery calcification (CAC) in a Central European population.Methods: A total of 1,743 participants from the Paracelsus 10,000 study were included. The participants underwent CAC scoring and were assessed for fatty liver index (FLI), fibrosing non-alcoholic steatohepatitis Index (FNI) and fibrosis-4 index (FIB-4 score), which are indicators for steatosis and fibrosis. Multivariable logistic regression models were calculated.Results: Results revealed an association between liver steatosis/fibrosis and CAC. A FLI > 60 was associated with higher odds of NAFLD (OR 3.38, 95% CI: 2.61-4.39, p < 0.01) and increased prevalence of CAC-Score >300 compared to FLI <30 (9% vs. 3%, p < 0.01), even after adjusting for traditional cardiometabolic risk factors. While the crude odds ratios of the FIB-4 scores ≥ 1.3 and FNI score were significantly associated with increased odds of CAC, they became non-significant after adjusting for age, sex, and MetS.Conclusion: This study reveals a significant association between NAFLD and CAC. The findings suggest that assessing liver fat and fibrosis could enhance assessment of cardiovascular risk, but further research is needed to determine whether hepatic fat plays an independent role in the development of atherosclerosis and whether targeting liver steatosis can mitigate vascular risk.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10534699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Glucagon Immunoreactivity in a Rat Model of Diet-induced Obesity following Sleeve Gastrectomy. 胰高血糖素免疫反应性在袖胃切除术后饮食诱导的肥胖大鼠模型中升高。

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-08-25 DOI: 10.1159/000533746

Suleiman Al-Sabah, Mohammad H Jamal, Ghanim Al-Khaledi, Carol Dsouza, Fatemah AlOtaibi AlOtaibi, Waleed Al-Ali, Preethi Cherian, Irina Al-Khairi, Hamad Ali, Mohammad Abu-Farha, Jehad Abubaker, Fahd Al-Mulla

{"title":"Increased Glucagon Immunoreactivity in a Rat Model of Diet-induced Obesity following Sleeve Gastrectomy.","authors":"Suleiman Al-Sabah, Mohammad H Jamal, Ghanim Al-Khaledi, Carol Dsouza, Fatemah AlOtaibi AlOtaibi, Waleed Al-Ali, Preethi Cherian, Irina Al-Khairi, Hamad Ali, Mohammad Abu-Farha, Jehad Abubaker, Fahd Al-Mulla","doi":"10.1159/000533746","DOIUrl":"10.1159/000533746","url":null,"abstract":"Objective: Bariatric surgery is currently the most effective treatment for obesity, and procedures such as Roux-en Y gastric bypass and sleeve gastrectomy (SG) also result in rapid improvements in insulin sensitivity and glucose tolerance. In addition, these procedures cause changes in the secretion of various gut-derived hormones. The role these hormones play in the mechanism of the beneficial effects of bariatric surgery is still debated, but nonetheless, their importance provides inspiration for novel obesity-targeted pharmacotherapies.Methods: Male Sprague Dawley rats were fed either regular chow or a cafeteria diet to induce obesity. A sub-group of the obese animals then underwent either sham surgery or SG.Results: Following a 4-week recovery period, SG rats weighed significantly less than obese or sham-operated rats. Improvements in glucose tolerance and insulin sensitivity also occurred in the SG group, but these were not always statistically significant. We measured the intracellular lipid content of liver samples and found that obese rats showed signs of non-alcoholic fatty liver disease, which were significantly ameliorated by SG. There were significantly higher glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) responses to a standard mixed meal in the SG group, as well as paradoxically higher glucagon secretion.Conclusion: These data highlight the need for more specific anti-glucagon antibodies to characterize the changes in proglucagon-derived peptide concentrations that occur following SG. Further studies are required to determine whether these peptides contribute to the therapeutic effects of SG.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10439131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between body composition and chronic low back pain in Korean adults aged over 50 years: The Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2011. 韩国50岁以上成年人身体成分与慢性腰痛的关系:2010-2011年韩国国家健康与营养调查(KNHANES)

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-08-07 DOI: 10.1159/000533354

Jae-Geum Shim, Kyoung-Ho Ryu, Eun-Ah Cho, Jin Hee Ahn, Jiyeon Park, Hyo-Won Lee, Suji Kang, So Young Han, Sung Hyun Lee

{"title":"Association between body composition and chronic low back pain in Korean adults aged over 50 years: The Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2011.","authors":"Jae-Geum Shim, Kyoung-Ho Ryu, Eun-Ah Cho, Jin Hee Ahn, Jiyeon Park, Hyo-Won Lee, Suji Kang, So Young Han, Sung Hyun Lee","doi":"10.1159/000533354","DOIUrl":"10.1159/000533354","url":null,"abstract":"Background The relationship between overweight or obesity and low back pain (LBP) has previously been investigated. Several recent studies have focused on the relationship between other indicators of obesity, particularly indicators of fat and the risk of LBP. However, the results of body composition and LBP have been inconsistent. Methods All data for the present retrospective, cross-sectional study was extracted from the Korea National Health and Nutrition Examination Survey (KNHANES) versions V-1 and 2 conducted in 2010 and 2011 by the Korean Centers for Disease Control and Prevention. In KNHANES V-1 (2010) and V-2 (2011), those over 50 years of age completed the surveys on LBP, body weight, and body composition assessed using dual-energy X-ray absorptiometry (DXA) were included. The multivariable logistic regression analysis was used to examine the relationship between the presence of chronic LBP and body composition adjusting for confounders. Results We analyzed 3,579 persons who completed the question. In the multivariable analyses adjusting for age and sex, none of the variables, including fat mass and fat-free mass, remained positively or negatively associated with LBP. Additionally, when depression, smoking, alcohol intake, physical activity, diabetes mellitus, and fat or lean tissue mass were included in the multivariable logistic model, no significant associations were found between all measures of fat mass, fat-free mass, and LBP Conclusion This study is contrary to previous studies that concluded that there is a correlation between obesity and fat mass and LBP. LBP is not associated with increased levels of obesity and fat mass.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9953614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the Bioimpedance Phase Angle and Quality of Life in Postmenopausal Osteoporosis. 绝经后骨质疏松症患者生物阻抗相位角与生活质量的关系。

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-01-01 DOI: 10.1159/000528004

Yuichi Ono, Yuji Kasukawa, Kana Sasaki, Naohisa Miyakoshi

{"title":"Association of the Bioimpedance Phase Angle and Quality of Life in Postmenopausal Osteoporosis.","authors":"Yuichi Ono, Yuji Kasukawa, Kana Sasaki, Naohisa Miyakoshi","doi":"10.1159/000528004","DOIUrl":"https://doi.org/10.1159/000528004","url":null,"abstract":"Objectives: Osteoporosis patients with fragility fractures and vertebral deformities have impaired quality of life (QOL). The phase angle, an index calculated from bioelectrical impedance analysis (BIA) measurements, has been reported to be related to clinical outcomes, mortality, and QOL in various diseases. We aimed to investigate the relationship between the phase angle and QOL in patients with postmenopausal osteoporosis.Methods: 81 female patients treated for postmenopausal osteoporosis from September 2019 to March 2020 underwent measurement of bone mineral density (BMD) by dual-energy X-ray absorptiometry, body composition by BIA, and QOL by the 36-item Short-Form Health Survey (SF-36).Results: The phase angle showed significant positive correlations with physical functioning (r = 0.270, p = 0.015) and physical component summary (PCS) (r = 0.251, p = 0.024) of the SF-36. The phase angle showed significant positive correlations with appendicular skeletal muscle mass index (ASMI) (r = 0.456, p < 0.001), lumbar spine BMD (r = 0.241, p = 0.030), and femoral neck BMD (r = 0.26, p = 0.021) and a significant negative correlation with age (r = -0.526, p < 0.001). Multiple regression analysis of the factors potentially associated with SF-36 PCS showed that the phase angle (r = 7.506, p = 0.012) was a significant contributor to PCS (R2 = 0.184).Conclusion: The phase angle in postmenopausal osteoporotic patients was significantly related to QOL after adjusting for age, BMI, ASMI, and BMD. As the phase angle is a parameter that can be measured easily and noninvasively, it might be a useful aid for QOL assessment in osteoporotic patients.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":"32 1","pages":"71-76"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/a6/mpp-0032-0071.PMC10267484.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Experience of Subcutaneous Levetiracetam in Palliative Care. 左乙拉西坦在姑息治疗中的应用体会。

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-01-01 DOI: 10.1159/000529461

Mariana Gaviria-Carrillo, Laura Mora-Muñoz, Andres Felipe Diaz-Forero, Juliana Vargas-Osorio, Viviana Torres-Ballesteros, Jhonatan Estrada, Alberto Vélez Van Meerbeke, Jesús Hernán Rodríguez

{"title":"Experience of Subcutaneous Levetiracetam in Palliative Care.","authors":"Mariana Gaviria-Carrillo, Laura Mora-Muñoz, Andres Felipe Diaz-Forero, Juliana Vargas-Osorio, Viviana Torres-Ballesteros, Jhonatan Estrada, Alberto Vélez Van Meerbeke, Jesús Hernán Rodríguez","doi":"10.1159/000529461","DOIUrl":"https://doi.org/10.1159/000529461","url":null,"abstract":"Background: Seizures are common in palliative care patients and its control is essential in the management of these patients as it helps to reduce suffering at the end of life. Subcutaneous levetiracetam has been used off-license for seizure control in palliative care.Objective: The objective of the study was to describe our experience with subcutaneous levetiracetam in two hospitals in Bogota, Colombia.Methods: We conducted a retrospective review of patients treated with subcutaneous levetiracetam in two hospitals in Colombia during 2019-2021. Data were extracted from medical records, and participants were followed up as outpatients.Results: Twenty-one patients were included into the study. No severe adverse effects or rise in ictal frequency were documented. Twelve patients died during hospitalization and nine continued treatments as outpatients. The principal diagnosis was structural focal epilepsy. The daily dose of levetiracetam ranged from 1,000 mg to 3,000 mg, and the duration of treatment varied among subjects between 1 and 360 days.Conclusion: Subcutaneous levetiracetam was well tolerated and effective in controlling seizures in palliative care when oral administration or intravenous access was not an option. Randomized controlled trials are needed to elucidate the efficacy and tolerability of subcutaneous levetiracetam in clinical practice.","PeriodicalId":18455,"journal":{"name":"Medical Principles and Practice","volume":"32 1","pages":"90-95"},"PeriodicalIF":3.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/b5/mpp-0032-0090.PMC10267486.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9704564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Professor Olav Thulesius. 奥拉夫·图莱修斯教授。

IF 3.2 3区医学

Medical Principles and Practice Pub Date : 2023-01-01 Epub Date: 2023-04-20 DOI: 10.1159/000530538

Jasbir S Juggi, Abdullatif Al-Bader

引用次数: 0