Prognostic Value of Inflammation and Nutrition-Based Scores in Non-Small Cell Lung Cancer.

IF 2.9 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medical Principles and Practice Pub Date : 2024-01-01 Epub Date: 2023-12-13 DOI:10.1159/000535781

Mert Erciyestepe, Oğuzhan Selvi, Şermin Dinç Sonuşen, Ahmet Emin Öztürk, Gülhan Dinç, Tuğçe Kübra Güneş, Okan Aydın, Nurgül Yaşar, Gözde Balkaya Aykut, Sezai Vatansever

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引用次数: 0

Abstract

Objective: In studies conducted on non-small cell lung cancer (NSCLC) patients, many factors such as age, stage, weight loss, lymph node, and pleural involvement have been shown to affect survival. On the other hand, systemic inflammation plays a critical role in proliferation, migration, invasion, and metastasis. Inflammation and nutrition-based prognostic scores are reported to be associated with survival in patients with NSCLC. The aim of our study is to show the effects of these scores on survival and disease progression in NSCLC patients.

Subjects and methods: Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS), and prognostic nutritional index (PNI) values in 102 patients with stages 1, 2, and 3A NSCLC were analyzed retrospectively.

Results: NLR (p < 0.001), PLR (p = 0.001), PNI (p < 0.001), and mGPS (p = 0.001) variables showed a statistically significant difference according to mortality groups. NLR and PLR values were higher in exitus patients. However, PNI values were higher in surviving patients. NLR (p < 0.001), PLR (p = 0.004), PNI (p = 0.001), and mGPS (p = 0.015) variables showed a statistically significant difference in terms of locoregional recurrence. PNI (p = 0.001) and mGPS (p = 0.001) in terms of distant metastasis development during follow-up and treatment showed a statistically significant difference.

Conclusion: NLR, PLR, PNI, and mGPS are easily accessible noninvasive parameters and provide predictive information about survival and disease course. We showed the effect of these parameters on the prognosis.

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非小细胞肺癌İnflammation和营养评分的预后价值

研究目的对非小细胞肺癌（NSCLC）患者进行的研究表明，年龄、分期、体重减轻、淋巴结和胸膜受累等许多因素都会影响患者的生存期。另一方面，全身炎症在增殖、迁移、侵袭和转移中起着至关重要的作用。据报道，炎症和基于营养的预后评分与 NSCLC 患者的生存率有关。我们的研究旨在显示这些评分对 NSCLC 患者生存和疾病进展的影响：对 102 例 1、2 和 3A 期 NSCLC 患者的中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、改良格拉斯哥预后评分（mGPS）和预后营养指数（PNI）值进行回顾性分析：结果：NLR（p < 0.001）、PLR（p = 0.001）、PNI（p < 0.001）和 mGPS（p = 0.001）变量在不同死亡率组别中存在显著统计学差异。出院患者的 NLR 和 PLR 值更高。然而，存活患者的 PNI 值更高。NLR（p < 0.001）、PLR（p = 0.004）、PNI（p = 0.001）和 mGPS（p = 0.015）变量在局部复发方面显示出显著的统计学差异。PNI（p = 0.001）和mGPS（p = 0.001）在随访和治疗期间的远处转移发展方面显示出统计学上的显著差异：结论：NLR、PLR、PNI 和 mGPS 是容易获得的非侵入性参数，可提供有关生存和病程的预测信息。我们展示了这些参数对预后的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Principles and Practice 医学-医学：内科

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Medical Principles and Practice'', as the journal of the Health Sciences Centre, Kuwait University, aims to be a publication of international repute that will be a medium for dissemination and exchange of scientific knowledge in the health sciences.