Metal-Based Drugs最新文献_第5页

Nematicidal, Fungicidal and Bactericidal Activities of Manganese (II) Complexes with Heterocyclic Sulphonamide Imines. 锰(II)杂环磺胺配合物的杀线虫、杀真菌和杀菌活性。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.53

Mukta Jain, Sampat Nehra, P C Trivedi, R V Singh

引用次数: 14

Quantification and localization of intracellular free mg in bovine chromaffin cells. 牛嗜铬细胞胞内游离mg的定量和定位。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.69

Liliana P Montezinho, Carla P Fonseca, Carlos F G C Geraldes, M Margarida C A Castro

{"title":"Quantification and localization of intracellular free mg in bovine chromaffin cells.","authors":"Liliana P Montezinho, Carla P Fonseca, Carlos F G C Geraldes, M Margarida C A Castro","doi":"10.1155/MBD.2002.69","DOIUrl":"https://doi.org/10.1155/MBD.2002.69","url":null,"abstract":"Magnesium is an essential element for all living systems. The quantification of free intracellular Mg(2+) concentration ([Mg(2+)](i)) is of utmost importance since changes in its basal value may be an indication of different pathologies due to abnormalities of Mg(2+) metabolism. In this work we used (31)P NMR and fluorescence spectroscopy to determine the resting [Mg(2+)](i) in bovine chromaffin cells, a neuron-like cellular model, as well as confocal laser scanning microscopy to study the free Mg(2+) spatial distribution in these cells. (31)P NMR spectroscopy did not prove to be effective for the determination of [Mg(2+)](i) in this particular case due to some special morphological and physiological properties of this cell type. A basal [Mg(2+)](i) value of 0.551 +/- 0.008 mM was found for these cells using fluorescence spectroscopy and the Mg(2+)-sensitive probe furaptra; this value falls in the concentration range reported in the literature for neurons from different sources. This technique proved to be an accurate and sensitive tool to determine the [Mg(2+)](i).lntraceilular free Mg(2+) seems to be essentially localized in the nucleus and around it, as shown by confocal microscopy with the Mg(2+)-sensitive probe Magnesium Green. It was not possible to derive any conclusion about free Mg(2+) localization inside the chromaffin granules and/or in the cytoplasm due to the lack of sufficient spatial resolution and to probe compartmentalization.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"9 1-2","pages":"69-80"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.69","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Antibacterial Role of SO(4), NO(3), C(2)O(4) and CH(3)CO(2) Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff Base. SO(4)、NO(3)、C(2)O(4)和CH(3)CO(2)阴离子对噻二唑衍生吡咯基席夫碱Cu(II)和Zn(II)配合物的抑菌作用

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.263

Zahid H Chohan, Humayun Pervez, Abdul Rauf, Claudiu T Supuran

引用次数: 28

Antitumour and Immunomodulatory Effects of Cu(II) Complexes of Thiobenzyhdrazide. 硫代乙酶肼铜(II)配合物的抗肿瘤和免疫调节作用。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.109

Nand K Singh, Saty B Singh, Anuraag Shrivastav

引用次数: 11

Bio-Inorganic Studies on the Fe(II) Sparfloxacin Complex. 铁(II)司帕沙星配合物的生物无机研究。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.1

Swati Jain, N K Jain, K S Pitre

{"title":"Bio-Inorganic Studies on the Fe(II) Sparfloxacin Complex.","authors":"Swati Jain, N K Jain, K S Pitre","doi":"10.1155/MBD.2002.1","DOIUrl":"https://doi.org/10.1155/MBD.2002.1","url":null,"abstract":"The qualitative and quantitative analysis of an antibiotic drug, 5-amino-1 cyclopropyl-7 (cis-3, 5 dimethyl-1-piperazyl)-6,8- dihydro-1, 4 dihydro-4-oxo-3-quinoline carboxylic acid (Sparfloxacin, SFX) and its pharmaceutical formulation i.e.sparx-100 tablet, has been done using polarographic and amperometric methods. Complexation behavior of SFX with Fe(II), both in solid and liquid phases has been studied by elemental analysis, IR.-spectra and polarographic and amperometric methods. SFX produces a single cathodic reduction wave in 0.1 M ammonium tartrate (supporting electrolyte) at pH 6.0 +/-0.1. The wave is diffusion controlled and wave height is proportional to the concentration of SFX. The complex is also reversibly reduced at the electrode surface with diffusion-controlled kinetics. The stoichiometry of the Fe(II)- SFX complex is 1:1. Antibacterial studies on the drug and its metal complex have been performed against different bacteria. The observed results revealed the complex to be more potent in its antibacterial activity as compared to the parent drug. On the basis of observed results it could be concluded that the prepared Fe(II)- SFX complex may be recommended to the therapeutic experts for its possible use as a more potent antibiotic drug.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"9 1-2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27437615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Synthesis, characterization and biological activity of dimethyltin dicarboxylates containing germanium. 含锗二甲基锡二羧酸盐的合成、表征及生物活性研究。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.275

M A Choudhary, M Mazhar, S Ali, X Song, G Eng

引用次数: 21

Cytotoxicity of Triorganophosphinegold(I) n-Mercaptobenzoates, n = 2, 3 and 4. 三有机膦金(I) n-巯基苯甲酸酯的细胞毒性，n = 2,3和4。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.303

Dick de Vos, Douglas R Smyth, Edward R T Tiekink

引用次数: 13

Development of Functional Models for a SOD. SOD功能模型的建立。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.9

Ali Arslantas

引用次数: 10

Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives. o -胆固醇- o -苯基- n -苯酰胺磷及其有机金属锡(lV)衍生物的细胞毒活性。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.333

Marcela López-Cardoso, Patricia García Y García, Raymundo Cea-Olivares, María-Luisa Villareal

引用次数: 0

Antimicrobial, Antifertility and Antiinflammatory Approach to Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II). 铁(II)和锰(II)四齿大环配合物的抗菌、抗生育和抗炎研究。

Metal-Based Drugs Pub Date : 2002-01-01 DOI: 10.1155/MBD.2002.347

Ashu Chaudhary, D P Jaroli, R V Singh

{"title":"Antimicrobial, Antifertility and Antiinflammatory Approach to Tetradentate Macrocyclic Complexes of Iron(II) and Manganese(II).","authors":"Ashu Chaudhary, D P Jaroli, R V Singh","doi":"10.1155/MBD.2002.347","DOIUrl":"https://doi.org/10.1155/MBD.2002.347","url":null,"abstract":"Some antifertility inhibitors of 18 to 24-membered tetraazamacrocyclic complexes of iron(II) and manganese(II) have been synthesised by the template condensation using 1,3-phenylenediamine with malonic acid, succinic acid, glutaric acid and adipic acid. The reaction proceed smoothly to completion. The complexes were characterized by elemental analyses, molecular weight determinations, infrared, electronic, magnetic moment, mössbaur and mass spectral studies. The elemental analyses are consistent with the formation of the complexes [M(N(4)L(n))Cl(2)] (M = Fe(lI) or Mn(II)). All these complexes are stable and monomeric in nature as indicated by the molecular weight determinations. The spectral studies confirm the octahedral geometry around the central metal atom. The complexes have been screened in vitro against a number of fungi and bacteria to assess their growth inhibiting potential. The testicular sperm density and testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trials and biochemical parameters of reproductive organs have been examined and discussed.","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 6","pages":"347-53"},"PeriodicalIF":0.0,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27440148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11