Marcela López-Cardoso, Patricia García Y García, Raymundo Cea-Olivares, María-Luisa Villareal
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引用次数: 0
摘要
O-胆固醇-O-苯基- n-苯基磷酰胺(1)和四种有机锡(lV)衍生物的双齿状O-胆固醇-O-苯基磷硫酸配体配制为Me(3) SnOSPR'R”(2)，Ph(3)SnOSPR'R”(3)，O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R”(4)，S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R”(5)，(R' = O-苯基;R"= o -胆固醇)对KB(鼻咽癌)、OVCAR-5(卵巢癌)和SQC-1 UlSO(宫颈鳞癌)细胞培养进行细胞毒性筛选。生物实验结果表明，这些化合物对所研究的人癌细胞具有较强的抗肿瘤活性。
Cytotoxic Activities of O-Cholesteryl-O-Phenyl-N-Phenylphosphoramidate and Its Organometallic Tin(lV) Derivatives.
O-Cholesteryl-O-phenyl-N-phenylphosphoramidate (1) and four organotin (lV) derivatives of the ambidentate O-cholesteryl-O -phenyl phosphorothioate ligand formulated as Me(3) SnOSPR'R"(2), Ph(3)SnOSPR'R"(3), O(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R"(4), S(CH(2)CH(2)S)(2)Sn(n-Bu)OSPR'R"(5), (R' = O-phenyl; R"= O-cholesteryl) were subjected to cytotoxicity screening against KB (nasopharingel carcinoma), OVCAR-5 (ovarium carcinoma) and SQC-1 UlSO (squamous cell cervix carcinoma) cell cultures. The results of the bioassay showed that these compounds possess potent antitumor activities against the studied human carcinoma cell lines.
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