{"title":"含锗二甲基锡二羧酸盐的合成、表征及生物活性研究。","authors":"M A Choudhary, M Mazhar, S Ali, X Song, G Eng","doi":"10.1155/MBD.2002.275","DOIUrl":null,"url":null,"abstract":"<p><p>A series of diorganotin dicarboxylates of the general formula (CH(3))(2)Sn(OCOCHR(3)CHR(2)GeR(1))(2) where R(1)=(C(6)H(5))(3), (P-CH(3)C(6)H(4))3, N(CH(2)CH(2)O)(3), R(2)=C(6)H(5), H, CH(3), P-CH(3)OC(6)H(4), P-ClC(6)H(4), P-CH(3)C(6)H(4), R(3)=CH(3) and H, have been synthesized by the reaction of dimethyltin oxide with germanium substituted propionic acid in 1:2 molar ratio in toluene. The H(2)O formed was removed azeotropically using a Dean and Stark apparatus. All the compounds have been characterized by IR, multinuclear ((1)H, (13)C, (119)Sn) NMR, mass and Mössbauer spectroscopies. All compounds were found to have potential activity against bacteria.</p>","PeriodicalId":18452,"journal":{"name":"Metal-Based Drugs","volume":"8 5","pages":"275-81"},"PeriodicalIF":0.0000,"publicationDate":"2002-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/MBD.2002.275","citationCount":"21","resultStr":"{\"title\":\"Synthesis, characterization and biological activity of dimethyltin dicarboxylates containing germanium.\",\"authors\":\"M A Choudhary, M Mazhar, S Ali, X Song, G Eng\",\"doi\":\"10.1155/MBD.2002.275\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>A series of diorganotin dicarboxylates of the general formula (CH(3))(2)Sn(OCOCHR(3)CHR(2)GeR(1))(2) where R(1)=(C(6)H(5))(3), (P-CH(3)C(6)H(4))3, N(CH(2)CH(2)O)(3), R(2)=C(6)H(5), H, CH(3), P-CH(3)OC(6)H(4), P-ClC(6)H(4), P-CH(3)C(6)H(4), R(3)=CH(3) and H, have been synthesized by the reaction of dimethyltin oxide with germanium substituted propionic acid in 1:2 molar ratio in toluene. The H(2)O formed was removed azeotropically using a Dean and Stark apparatus. All the compounds have been characterized by IR, multinuclear ((1)H, (13)C, (119)Sn) NMR, mass and Mössbauer spectroscopies. All compounds were found to have potential activity against bacteria.</p>\",\"PeriodicalId\":18452,\"journal\":{\"name\":\"Metal-Based Drugs\",\"volume\":\"8 5\",\"pages\":\"275-81\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2002-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/MBD.2002.275\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Metal-Based Drugs\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/MBD.2002.275\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metal-Based Drugs","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/MBD.2002.275","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis, characterization and biological activity of dimethyltin dicarboxylates containing germanium.
A series of diorganotin dicarboxylates of the general formula (CH(3))(2)Sn(OCOCHR(3)CHR(2)GeR(1))(2) where R(1)=(C(6)H(5))(3), (P-CH(3)C(6)H(4))3, N(CH(2)CH(2)O)(3), R(2)=C(6)H(5), H, CH(3), P-CH(3)OC(6)H(4), P-ClC(6)H(4), P-CH(3)C(6)H(4), R(3)=CH(3) and H, have been synthesized by the reaction of dimethyltin oxide with germanium substituted propionic acid in 1:2 molar ratio in toluene. The H(2)O formed was removed azeotropically using a Dean and Stark apparatus. All the compounds have been characterized by IR, multinuclear ((1)H, (13)C, (119)Sn) NMR, mass and Mössbauer spectroscopies. All compounds were found to have potential activity against bacteria.
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