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Clinical research on triple-negative breast cancer that targets the PIK3CA pathway. 针对 PIK3CA 通路的三阴性乳腺癌临床研究。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02493-4
Kadri Altundag
{"title":"Clinical research on triple-negative breast cancer that targets the PIK3CA pathway.","authors":"Kadri Altundag","doi":"10.1007/s12032-024-02493-4","DOIUrl":"10.1007/s12032-024-02493-4","url":null,"abstract":"","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosomal microRNA as a key regulator of PI3K/AKT pathways in human tumors. 作为人类肿瘤中 PI3K/AKT 通路关键调节因子的外泌体 microRNA。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02529-9
Saade Abdalkareem Jasim, Abdulrahman T Ahmed, Aziz Kubaev, Ashishkumar Kyada, Mohammad Y Alshahrani, Shilpa Sharma, Hussein Riyadh Abdul Kareem Al-Hetty, Raghav Vashishth, Ashish Singh Chauhan, Munther Kadhim Abosaoda
{"title":"Exosomal microRNA as a key regulator of PI3K/AKT pathways in human tumors.","authors":"Saade Abdalkareem Jasim, Abdulrahman T Ahmed, Aziz Kubaev, Ashishkumar Kyada, Mohammad Y Alshahrani, Shilpa Sharma, Hussein Riyadh Abdul Kareem Al-Hetty, Raghav Vashishth, Ashish Singh Chauhan, Munther Kadhim Abosaoda","doi":"10.1007/s12032-024-02529-9","DOIUrl":"10.1007/s12032-024-02529-9","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are conserved non-protein-coding RNAs that are naturally present in organisms and can control gene expression by suppressing the translation of mRNA or causing the degradation of mRNA. MicroRNAs are highly concentrated in the PI3K/AKT pathway, and abnormal activation of the PI3K/AKT pathway plays a role in cancer progression. The AKT/PI3K pathway is critical for cellular functions and can be stimulated by cytokines and in normal situations. It is involved in regulating various intracellular signal transduction, including development, differentiation, transcriptional regulation, protein, and synthesis. There is a growing body of evidence indicating that miRNAs, which are abundant in exosomes released by different cells, can control cellular biological activities via modulating the PI3K/AKT pathway, hence influencing cancer progression and drug resistance. This article provides an overview of the latest research progress regarding the function and medical use of the PI3K/AKT pathway and exosomal miRNA/AKT/PI3K axis in the behaviors of cancer cells.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: Comment on "possible protective effect of rosuvastatin in chemotherapy-induced cardiotoxicity in HER2 positive breast cancer patients: a randomized controlled trial". 致编辑的信：就 "罗伐他汀对HER2阳性乳腺癌患者化疗引起的心脏毒性的可能保护作用：随机对照试验 "发表评论。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02502-6
Jiaan Lu, Ziye Zhuang, Hao Chi
{"title":"Letter to the editor: Comment on \"possible protective effect of rosuvastatin in chemotherapy-induced cardiotoxicity in HER2 positive breast cancer patients: a randomized controlled trial\".","authors":"Jiaan Lu, Ziye Zhuang, Hao Chi","doi":"10.1007/s12032-024-02502-6","DOIUrl":"10.1007/s12032-024-02502-6","url":null,"abstract":"<p><p>We have read with keen interest the original article by Kettana et al., which investigates the potential cardioprotective effects of rosuvastatin in HER2-positive breast cancer patients undergoing chemotherapy. We appreciate the study's meticulous methodology and its contribution to medicine oncology. However, we suggest a cautious interpretation of the results due to unmeasured confounding variables that could influence cardiotoxicity development and treatment efficacy. The study's fixed dosing approach to rosuvastatin precludes the assessment of dose-dependent effects, prompting a recommendation for future dose-response analyses. We also highlight the need to incorporate patient-reported outcomes for a more holistic treatment efficacy evaluation. Furthermore, we propose metabolomic analysis to uncover the drug's mechanisms of action and computational methods like molecular docking to predict its potential targets, which could refine drug design and inform personalized treatment strategies. Our commentary aims to refine the study's conclusions and encourage research that maximizes the understanding and clinical management of chemotherapy-induced cardiotoxicity.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert-consensus on lymphedema surgeries: candidacy, prehabilitation, and postoperative care. 淋巴水肿手术专家共识：候选资格、术前康复和术后护理。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02449-8
Justin Sacks, Breanne Riley, David Doubblestein, John P Kirby, Anna Towers, Kathy Weatherly
{"title":"Expert-consensus on lymphedema surgeries: candidacy, prehabilitation, and postoperative care.","authors":"Justin Sacks, Breanne Riley, David Doubblestein, John P Kirby, Anna Towers, Kathy Weatherly","doi":"10.1007/s12032-024-02449-8","DOIUrl":"10.1007/s12032-024-02449-8","url":null,"abstract":"<p><p>For over 2 decades, the mainstay of lymphedema treatment has been complete decongestive therapy, however, surgical options are available when conservative treatment is not successful in reducing lymphedema. Standardized pre-surgical and post-surgical guidelines for candidates are not readily available. As part of the 2023 Lymphedema Summit that was sponsored by the American Cancer Society, and the Lymphology Association of North America, an expert consensus workgroup was formed and developed an expert consensus which affirms the importance of pre-surgical guidelines for candidates with lymphedema. The workgroup recommended that guidelines should be tailored to four major end-user groups: (1) patients, (2) referring physicians, (3) allied health professionals, and (4) surgeons.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormones as a double-edged sword: the role of hormones in cancer progression and the potential of targeted hormone therapies. 荷尔蒙是一把双刃剑：荷尔蒙在癌症发展中的作用以及荷尔蒙靶向疗法的潜力。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02517-z
Dixita Joshi, Janaki Patel, Muskaan Munshi, Zeel Mistry, Alok Prajapati, Asmi Mukherjee, A V Ramachandran, Nidarshana Chaturvedi Parashar, Gaurav Parashar, Shafiul Haque, Hardeep Singh Tuli
{"title":"Hormones as a double-edged sword: the role of hormones in cancer progression and the potential of targeted hormone therapies.","authors":"Dixita Joshi, Janaki Patel, Muskaan Munshi, Zeel Mistry, Alok Prajapati, Asmi Mukherjee, A V Ramachandran, Nidarshana Chaturvedi Parashar, Gaurav Parashar, Shafiul Haque, Hardeep Singh Tuli","doi":"10.1007/s12032-024-02517-z","DOIUrl":"10.1007/s12032-024-02517-z","url":null,"abstract":"<p><p>Cancer remains a significant cause of mortality in the world, with increasing prevalence worldwide. There are numerous treatments ranging from surgery to chemotherapy and radiotherapy, but since cancer is a heterogeneous disease, only few patients possibly respond to treatments. However, it opens a huge space for the advent of targeted therapies such as hormone therapy, immunotherapy, and target-specific drugs. Hormonal therapy using hormone agonists/antagonists or hormone receptor inhibitors-called the next-generation hormonal agents-hits distinct hormonal pathways that are involved in breast, prostate and ovarian cancer. Preliminary results show that through combination of drugs, it is possible that the synergistic effects may actually lead to better survival than with the use of single drugs. With manageable adverse effects, hormonal therapy offers much hope for treatment of this rather challenging malignancy of the hormone-sensitive cancers, especially in combination with other treatments.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1. YBX1通过转录调控PLRG1促进肝细胞癌的上皮-间质转化
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02516-0
Jae Hwan Kwon, Sang Hoon Kim
{"title":"YBX1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma via transcriptional regulation of PLRG1.","authors":"Jae Hwan Kwon, Sang Hoon Kim","doi":"10.1007/s12032-024-02516-0","DOIUrl":"10.1007/s12032-024-02516-0","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) ranks as the sixth most prevalent cancer worldwide. The epithelial-mesenchymal transition (EMT) is a critical process in cancer progression, contributing to increased malignancy. While Pleiotropic Regulator 1 (PLRG1) is upregulated in HCC and is associated with enhanced cell proliferation, its oncogenic role in EMT remains unclear. In this study, we demonstrate that PLRG1 promotes EMT in HCC cells. Knockdown of PLRG1 in Huh7 cells resulted in decreased expression of the EMT markers N-cadherin and Snail, and impaired cell migration and invasion. Chromatin immunoprecipitation (ChIP) and luciferase assays identified Y-box binding protein 1 (YBX1) as a direct regulator of PLRG1 transcription, binding to its promoter region. Overexpression of YBX1 in SNU-449 cells led to increased PLRG1 expression and subsequent EMT activation, as well as enhanced migration, and invasion. These effects were attenuated by PLRG1 knockdown. Our findings indicate that YBX1 drives EMT in HCC by upregulating PLRG1, offering novel insights into the molecular mechanisms underlying HCC progression.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Anticancer effects of Artemisia campestris extract on acute myeloid leukemia cells: an ex vivo study". 关于 "青蒿提取物对急性髓性白血病细胞的抗癌作用：体内外研究 "的评论
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02498-z
Lavanya Kubendiran
{"title":"Comment on \"Anticancer effects of Artemisia campestris extract on acute myeloid leukemia cells: an ex vivo study\".","authors":"Lavanya Kubendiran","doi":"10.1007/s12032-024-02498-z","DOIUrl":"10.1007/s12032-024-02498-z","url":null,"abstract":"","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Gd-GQDs as nanotheranostic platform for the treatment of HPV-positive oropharyngeal cancer". 就 "Gd-GQDs 作为治疗 HPV 阳性口咽癌的纳米otheranostic 平台 "发表评论。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02499-y
Lavanya Kubendiran
{"title":"Comment on \"Gd-GQDs as nanotheranostic platform for the treatment of HPV-positive oropharyngeal cancer\".","authors":"Lavanya Kubendiran","doi":"10.1007/s12032-024-02499-y","DOIUrl":"10.1007/s12032-024-02499-y","url":null,"abstract":"","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PI3K/AKT/mTOR inhibitors for the management of triple-negative breast cancer. 用于治疗三阴性乳腺癌的 PI3K/AKT/mTOR 抑制剂。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02515-1
Kadri Altundag
{"title":"PI3K/AKT/mTOR inhibitors for the management of triple-negative breast cancer.","authors":"Kadri Altundag","doi":"10.1007/s12032-024-02515-1","DOIUrl":"10.1007/s12032-024-02515-1","url":null,"abstract":"","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of kinesin superfamily proteins in hepatocellular carcinoma. 驱动蛋白超家族蛋白在肝细胞癌中的作用。
IF 2.8 4区 医学
Medical Oncology Pub Date : 2024-10-14 DOI: 10.1007/s12032-024-02497-0
Zahraa Sabah Ghnim, Morug Salih Mahdi, Suhas Ballal, Mamata Chahar, Rajni Verma, Ali M Ali Al-Nuaimi, M Ravi Kumar, Rouaida Kadhim A Al-Hussein, Mohaned Adil, Mahmood Jasem Jawad
{"title":"The role of kinesin superfamily proteins in hepatocellular carcinoma.","authors":"Zahraa Sabah Ghnim, Morug Salih Mahdi, Suhas Ballal, Mamata Chahar, Rajni Verma, Ali M Ali Al-Nuaimi, M Ravi Kumar, Rouaida Kadhim A Al-Hussein, Mohaned Adil, Mahmood Jasem Jawad","doi":"10.1007/s12032-024-02497-0","DOIUrl":"10.1007/s12032-024-02497-0","url":null,"abstract":"<p><p>The most prevalent form of primary liver cancer, hepatocellular carcinoma (HCC) poses a significant global health challenge due to its limited therapeutic options. Researchers are currently focused on the complex molecular landscape that governs the initiation and progression of HCC in order to identify new avenues for diagnosis, prognosis, and treatment. In the context of HCC, the Kinesin Superfamily Proteins (KIFs) have become critical regulators of cellular processes, prompting a growing interest in their function among the diverse array of molecular actors implicated in cancer. The KIFs, a family of microtubule-based molecular motors, are renowned for their essential roles in the dynamics of mitotic spindles and intracellular transport. Beyond their well-established functions in normal cellular physiology, emerging evidence indicates that dysregulation of KIFs significantly contributes to the pathogenesis of HCC. Novel therapeutic targets and diagnostic markers are revealed through the unique opportunity to comprehend the complex interplay between KIFs and the molecular events that drive HCC.</p>","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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