Medical Oncology最新文献_第4页

Targeting the mevalonate pathway enhances the efficacy of 5-fluorouracil by regulating pyroptosis. 以甲羟戊酸途径为靶点，通过调节化脓过程提高 5-氟尿嘧啶的疗效。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-20 DOI: 10.1007/s12032-024-02557-5

Zongrui Xing, Yong Ma, Xiangyan Jiang, Huiguo Qing, Yuxia Wu, Shengfu Che, Zhongti Gao, Keshen Wang, Tao Wang, Qichen He, Zhigang Li, Bin Zhao, Wenbo Liu, Haonan Sun, Zeyuan Yu

{"title":"Targeting the mevalonate pathway enhances the efficacy of 5-fluorouracil by regulating pyroptosis.","authors":"Zongrui Xing, Yong Ma, Xiangyan Jiang, Huiguo Qing, Yuxia Wu, Shengfu Che, Zhongti Gao, Keshen Wang, Tao Wang, Qichen He, Zhigang Li, Bin Zhao, Wenbo Liu, Haonan Sun, Zeyuan Yu","doi":"10.1007/s12032-024-02557-5","DOIUrl":"10.1007/s12032-024-02557-5","url":null,"abstract":"The 5-fluorouracil (5-FU)-based chemotherapy regimen is a primary strategy for treating pancreatic cancer (PC). However, challenges related to 5-FU resistance persist. Investigating the mechanisms of 5-FU resistance and identifying a clinically viable therapeutic strategy are crucial for improving the prognosis of PC. Here, through clinical samples analysis, we found that the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in mevalonate metabolism, is negatively correlated with the efficacy of 5-FU treatment. There is a significant correlation between HMGCR and the pyroptosis marker gasdermin D (GSDMD), and the HMGCR inhibitor simvastatin can significantly inhibit the activation of pyroptosis signaling. The exogenous addition of geranylgeranyl pyrophosphate (GGPP), a key metabolite of the mevalonate pathway, can significantly reduce sensitivity to 5-FU, and simvastatin combined with 5-FU demonstrates a strong synergistic effect. Furthermore, in organoid models and genetically engineered mice with spontaneous PC, the combination of simvastatin and 5-FU significantly inhibits tumor growth. In conclusion, our study reveals the critical role of the mevalonate pathway in 5-FU resistance and proposes a clinically feasible combination therapy strategy.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 1","pages":"9"},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thapsigargin and its prodrug derivatives: exploring novel approaches for targeted cancer therapy through calcium signaling disruption. Thapsigargin 及其原药衍生物：通过钙信号干扰探索癌症靶向治疗的新方法。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-19 DOI: 10.1007/s12032-024-02541-z

Iqra Khurram, Muhammad Umer Khan, Saooda Ibrahim, Muhammad Usman Ghani, Iram Amin, Luca Falzone, Jesús Herrera-Bravo, William N Setzer, Javad Sharifi-Rad, Daniela Calina

{"title":"Thapsigargin and its prodrug derivatives: exploring novel approaches for targeted cancer therapy through calcium signaling disruption.","authors":"Iqra Khurram, Muhammad Umer Khan, Saooda Ibrahim, Muhammad Usman Ghani, Iram Amin, Luca Falzone, Jesús Herrera-Bravo, William N Setzer, Javad Sharifi-Rad, Daniela Calina","doi":"10.1007/s12032-024-02541-z","DOIUrl":"10.1007/s12032-024-02541-z","url":null,"abstract":"Thapsigargin, a sesquiterpene lactone derived from Thapsia garganica L., has demonstrated mixed potential as an anticancer agent due to its potent ability to disrupt calcium signaling and induce apoptosis. This review evaluates the chemopreventive and chemotherapeutic potential of thapsigargin, focusing on its molecular mechanisms and toxicity. An extensive literature review of studies published since 2015 was conducted using databases such as PubMed/MedLine and Science Direct. Findings indicate that thapsigargin's primary mechanism is the inhibition of sarco/endoplasmic reticulum calcium ATPase, leading to endoplasmic reticulum stress and cell death in various cancer types. Despite these effects, thapsigargin's non-specific cytotoxicity results in significant side effects, including organ damage and histamine-related reactions. Recent advances in targeted delivery, especially with the prodrug mipsagargin, initially suggested promise in minimizing these toxicities by selectively activating in cancer cells expressing prostate-specific membrane antigen (PSMA). However, the completion of clinical trials with no ongoing studies suggests that the viability of mipsagargin and other prodrugs remains uncertain, especially in light of the toxicities observed. While thapsigargin and its derivatives present a potential pathway in cancer treatment, their future role in oncology requires careful re-evaluation.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 1","pages":"7"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red wavelength-induced photobiomodulation enhances indocyanine green-based anticancer photodynamic therapy. 红色波长诱导的光生物调节增强了基于吲哚菁绿的抗癌光动力疗法。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-19 DOI: 10.1007/s12032-024-02558-4

Büşra Sirek, Nermin Topaloğlu

{"title":"Red wavelength-induced photobiomodulation enhances indocyanine green-based anticancer photodynamic therapy.","authors":"Büşra Sirek, Nermin Topaloğlu","doi":"10.1007/s12032-024-02558-4","DOIUrl":"10.1007/s12032-024-02558-4","url":null,"abstract":"Cancer is a global concern worldwide. Prostate cancer has high prevalence and mortality rates among men. Photodynamic therapy (PDT) is an alternative treatment that is promising and effective with fewer side-effects than conventional therapies. However, some factors may limit its efficacy. For this, PDT can be combined with other modalities such as photobiomodulation (PBM) which is commonly used for increased cell proliferation/differentiation and wound healing. In this study, PBM pre-treatment at 655 nm of wavelength with 1, 3, and 5 J/cm2 energy densities was applied to prostate cancer cells to investigate its role in indocyanine green (ICG)-mediated PDT applications. Following PBM treatment, various analyses were assessed including cell viability, cellular uptake of ICG, ATP production, nitric oxide release, reactive oxygen species generation, and the changes in mitochondrial membrane potential. Increased cell death was observed with the PBM pre-treatment at 1 and 3 J/cm2 energy densities depending on ICG incubation time. Intracellular ROS generation and nitric oxide release by PBM had a significant impact on anticancer PDT action. An enhanced anticancer PDT effect was obtained with the PBM pre-treatment which may become a valuable modality to increase the sensitivity of the cancerous cells to PDT applications.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 1","pages":"8"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRIM2 promotes proliferation and metastasis of pancreatic ductal adenocarcinoma through interactions with FAM111B. PRIM2 通过与 FAM111B 相互作用促进胰腺导管腺癌的增殖和转移。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-18 DOI: 10.1007/s12032-024-02554-8

Jingyang Yin, Fanbo Qin, Hui Chen, Xianxing Wang, Renpei Xia, Bing Ni, Huaizhi Wang

引用次数: 0

Recent advancements at ASCO 2024 in PD-L1 and PD-1 bispecific antibodies. 2024 年 ASCO 上 PD-L1 和 PD-1 双特异性抗体的最新进展。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-17 DOI: 10.1007/s12032-024-02559-3

Shaza Hammad, Marc Boutros, Fouad Attieh, Hampig Raphaël Kourie

引用次数: 0

Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy. 类胡萝卜素作为 PI3K/Akt/mTOR 通路的调节剂：癌症治疗的创新策略。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-16 DOI: 10.1007/s12032-024-02551-x

Biswajit Kumar Utpal, Zerrouki Dehbia, B M Redwan Matin Zidan, Sherouk Hussein Sweilam, Laliteshwar Pratap Singh, M S Arunkumar, M Sona, Uttam Prasad Panigrahy, R Keerthana, Sandhya Rani Mandadi, Safia Obaidur Rab, Mohammed Ali Alshehri, Doukani Koula, Muath Suliman, Mohamed H Nafady, Talha Bin Emran

{"title":"Carotenoids as modulators of the PI3K/Akt/mTOR pathway: innovative strategies in cancer therapy.","authors":"Biswajit Kumar Utpal, Zerrouki Dehbia, B M Redwan Matin Zidan, Sherouk Hussein Sweilam, Laliteshwar Pratap Singh, M S Arunkumar, M Sona, Uttam Prasad Panigrahy, R Keerthana, Sandhya Rani Mandadi, Safia Obaidur Rab, Mohammed Ali Alshehri, Doukani Koula, Muath Suliman, Mohamed H Nafady, Talha Bin Emran","doi":"10.1007/s12032-024-02551-x","DOIUrl":"10.1007/s12032-024-02551-x","url":null,"abstract":"Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mTOR (PAMT) pathway playing a central role. This pathway significantly contributes to the proliferation and survival of cancer cells, and its hyperactivity is a major challenge in managing several types of malignancies. This article delves into the promising potential of carotenoids, natural pigments found in abundance in fruits and vegetables, as a novel therapeutic strategy for cancer treatment. By specifically targeting and inhibiting the PAMT pathway, carotenoids may effectively disrupt the growth and survival of cancer cells. The article examines the complex mechanisms underlying these interactions and highlights the obstacles faced in cancer treatment. It proposes a compelling approach to developing therapies that leverage natural products to target this critical pathway, offering a fresh perspective on cancer treatment. Further research is essential to enhance the therapeutic efficacy of these compounds.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 1","pages":"4"},"PeriodicalIF":2.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the understanding of doxorubicin's therapeutic impact in breast cancer. 进一步了解多柔比星对乳腺癌的治疗效果。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-15 DOI: 10.1007/s12032-024-02565-5

Ziye Zhuang, Rui Wang, Hao Chi

引用次数: 0

Clinicopathologic feature and treatment progress of high-grade ovarian neuroendocrine tumors. 高级别卵巢神经内分泌肿瘤的临床病理特征和治疗进展。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-14 DOI: 10.1007/s12032-024-02544-w

Qionghua He, Chenyan Wang, Da Huang, Jiayu Shen, Rui Liu, Yutao Guan, Jianwei Zhou

{"title":"Clinicopathologic feature and treatment progress of high-grade ovarian neuroendocrine tumors.","authors":"Qionghua He, Chenyan Wang, Da Huang, Jiayu Shen, Rui Liu, Yutao Guan, Jianwei Zhou","doi":"10.1007/s12032-024-02544-w","DOIUrl":"https://doi.org/10.1007/s12032-024-02544-w","url":null,"abstract":"High-grade Ovarian neuroendocrine tumors represent a rare subset of ovarian neoplasms characterized by aggressive behavior, poor prognosis, and early metastasis. Despite their clinical significance, the management of these tumors lacks consensus due to their low incidence. This comprehensive review encompasses literature spanning from 1991 to 2024, focusing on the clinical presentation, diagnostic criteria, differential diagnosis, prognostic indicators, treatment modalities, and recent advancements in the understanding of this condition. Notably, a substantial proportion of affected individuals present during the perimenopausal period with unilateral lesions displaying mixed histological components. Biomarkers such as CA125, CA199, and NSE hold promise for aiding in the diagnosis and screening of ovarian neuroendocrine tumors. Unfortunately, patients exhibit a dismal prognosis even diagnosed at an early stage. Primary treatment strategies predominantly involve surgical intervention coupled with etoposide-cisplatin combination chemotherapy. In cases of recurrence, second-line chemotherapeutic agents including paclitaxel, irinotecan, and doxorubicin are commonly employed alongside localized radiotherapy. While specific genetic mutations remain elusive, emerging evidence suggests potential therapeutic effect involving mTOR inhibitors, PD-1 monoclonal antibodies, and antiangiogenic agents based on isolated case reports. The exploration of representative set of mutations will help for precise targeted therapies and remains a focal point of our ongoing research efforts.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"42 1","pages":"2"},"PeriodicalIF":2.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissecting the epigenetic orchestra of HDAC isoforms in breast cancer development: a review. 剖析乳腺癌发展过程中 HDAC 同工酶的表观遗传乐团：综述。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-12 DOI: 10.1007/s12032-024-02553-9

Maria Debbarma, Kakali Sarkar, Samir Kumar Sil

引用次数: 0

lncRNAs'p potential roles in the pathogenesis of cancer via interacting with signaling pathways; special focus on lncRNA-mediated signaling dysregulation in lung cancer. lncRNA 与信号通路相互作用，在癌症发病机制中发挥潜在作用；特别关注肺癌中 lncRNA 介导的信号失调。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-11-08 DOI: 10.1007/s12032-024-02536-w

Sulieman Ibrahim Shelash, Ibraheem Abdulnabi Shabeeb, Irfan Ahmad, Hiba Muwafaq Saleem, Pooja Bansal, Abhinav Kumar, Mahamedha Deorari, Anaheed Hussein Kareem, Ahmed Muzahem Al-Ani, Munther Kadhim Abosaoda

{"title":"lncRNAs'p potential roles in the pathogenesis of cancer via interacting with signaling pathways; special focus on lncRNA-mediated signaling dysregulation in lung cancer.","authors":"Sulieman Ibrahim Shelash, Ibraheem Abdulnabi Shabeeb, Irfan Ahmad, Hiba Muwafaq Saleem, Pooja Bansal, Abhinav Kumar, Mahamedha Deorari, Anaheed Hussein Kareem, Ahmed Muzahem Al-Ani, Munther Kadhim Abosaoda","doi":"10.1007/s12032-024-02536-w","DOIUrl":"10.1007/s12032-024-02536-w","url":null,"abstract":"Lung cancer ranks among the most lethal types of cancer globally, with a high occurrence and fatality rate. The spread of cancer to other parts of the body, known as metastasis, is the primary cause of treatment failure and death in lung cancer cases. Current approaches for treating advanced lung cancer typically involve a combination of chemotherapy and targeted therapy. However, the majority of patients ultimately develop resistance to these treatments, leading to a worsened prognosis. In recent years, cancer biology research has predominantly focused on the role of protein-encoding genes in cancer development. Long non-coding RNAs (lncRNAs) are transcripts over 200 nucleotides in length that do not encode proteins but are crucial RNA molecules involved in numerous biological functions. While many functions of lncRNAs remain unknown, some have been linked to human diseases, including cancer. Studies have demonstrated that lncRNAs interact with other large molecules in the cell, such as proteins, DNA, and RNA, influencing various critical aspects of cancer. LncRNAs play a significant role in regulating gene expression and have a crucial function in the transcriptional regulation of cancer cells. They mediate various biological and clinical processes such as invasion, metastasis, apoptosis, and cell proliferation. Dysregulation of lncRNAs has been found to impact the process of carcinogenesis through advanced technologies like RNA sequencing and microarrays. Collectively, these long non-coding RNAs hold promise as potential biomarkers and therapeutic targets for human cancers. In this segment, we provide a comprehensive summary of the literature on the characteristics and formation of lncRNAs, along with an overview of their current known roles in lung cancer.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":"41 12","pages":"310"},"PeriodicalIF":2.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0