Medical Oncology最新文献_第10页

Comment on "Pharmacokinetic studies, molecular docking, and molecular dynamics simulations of phytochemicals from Morus alba: a multi-receptor approach for potential therapeutic agents in colorectal cancer". 关于 "桑叶中植物化学物质的药代动力学研究、分子对接和分子动力学模拟：结直肠癌潜在治疗药物的多受体方法 "的评论

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-08-05 DOI: 10.1007/s12032-024-02460-z

YuHan Wang, YaLing Li, Jun Li

引用次数: 0

Tetrahydroisoquinoline reduces angiogenesis by interacting myeloma cells with HUVECs mediated by extracellular vesicles. 四氢异喹啉通过细胞外囊泡介导骨髓瘤细胞与 HUVEC 的相互作用，减少血管生成。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-08-05 DOI: 10.1007/s12032-024-02465-8

Ahmad Kooshari, Fahimeh Shahriyary, Minoo Shahidi, Mahshid Vafajoo, Mohammad Reza Amirzargar

{"title":"Tetrahydroisoquinoline reduces angiogenesis by interacting myeloma cells with HUVECs mediated by extracellular vesicles.","authors":"Ahmad Kooshari, Fahimeh Shahriyary, Minoo Shahidi, Mahshid Vafajoo, Mohammad Reza Amirzargar","doi":"10.1007/s12032-024-02465-8","DOIUrl":"10.1007/s12032-024-02465-8","url":null,"abstract":"Multiple myeloma (MM) is a neoplastic condition resulting from the uncontrolled expansion of B-cell-derived plasma cells. The importance of angiogenesis in MM development has also been demonstrated. Extracellular vesicles (EVs) have vital functions in interactions between neighboring cells, such as angiogenesis. The objective of this in vitro study was to examine the transfection and angiogenesis effects of MM-EVs on endothelial cells (ECs) upon treatment with Tetrahydroisoquinoline (THIQ) as a bioactive organic compound derivative from isoquinoline. Following treatment of multiple myeloma cells (U266) with THIQ, MM-EVs were harvested and transmigrated to human umbilical vein endothelial cells (HUVEC) in a co-culture model. EVs transmigration was traced by flow cytometry. Correspondingly, the expression of angiogenic genes and/or proteins in U266 cells and HUVECs was measured by RT-PCR and ELISA methods. Likewise, the proliferation and migration of HUVECs treated with THIQ-treated MM-EVs were visualized and estimated by performing both tube formation and scratch wound healing methods. Surprisingly, the anti-angiogenic effect of THIQ-treated MM-EVs was evident by the decreased expression of CD34, VEGFR2, and IL-6 at the mRNA and/or protein levels after internalization of MM-EVs in HUVEC. Finally, tube formation and scratch wound healing experiments showed inhibition of HUVEC cell proliferation and migration by THIQ-treated MM-EVs compared to control MM-EVs. MM-EVs derived from THIQ-treated myeloma cells (U266) inhibited angiogenesis in HUVECs. This phenomenon is coordinated by the internalized THIQ-treated MM-EVs in HUVECs, and ultimately the reduction of angiogenic factors and inhibition of tube formation and scratch wound healing.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay. 揭示 LncRNA 在胃癌发病机制中的影响：侧重于信号通路相互作用的全面综述。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-08-05 DOI: 10.1007/s12032-024-02455-w

Hanan Elimam, Sherif S Abdel Mageed, Abdulrahman Hatawsh, Rewan Moussa, Abdullah F Radwan, Nourhan Elfar, Nora A A Alhamshry, Mai A Abd-Elmawla, Osama A Mohammed, Mohamed Bakr Zaki, Ahmed S Doghish

{"title":"Unraveling the influence of LncRNA in gastric cancer pathogenesis: a comprehensive review focus on signaling pathways interplay.","authors":"Hanan Elimam, Sherif S Abdel Mageed, Abdulrahman Hatawsh, Rewan Moussa, Abdullah F Radwan, Nourhan Elfar, Nora A A Alhamshry, Mai A Abd-Elmawla, Osama A Mohammed, Mohamed Bakr Zaki, Ahmed S Doghish","doi":"10.1007/s12032-024-02455-w","DOIUrl":"10.1007/s12032-024-02455-w","url":null,"abstract":"Gastric cancers (GCs) are among the most common and fatal malignancies in the world. Despite our increasing understanding of the molecular mechanisms underlying GC, further biomarkers are still needed for more in-depth examination, focused prognosis, and treatment. GC is one among the long non-coding RNAs, or lncRNAs, that have emerged as key regulators of the pathophysiology of cancer. This comprehensive review focuses on the diverse functions of long noncoding RNAs (lncRNAs) in the development of GC and their interactions with important intracellular signaling pathways. LncRNAs affect GC-related carcinogenic signaling cascades including pathways for EGFR, PI3K/AKT/mTOR, p53, Wnt/β-catenin, JAK/STAT, Hedgehog, NF-κB, and hypoxia-inducible factor. Dysregulated long non-coding RNA (lncRNA) expression has been associated with multiple characteristics of cancer, such as extended growth, apoptosis resistance, enhanced invasion and metastasis, angiogenesis, and therapy resistance. For instance, lncRNAs such as HOTAIR, MALAT1, and H19 promote the development of GC via altering these pathways. Beyond their main roles, GC lncRNAs exhibit potential as diagnostic and prognostic biomarkers. The overview discusses CRISPR/Cas9 genome-modifying methods, antisense oligonucleotides, small molecules, and RNA interference as potential therapeutic approaches to regulate the expression of long noncoding RNAs (lncRNAs). An in-depth discussion of the intricate functions that lncRNAs play in the development of the majority of stomach malignancies is provided in this review. It provides the groundwork for future translational research in lncRNA-based whole processes toward GC by highlighting their carcinogenic effects, regulatory roles in significant signaling cascades, and practical scientific uses as biomarkers and therapeutic targets.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted gene therapy for cancer: the impact of microRNA multipotentiality. 癌症的靶向基因疗法：microRNA 多态性的影响。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-08-01 DOI: 10.1007/s12032-024-02450-1

Nourhan A Abou Madawi, Zeinab E Darwish, Enas M Omar

{"title":"Targeted gene therapy for cancer: the impact of microRNA multipotentiality.","authors":"Nourhan A Abou Madawi, Zeinab E Darwish, Enas M Omar","doi":"10.1007/s12032-024-02450-1","DOIUrl":"10.1007/s12032-024-02450-1","url":null,"abstract":"Cancer is a life-threatening disease and its management is difficult due to its complex nature. Cancer is characterized by genomic instability and tumor-associated inflammation of the supporting stoma. With the advances in omics science, a treatment strategy for cancer has emerged, which is based on targeting cancer-driving molecules, known as targeted therapy. Gene therapy, a form of targeted therapy, is the introduction of nucleic acids into living cells to replace a defective gene, promote or repress gene expression to treat a disease. MicroRNAs (miRNAs) are non-coding RNAs (ncRNAs) that regulate gene expression and thus are involved in physiological processes like cell proliferation, differentiation, and cell death. miRNAs control the actions of many genes. They are deregulated in cancer and their abnormal expression influences genetic and epigenetic alterations inducing carcinogenesis. In this review, we will explain the role of miRNAs in normal and abnormal gene expression and their usefulness in monitoring cancer patients. Besides, we will discuss miRNA-based therapy as a method of gene therapy and its impact on the success of cancer management.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on 'Therapeutic targeting of TNIK in papillary thyroid carcinoma: a novel approach for tumor growth suppression'. 就 "针对甲状腺乳头状癌 TNIK 的治疗：抑制肿瘤生长的新方法 "发表评论。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-08-01 DOI: 10.1007/s12032-024-02463-w

Nilina James

引用次数: 0

Correction to: Auraptene‑induced cytotoxic effects in acute myeloid leukemia cell Lines. 更正：Auraptene-induced cytotoxic effects in acute myeloid leukemia cell Lines.

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-07-30 DOI: 10.1007/s12032-024-02409-2

Majid Ghorbani, Mohammad Soukhtanloo, Amir Salek Farrokhi, Seyed Mahdi Hassanian, Fatemeh Ghorbani, Amir Reza Afshari, Mohsen Taherian, Mohammad Hadi Sadeghian

引用次数: 0

Marine sponge-derived alkaloid inhibits the PI3K/AKT/mTOR signaling pathway against diffuse large B-cell lymphoma. 海洋海绵生物碱抑制弥漫性大 B 细胞淋巴瘤的 PI3K/AKT/mTOR 信号通路

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-07-29 DOI: 10.1007/s12032-024-02448-9

Jie Liu, Yung-Ting Chang, Yan-Yu Kou, Pei-Pei Zhang, Qing-Li Dong, Ruo-Yu Guo, Li-Yun Liu, Hou-Wen Lin, Fan Yang

{"title":"Marine sponge-derived alkaloid inhibits the PI3K/AKT/mTOR signaling pathway against diffuse large B-cell lymphoma.","authors":"Jie Liu, Yung-Ting Chang, Yan-Yu Kou, Pei-Pei Zhang, Qing-Li Dong, Ruo-Yu Guo, Li-Yun Liu, Hou-Wen Lin, Fan Yang","doi":"10.1007/s12032-024-02448-9","DOIUrl":"10.1007/s12032-024-02448-9","url":null,"abstract":"Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous non-Hodgkin lymphoma that is extremely aggressive and has an intermediate to high malignancy. Some patients still experience treatment failure, relapse, or resistance to rituximab, cyclophosphamide, adriamycin, vincristine, and prednisone (R-CHOP) therapy. Therefore, there is an urgent need for further research on new agents for the treatment of DLBCL. AP-48 is an aaptamine alkaloid analog with potent anti-tumor effects that originates from marine natural products. In this study, we found that AP-48 exhibits dose-dependent cytotoxicity in DLBCL cell lines. Flow cytometry showed that AP-48 induced cell cycle arrest in the G0/G1 phase in SU-DHL-4 and Farage cells and in the S phase in WSU-DLCL-2 cells. AP-48 also accelerated apoptosis via the caspase-3-mediated intrinsic apoptotic pathway. Further experiments demonstrated that AP-48 exerted its anti-DLBCL effects through the PI3K/AKT/mTOR pathway, and that the PI3K agonist YS49 partially alleviated the inhibition of cell proliferation and apoptosis induced by AP-48. Finally, in a tumor xenograft model, AP-48 inhibited tumor growth and promoted apoptosis in tumor tissues, indicating its therapeutic potential in DLBCL.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mining parasites for their potential as novel therapeutic agents against cancer. 挖掘寄生虫作为新型癌症治疗药物的潜力。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-07-29 DOI: 10.1007/s12032-024-02458-7

Neha Sylvia Walter, Shalmoli Bhattacharyya

引用次数: 0

Allicin: a promising modulator of apoptosis and survival signaling in cancer. 大蒜素：癌症细胞凋亡和存活信号的有效调节剂。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-07-26 DOI: 10.1007/s12032-024-02459-6

Sunaina Bhuker, Avneet Kaur, Kanitha Rajauria, Hardeep Singh Tuli, Adesh K Saini, Reena V Saini, Madhu Gupta

{"title":"Allicin: a promising modulator of apoptosis and survival signaling in cancer.","authors":"Sunaina Bhuker, Avneet Kaur, Kanitha Rajauria, Hardeep Singh Tuli, Adesh K Saini, Reena V Saini, Madhu Gupta","doi":"10.1007/s12032-024-02459-6","DOIUrl":"10.1007/s12032-024-02459-6","url":null,"abstract":"According to the World Health Organization, cancer is the foremost cause of mortality globally. Various phytochemicals from natural sources have been extensively studied for their anticancer properties. Allicin, a powerful organosulfur compound derived from garlic, exhibits anticancer, antioxidant, anti-inflammatory, antifungal, and antibacterial properties. This review aims to update and evaluate the chemistry, composition, mechanisms of action, and pharmacokinetics Allicin. Allicin has garnered significant attention for its potential role in modulating Fas-FasL, Bcl2-Bax, PI3K-Akt-mTOR, autophagy, and miRNA pathways. At the molecular level, allicin induces the release of cytochrome c from the mitochondria and enhances the activation of caspases-3, -8, and -9. This is accompanied by the simultaneous upregulation of Bax and Fas expression in tumor cells. Allicin can inhibit excessive autophagy by activating the PI3K/Akt/mTOR and MAPK/ERK/mTOR signaling pathways. Allicin-loaded nano-formulations efficiently induce apoptosis in cancer cells while minimizing toxicity to normal cells. Safety and clinical aspects are meticulously scrutinized, providing insights into the tolerability and adverse effects associated with allicin administration, along with an overview of current clinical trials evaluating its therapeutic potential. In conclusion, this review underscores the promising prospects of allicin as a dietary-derived medicinal compound for cancer therapy. It emphasizes the need for further research to elucidate its precise mechanisms of action, optimize delivery strategies, and validate its efficacy in clinical settings.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current advances in cancer energy metabolism under dietary restriction: a mini review. 饮食限制下癌症能量代谢的最新进展：小型综述。

IF 2.8 4区医学

Medical Oncology Pub Date : 2024-07-26 DOI: 10.1007/s12032-024-02452-z

Liuxin Yang, Yudian Shao, Tingting Gao, Ousman Bajinka, Xingxing Yuan

{"title":"Current advances in cancer energy metabolism under dietary restriction: a mini review.","authors":"Liuxin Yang, Yudian Shao, Tingting Gao, Ousman Bajinka, Xingxing Yuan","doi":"10.1007/s12032-024-02452-z","DOIUrl":"10.1007/s12032-024-02452-z","url":null,"abstract":"The manipulation of the energy or source of food for cancer cells has attracted significant attention in oncology research. Metabolic reprogramming of the immune system allows for a deeper understanding of cancer cell mechanisms, thereby impeding their progression. A more targeted approach is the restriction of cancer cells through dietary restriction (CR), which deprives cancer cells of the preferred energy sources within the tumor microenvironment, thereby enhancing immune cell efficacy. Although there is a plethora of CR strategies that can be employed to impede cancer progression, there is currently no comprehensive review that delineates the specific dietary restrictions that target the diverse metabolic pathways of cancer cells. This mini-review introduces amino acids as anti-cancer agents and discusses the role of dietary interventions in cancer prevention and treatment. It highlights the potential of a ketogenic diet as a therapeutic approach for cancer, elucidating its distinct mechanisms of action in tumor progression. Additionally, the potential of plant-based diets as anti-cancer agents and the role of polyphenols and vitamins in anti-cancer therapy were also discussed, along with some prospective interventions for CR as anti-tumor progression.","PeriodicalId":18433,"journal":{"name":"Medical Oncology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0