Mechanistic insights into the therapeutic potential of β-elemene on glioma and other central nervous system diseases.

IF 3.5 4区 医学 Q2 ONCOLOGY
Xiaoyu Wang, Lin Lin, Yu Cheng, Yongjie Wang
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引用次数: 0

Abstract

The central nervous system (CNS) governs critical physiological processes, and its dysregulation drives severe pathologies, particularly glioma, a life-threatening malignancy with limited therapeutic options. β-elemene (ELE), the bioactive compound derived from Curcuma wenyujin, exhibits potent anti-glioma activity as both a monotherapy and in synergy with chemo- or radiotherapy. Beyond glioma, ELE demonstrates therapeutic versatility across CNS disorders, including traumatic brain injury, ischemic stroke, spinal cord injury, neuropathic pain, experimental autoimmune encephalomyelitis, and obesity-associated microbiota-gut-brain axis dysfunction. Mechanistically, modulation of key signaling pathways implicated in neoplastic proliferation, metastasis, neuroinflammation, apoptosis, and oxidative stress positions ELE as a promising candidate for repurposing traditional medicine in modern neurotherapeutics. This review synthesizes ELE's therapeutic efficacy, elucidates the underlying molecular mechanisms, and highlights outstanding questions to guide future research for ELE therapies, advocating for integrating traditional Chinese medicine-driven approaches into modern pharmacological innovation with favorable treatment outcomes.

β-榄香烯治疗神经胶质瘤和其他中枢神经系统疾病潜力的机制见解。
中枢神经系统(CNS)控制着关键的生理过程,其失调导致严重的病理,特别是胶质瘤,这是一种危及生命的恶性肿瘤,治疗选择有限。β-榄香烯(ELE)是一种从姜黄文玉金中提取的生物活性化合物,无论是单独治疗还是与化疗或放疗协同治疗,都显示出强大的抗胶质瘤活性。除了神经胶质瘤,ELE在治疗中枢神经系统疾病方面具有多功能性,包括创伤性脑损伤、缺血性中风、脊髓损伤、神经性疼痛、实验性自身免疫性脑脊髓炎和肥胖相关的微生物-肠-脑轴功能障碍。从机制上讲,与肿瘤增殖、转移、神经炎症、细胞凋亡和氧化应激有关的关键信号通路的调节使ELE成为现代神经治疗中重新利用传统药物的有希望的候选者。本文综述了ELE的治疗效果,阐明了其潜在的分子机制,并提出了指导未来ELE治疗研究的突出问题,倡导将传统中医驱动的方法与现代药理学创新相结合,并取得良好的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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