Metabolic syndrome and related disorders最新文献

{"title":"Metabolic Disorders During Prolactinomas.","authors":"Mouna Elleuch, Molka Ben Bnina, Fatma Loukil, Faten Hadj Kacem, Khouloud Boujelben, Mouna Mnif, Fatma Mnif, Nadia Charfi, Nabila Rekik, Dhouha Ben Salah, Mohamed Abid","doi":"10.1089/met.2023.0174","DOIUrl":"10.1089/met.2023.0174","url":null,"abstract":"<p><p>The metabolic profile during prolactinoma may be subject to significant changes. We aimed to describe the different metabolic aspects in patients monitored for prolactinoma and to study the correlations between the size of the prolactinoma and the metabolic parameters. We conducted a retrospective, descriptive, and analytical study of 77 cases of prolactinomas collected and monitored at the endocrinology and diabetology department of the Hedi Chaker Hospital in Sfax between 2000 and 2017. Our patients were divided into three groups according to the size of their prolactinomas. Statistical correlations were sought between tumor size and clinical and biological parameters. The mean age of our patients was 38.3 ± 14.2 years. They were divided into 51 women (66.2%) and 26 men (33.7%). Pituitary tumor syndrome was the most common circumstance of discovery in our population (62.3%). The clinical examination revealed an average waist circumference of 95.71 cm. Android fat distribution was observed in 25 women (49%) and 12 men (46.1%). A statistically significant positive correlation was objectified between waist circumference and tumor size (<i>r</i> = 0.29 and <i>P</i> = 0.019). The average body mass index was 28.08 kg/m². Obesity was noted in 56 cases (72.7%). Glucose tolerance disorders and hypertriglyceridemia were also more evident each time prolactinoma size increased in contrast to the level of high-density lipoprotein cholesterol which decreased with adenoma size. Our study highlighted the metabolic and hormonal repercussions of prolactinomas. Metabolic syndrome was more common in patients with larger prolactinoma. These results should guide the initial assessment and therapeutic management of prolactin adenomas.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Correction to:</i> The Role of Remnant Cholesterol Beyond Low-Density Lipoprotein Cholesterol in Arterial Stiffness: A Cross-Sectional Study, by Zhang et al. <i>Metab Syndr Relat Disord</i> 2023;21(9):526-534; doi: 10.1089/met.2023.0101.","authors":"","doi":"10.1089/met.2023.0101.correx","DOIUrl":"10.1089/met.2023.0101.correx","url":null,"abstract":"","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle and Health Behaviors Associated with Metabolic Syndrome and Cardiovascular Disease.","authors":"Goeun Chung, Hye-Jin Kim","doi":"10.1089/met.2023.0152","DOIUrl":"10.1089/met.2023.0152","url":null,"abstract":"<p><p><b><i>Background:</i></b> As the prevalence of cardiovascular disease increases, the socioeconomic burden is expected to increase further. This study aimed to investigate lifestyle and health behaviors related to metabolic syndrome (MetS), myocardial infarction (MI), and stroke prevalence in men and women 50-79 years of age to assess clustering of risk factors. <b><i>Methods:</i></b> This study used raw data from the eighth Korea National Health and Nutrition Examination Survey (KNHANES) in 2021. Collected data were analyzed using SPSS 29.0 program. Complex Samples General Linear Model procedure and Complex Samples Logistic Regression procedure were performed. <b><i>Results:</i></b> Body mass index of more than 25.0 kg/m², being a woman, having a middle school education or less, reporting a lower middle economic status, and performing exercise for less than 150 min a week were associated with MetS prevalence. Stress was associated with MI prevalence in men and women. Depression was associated with stroke prevalence in men. <b><i>Conclusions:</i></b> This study found that an education on obesity control in men and women is needed to reduce the prevalence of MetS. To reduce the prevalence of MI, stress management is required for men and women. To decrease stroke prevalence, depression management is needed for men.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138445280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Roundness Index Is Better Correlated with Insulin Sensitivity than Body Shape Index in Young and Middle-Aged Japanese Persons.","authors":"Norimitsu Murai, Naoko Saito, Rie Oka, Sayuri Nii, Hiroto Nishikawa, Asami Suzuki, Eriko Kodama, Tatsuya Iida, Kentaro Mikura, Hideyuki Imai, Mai Hashizume, Rie Tadokoro, Chiho Sugisawa, Toru Iizaka, Fumiko Otsuka, Shun Ishibashi, Shoichiro Nagasaka","doi":"10.1089/met.2023.0175","DOIUrl":"10.1089/met.2023.0175","url":null,"abstract":"<p><p><b><i>Aims:</i></b> The present study aimed to clarify the relationships between novel and traditional anthropometric indices and insulin sensitivity (SI) in young and middle-aged Japanese persons with normal glucose tolerance (NGT), and middle-aged Japanese persons with NGT and glucose intolerance. <b><i>Methods:</i></b> Plasma glucose and insulin levels were measured in 1270 young (age <40 years) and 2153 middle-aged persons with NGT (<i>n</i> = 1531) and glucose intolerance (<i>n</i> = 622) during a 75-g oral glucose tolerance test. Height (Ht), weight, and waist circumference (WC) were measured. The body mass index (BMI), WC, and the WC/Ht ratio were used as traditional anthropometric indices. A body shape index (ABSI) and the body roundness index (BRI) were calculated as novel indices. Indices of SI (Matsuda index and 1/homeostasis model assessment of insulin resistance) were calculated and compared with anthropometric indices. <b><i>Results:</i></b> The ABSI showed a weak correlation with SI indices in all groups. The BRI showed almost the same correlation with SI indices as the BMI, WC, and WC/Ht in all groups. The inverse correlation between each of the anthropometric indices other than ABSI and SI indices was weak in young persons, at 0.16-0.27 (Spearman's ρ values), but strong in middle-aged persons, at 0.38-1.00. On receiver-operating characteristic (ROC) curve analysis for detection of insulin resistance, the ABSI had a lower area under the ROC curve (AUC) than the other anthropometric indices, and the BRI and the WC/Ht ratio showed similar AUCs. The AUCs for the BRI and WC/Ht ratio were the highest in middle-aged men with NGT and glucose intolerance. <b><i>Conclusions:</i></b> The BRI, not the ABSI, was better correlated with SI in young and middle-aged Japanese persons. The BRI and WC/Ht ratio were comparable in their correlations with SI and the detection of insulin resistance in the participants of the present study.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10951619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Absolute and Relative Grip Strength to Predict Incidence of Metabolic Syndrome: Eight-Year Follow-Up Study in Korea.","authors":"DooYong Park, JinWon Rho, YeonSoo Kim, Eunkyung Kim","doi":"10.1089/met.2023.0206","DOIUrl":"10.1089/met.2023.0206","url":null,"abstract":"<p><p><b><i>Background:</i></b> This study aimed to conduct an analysis of longitudinal study to investigate the association of absolute grip strength, and relative grip strength with incidence of metabolic syndrome. <b><i>Materials and Methods:</i></b> Participants who participated in the Korean Genome and Epidemiology Study, a chronic screening program conducted in Ahnseong-si, Gyeonggi-do, a primary survey conducted from 2013 to 2014 were selected. The presence of metabolic syndrome was classified using the standards of the International Diabetes Foundation following previous studies. Grip strength was measured using a JAMA 5030J1 (Saehan, Korea) and calculated the absolute grip strength and relative grip strength. To evaluate the relationship between the absolute grip strength, relative grip strength, and incidence of metabolic syndrome, independent hazard ratios (HRs) and 95% confidence intervals (CIs) for metabolic syndrome were calculated according to absolute and relative grip strength levels using a multivariate extended Cox regression model. <b><i>Results:</i></b> The incidence of metabolic syndrome was reduced by 38% (HR = 0.62, 95% CI = 0.43-0.88) for the high absolute grip strength group, compared to the low absolute grip strength group. Also, this study confirmed that the incidence of metabolic syndrome for mid relative grip strength and high relative grip strength groups were reduced by 27% (HR = 0.73, 95% CI = 0.55-0.98) and 55% (HR = 0.45, 95% CI = 0.32-0.64) respectively. Moreover, the incidence of metabolic syndrome was reduced by 45% (HR = 0.55, 95% CI = 0.37-0.82) and 57% (HR = 0.43, 95% CI = 0.29-0.65) for the low-level body mass index (BMI) group with high or low absolute grip strength, respectively. Finally, this study confirmed the association of sex, absolute grip strength, and relative grip strength according to age with incidence of metabolic syndrome was different. <b><i>Conclusion:</i></b> We observed that relative grip strength has a higher association with incidence of metabolic syndrome than absolute grip strength. Also, BMI has a higher association with metabolic syndrome than the absolute grip strength.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Lipoprotein(a) Is Not Associated with Graves' Ophthalmopathy.","authors":"Cem Sulu, Selin Ece Dedeoglu, Busenur Gonen, Mustafa Hepokur, Adnan Nuri Guzel, Serdar Sahin, Ahmet Numan Demir, Zehra Kara, Dildar Konukoglu, Taner Damci, Mustafa Sait Gonen","doi":"10.1089/met.2023.0162","DOIUrl":"10.1089/met.2023.0162","url":null,"abstract":"<p><p><b><i>Aim:</i></b> To investigate the relationship of serum lipoprotein(a) [Lp(a)] and other serum lipids with presence of Graves' ophthalmopathy (GO). <b><i>Methods:</i></b> A total of 99 consecutive patients diagnosed with Graves' disease (GD), aged 18-65 years, who had not received prior treatment for GO, thyroid surgery, or radioactive iodine therapy, were recruited between June 2020 and July 2022. In addition, 56 healthy controls (HCs) were included as the control group. All patients underwent an ophthalmological examination, and were classified based on the presence of GO into the GO group (<i>n</i> = 45) and no GO group (<i>n</i> = 54). Fasting blood samples were collected from all participants to analyze serum lipid parameters, including Lp(a), total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides. <b><i>Results:</i></b> The median serum levels of Lp(a) were 5.7 [4.3-9.2] in the GO group, 6.7 [3.7-9.9] in the no GO group, and 4.7 [3-7.6] in the HC group. The intergroup comparisons of serum Lp(a) levels showed no significant result. The serum levels of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were also similar between the groups (<i>P</i> > 0.05 for all). However, when analyzing only euthyroid GD patients and the control group, the serum LDL cholesterol levels were found to be significantly higher in the euthyroid GO group [median: 132 interquartile range (IQR) (110-148) mg/dL] than in the HCs [median: 96 IQR (94-118) mg/dL] (<i>P</i> = 0.002). <b><i>Conclusion:</i></b> The findings of our study did not support the association between serum Lp(a) levels and GO.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54229914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Perivascular Adipose Tissue and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.","authors":"Anna Bragina, Yulia Rodionova, Natalia Druzhinina, Alexandr Suvorov, Konstantin Osadchiy, Tatiana Ishina, Maria Vasilchenko, Milena Khalenyan, Selen Dishkaya, Valeriy Podzolkov","doi":"10.1089/met.2023.0097","DOIUrl":"10.1089/met.2023.0097","url":null,"abstract":"<p><p>We conducted a systematic review and meta-analysis aimed at estimating the association between perivascular adipose tissue (PVAT) and some of the cardiovascular risk factors. A systematic search was conducted from January 1980 up to and including 2022 to identify studies that examined the relationship between PVAT and cardiovascular risk factors as obesity and its indices, hypertension, lipids, and glucose intolerance/diabetes. The Medline and Embase databases were searched using the PubMed and Scopus. Data were extracted from 23 studies that fit the criteria. To conduct meta-analysis, we used an approximation of equating the method of correlating assessment because different authors used either Pearson or Spearman correlation. Interrelations of PVAT and body mass index were analyzed in eight studies. Most studies revealed reliable direct correlation; the results of the meta-analysis also showed a significant (<i>P</i> = 0.37, <i>P</i> < 0.01, <i>n</i> = 12,346) correlation. PVAT and waist circumference were analyzed in six studies. Meta-analysis on the selected sample (<i>n</i> = 10,947) showed a significant (<i>r</i> = 0.45, <i>P</i> < 0.01) correlation. Relationship between PVAT and hypertension was revealed in three studies. Direct correlations were found in all studies. Meta-analysis showed the reliability of the correlation dependence (<i>r</i> = 0.21, <i>P</i> < 0.01, <i>n</i> = 3996). PVAT and blood glucose was evaluated in three studies (<i>n</i> = 3689). In each study a reliable (<i>P</i> < 0.05) direct correlation was obtained. Meta-analysis showed a significant correlation of weak strength (<i>r</i> = 0.24, <i>P</i> < 0.01). We demonstrated significant positive correlations of PVAT with the levels of total cholesterol (<i>r</i> = 0.05, <i>P</i> < 0.01), low-density lipoprotein cholesterol (<i>r</i> = 0.13, <i>P</i> < 0.01), and triglycerides (<i>r</i> = 0.29, <i>P</i> < 0.01), and a negative relationship with high-density lipoprotein cholesterol (<i>r</i> = -0.18, <i>P</i> < 0.01) in this meta-analysis. Despite some limitations, the findings of this systematic review and meta-analysis confirmed that PVAT significantly correlates with studied cardiovascular risk factors. Because PVAT presents a great interest in terms of cardiovascular remodeling and cardiovascular disease, its assessment in patients with and without cardiovascular pathology needs further research.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50162113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment of Reviewers 2023.","authors":"","doi":"10.1089/met.2023.29005.ack","DOIUrl":"10.1089/met.2023.29005.ack","url":null,"abstract":"","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss Attempts Increased in Korean Adults from 2005 to 2021, Excluding Those with Obesity.","authors":"Kayoung Lee","doi":"10.1089/met.2023.0147","DOIUrl":"10.1089/met.2023.0147","url":null,"abstract":"<p><p><b><i>Background:</i></b> Studies on trends in the proportions of past-year weight loss attempts among Asian adults are limited. Our hypotheses were that trends in the proportions would increase and sociodemographic, weight, and health-related factors would be associated with these attempts. <b><i>Methods:</i></b> Using data from the Korea National Health and Nutrition Examination Survey 2005-2021, this study evaluated the trends and their related factors among Korean adults. Complex sample design analyses were applied to the data of 80,160 adults. <b><i>Results:</i></b> The weighted proportion of past-year weight loss attempts increased from 35.2% in 2005 to 41.3% in 2021. The proportion of past-year weight loss attempts increased for individuals with nonobese body mass index (BMIs) (<25 kg/m²), decreased for males with obese BMIs (≥25 kg/m²), and did not change for females with obese BMIs. A multivariate-adjusted model showed that the proportion of weight loss attempts decreased for males and increased for females over the 16-year period [odds ratio (OR) (95% confidence interval): males, 0.993 (0.988-0.998); females, 1.013 (1.009-1.017)]. The OR of weight loss attempts was higher for females, younger individuals, and those with higher economic status, higher BMIs, self-perceived larger body shapes, self-rated better health, and chronic diseases. These characteristics decreased the odds of individuals with obese BMIs making no weight loss attempts. <b><i>Conclusions:</i></b> The proportion of past-year weight loss attempts increased over the 16-year period among all participants, but a declining trend was observed for those with obesity. In addition to BMI, socioeconomic factors, subjective perceptions of body shape, and health-related factors were related to weight loss attempts.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41204648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Metformin on Oxidative Stress and Left Ventricular Geometry in Nondiabetic Heart Failure Patients: A Randomized Controlled Trial.","authors":"Ahmed M Kamel, Batool Ismail, Gamal Abdel Hafiz, Nirmeen Sabry, Samar Farid","doi":"10.1089/met.2023.0164","DOIUrl":"10.1089/met.2023.0164","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> There is an increasing interest in using metformin in cardiovascular diseases and its potential new roles. Only two randomized controlled trials investigated the effect of metformin in nondiabetic heart failure (HF) patients. However, none of these studies assess the role of metformin in reducing oxidative stress. We hypothesized that metformin might improve oxidative stress and left ventricular remodeling in nondiabetic HF patients with reduced ejection fraction (HFrEF). <b><i>Methods and Methods:</i></b> Seventy HFrEF patients (EF 37% ± 8%; median age 66 years) were randomized to metformin (<i>n</i> = 35) or standard of care (SOC) for HF (<i>n</i> = 35) for 6 months in addition to standard therapy. Outcomes included the difference in the change (Δ) in total antioxidant capacity (TAC) and malondialdehyde (MDA), both assessed colorimetrically and left ventricular mass index (LVMI) assessed through transthoracic echocardiography. <b><i>Results:</i></b> Compared with the SOC, metformin treatment increased TAC [Δ = 0.12 mmol/L, confidence intervals (95% CIs): 0.03-0.21; <i>P</i> = 0.007]. TAC increased significantly only in the metformin group (0.90 ± 0.08 mmol/L at baseline vs. 1.04 ± 0.99 mmol/L at 6 months, <i>P</i> < 0.05). Metformin therapy preserved LVMI (Δ = -23 g/m², 95% CI: -42.91 to -4.92; <i>P</i> = 0.014) and reduced fasting plasma glucose (Δ = -6.16, 95% CI: -12.31 to -0.02, <i>P</i> = 0.047) compared with the SOC. Results did not change after adjusting for baseline values. Changes in MDA left ventricular ejection fraction (LVEF) and blood pressure were not significantly different between groups. <b><i>Conclusion:</i></b> Metformin treatment in HF patients with reduced LVEF improved TAC and prevented the increase in LVMI compared with the SOC. These effects of metformin warrant further research in HF patients without diabetes to explore the potential benefits of metformin. <b><i>Trial Registration Number:</i></b> This protocol was registered in ClinicalTrials.gov under the number NCT05177588.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41204646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}