Metabolic syndrome and related disorders最新文献

{"title":"Effectiveness of Low Doses of Semaglutide on Weight Loss and Body Composition Among Women in Their Menopause.","authors":"Joana Nicolau, Jorge Blanco-Anesto, Aina Bonet, Juan José Félix-Jaume, Apolonia Gil-Palmer","doi":"10.1089/met.2024.0124","DOIUrl":"https://doi.org/10.1089/met.2024.0124","url":null,"abstract":"<p><p><b><i>Background and Aims:</i></b> Menopause is a complex period in women's life, when weight gain and predisposition to obesity are frequent. Moreover, even during menopause transition, women begin to lose lean mass up to 0.5% and, therefore, an increase in the percentage of fat mass with central distribution and an increased risk of metabolic syndrome. Despite lifestyle habits remain the cornerstone in this period, their long-term effectiveness is a challenge. In this sense, GLP-1 analogs have shown their efficacy in improving weight loss and other cardiovascular risk factors. <b><i>Methods:</i></b> To assess the effectiveness of low doses of semaglutide on body weight and composition for 4 months during menopause compared with premenopausal women. <b><i>Results:</i></b> Baseline weight and body mass index were significantly greater among postmenopausal women (95 ± 23.4 vs. 86.4 ± 12.8 kg and 35.9 ± 7.3 vs. 32.9 ± 4.7 kg/m²; <i>P</i> = 0.02 and <i>P</i> = 0.03, respectively). Fat mass was higher among postmenopausal women (45.2 ± 17.1 vs. 38.2 ± 9.8 kg; <i>P</i> = 0.03). The percentage of fat mass and lean mass were comparable between the two groups (43.2 ± 8.1% vs. 40.9 ± 7.1% and 29.6 ± 5.5 vs. 32.4 ± 8.4 kg; <i>P</i> = 0.2 and <i>P</i> = 0.08, respectively). After 4 months of semaglutide 1 mg, either weight loss (5.9 ± 5.2 vs. 4.5 ± 3.5 kg; <i>P</i> = 0.1) or percentage of weight loss (5.8 ± 4.7% vs. 5.1 ± 3.2%; <i>P</i> = 0.4) were comparable. Furthermore, both fat mass loss in kilos (4.1 ± 4.5 vs. 3.1 ± 3.7 kg; <i>P</i> = 0.3) and lean mass loss (-0.4 ± 1.7 vs. -1.1 ± 3.7 kg; <i>P</i> = 0.1) were similar between the two groups. <b><i>Conclusions:</i></b> Despite a greater initial weight and fat mass among postmenopausal women, after 4 months of treatment with semaglutide 1 mg, either fat mass loss or weight loss were similar to premenopausal women.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Receptor <i>TaqI</i> Gene Polymorphism and Risk of Type 2 Diabetes Mellitus: A Case-Control Study Among Ethiopian Population.","authors":"Endalech Nakachew, Addisu Melake, Marye Alemu, Tewodros Eshetie, Nega Berhane","doi":"10.1089/met.2024.0157","DOIUrl":"https://doi.org/10.1089/met.2024.0157","url":null,"abstract":"<p><p><b><i>Background:</i></b> Type 2 diabetes mellitus (T2DM) is a complex and diverse illness that is influenced by several vulnerable genes as well as environmental risk factors. The aim of this study was to ascertain the relationship between the vitamin D receptor <i>TaqI</i> gene polymorphisms and the risk of T2DM at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. <b><i>Methods:</i></b> An age- and sex-matched hospital-based case-control study involved 70 patients with T2DM and 70 nondiabetic healthy controls. Demographic information was assessed in order to identify the associated risk variables. To ascertain the <i>TaqI</i> genotypes, DNA was taken from blood samples and used in a polymerase chain reaction and agarose gel electrophoresis analysis. <b><i>Results:</i></b> The frequency of the homozygous <i>TaqI</i>-tt genotype [odds ratios (OR): 2.69; 95% confidence level (CL): 1.05-6.44; <i>P</i> = 0.38], and the t allele (OR: 1.90; 95% CL: 1.16-3.12; <i>P</i> = 0.0099) was significantly higher in patients with T2DM compared to nondiabetic controls. <b><i>Conclusion:</i></b> The results suggest that the <i>TaqI</i> gene polymorphism may be related to the onset of T2DM in the Ethiopian population under study.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Laboratory-Measured Euthyroid Hashimoto's Thyroiditis on Reproductive Hormone Profile in Women with Obesity.","authors":"Feray Akbas, Zeynep Banu Teke, Vahit Can Cavdar, Hasan Zerdali","doi":"10.1089/met.2024.0181","DOIUrl":"https://doi.org/10.1089/met.2024.0181","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Hashimoto's thyroiditis is a common endocrinological disorder that often coexists with obesity. Thyroid hormones interact with the regulation of sex steroids, and thyroid autoimmunity has a negative impact on female fertility. There are studies showing when euthyroid state is achieved with hormone replacement therapy (HRT), the reproductive hormone profile is improved but they usually compare the reproductive hormones before and after HRT in the same individuals. Studies comparing patients with Hashimoto's thyroiditis in an euthyroid state receiving HRT with individuals having normal thyroid function are limited. Here, it was aimed to search the impact of euthyroid Hashimoto's thyroiditis on reproductive hormone profile in women living with obesity. <b><i>Materials and Methods:</i></b> Sixty-one randomly selected female patients with Hashimoto's thyroiditis were included as the case group and 60 patients without Hashimoto's thyroiditis were included as the control group, from our obesity center. The case group included patients who had menstrual cycles and were euthyroid under l-thyroxine treatment for at least 6 months. Data on weight, height, body mass index (BMI), waist circumference (WC), free thyroxine (fT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), cortisol, insulin, prolactin (PRL), follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E₂), progesterone (prog), testosterone (T), and dehydroepiandrosterone sulfate (DHEAS) levels, l-thyroxine treatment dosage (for case group), and accompanying diseases were recorded. The results were evaluated using SPSS. <b><i>Results:</i></b> A total of 121 patients were included in the study. Mean age was 41.8 ± 8.5 years in case and 38.6 ± 8.9 years in control group. There was no significant difference in weight, height, BMI, WC, or accompanying diseases between Hashimoto's thyroiditis and control group. fT4, anti-TPO, cortisol levels were higher in Hashimoto's thyroiditis group when compared with control group, but there was no significant difference for TSH, insulin, FSH, LH, E₂, prog, T, DHEAS, or PRL. <b><i>Conclusion:</i></b> In women living with obesity, it is important to screen for Hashimoto's thyroiditis and achieve euthyroidism through effective LT4 treatment to promote a healthy reproductive system and improve fertility rates.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic Status and Lifestyle Factors Differences in the Association Between Dietary Patterns and Metabolic Syndrome: Tehran Lipid and Glucose Study.","authors":"Somayeh Hosseinpour-Niazi, Hamid Abbasi, Parvin Mirmiran, Hanieh Malmir, Fereidoun Azizi","doi":"10.1089/met.2023.0225","DOIUrl":"https://doi.org/10.1089/met.2023.0225","url":null,"abstract":"<p><p><b><i>Background:</i></b> Socioeconomic status and lifestyle factors could potentially modify the association between diet and chronic diseases such as metabolic syndrome (MetS). <b><i>Objective:</i></b> This study aimed to investigate the combined effect of socioeconomic status, lifestyle factors, and dietary patterns on the MetS risk. <b><i>Methods:</i></b> During 8.9 years of follow-up, dietary information of 1915 individuals was collected by a validated Food Frequency Questionnaire (FFQ). Dietary patterns were derived using principal component analysis. <b><i>Results:</i></b> Two major dietary patterns including healthy dietary and Western dietary patterns were identified. In the crude and fully adjusted models, an association was not found between Western and healthy dietary patterns and the risk of MetS. There was a significant decrease in the risk of MetS among participants with higher levels of education who adhered to a healthy dietary pattern (hazard ratio: 0.71, 95% confidence interval: 0.34-0.89). Furthermore, the risk of MetS decreased in the fourth quartile of healthy dietary pattern among nonemployed (0.78, 0.51-0.94). According to the stratification of physical activity levels, it was shown that the healthy dietary pattern had a negative association with the risk of MetS only among participants who engaged in a high level of physical activity (0.70, 0.40-0.91). About the smoking status, it was shown that among non-smoker participants, higher adherence to a healthy dietary pattern was associated with a reduction in the risk of MetS. The risk of MetS reduced by 36% (0.64, 0.51-0.97) in the third quartile and by 39% (0.61, 0.54-0.95) in the fourth quartile of the healthy dietary pattern. No association was found between Western dietary pattern with MetS in different status of socioeconomic and lifestyle factors. <b><i>Conclusions:</i></b> Adhering to a healthy dietary pattern, engaging in regular physical activity, and abstaining from smoking could reduce incidents of MetS. Moreover, socioeconomic status modified the association between healthy dietary pattern and MetS.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confusion Concerning the Calculation of the Triglyceride-Glucose Index: An Urgent Need for Clarity.","authors":"Ishwarlal Jialal","doi":"10.1089/met.2024.0193","DOIUrl":"https://doi.org/10.1089/met.2024.0193","url":null,"abstract":"","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Truncated Albumins as Novel Surrogate Biomarkers in Diabetes Therapy: Epiphenomena and Potential Clinical Applications.","authors":"Madhumati S Vaishnav, Namita Kumari, Sathyanarayana Srikanta, Vinaya Simha, Patnam R Krishnaswamy, Navakanta Bhat","doi":"10.1089/met.2024.0143","DOIUrl":"10.1089/met.2024.0143","url":null,"abstract":"<p><p><b><i>Aims/Hypothesis:</i></b> Among various albumin posttranslational modifications (PTMs), N- and C-terminal truncations (HSA-DA and HSA-L) have also shown biomarker potential in disease states. We examined albumin truncation longitudinal trends and correlations during diabetes therapy toward possible future clinical applications. <b><i>Methods:</i></b> In a preliminary longitudinal therapy investigation, mass spectrometry was employed to track PTMs of human serum albumin (HSA), including glycation (GA), cysteinylation (CA or HNA1; reversible), di/trioxidation (OA or HNA2; irreversible), and truncation (TA). These modifications were correlated with ongoing therapy in four distinct subject groups: type 1 diabetes (T1DM), type 2 diabetes (T2DM), prediabetes-obesity (PDOB), and healthy controls (NORM), observed over a follow-up period extending up to 280 days. <b><i>Results:</i></b> Diabetes was associated with significant reduction (\"deficiency\") of measured albumin truncations (For HSA-DA: T2DM = 0.32 ± 0.3%, <i>p</i> = 2E-08; T1DM = 1.02 ± 0.4%, <i>p</i> = 3E-05; PDOB = 1.61 ± 0.2%, <i>p</i> = 0.004; compared to NORM = 2.08 ± 0.2%). Albumin truncation reduction was more striking in T2DM (HSA-DA: T2DM vs. T1DM: <i>p</i> = 0.004). Improvements in glycemic control and decrease of albumin glycation during diabetes therapy were associated with concomitant increase of albumin truncations toward the \"healthy\" normal ranges, and vice versa (\"mirror image\" trends). Accordingly, albumin truncation correlated inversely with albumin glycation (HSA-DA vs. GA: R = -0.53, <i>p</i> = 1E-09). <b><i>Conclusions:</i></b> The \"epiphenomenon\" of albumin truncation (reflecting the severity of mean hyperglycemia and also insulin resistance) can possibly provide novel, sensitive, and complementary biomarkers (<i>e.g.,</i> via simpler HSA-DA peptide fragment immunoassays) to monitor efficacy of diabetes therapy and also progression from \"healthy\" to prediabetes and type 2 diabetes, highlighting potential diagnostic and prognostic utility in clinical diabetes care.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"743-752"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation Between Serum Concentrations of Lipocalin-2 and Metabolic Syndrome and its Components in Korean-Chinese and Han-Chinese Individuals from Yanbian Area.","authors":"Songyun Zheng, Yuanyuan Tan, Shuhan Yang, Zhenyu Quan","doi":"10.1089/met.2024.0099","DOIUrl":"10.1089/met.2024.0099","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> To investigate the association between the blood concentration of lipocalin-2 (LCN2) in local multiethnic residents and the increased risk for the development of metabolic syndrome (MS) in the Yanbian Korean Autonomous Prefecture population. <b><i>Methods:</i></b> A total of 2078 subjects with (study group) or without (control group) MS (1217 Korean-Chinese and 861 Han-Chinese subjects) were included in this study. MS subjects were divided into five groups according to ethnicity and MS components. They were assessed for smoking history, drinking history, past medical history, general demographic characteristics, and LCN2 concentrations. <b><i>Results:</i></b> LCN2 concentrations were higher in all ethnic MS groups than in the control group, and the highest concentrations were detected in Han-Chinese subjects with dyslipidemia. Moreover, LCN2 concentrations were significantly higher in Korean-Chinese individuals with all MS components than in the control group. Logistic regression analyses were conducted. In the unadjusted models, Korean-Chinese and Han-Chinese individuals with high LCN2 concentrations both faced a risk of MS with odds ratios (ORs) of 2.339 (95% confidence interval [CI]: 1.632-3.352) and 1.523 (95% CI: 1.101-2. 108), respectively. After the adjustment, the risk only remained in Korean-Chinese individuals, with an OR of 1.818 (95% CI: 1.031-3.207). <b><i>Conclusion:</i></b> Elevated circulating LCN2 was associated with the increased incidence of MS, and the effect in Korean-Chinese individuals was stronger than that in Han-Chinese individuals.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"735-742"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin/Ghrelin Axis and Antibodies Reactive to Both Hormones in Relation to Metabolic Syndrome Components in Mexican Children.","authors":"Rafael Vázquez-Solórzano, Mayra Alejandra Enciso-Ramírez, Berenice Sánchez-Caballero, Isela Parra-Rojas, Elia Valdés-Miramontes, Lourdes Barajas-García, Lidia García-Ortíz, Zyanya Reyes-Castillo","doi":"10.1089/met.2024.0109","DOIUrl":"10.1089/met.2024.0109","url":null,"abstract":"<p><p><b><i>Background:</i></b> Metabolic syndrome (MetS) in children is a rising health issue that is strongly associated with cardiovascular diseases and type 2 diabetes mellitus development. Low-affinity antibodies reactive to leptin and ghrelin are suggested to regulate hormone stability and function; nevertheless, the role of the leptin/ghrelin axis and antibodies reactive to both hormones in relation to MetS or its components in the pediatric population remains unknown. <b><i>Methods:</i></b> Fifty-eight children (7-12 years) were included and categorized according to the presence of one or more criteria for the diagnosis of MetS or according to body mass index. Body composition, biochemical variables, and metabolic risk indexes were determined. Antibodies reactive to leptin and ghrelin were quantified by an in-house enzyme-linked immunosorbent assay test. Ratios of leptin/ghrelin hormones and anti-leptin/anti-ghrelin immune complexes were obtained. <b><i>Results:</i></b> The biochemical variables glucose (<i>P</i> = 0.0009), insulin (<i>P</i> = 0.0001), leptin (<i>P</i> = 0.0036), HOMA-IR (homeostatic model assessment for insulin resistance) (<i>P</i> < 0.0001), and plasma atherogenic index (<i>P</i> < 0.0001) were significantly higher in children with two or three components of MetS (MetS 2-3) in comparison to children with none or one component (MetS 0-1). Ratios of leptin/ghrelin (<i>P</i> = 0.0307) and anti-leptin/anti-ghrelin immune complexes (<i>P</i> = 0.0338) were higher in MetS 2-3 group versus MetS 0-1 group. In MetS 2-3 group, both insulin (<i>r</i> = 0.4361, <i>P</i> = 0.0293) and HOMA-IR (<i>r</i> = 0.4761, <i>P</i> = 0.0161) were positively correlated with the leptin/ghrelin hormone ratio. <b><i>Conclusions:</i></b> The higher leptin/ghrelin hormone ratio scores observed in MetS 2-3 group, along with their correlation with insulin levels and HOMA-IR, highlight the role of leptin and ghrelin on insulin sensitivity and metabolic regulation. An increased ratio of anti-leptin/anti-ghrelin immune complexes suggests affinity changes in these antibodies that may lead to alterations in hormone function.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"717-725"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification and Correlation Analysis of <i>Bacteroides</i> Species with Diabetes-Related Amino Acids in Individuals with Prediabetes and Type 2 Diabetes Mellitus.","authors":"Nahid Safari-Alighiarloo, Narjess Bostanghadiri, Mansour Sedighi, Ali Mohebbi, Elahe Vafaei, Maryam Mirshekar, Shabnam Razavi, Fariba Alaei-Shahmiri","doi":"10.1089/met.2024.0071","DOIUrl":"10.1089/met.2024.0071","url":null,"abstract":"<p><p><b><i>Background:</i></b> The relationship between gut microbiota and diabetes-related amino acids significantly impacts insulin resistance and obesity. We aimed to quantify two <i>Bacteroidetes</i> species and their correlation with branched-chain amino acids, aromatic amino acids, and glutamate in prediabetes (preDM) and type 2 diabetes mellitus (T2DM). <b><i>Methods:</i></b> Fecal samples were collected from 68 participants, including 21 with T2DM, 23 with preDM, and 24 with normal glycemic tolerance (NGT). The abundance of <i>Bacteroides vulgatus</i> and <i>Bacteroides thetaiotaomicron</i> was determined by quantitative real-time polymerase chain reaction. Plasma amino acid measurements were performed using liquid chromatography coupled with tandem mass spectrometry. <b><i>Results:</i></b> The quantities of <i>B. vulgatus</i> and <i>B. thetaiotaomicron</i> were reduced in preDM and T2DM than in NGT subjects, but it was not statistically significant. The concentrations of leucine, valine, and tyrosine were significantly higher in preDM and T2DM than in NGT subjects (<i>P</i> < 0.05). A negative correlation was observed between <i>B. thetaiotaomicron</i> abundance and two aromatic amino acids (tyrosine, <i>r</i> = -0.28, <i>P</i> = 0.04; phenylalanine, <i>r</i> = -0.26, <i>P</i> = 0.05). <b><i>Conclusions:</i></b> These findings imply that, since gut microbiota varies throughout ethnic groups, further research with many participants will be required to determine the abundance of <i>B. vulgatus</i> and <i>B. thetaiotaomicron</i> in preDM and T2DM and their association with diabetes-related amino acids.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"753-760"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shift Work Increases the Risk of Circadian Syndrome Rather than Metabolic Syndrome: A Cross-Sectional Study of NHANES 2005-2010.","authors":"Lin Wang, Sutong Wang, Yongcheng Wang, Yuehua Jiang, Jifu He, Xiao Li","doi":"10.1089/met.2024.0075","DOIUrl":"10.1089/met.2024.0075","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Shift work disrupts sleep-wake cycles and may lead to adverse health outcomes, including cardiovascular disease and metabolic disorders. This study examines the association between shift work and the risks of metabolic syndrome (MetS) and circadian syndrome (CircS) in U.S. workers. <b><i>Methods:</i></b> We analyzed data from 4173 participants aged 18 and above from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2010. Shift work status was determined based on work hours, and MetS and CircS were defined using established criteria. Statistical analyses included weighted multivariate logistic regression models, weighted multivariate linear regression models, and inverse probability weighted propensity score matching to ensure accurate comparison between shift and nonshift workers. <b><i>Results:</i></b> The study found no significant association between shift work and the prevalence of MetS. However, shift workers exhibited a higher prevalence of CircS compared with nonshift workers. This association was more pronounced in specific subgroups, including those under 60 years of age and various ethnicities. The study highlights the heightened risk of CircS among shift workers, underscoring the potential impact of shift work on circadian rhythm disruptions. <b><i>Conclusion:</i></b> Shift work is associated with an increased risk of CircS but not MetS, according to NHANES 2005-2010 data.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"761-769"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}