Metabolic syndrome and related disorders最新文献

{"title":"Screening Risk of Sarcopenic Obesity Using SARC-F and Handgrip Strength in Outpatients with Diabetes.","authors":"Ozlem Yilmaz, Cemile Idiz, Cihan Kilic, Sena Gurkas, Pinar Kucukdaglı, Nurdan Senturk Durmus, Hanife Usta Atmaca, Gulistan Bahat, Ilhan Satman, Mehmet Akif Karan","doi":"10.1177/15578518251386225","DOIUrl":"https://doi.org/10.1177/15578518251386225","url":null,"abstract":"<p><p><b><i>Background:</i></b> Sarcopenic obesity (SO), defined as the coexistence of low muscle mass and function and excessive fat mass, is increasingly recognized as a health concern in older individuals with diabetes. Despite its clinical importance, SO often remains undiagnosed in outpatient settings due to complex diagnostic requirements. <b><i>Objective:</i></b> This study aimed to investigate the risk of SO using simple screening tools, namely the SARC-F questionnaire and handgrip strength (HGS), and to identify associated clinical, functional, and metabolic factors in diabetic patients aged 50 and older. <b><i>Methods:</i></b> A cross-sectional analysis was conducted with 276 diabetic outpatients. Risk of SO was defined based on a body mass index of 30 kg/m² or more, combined with either a SARC-F score of 4 or above or low HGS values (below 35 kg for men and 20 kg for women). Data on comorbidities, functionality, falls, depression, and metabolic control were collected. <b><i>Results:</i></b> The prevalence of SO risk was 16.2% with HGS and 8.7% with SARC-F. Falls, depressive symptoms, and reduced quality of life were associated with SARC-F-based SO, while hypertension, elevated HbA1c, and lower quality of life were linked to HGS-based SO. <b><i>Conclusion:</i></b> Simple screening methods can help identify SO risk in diabetic outpatients and support timely clinical decision-making.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gestational Diabetes Mellitus: The Impact of Body Mass Index on Clinical Outcomes.","authors":"Mitra Moazzami, Samyuktha Prabu, Nanditha Venkatesan, Kamalnath Sankaran Rajagopalan, Marina Takawy, Moustafa Hegazi, Carl H Rose, Adrian Vella, Aoife M Egan","doi":"10.1177/15578518251366372","DOIUrl":"10.1177/15578518251366372","url":null,"abstract":"<p><p><b><i>Background:</i></b> Increasing maternal body mass index (BMI) represents a risk factor for Gestational Diabetes Mellitus (GDM) and adverse obstetrical and perinatal outcomes. <b><i>Objective:</i></b> To stratify clinical outcomes for pregnancies affected by GDM according to maternal BMI. <b><i>Methods:</i></b> Retrospective cohort study including individuals ≥18 years of age who were diagnosed with GDM from 2018 to 2022. Universal GDM screening was employed with a 50 g oral glucose challenge test ± a 100 g oral glucose tolerance test. Maternal demographics, preexisting medical conditions, and selected obstetric and neonatal morbidities were evaluated. <b><i>Results:</i></b> A total of 2193 pregnancies in 2110 women affected by GDM were identified. This included 506 (23.0%) with normal baseline maternal BMI, 596 (27.2%) with overweight, and 1091 (49.7%) with obese BMI. Adverse maternal outcomes were more frequent in the obese compared to overweight or normal BMI categories (cesarean delivery: normal 26.9% vs. overweight 28.5% vs. obese 40.9%; <i>p</i> < 0.001; hypertensive disorders of pregnancy: normal 8.7% vs. overweight 12.1% vs. obese 16.8%; <i>p</i> < 0.001). Postpartum glucose intolerance was higher in women with obesity (normal 7.3% vs. overweight 5.9% vs. obese 14.9%; <i>p</i> < 0.001). Infants born to mothers with obesity had higher birthweights (normal 3.3 kg vs. overweight 3.4 kg vs. obese 3.5 kg; <i>p</i> < 0.001), were more likely to have neonatal hypoglycemia (normal 29.4% vs. overweight 24.3% vs. obese 41.9%; <i>p</i> < 0.001) and require intensive care unit admission (normal 8.1% vs. overweight 5.9% vs. obese 11.9%; <i>p</i> < 0.001). <b><i>Conclusions:</i></b> Patients with GDM and baseline BMI in the obese range experienced the highest rate of adverse outcomes, while those with overweight BMI had similar outcomes to individuals who had normal BMI at baseline.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"388-393"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12501887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride Glucose Index and Related Parameters Are Effective Biomarkers to Identify Metabolic Dysfunction-Associated Steatotic Liver Disease Among Egyptian Adults with Type 2 Diabetes.","authors":"Magdy H Megalaa, Ahmed Zeid, Mohamed Zietoun, Dina M Salem, Shimaa M Elrahmany","doi":"10.1177/15578518251377780","DOIUrl":"10.1177/15578518251377780","url":null,"abstract":"<p><p><b><i>Background:</i></b> The triglyceride-glucose (TyG) index and related parameters have recently been advocated as efficient diagnostic markers for metabolic dysfunction-associated steatotic liver disease (MASLD) in the general population. Yet, there is a paucity of data addressing their significance in MASLD diagnosis and severity assessment in the vulnerable population of type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the predictive capacity of TyG-related indices for MASLD diagnosis in patients with T2DM, and to investigate the relationship of these parameters with hepatic steatosis severity. <b><i>Methods:</i></b> This cross-sectional study encompassed a cohort of 600 adults diagnosed with T2DM, who were enrolled from the diabetes and metabolism outpatient clinic at Alexandria Main University Hospital. After excluding secondary causes, hepatic steatosis was diagnosed using the FibroScan 430 mini+ machine (EchoSense, Paris, France), with results expressed as the controlled attenuation parameter. Anthropometric and biochemical measurements were utilized to derive TyG-related indices, including TyG index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), and TyG-waist to height ratio (TyG-WHtR). <b><i>Results:</i></b> MASLD was diagnosed in 83% of the recruited subjects. The studied TyG-related parameters were markedly higher in patients with severe steatosis. Moreover, multivariate analysis identified TyG-BMI as an independent risk factor for severe steatosis. Furthermore, the receiver operating characteristic curve was used to assess the diagnostic performance of the studied TyG indices for detecting MASLD in individuals with T2DM. The area under the curve for each of the four indicators was as follows: 0.775 for TyG-BMI, followed by 0.755 for TyG-WC, 0.741 for TyG-WHtR, and 0.637 for TyG index. These findings revealed good predictive capacity for all four parameters, especially TyG-BMI, which exhibited the highest level of predictive accuracy. <b><i>Conclusion:</i></b> The TyG index and related parameters, particularly TyG-BMI, are reliable and cost-effective biomarkers for detecting and assessing the severity of MASLD.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"394-404"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of Mean Platelet Volume in Assessing Amputation Risk in Patients with Diabetic Foot Ulcers: A Cohort Study.","authors":"Alı Erol, Mutlu Güneş, Zeliha Asiye Arı, Fatıh Alp, Feridun Gürlek, Mehmet Karaçalı, Hasan Esat Yıldırım, Aydın Dursun, Muhammed Fatih Şahin, Oğuzhan Er","doi":"10.1089/met.2025.0034","DOIUrl":"10.1089/met.2025.0034","url":null,"abstract":"<p><p><b><i>Objective:</i></b> Diabetic foot ulcer is a condition associated with type 2 diabetes mellitus (T2DM). This study aims to examine the influence of mean platelet volume (MPV) on predicting amputation decisions in patients with diabetic foot ulcers. <b><i>Methods:</i></b> Patients with diabetic foot ulcers who presented to the tertiary healthcare facility from June 2023 to June 2024 were included. The first group comprises individuals who opted for amputation, whereas the second group includes patients without indications for amputation. <b><i>Results:</i></b> The mean age of patients with diabetic foot ulcers is 62.68 years, and the mean glycated hemoglobin A1c level is 9.62%. The initial group comprises 61 patients who opted for amputation, whereas the subsequent group includes 56 individuals who lacked an indication for amputation. The initial group exhibits markedly elevated values for MPV, total cholesterol, and low-density lipoprotein (LDL) (<i>P</i> = 0.001, <i>P</i> = 0.004, <i>P</i> = 0.020). Logistic regression research indicates that elevated levels of LDL and MPV substantially heighten the chance of amputation. The receiver operating characteristic curve study established the MPV cutoff value for amputation prediction at 11.2. The sensitivity and specificity of this value in predicting amputation were [<i>β</i> = 0.01, OR (odds ratio) = 1.01, 95% confidence interval (CI): 1.00-1.03, <i>P</i> = 0.006] for LDL and (<i>β</i> = 0.52, OR = 1.68, 95% CI: 1.18-2.39, <i>P</i> = 0.003) for MPV. Every unit increment in the MPV value corresponds to an approximate 68.8% elevation in the probability of amputation. <b><i>Conclusion:</i></b> In individuals with diabetic foot ulcers, MPV and LDL levels are independent variables affecting amputation and may function as predictors for amputation.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"381-387"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Disturbances and Metabolic Syndrome in Shift Workers: A Systematic Review.","authors":"Da-In Park, Esther Wegener","doi":"10.1177/15578518251376624","DOIUrl":"10.1177/15578518251376624","url":null,"abstract":"<p><p><b><i>Background:</i></b> Poor sleep has been identified as a strong risk factor for metabolic syndrome. Shift workers, who often experience reduced and misaligned sleep due to nighttime work schedules, are particularly susceptible to both sleep disturbances and metabolic syndrome. However, the interplay among shift work, sleep disturbances, and metabolic syndrome remains insufficiently explored. This systematic review aimed to critically appraise, compare, and synthesize the current evidence on the pathways linking these factors. <b><i>Methods:</i></b> A comprehensive literature search was conducted across major electronic databases and peer-reviewed journals specializing in metabolic disorders and sleep disorders. Two independent reviewers screened titles, abstracts, and full texts for relevance. Methodological quality was assessed using the Newcastle-Ottawa Scale. <b><i>Results:</i></b> Out of 4,982 studies identified, 15 met the predefined inclusion criteria, encompassing diverse occupational groups with fixed and rotating shift patterns and totaling 37,147 participants. Most studies demonstrated a positive association between shift work and sleep disturbances, particularly among fixed night shift workers. Longer durations of night shift exposure were linked to increased risk of metabolic syndrome. Notably, reduced sleep quantity was more strongly associated with metabolic syndrome than impaired sleep quality. The methodological quality of the included studies was moderate to high. <b><i>Conclusion:</i></b> This review highlights a consistent association between shift work, sleep disturbances, and metabolic syndrome. Shift work appears to impact both sleep health and metabolic outcomes independently. These findings underscore the need for targeted interventions and longitudinal studies to further elucidate causal pathways and inform occupational health strategies.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"371-380"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Dysfunction Associated to Steatotic Liver Disease: A Review.","authors":"Janna Vanessa Diaz Torres, Vanessa Rocío Villanueva Guerrero, Jennifer Patricia Vargas Gómez, Fredy Javier Pacheco Miranda, Lorena Rocío Orozco Álvarez, Joseph David León Insignares, Marian Mares, Héctor Mario Rodríguez Ortiz, Evelyn Mendoza-Torres","doi":"10.1177/15578518251382048","DOIUrl":"https://doi.org/10.1177/15578518251382048","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced the term nonalcoholic fatty liver disease to better reflect its relationship with metabolic dysfunction without creating stigma. MASLD is defined by the presence of hepatic steatosis associated with risk factors, such as type 2 diabetes and overweight/obesity, without the need to exclude other causes of chronic liver disease. The global prevalence of MASLD is high, having an impact in more than one-third of the world's population, particularly in adults with overweight or obesity. When we talk about gender, it is more common in men than in women. MASLD is a complex disorder resulting from the interaction of environmental, genetic, and epigenetic factors, which leads to the dysregulation of lipid metabolism and liver accumulation of fatty acids. MASLD could be diagnosed through imaging methods and serological biomarkers. Elastography and magnetic resonance imaging are the most precise techniques for evaluating liver fibrosis. The treatment focuses on lifestyle modification, which involves weight loss, regular exercise, and a balanced diet. The Mediterranean diet and coffee consumption also have beneficial effects. Several pharmacological therapies are currently being studied, with promising results reported to date. This review aims to provide a comprehensive clinical overview of MASLD, laying the groundwork for understanding the change in nomenclature and becoming familiar with the new term, diagnosis, and treatment.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck to Waist Circumference Ratio and Insulin Resistance in Adult Korean Population Under 50 Years.","authors":"Kyu Rae Lee","doi":"10.1177/15578518251379854","DOIUrl":"https://doi.org/10.1177/15578518251379854","url":null,"abstract":"<p><p>To investigate the association between neck to waist circumference (N/W) ratio and insulin resistance in the adult general population under 50 years. We analyzed data from the 2020 Korea Health National Analysis Nutrition Examination Survey (KNHANES) to examine the relationship between N/W ratio and insulin resistance in the general population under 50. After adjusting for age, sex, and various cardiometabolic variables, the N/W ratio was significantly associated with fasting blood glucose, insulin, HbA1c, and homeostatic model assessment of insulin resistance (HOMA-IR) index, as well as BMI (<i>p</i> < 0.01). In the lowest N/W ratio quartile (Q1), metabolic risk indicators including BMI, waist circumference, blood pressure, fasting plasma glucose, HDL cholesterol, and HOMA-IR index were notably higher than those in the highest quartile (Q4) (<i>p</i> < 0.0001). This suggests that a higher N/W ratio may be associated with a lower metabolic risk profile. The N/W ratio is a significant predictor of insulin resistance, independent of other risk factors, in the general Korean population under 50. These findings underscore the utility of the N/W ratio as an accessible screening tool for assessing cardiometabolic risks.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rs1558902 <i>FTO</i> Variant Is Associated with Body Mass Index but Not with Knee Osteoarthritis in a Mexican Mestizo Population.","authors":"Denisse Prone-Olazabal, María Fernanda Alemán-Anguiano, Alejandra Méndez-Hernández, Rafael Argüello-Astorga, Adria Imelda Prieto-Hinojosa, Rubén Daniel Arellano-Pérez Vertti, Faviel Francisco González-Galarza","doi":"10.1177/15578518251380103","DOIUrl":"https://doi.org/10.1177/15578518251380103","url":null,"abstract":"<p><p><b><i>Background:</i></b> Knee osteoarthritis (KOA) is a multifactorial degenerative joint disease and a leading cause of disability in older adults. Obesity is the most modifiable risk factor for KOA. Previous studies have suggested an association between polymorphisms in the <i>FTO</i> (fat mass and obesity associated) genes and KOA, potentially mediated by obesity. This study aimed to evaluate the association between the rs1558902 <i>FTO</i> genetic variant, obesity, and KOA in a northern Mexican Mestizo population. <b><i>Materials and Methods:</i></b> A total of 462 individuals were included in the study. Participants were classified into three groups: (i) a reference population (<i>n</i> = 189), (ii) individuals with primary KOA (<i>n</i> = 130), and (iii) non-KOA individuals (<i>n</i> = 143). The rs1558902 variant was genotyped using DNA microarray technology in the reference population and by real-time PCR in the KOA and non-KOA groups. Binary and multinomial regression analyses were performed. <b><i>Results:</i></b> The rs1558902 variant showed a significant association with obesity in the reference population under codominant (<i>p</i> = 0.012) and recessive (<i>p</i> = 0.008) genetic models. These associations remained statistically significant after adjustment for sex and age using multinomial logistic regression. In the codominant model, the association with an odds ratio (OR) of 6.884 (95% confidence interval [CI]: 1.470-32.225; <i>p</i> = 0.014), while in the recessive model, the OR was 7.429 (95% CI: 1.619-34.091; <i>p</i> = 0.010). However, no significant association was observed between rs1558902 and KOA. <b><i>Conclusions:</i></b> These findings confirm the association between the rs1558902 <i>FTO</i> variant and overweight/obesity in a northern Mexican Mestizo population, but not with KOA. Further research is needed to explore this association in the context of other genetic and clinical factors.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Silent Threat: Metabolic Dysfunction-Associated Steatotic Liver Disease Risk in Young Adults Through Noninvasive Assessment.","authors":"Vahit Can Cavdar, Basak Ballica, Emre Cem Gokce, Bedriye Gizem Tekin, Erengul Pektas, Mert Aric, Hasan Zerdali, Feray Akbas","doi":"10.1177/15578518251371498","DOIUrl":"https://doi.org/10.1177/15578518251371498","url":null,"abstract":"<p><p><b><i>Background:</i></b> The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing, particularly among young adults, posing significant long-term health risks. Early identification of at-risk individuals is crucial for timely intervention and prevention of liver fibrosis. This study aimed to evaluate the prevalence of MASLD in young adults aged 18-30 years and assess the utility of noninvasive fibrosis scores (fibrosis 4 index, AST-to-platelet ratio index [APRI], Hepamet fibrosis score) in risk stratification. <b><i>Methods:</i></b> A retrospective study was conducted on 327 young adults who attended internal medicine outpatient clinics. The diagnosis of MASLD was established based on imaging findings and the presence of metabolic risk factors. Noninvasive fibrosis assessment was performed using the FIB-4, APRI, and hepamet scores, which were subsequently compared between the MASLD and non-MASLD groups. Statistical analyses included parametric and nonparametric tests, with a significance threshold set at <i>p</i> < 0.05. <b><i>Results:</i></b> Among the 327 participants, 36.8% (<i>n</i> = 120) were diagnosed with MASLD. Patients in the MASLD group exhibited significantly higher FIB-4, APRI, and Hepamet scores compared to those in the non-MASLD group (<i>p</i> < 0.05). Additionally, the MASLD group had significantly elevated body mass index, blood pressure, fasting glucose, triglyceride levels, and insulin resistance compared to the non-MASLD group (<i>p</i> < 0.05 for all comparisons). <b><i>Conclusions:</i></b> MASLD is highly prevalent among young adults and associated with metabolic risk factors. Noninvasive fibrosis scores provide an effective, accessible tool for early risk assessment and should be integrated into routine clinical practice for young adults to prevent future liver-related complications.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Health-Related Quality of Life and Its Influencing Factors Among Patients with Non-Alcoholic Fatty Liver Disease in Hangzhou, China: A Cross-Sectional Study.","authors":"Han Fei, Kexin Lv, Jiayin Xu, Haojie Hao, Yidan Quan, Junping Shi, Wei Zhang","doi":"10.1177/15578518251363914","DOIUrl":"10.1177/15578518251363914","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> This study aimed to investigate health-related quality of life (HRQOL) and related factors in Hangzhou, China, in patients with non-alcoholic fatty liver disease (NAFLD). <b><i>Methods:</i></b> The Chinese version of the EQ-5D-5L questionnaire was employed to assess HRQOL in 594 patients. A standardized questionnaire was employed to gather data regarding demographics, clinical characteristics, and lifestyle. This study employed Tobit regression models alongside multiple linear regression to examine the components influencing HRQOL, encompassing utility values and the EQ visual analogue scale (EQ-VAS). <b><i>Results:</i></b> This study included 594 participants with a mean age of 42.03 ± 13.83 years. The median utility index was 0.951 (P25-P75: 0.934-1.000), and the median EQ-VAS score was 76 (P25-P75: 66-82). Anxiety and depression were the predominant entry (31.9%) among the five health dimensions. Tobit regression models indicated that retirement (<i>P</i> = 0.011), monthly income >6000 (<i>P</i> = 0.002), alcohol consumption (<i>P</i> = 0.012), low-intensity activity (<i>P</i> = 0.002), obesity (<i>P</i> = 0.004), and cirrhosis (<i>P</i> = 0.038) were correlated with diminished HRQOL. The outcomes of multiple linear regression analyses indicated that regular exercise (β = 3.200; <i>P</i> = 0.003) and alcohol consumption (β = 2.466; <i>P</i> = 0.049) exhibited significant positive correlations with EQ-VAS scores, whereas obesity (β = -4.259; <i>P</i> = 0.005) and severe hepatic steatosis (β = -3.912; <i>P</i> = 0.036) demonstrated significant negative correlations. <b><i>Conclusions:</i></b> The anxiety/depression dimension was the most prevalent problem. The current investigation identified a notable correlation between HRQOL and low-intensity activity, obesity, and cirrhosis. Obesity and severe hepatic steatosis exhibited a substantial negative correlation with the EQ-VAS score. Future efforts should focus on enhancing the mental health and lifestyle of NAFLD patients.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"329-337"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}