Alı Erol, Mutlu Güneş, Zeliha Asiye Arı, Fatıh Alp, Feridun Gürlek, Mehmet Karaçalı, Hasan Esat Yıldırım, Aydın Dursun, Muhammed Fatih Şahin, Oğuzhan Er
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The initial group comprises 61 patients who opted for amputation, whereas the subsequent group includes 56 individuals who lacked an indication for amputation. The initial group exhibits markedly elevated values for MPV, total cholesterol, and low-density lipoprotein (LDL) (<i>P</i> = 0.001, <i>P</i> = 0.004, <i>P</i> = 0.020). Logistic regression research indicates that elevated levels of LDL and MPV substantially heighten the chance of amputation. The receiver operating characteristic curve study established the MPV cutoff value for amputation prediction at 11.2. The sensitivity and specificity of this value in predicting amputation were [<i>β</i> = 0.01, OR (odds ratio) = 1.01, 95% confidence interval (CI): 1.00-1.03, <i>P</i> = 0.006] for LDL and (<i>β</i> = 0.52, OR = 1.68, 95% CI: 1.18-2.39, <i>P</i> = 0.003) for MPV. Every unit increment in the MPV value corresponds to an approximate 68.8% elevation in the probability of amputation. <b><i>Conclusion:</i></b> In individuals with diabetic foot ulcers, MPV and LDL levels are independent variables affecting amputation and may function as predictors for amputation.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Significance of Mean Platelet Volume in Assessing Amputation Risk in Patients with Diabetic Foot Ulcers: A Cohort Study.\",\"authors\":\"Alı Erol, Mutlu Güneş, Zeliha Asiye Arı, Fatıh Alp, Feridun Gürlek, Mehmet Karaçalı, Hasan Esat Yıldırım, Aydın Dursun, Muhammed Fatih Şahin, Oğuzhan Er\",\"doi\":\"10.1089/met.2025.0034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Objective:</i></b> Diabetic foot ulcer is a condition associated with type 2 diabetes mellitus (T2DM). This study aims to examine the influence of mean platelet volume (MPV) on predicting amputation decisions in patients with diabetic foot ulcers. <b><i>Methods:</i></b> Patients with diabetic foot ulcers who presented to the tertiary healthcare facility from June 2023 to June 2024 were included. The first group comprises individuals who opted for amputation, whereas the second group includes patients without indications for amputation. <b><i>Results:</i></b> The mean age of patients with diabetic foot ulcers is 62.68 years, and the mean glycated hemoglobin A1c level is 9.62%. The initial group comprises 61 patients who opted for amputation, whereas the subsequent group includes 56 individuals who lacked an indication for amputation. The initial group exhibits markedly elevated values for MPV, total cholesterol, and low-density lipoprotein (LDL) (<i>P</i> = 0.001, <i>P</i> = 0.004, <i>P</i> = 0.020). Logistic regression research indicates that elevated levels of LDL and MPV substantially heighten the chance of amputation. The receiver operating characteristic curve study established the MPV cutoff value for amputation prediction at 11.2. The sensitivity and specificity of this value in predicting amputation were [<i>β</i> = 0.01, OR (odds ratio) = 1.01, 95% confidence interval (CI): 1.00-1.03, <i>P</i> = 0.006] for LDL and (<i>β</i> = 0.52, OR = 1.68, 95% CI: 1.18-2.39, <i>P</i> = 0.003) for MPV. 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引用次数: 0
摘要
目的:糖尿病足溃疡是一种与2型糖尿病(T2DM)相关的疾病。本研究旨在探讨平均血小板体积(MPV)对预测糖尿病足溃疡患者截肢决定的影响。方法:纳入2023年6月至2024年6月在三级医疗机构就诊的糖尿病足溃疡患者。第一组包括选择截肢的个体,而第二组包括没有截肢指征的患者。结果:糖尿病足溃疡患者的平均年龄为62.68岁,平均糖化血红蛋白水平为9.62%。初始组包括61名选择截肢的患者,而后续组包括56名缺乏截肢指征的患者。初始组MPV、总胆固醇和低密度脂蛋白(LDL)显著升高(P = 0.001, P = 0.004, P = 0.020)。Logistic回归研究表明,LDL和MPV水平升高会显著增加截肢的几率。受试者工作特征曲线研究确定截肢预测的MPV截止值为11.2。该值预测截肢的敏感性和特异性对LDL和MPV的预测分别为[β = 0.01, OR(比值比)= 1.01,95%可信区间(CI): 1.00-1.03, P = 0.006]和(β = 0.52, OR = 1.68, 95% CI: 1.18-2.39, P = 0.003)。MPV值每增加一个单位,截肢概率就增加68.8%。结论:在糖尿病足溃疡患者中,MPV和LDL水平是影响截肢的独立变量,可以作为截肢的预测因素。
The Significance of Mean Platelet Volume in Assessing Amputation Risk in Patients with Diabetic Foot Ulcers: A Cohort Study.
Objective: Diabetic foot ulcer is a condition associated with type 2 diabetes mellitus (T2DM). This study aims to examine the influence of mean platelet volume (MPV) on predicting amputation decisions in patients with diabetic foot ulcers. Methods: Patients with diabetic foot ulcers who presented to the tertiary healthcare facility from June 2023 to June 2024 were included. The first group comprises individuals who opted for amputation, whereas the second group includes patients without indications for amputation. Results: The mean age of patients with diabetic foot ulcers is 62.68 years, and the mean glycated hemoglobin A1c level is 9.62%. The initial group comprises 61 patients who opted for amputation, whereas the subsequent group includes 56 individuals who lacked an indication for amputation. The initial group exhibits markedly elevated values for MPV, total cholesterol, and low-density lipoprotein (LDL) (P = 0.001, P = 0.004, P = 0.020). Logistic regression research indicates that elevated levels of LDL and MPV substantially heighten the chance of amputation. The receiver operating characteristic curve study established the MPV cutoff value for amputation prediction at 11.2. The sensitivity and specificity of this value in predicting amputation were [β = 0.01, OR (odds ratio) = 1.01, 95% confidence interval (CI): 1.00-1.03, P = 0.006] for LDL and (β = 0.52, OR = 1.68, 95% CI: 1.18-2.39, P = 0.003) for MPV. Every unit increment in the MPV value corresponds to an approximate 68.8% elevation in the probability of amputation. Conclusion: In individuals with diabetic foot ulcers, MPV and LDL levels are independent variables affecting amputation and may function as predictors for amputation.
期刊介绍:
Metabolic Syndrome and Related Disorders is the only peer-reviewed journal focusing solely on the pathophysiology, recognition, and treatment of this major health condition. The Journal meets the imperative for comprehensive research, data, and commentary on metabolic disorder as a suspected precursor to a wide range of diseases, including type 2 diabetes, cardiovascular disease, stroke, cancer, polycystic ovary syndrome, gout, and asthma.
Metabolic Syndrome and Related Disorders coverage includes:
-Insulin resistance-
Central obesity-
Glucose intolerance-
Dyslipidemia with elevated triglycerides-
Low HDL-cholesterol-
Microalbuminuria-
Predominance of small dense LDL-cholesterol particles-
Hypertension-
Endothelial dysfunction-
Oxidative stress-
Inflammation-
Related disorders of polycystic ovarian syndrome, fatty liver disease (NASH), and gout