Seamon Kang, Jiwoo Im, Minjeong Kang, Jeonghyeon Kim, Hyunsik Kang
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引用次数: 0
Abstract
Background: Triglyceride-glucose (TyG) index and its relationship with metabolic syndrome (MetS), physical activity (PA), and physical fitness in the pediatric population remain unclear. This cross-sectional study explored the mediating effect of central obesity and PA on the relationship between the TyG index and physical fitness in a pediatric population. Methods: A total of 614 Korean children (320 boys and 294 girls) aged 7-12 years participated in this study. MetS was defined as the continuous MetS risk value in the 4th quartile obtained by adding standardized scores for the syndrome components. PA was quantified using an accelerometer, and physical fitness was evaluated using composite scores for the endurance, strength, power, and flexibility domains. Results: Receiver operating characteristic curve analysis revealed that the TyG index outperformed body mass index (z = 3.005, P = 0.003) and the homeostasis assessment model for insulin resistance (z = 3.543, P = 0.001) in detecting the presence of MetS. Mediation analysis revealed that while the TyG index has a direct effect on composite physical fitness scores (β = -0.3832 and SE = -2.0942, 95% confidence interval, CI = -0.7426 to -0.0239), there was an indirect effect of the TyG index on physical fitness via vigorous PA (β = -0.0802 and SE = 0.0377) and waist-to-hip ratio (β = -0.1318, SE = 0.0509). Conclusion: The TyG index has a significant impact on physical fitness in the presence of the two mediators (β = 0.3832, SE = -2.0942, 95% CI = -0.7426 to 0.0239).
期刊介绍:
Metabolic Syndrome and Related Disorders is the only peer-reviewed journal focusing solely on the pathophysiology, recognition, and treatment of this major health condition. The Journal meets the imperative for comprehensive research, data, and commentary on metabolic disorder as a suspected precursor to a wide range of diseases, including type 2 diabetes, cardiovascular disease, stroke, cancer, polycystic ovary syndrome, gout, and asthma.
Metabolic Syndrome and Related Disorders coverage includes:
-Insulin resistance-
Central obesity-
Glucose intolerance-
Dyslipidemia with elevated triglycerides-
Low HDL-cholesterol-
Microalbuminuria-
Predominance of small dense LDL-cholesterol particles-
Hypertension-
Endothelial dysfunction-
Oxidative stress-
Inflammation-
Related disorders of polycystic ovarian syndrome, fatty liver disease (NASH), and gout