Triglyceride-Glucose Index and Its Relation to Metabolic Syndrome and Physical Fitness in Children.

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Seamon Kang, Jiwoo Im, Minjeong Kang, Jeonghyeon Kim, Hyunsik Kang
{"title":"Triglyceride-Glucose Index and Its Relation to Metabolic Syndrome and Physical Fitness in Children.","authors":"Seamon Kang, Jiwoo Im, Minjeong Kang, Jeonghyeon Kim, Hyunsik Kang","doi":"10.1089/met.2025.0012","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> Triglyceride-glucose (TyG) index and its relationship with metabolic syndrome (MetS), physical activity (PA), and physical fitness in the pediatric population remain unclear. This cross-sectional study explored the mediating effect of central obesity and PA on the relationship between the TyG index and physical fitness in a pediatric population. <b><i>Methods:</i></b> A total of 614 Korean children (320 boys and 294 girls) aged 7-12 years participated in this study. MetS was defined as the continuous MetS risk value in the 4th quartile obtained by adding standardized scores for the syndrome components. PA was quantified using an accelerometer, and physical fitness was evaluated using composite scores for the endurance, strength, power, and flexibility domains. <b><i>Results:</i></b> Receiver operating characteristic curve analysis revealed that the TyG index outperformed body mass index (z = 3.005, <i>P</i> = 0.003) and the homeostasis assessment model for insulin resistance (z = 3.543, <i>P</i> = 0.001) in detecting the presence of MetS. Mediation analysis revealed that while the TyG index has a direct effect on composite physical fitness scores (β = -0.3832 and SE = -2.0942, 95% confidence interval, CI = -0.7426 to -0.0239), there was an indirect effect of the TyG index on physical fitness via vigorous PA (β = -0.0802 and SE = 0.0377) and waist-to-hip ratio (β = -0.1318, SE = 0.0509). <b><i>Conclusion:</i></b> The TyG index has a significant impact on physical fitness in the presence of the two mediators (β = <math><mo>-</mo></math>0.3832, SE = -2.0942, 95% CI = -0.7426 to <math><mo>-</mo></math>0.0239).</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Metabolic syndrome and related disorders","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1089/met.2025.0012","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Triglyceride-glucose (TyG) index and its relationship with metabolic syndrome (MetS), physical activity (PA), and physical fitness in the pediatric population remain unclear. This cross-sectional study explored the mediating effect of central obesity and PA on the relationship between the TyG index and physical fitness in a pediatric population. Methods: A total of 614 Korean children (320 boys and 294 girls) aged 7-12 years participated in this study. MetS was defined as the continuous MetS risk value in the 4th quartile obtained by adding standardized scores for the syndrome components. PA was quantified using an accelerometer, and physical fitness was evaluated using composite scores for the endurance, strength, power, and flexibility domains. Results: Receiver operating characteristic curve analysis revealed that the TyG index outperformed body mass index (z = 3.005, P = 0.003) and the homeostasis assessment model for insulin resistance (z = 3.543, P = 0.001) in detecting the presence of MetS. Mediation analysis revealed that while the TyG index has a direct effect on composite physical fitness scores (β = -0.3832 and SE = -2.0942, 95% confidence interval, CI = -0.7426 to -0.0239), there was an indirect effect of the TyG index on physical fitness via vigorous PA (β = -0.0802 and SE = 0.0377) and waist-to-hip ratio (β = -0.1318, SE = 0.0509). Conclusion: The TyG index has a significant impact on physical fitness in the presence of the two mediators (β = -0.3832, SE = -2.0942, 95% CI = -0.7426 to -0.0239).

甘油三酯-葡萄糖指数及其与儿童代谢综合征和体质的关系
背景:在儿科人群中,甘油三酯-葡萄糖(TyG)指数及其与代谢综合征(MetS)、身体活动(PA)和身体健康的关系尚不清楚。本横断面研究探讨中心性肥胖和PA在儿童TyG指数与体质关系中的中介作用。方法:共614名7-12岁的韩国儿童(男孩320名,女孩294名)参与本研究。MetS定义为第4个四分位数的连续MetS风险值,该风险值由综合征组成部分的标准化评分相加得到。使用加速度计量化PA,使用耐力、力量、力量和柔韧性领域的综合得分评估体能。结果:受试者工作特征曲线分析显示,TyG指数在检测MetS存在方面优于体质指数(z = 3.005, P = 0.003)和胰岛素抵抗稳态评估模型(z = 3.543, P = 0.001)。中介分析结果显示,TyG指数对综合体质评分有直接影响(β = -0.3832, SE = -2.0942, 95%可信区间CI = -0.7426 ~ -0.0239),而TyG指数对体质评分有间接影响(β = -0.0802, SE = 0.0377),腰臀比有间接影响(β = -0.1318, SE = 0.0509)。结论:两种介质存在时,TyG指数对体质有显著影响(β = -0.3832, SE = -2.0942, 95% CI = -0.7426 ~ -0.0239)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Metabolic syndrome and related disorders
Metabolic syndrome and related disorders MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.40
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: Metabolic Syndrome and Related Disorders is the only peer-reviewed journal focusing solely on the pathophysiology, recognition, and treatment of this major health condition. The Journal meets the imperative for comprehensive research, data, and commentary on metabolic disorder as a suspected precursor to a wide range of diseases, including type 2 diabetes, cardiovascular disease, stroke, cancer, polycystic ovary syndrome, gout, and asthma. Metabolic Syndrome and Related Disorders coverage includes: -Insulin resistance- Central obesity- Glucose intolerance- Dyslipidemia with elevated triglycerides- Low HDL-cholesterol- Microalbuminuria- Predominance of small dense LDL-cholesterol particles- Hypertension- Endothelial dysfunction- Oxidative stress- Inflammation- Related disorders of polycystic ovarian syndrome, fatty liver disease (NASH), and gout
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信