Metabolic syndrome and related disorders最新文献

{"title":"Visual and Neurological Outcomes Following Glucagon-Like Peptide-1 Receptor Agonist Therapy and Bariatric Surgery in Idiopathic Intracranial Hypertension: A Network Meta-Analysis.","authors":"Somkiat Phutinart, Noppachai Siranart, Patavee Pajareya, Watsapon Chuanchai, Abhishet Varama, Prakit Anukoolwittaya, Sekh Thanprasertsuk, Gavin W Roddy","doi":"10.1177/15578518261442833","DOIUrl":"https://doi.org/10.1177/15578518261442833","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) is commonly linked to obesity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and bariatric surgery may improve outcomes beyond conventional therapy, but comparative evidence is limited.</p><p><strong>Methods: </strong>We systematically searched MEDLINE, EMBASE, and Cochrane from inception until June 2025. Eligible randomized and observational studies compared GLP-1RAs or bariatric surgery (each plus conventional care) against conventional management. Primary outcomes were the change in papilledema, visual acuity, and visual field. Secondary outcomes included body mass index (BMI), retinal nerve fiber layer (RNFL) thickness, monthly headache days, and risks of papilledema, visual disturbance, and headache. Pairwise random-effects meta-analyses and frequentist network meta-analysis (<i>P</i>-scores) were performed.</p><p><strong>Results: </strong>Out of 429 records, 8 studies were included. Versus conventional therapy, GLP-1RAs reduced BMI (mean difference -1.55 kg/m²; 95% confidence interval [CI]: -2.13 to -0.97) and lowered risks of papilledema (relative risk [RR]: 0.47; 95% CI: 0.34-0.65), visual disturbance (RR: 0.48; 95% CI: 0.24-0.98), and headache (RR: 0.78; 95% CI: 0.69-0.88). Changes in papilledema severity and RNFL thickness were not different; visual acuity favored GLP-1RAs at the end of follow-up, whereas visual field values were worse at some time points. In indirect comparisons with bariatric surgery, no significant differences were detected across outcomes.</p><p><strong>Conclusions: </strong>Adjunctive GLP-1RA therapy may be associated with weight loss and improved clinical/ophthalmic outcomes in IIH relative to conventional care, with a signal for worse visual fields at certain time points. Indirect comparisons suggest comparable efficacy to bariatric surgery. High-quality randomized trials are needed to define comparative effectiveness, safety, and optimal use.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261442833"},"PeriodicalIF":1.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adiposity Measures Derived from Bioelectrical Impedance are Associated with Cardiometabolic Markers in Women with Polycystic Ovary Syndrome.","authors":"Lenora Maria Camarate Silveira Martins Leão, Rebeca Bandeira de Melo Cavalcante, Karynne Grutter Lopes, Luiz Guilherme Kraemer-Aguiar, Ana Beatriz Winter Tavares","doi":"10.1177/15578518261437788","DOIUrl":"https://doi.org/10.1177/15578518261437788","url":null,"abstract":"<p><strong>Background: </strong>To compare bioelectrical impedance analysis (BIA)-derived body composition between women with polycystic ovary syndrome (PCOS) and body mass index (BMI)-matched controls, and to investigate associations with metabolic, hormonal, and inflammatory markers.</p><p><strong>Methods: </strong>This cross-sectional study included 35 women with PCOS and 37 BMI-matched healthy controls, aged 18-40 years, with BMI <35 kg/m². Clinical, anthropometric, metabolic, hormonal, and inflammatory parameters were assessed. Body composition was determined by direct segmental multifrequency BIA, including fat mass (FM), trunk fat mass (trunk FM), lean mass (LM), FM index, fat-to-lean mass ratio (F/L ratio), and trunk-to-peripheral fat ratio.</p><p><strong>Results: </strong>Women with PCOS (28 ± 5.3 years, 26.6 ± 3.6 kg/m²) had higher FM index, trunk FM, and F/L ratio, while LM did not differ. They also showed higher fasting insulin, homeostatic model assessment for insulin resistance (HOMA-IR), glycated hemoglobin type A1c (HbA1c), low-density lipoprotein cholesterol, free androgen index, testosterone, androstenedione, and dehydroepiandrosterone sulfate, and lower sex hormone-binding globulin (SHBG). Among BIA parameters, FM, FM index, and F/L ratio showed more consistent associations with insulin resistance and selected inflammatory markers than trunk FM. In women with PCOS, these measures were positively correlated with fasting insulin and HOMA-IR and inversely correlated with SHBG. Associations with HbA1c and IL-6 were modest and not uniformly observed across all adiposity measures. No significant correlations were found with fasting glucose, HDL-c, triglycerides, or androgen levels.</p><p><strong>Conclusions: </strong>Women with PCOS exhibit higher adiposity, particularly reflected by FM index and F/L ratio, which show closer associations with metabolic and inflammatory dysfunction than trunk FM. These findings support the potential use of BIA as an accessible, low-cost, and noninvasive tool for the cross-sectional assessment of metabolic dysfunction in PCOS. Longitudinal studies are needed to clarify the clinical relevance of these associations.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261437788"},"PeriodicalIF":1.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint Impact of Body Mass Index and High-Sensitivity C-Reactive Protein on Metabolic Dysfunction-Associated Steatotic Liver Disease Risk in Type 2 Diabetes.","authors":"Chenyang Jiao, Qian Xu, Xiangrong Li, Jun Weng, Kaiyue Lian, Hui Liu","doi":"10.1177/15578518261438418","DOIUrl":"https://doi.org/10.1177/15578518261438418","url":null,"abstract":"<p><strong>Background and aims: </strong>Prospective data on the joint impact of adiposity and systemic inflammation on incident metabolic dysfunction-associated steatotic liver disease (MASLD) in type 2 diabetes (T2D) are limited. We examined the individual and combined associations of body mass index (BMI) and high-sensitivity C-reactive protein (hsCRP) with incident MASLD in patients with T2D.</p><p><strong>Materials and methods: </strong>This prospective cohort study included 2796 adults with T2D free of MASLD from the Kailuan study (China). Over a 14-year follow-up, participants were classified by baseline BMI: (<24 vs. ≥24 kg/m²) and hsCRP (<3 vs. ≥3 mg/L). Multivariable Cox models estimated hazard ratios (HRs) for incident ultrasonographic steatosis.</p><p><strong>Results: </strong>The cumulative incidence of MASLD was 53.9%. Higher BMI: and hsCRP were independently associated with increased risk. In joint analyses, the high BMI/high hsCRP group had the highest risk [adjusted HR: 2.31; 95% confidence interval (CI): 1.94-2.74] compared with the low BMI/low hsCRP group. This risk was greater than isolated high hsCRP (HR: 1.37) or isolated high BMI: (HR: 1.93).</p><p><strong>Conclusions: </strong>Elevated BMI: and hsCRP are independently associated with incident MASLD in T2D. Co-elevation of both factors confers the greatest risk, suggesting that incorporating both adiposity and inflammatory markers improves risk stratification for targeted preventive strategies.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261438418"},"PeriodicalIF":1.7,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albuminuria and Metabolic Dysfunction-Associated Steatotic Liver Disease with Advanced Fibrosis in Primary Care.","authors":"Jingwen Zhang, Ahmed Mohamed, Justin Marsden, Chloe Bays, Andrew D Schreiner","doi":"10.1177/15578518251406217","DOIUrl":"10.1177/15578518251406217","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD) are linked through the cardiovascular-kidney-metabolic (CKM) health spectrum. This study examines the association between albuminuria and advanced liver fibrosis, both prognostic risk factors for severe kidney and liver outcomes, in patients with MASLD.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional study of primary care patients with MASLD between 2012 and 2023. Urinary microalbumin-to-creatinine ratio (uACR) was the primary predictor variable and categorized as elevated (≥30 mg/g) or normal (<30 mg/g). The primary outcome was a fibrosis-4 index (FIB-4) at high risk for advanced fibrosis (≥2.67). Bivariate analyses described the cohort overall and by uACR status. Logistic regression models estimated the association of an elevated uACR with a FIB-4 at high risk for advanced fibrosis.</p><p><strong>Results: </strong>The sample included 463 patients of whom 45% had a uACR ≥30 mg/g and 9% had an FIB-4 ≥2.67. In the unadjusted logistic Firth regression model, uACR ≥30 mg/g was associated with an increased odds of having a high-risk FIB-4 (odds ratio [OR] 2.04; 95% confidence interval [CI] 1.06-3.90). After adjusting for estimated glomerular filtration rate (eGFR), there was no significant association between uACR ≥30 mg/g and a high-risk FIB-4 (OR: 1.73; 95% CI: 0.88-3.39). Using a predictor variable combining uACR and eGFR measures, the unadjusted (OR: 3.83; 95% CI: 1.77-8.25) and adjusted (OR: 2.87; 95% CI: 1.29-6.37) logistic Firth regression models demonstrated an association between ACR ≥30 mg/g and eGFR <59 mL/min with the outcome of a high-risk FIB-4.</p><p><strong>Conclusion: </strong>Albuminuria and reduced eGFR were associated with measures of advanced fibrosis in primary care patients with MASLD, highlighting the link between CKD and MASLD along the CKM health spectrum.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"103-111"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide-Induced Weight Loss Is the Main Determinant for the Improvement of Hepatic Biochemistry and Elastographic Repeated Measurements with FibroScan® in Patients with Type 2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Savvoula Savvidou, Elektra Augousti-Varela, Aikaterini Damianakou, Miltiadis Chalkias, Ioannis Stergiou","doi":"10.1177/15578518251409025","DOIUrl":"https://doi.org/10.1177/15578518251409025","url":null,"abstract":"<p><strong>Background: </strong>Semaglutide is currently being investigated for its effectiveness in metabolic dysfunction-associated steatotic liver disease (MASLD), irrespective of type 2 diabetes mellitus (T2DM) presence, even though its action on hepatic fibrosis is still debated. The aim of this study was to examine the effect of semaglutide on hepatic parameters in patients with both T2DM and MASLD in real-world clinical practice, and to further assess the significance of weight loss during treatment.</p><p><strong>Methods: </strong>In consecutive patients with T2DM and MASLD, hepatic biochemistry and Fibrosis-4 (FIB-4) score were recorded. In participants with high FIB-4, elastographic liver stiffness measurements (LSM) and controlled attenuation parameter (CAP) were acquired with FibroScan® before and after treatment with semaglutide. For within-group comparisons, Wilcoxon signed ranked test for related samples was performed, while the role of weight loss was further investigated.</p><p><strong>Results: </strong>A total of 111 patients were included: 31 males (27.9%), with a mean age 56.4 ± 9.7 years old, body mass index 32.7 ± 6.3 kg/m², and median glycated hemoglobin (HbA1c) 5.8% (interquartile range [IQR]: 5.6-6.2). Semaglutide (0.5-2.4 mg/week) was administered subcutaneously for a median of 12 months (IQR: 6.6-17). Thirty-three patients (29.7%) had aspartate aminotransferase and/or alanine aminotransferase above normal, and 35 (31.5%) high FIB-4 score. Apart from an overall drop in HbA1c of 5.6% (IQR: 1.6-8.6) and weight loss of 10% (IQR: 3.2-19.6), statistically significant reductions were recorded in all liver enzymes and elastographic parameters (<i>p</i> < 0.001). In multiple regression analysis, weight loss was found to independently predict improvements in aminotransferases and measured CAP (<i>p</i> < 0.001), irrespective of treatment duration and baseline FIB-4.</p><p><strong>Conclusion: </strong>In this cohort of T2DM/MASLD patients with baseline optimal glycemic control, semaglutide-induced weight loss led to significant improvements of all hepatic parameters (biochemistry, liver stiffness, and steatosis assessed with CAP), even in MASLD patients with baseline liver enzymes within normal. This study supports the advantages of semaglutide administration in concomitant T2DM and MASLD.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":"24 3","pages":"121-128"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Body Mass Index and Blood Pressure Circadian Rhythm in Patients with Essential Hypertension, and Differences in Blood Lipids and Carotid Plaque Formation Among Patients with Different Blood Pressure Circadian Rhythms.","authors":"Ningjun Zhu, Yanmei Zhang, Mengli Li, Zhen Wang","doi":"10.1177/15578518251409719","DOIUrl":"10.1177/15578518251409719","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the relationship between body mass index (BMI) and blood pressure (BP) circadian rhythm in patients with essential hypertension, and to analyze differences in lipid profiles and carotid plaque prevalence across different dipping patterns.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 443 patients with essential hypertension were enrolled from the Department of Cardiology, the Second Affiliated Hospital of Anhui Medical University, between July 1, 2024, and July 30, 2025. Based on 24-hour ambulatory BP monitoring (ABPM), they were categorized into four groups: dippers (&lt;i&gt;n&lt;/i&gt; = 79), nondippers (&lt;i&gt;n&lt;/i&gt; = 224), reverse-dippers (&lt;i&gt;n&lt;/i&gt; = 127), and extreme-dippers (&lt;i&gt;n&lt;/i&gt; = 13). Clinical data were collected to analyze the associations between BP circadian rhythm, BMI, blood lipid profiles, and carotid plaque formation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Significant differences were observed among the four groups in BMI (&lt;i&gt;P&lt;/i&gt; = 0.038, η&lt;sup&gt;2&lt;/sup&gt; = 0.019), total cholesterol (&lt;i&gt;P&lt;/i&gt; = 0.040, η&lt;sup&gt;2&lt;/sup&gt; = 0.019), low-density lipoprotein cholesterol (LDL-C) (&lt;i&gt;P&lt;/i&gt; = 0.028, η&lt;sup&gt;2&lt;/sup&gt; = 0.021), and triglyceride levels (&lt;i&gt;P&lt;/i&gt; = 0.025). The prevalence of carotid intima-media thickening (&lt;i&gt;P&lt;/i&gt; &lt; 0.05, Cramer's V = 0.265) and carotid plaque formation (&lt;i&gt;P&lt;/i&gt; &lt; 0.05, Cramer's V = 0.303) also significantly differed among the groups. The reverse-dipper group had a higher detection rate of carotid intima-media thickening (85, 66.9%) than the dipper (27, 34.2%) and nondipper (90, 40.2%) groups. The detection rate of carotid plaque formation in the reverse-dipper group (80, 63%) was higher than in the other three groups. BMI levels were significantly higher in the nondipper group (26.43 ± 4.30) and the reverse-dipper group (26.25 ± 4.41) compared with the dipper group (24.82 ± 4.48) (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Total cholesterol levels were significantly higher in the nondipper group (4.89 ± 1.09) than in the dipper group (4.52 ± 1.03) (&lt;i&gt;P&lt;/i&gt; = 0.006). LDL-C levels were significantly elevated in the nondipper group (3.06 ± 0.84) and the extreme-dipper group (3.38 ± 0.93) compared with the dipper group (2.77 ± 0.82) (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Triglyceride levels were significantly higher in the nondipper group (1.79 [1.38, 2.53]) than in the dipper group (1.44 [0.95, 2.36]) (&lt;i&gt;P&lt;/i&gt; = 0.015). Logistic regression analysis indicated that BMI and the presence of carotid plaque were independent risk factors for an abnormal BP circadian rhythm (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). Advanced age, an abnormal BP circadian rhythm, and comorbid coronary heart disease were identified as risk factors for carotid plaque formation (&lt;i&gt;P&lt;/i&gt; &lt; 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In patients with essential hypertension, elevated BMI levels and carotid plaque formation may be associated with abnormal circadian BP rhythms. Patients with abnormal circadian BP rhythms exhibit varying degrees of elevated blood lipid levels, which may also be","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"129-136"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waist Circumference as a Predictor of Hepatic Steatosis and Fibrosis in the NHANES 2017-2018 Cohort.","authors":"Nikhila Janakiram, Sadhana Puri, Arthi Thirumalai","doi":"10.1177/15578518261419363","DOIUrl":"10.1177/15578518261419363","url":null,"abstract":"<p><strong>Purpose: </strong>Steatotic liver disease (SLD) is a prevalent condition that can progress to fibrosis if untreated. The most commonly used screening tool for liver disease is the FIB-4 score, which can help rule out advanced liver fibrosis. This study aims to assess whether a simple tool such as waist circumference (WC) can screen for both hepatic steatosis and fibrosis.</p><p><strong>Methods: </strong>This study was based on analysis of patient data from the NHANES 2017-2018 database, including WC, laboratory values, and Fibroscan data. Of 9254 participants, 6846 were excluded due to incomplete or missing lab and Fibroscan data (2408 included). Receiver operator characteristics (ROC) curve analyses assessed the performance of WC, fatty liver index (FLI), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in predicting steatosis at two cut-off points: controlled attenuation parameter (CAP) ≥248 dB/m and ≥294 dB/m. ROC analyses also compared WC and FIB-4 performance in predicting significant fibrosis based on liver stiffness measurement (LSM) cutoff: <8.2 kPa (F0-F1) or ≥8.2 kPa (F2-F4). Analyses were performed using JMP Pro version 17.</p><p><strong>Results: </strong>WC was shown to be a strong predictor of steatosis and fibrosis among men and women. WC and FLI were comparable predictors for steatosis among men; however, FLI outperformed WC as a predictor of steatosis among women. WC and FLI were shown to be more effective predictors of steatosis in men and women at both CAP cutoff values when compared with HOMA-IR. All three measures were more predictive of steatosis in men than in women. In a subgroup analysis of 1053 participants ages 35-65 years, WC outperformed FIB-4 in predicting significant fibrosis.</p><p><strong>Conclusion: </strong>WC is an independent predictor of hepatic steatosis and fibrosis among US adults. WC should be measured routinely in primary care settings, facilitating earlier intervention for those at risk for liver steatosis and fibrosis.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"112-120"},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast Growth Factor 21 Resistance and Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Mateo Chvatal-Medina, Adrian Post, Robin P F Dullaart","doi":"10.1177/15578518261427700","DOIUrl":"https://doi.org/10.1177/15578518261427700","url":null,"abstract":"","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261427700"},"PeriodicalIF":1.7,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147530454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociation Between Hepatic Steatosis and Paraspinal Myosteatosis on Quantitative MRI.","authors":"Betul Akdal Dolek, Eda Sener, Berkan Alcin","doi":"10.1177/15578518261436372","DOIUrl":"https://doi.org/10.1177/15578518261436372","url":null,"abstract":"<p><strong>Background: </strong>Hepatic steatosis and skeletal muscle fat infiltration represent key features of metabolic dysfunction, yet their interrelationship remains poorly defined. Paraspinal muscles are routinely visualized during abdominal MRI, offering an accessible site for quantifying myosteatosis using proton density fat fraction (PDFF).</p><p><strong>Objectives: </strong>To identify metabolic determinants of hepatic and paraspinal muscle PDFF and assess whether paraspinal myosteatosis provides independent diagnostic value for diabetes mellitus.</p><p><strong>Methods: </strong>In this retrospective study, 266 adults who underwent abdominal MRI with quantitative fat mapping were evaluated. Hepatic and paraspinal PDFF were measured using MRI-PDFF, and metabolic associations were analyzed using correlation, regression, and logistic models. ROC curves assessed whether paraspinal PDFF improved diabetes discrimination beyond age, sex, body mass index (BMI), and hepatic PDFF.</p><p><strong>Results: </strong>Hepatic PDFF correlated strongly with BMI (<i>r</i> = 0.46) and ALT (<i>r</i> = 0.29), while showing no association with paraspinal PDFF (<i>r</i> = 0.01). Paraspinal PDFF was higher in diabetes (14.0% vs. 10.6%) but was not an independent predictor after adjusting for age, sex, BMI, and hepatic PDFF. Adding hepatic PDFF minimally improved diabetes prediction (AUC = 0.794→0.799), and paraspinal PDFF offered no additional improvement. An exploratory threshold of 11.8% paraspinal PDFF yielded moderate sensitivity (63%) and specificity (70%).</p><p><strong>Conclusions: </strong>Hepatic steatosis and paraspinal myosteatosis are metabolically distinct ectopic fat depots. Although paraspinal fat is elevated in diabetes, it does not enhance metabolic risk prediction beyond BMI. These findings support organ-specific lipid pathways and highlight the need for longitudinal and volumetric analyses to clarify their independent clinical roles.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261436372"},"PeriodicalIF":1.7,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vasomotor Function and Its Modulation by Perivascular Adipose Tissue Vary Depending on Metabolic Syndrome Stage.","authors":"Satomi Kagota, Kana Maruyama-Fumoto, Aya Niki, Kazumasa Shinozuka","doi":"10.1177/15578518261431679","DOIUrl":"https://doi.org/10.1177/15578518261431679","url":null,"abstract":"<p><strong>Background: </strong>Perivascular adipose tissue (PVAT), found outside blood vessels, enhances vasorelaxation when endothelium-mediated vasorelaxation fails, as observed in the mesenteric arteries of rats with metabolic syndrome (MetS) and hypertension; however, whether high blood pressure contributes to PVAT dysfunction remains unclear. We, therefore, aimed to investigate vascular function and PVAT modulation in the mesenteric arteries of rats with MetS but no hypertension.</p><p><strong>Methods: </strong>Mesenteric arteries were isolated from both lean and obese male Zucker fatty (ZF) and ZF diabetes mellitus (ZFDM) rats at 20 and 30 weeks of age. Vasorelaxation was examined in arteries with or without PVAT; mRNA levels in PVAT and arteries were examined using the organ bath method and quantitative reverse transcription polymerase chain reaction, respectively.</p><p><strong>Results: </strong>Sodium nitroprusside-induced relaxations were lower in the obese versus lean ZF rats, and PVAT increased them to levels comparable to those in lean rats at 20 weeks. These enhancements disappeared after 30 weeks. The mRNA expression of apelin in PVAT and its receptor was upregulated in the arteries of obese rats, and its levels correlated positively with the enhancing effect of PVAT. In obese ZFDM rats, PVAT attenuated relaxation at both 20 and 30 weeks. Levels of chemerin mRNA expression in PVAT were higher in ZFDM versus ZF rats; however, treatment with chemerin or a chemerin receptor antagonist did not alter vasorelaxation in ZFDM rats.</p><p><strong>Conclusions: </strong>Apelin may contribute to compensatory PVAT modulation during vascular dysfunction in obese ZF rats. PVAT inhibits vasorelaxation by releasing a contractile factor other than chemerin in ZFDM rats. Thus, it may modulate vascular tone differently depending on MetS stage.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261431679"},"PeriodicalIF":1.7,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}