Metabolic syndrome and related disorders最新文献

{"title":"Association of Vaspin rs2236242 with Metabolic Syndrome: A Meta-Analysis of Case-Control Studies.","authors":"Wei-Yue Lim, Amira Elina Amirul, Yuh-Fen Pung, Rosmawati Mohamed, Rong-Xiang Ng, Shamsul Mohd Zain","doi":"10.1177/15578518261429025","DOIUrl":"https://doi.org/10.1177/15578518261429025","url":null,"abstract":"<p><strong>Background/purpose of the study: </strong>Metabolic syndrome (MetS) is a multifactorial condition characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, all of which increase the risk of cardiovascular disease and type 2 diabetes mellitus. Genetic variants affecting adipokine signaling, such as polymorphisms in the vaspin gene (SERPINA12), have gained attention due to their potential role in modulating metabolic traits. Among these, the single nucleotide polymorphism rs2236242 (T>A) has shown conflicting associations with MetS across populations. This study presents the first comprehensive meta-analysis investigating the association between rs2236242 polymorphism and MetS susceptibility.</p><p><strong>Methods: </strong>We searched PubMed, Google Scholar, Scopus, and Web of Science for relevant articles published up to 12 December 2025. Data were extracted, and summary estimates of the association between vaspin rs2236242 and MetS were assessed. Odds ratios (ORs) and confidence intervals (CIs) were used to measure the effect. Four eligible case-control studies involving 918 participants from Caucasian, African, and Western Asian populations were included.</p><p><strong>Results: </strong>Our results demonstrate that the A allele of rs2236242 is significantly associated with a 37% reduced risk of MetS compared to the T allele, with consistent protective effects observed across multiple genetic models (dominant, recessive, homozygous, and heterozygous). These findings align with previous studies suggesting the metabolic benefits of vaspin, including improved insulin sensitivity. Moreover, sensitivity analyses identified the study by Suliga et al. as an outlier, its exclusion reduced heterogeneity to 0% while maintaining the significance of the protective association.</p><p><strong>Conclusion: </strong>We performed the first meta-analysis on the association of vaspin rs2236242 with MetS and found that the vaspin rs2236242 A allele confers a significant protective effect against MetS.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261429025"},"PeriodicalIF":1.7,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Trait Genome-Wide Association Studies Identify Shared Genetic Risk Loci Between Psoriasis and Metabolic Syndrome and Their Associated Traits.","authors":"Xin Jiang, Ping Zhou, Qi Zhang, WanChun Wang, Dan Wang","doi":"10.1177/15578518261426293","DOIUrl":"10.1177/15578518261426293","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis (PsO) demonstrates frequent co-occurrence with metabolic syndrome (MetS). Nevertheless, the shared genetic architecture underlying both pathological conditions remains incompletely characterized. This investigation sought to examine genetic correlations between PsO and multiple MetS-associated traits, and to identify shared genetic risk loci and genes contributing to their coexistence.</p><p><strong>Methods: </strong>Genome-wide association study data for PsO, MetS, and related traits in European populations were integrated to evaluate genetic associations between traits and to identify shared loci. Bayesian colocalization analysis was applied to determine whether association signals for different traits at the same locus were attributable to a common causal variant. Functional annotation and gene mapping were conducted for shared loci, followed by functional classification and pathway enrichment analyses of pleiotropic gene sets. In addition, summary data-based Mendelian randomization and transcriptome-wide association study analyses were applied to prioritize candidate genes with potential therapeutic relevance.</p><p><strong>Results: </strong>Significant genetic associations were observed between PsO and five metabolic traits, including body mass index, high-density lipoprotein cholesterol, triglycerides, waist circumference, and type 2 diabetes mellitus, while MetS, as a composite trait, also exhibited a genetic association with PsO. Pleiotropic Analysis under composite null hypothesis (PLACO) analysis revealed a total of 141 shared risk loci, with 22 loci substantiated by Bayesian colocalization analysis findings (<i>PP.H4</i> ≥ 0.75). Multimarker analysis of genomic annotation analysis identified 195 distinct pleiotropic genes. The pathway enrichment analysis indicated that these genes were predominantly involved in immune and inflammatory pathways, transcriptional and epigenetic regulation, autophagy, and lipid-cholesterol metabolism, indicating that such biological processes may contribute to the shared genetic background of PsO and MetS-related traits. Through integrative evidence from multiple analytical approaches, three candidate therapeutic target genes, namely, <i>KAT8, STX4,</i> and <i>VKORC1</i>, were prioritized.</p><p><strong>Conclusions: </strong>Shared genetic loci, pleiotropic genes, and core biological pathways between PsO and multiple MetS-related traits were identified, and potential intervention targets were highlighted, providing genetic evidence to support subsequent functional investigations.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261426293"},"PeriodicalIF":1.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Body Roundness Index with Hypertension Risk and Blood Pressure in Diabetes and Prediabetes Adults: A Study Based on the NHANES Databas.","authors":"Xiao-Jing Li, Pei-Pei Wang, Yong-Qiang Fan, Qing-Hua Han","doi":"10.1177/15578518261429030","DOIUrl":"https://doi.org/10.1177/15578518261429030","url":null,"abstract":"<p><strong>Background: </strong>Visceral obesity is considered an important risk factor for hypertension. However, there is little research on visceral obesity and hypertension in patients with diabetes or prediabetes. Body roundness index (BRI) serves as a proxy for visceral adiposity. Therefore, the purpose of this study is to investigate the relationship between BRI and hypertension and blood pressure in diabetes (DM) or prediabetes (preDM).</p><p><strong>Methods: </strong>This study includes data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, including 5368 participants with DM and preDM. Weighted multiple regression, restricted cubic spline (RCS), and subgroup analysis were used to evaluate the correlation between BRI and hypertension risk as well as blood pressure.</p><p><strong>Results: </strong>This study included a total of 1565 DM subjects and 3803 preDM participants. The prevalence of hypertension in the two groups was 67.80% and 42.28%, respectively. After adjusting for potential confounding factors, BRI was significantly positively correlated with the risk of hypertension, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in both DM and preDM. In the fully adjusted model, an increase in BRI was positively associated with the risk of hypertension in both DM and preDM participants (DM OR: 1.25, 95% CI: 1.16-1.34, <i>P</i> < 0.0001; preDM OR: 1.20, 95% CI: 1.14-1.26, <i>P</i> < 0.0001). Further RCS analysis revealed a significant nonlinear relationship between BRI and hypertension and DBP in DM and preDM, while there was a linear positive correlation with SBP. Interaction analysis indicated that in male preDM, BRI was associated with a higher risk of hypertension (male OR: 1.28, 95% CI: 1.19-1.39, female OR: 1.12, 95% CI: 1.07-1.17, <i>P</i> for interaction <0.01). Additionally, in preDM under the age of 60, BRI showed a stronger positive correlation with SBP and DBP (OR: 1.23, 95% CI: 0.94-1.52, <i>P</i> < 0.0001; OR: 0.68, 95% CI: 0.45-0.90, <i>P</i> < 0.0001). However, these findings were not observed in DM.</p><p><strong>Conclusions: </strong>In diabetes and prediabetes, BRI exhibits a significant positive correlation with the risk of hypertension, as well as with systolic and diastolic blood pressure. Based on these findings, BRI may serve as a biomarker for managing the progression of hypertension in patients with DM and preDM.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261429030"},"PeriodicalIF":1.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allostatic Load in Patients with Type 2 Diabetes Treated with GLP-1 Receptor Agonists.","authors":"Yang Yu, Susan Groth","doi":"10.1177/15578518261431688","DOIUrl":"https://doi.org/10.1177/15578518261431688","url":null,"abstract":"<p><strong>Background: </strong>In patients with type 2 diabetes (T2DM), glucagon-like peptide-1 (GLP-1) receptor agonists improve glycemic control and have been shown to enhance stress regulation, potentially attenuating the cumulative impact of chronic stress. Despite these links, few studies have examined allostatic load in patients with T2DM treated with GLP-1s.</p><p><strong>Objectives: </strong>To compare allostatic load among patients with T2DM treated with GLP-1s and three comparison groups: individuals without T2DM, individuals with T2DM not receiving medication treatment, and individuals with T2DM treated with non-GLP-1 medications.</p><p><strong>Methods: </strong>We analyzed data from 16,830 adults in the 2007-2018 National Health and Nutrition Examination Survey. Medication status was based on self-reported prescription use within the past month. Allostatic load was calculated primarily using a 13 biomarker index spanning metabolic, autonomic, and immune function and secondarily using a modified score that excluded HbA1c and insulin resistance. General linear regression was used to assess associations, adjusting for sociodemographics, comorbidities, and health behaviors.</p><p><strong>Results: </strong>Participants with T2DM treated with GLP-1s had higher allostatic load than those without T2DM (<i>β</i> = 1.57, 95% CI: 0.88, 2.25) but did not differ from participants with T2DM who were untreated or treated with non-GLP-1s. After excluding HbA1c and insulin resistance from the score, allostatic load in the GLP-1s-treated group was comparable across all comparison groups.</p><p><strong>Conclusions: </strong>GLP-1 treatment was not associated with lower allostatic load compared with other treatment regimens in patients with T2DM. Longitudinal studies with neuroendocrine measures are needed to better characterize its effects on stress regulation.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261431688"},"PeriodicalIF":1.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Gene Expression, Insulin Resistance, and Circulating Markers Vary by Visceral Adiposity in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease.","authors":"Yi-Hsuan Lin, Chia-Chen Ma, Shin-Yu Tsai, Shiao-Ya Hong, Ying-Ying Yang, Chien-Wei Su, Hsiao-Chin Shen, Ming-Chih Hou","doi":"10.1177/15578518261427179","DOIUrl":"10.1177/15578518261427179","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is driven by complex immune and inflammatory mechanisms. Visceral adiposity, a key contributor, worsens inflammation, immune dysregulation, and insulin resistance.</p><p><strong>Objective: </strong>This study examines correlations between inflammatory genes, insulin resistance markers, and inflammatory markers across visceral adiposity levels in patients with MASLD.</p><p><strong>Methods: </strong>This cross-sectional study included 102 patients with MASLD. Assessments included body mass index, visceral adiposity index (VAI), a body shape index (ABSI), inflammatory markers, gene expression from peripheral white blood cells, and serologic inflammatory proteins. We calculated insulin resistance markers, such as homeostasis model assessment-insulin resistance index (HOMA-IR), triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride-glucose (TyG) index, and neutrophil-to-HDL ratio (NHR). Pearson correlation coefficients evaluated parameter associations between low and high VAI and ABSI groups.</p><p><strong>Results: </strong>The higher VAI group presented with some elevated markers, such as HOMA-IR (5.21 ± 3.42 <i>vs.</i> 4.34 ± 4.62), TG/HDL-C (4.08 ± 1.97 <i>vs.</i> 2.20 ± 1.07), TyG (9.03 ± 0.48 <i>vs</i>. 8.70 ± 0.51), and NHR (1.86 ± 0.75 <i>vs.</i> 1.45 ± 0.64) compared with the low VAI group, indicating potentially greater insulin resistance and systemic inflammation. Monocyte chemoattractant protein-1 and interleukin-6 genes were strongly correlated in the low VAI group (<i>R</i> = 0.94, <i>P</i> < 0.001) but more weakly correlated in the high VAI group (<i>R</i> = 0.63, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>These findings highlight differential immune changes across visceral adiposity levels in MASLD, supporting the need for tailored interventions based on adiposity profiles.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261427179"},"PeriodicalIF":1.7,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sterol Regulatory Element-Binding Proteins and Metabolic Diseases: Mechanisms, Implications, and Therapeutic Strategies.","authors":"Xiaofei Zhang, Kexin Zhang, Yuqun Wang, Qiming Fan, Chengxia Kan, Yujie Ma, Sufang Sheng, Ningning Hou, Xiaodong Sun","doi":"10.1177/15578518251407655","DOIUrl":"10.1177/15578518251407655","url":null,"abstract":"<p><p>Metabolic diseases, including obesity, diabetes, and cardiovascular disorders, are increasingly prevalent due to genetic, environmental, and lifestyle factors. Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that regulate genes involved in lipid synthesis and cholesterol homeostasis. Dysregulation of SREBPs contributes to metabolic disorders, with overactivation of SREBP-1c driving excessive lipid synthesis, leading to hyperlipidemia. In diabetes, altered SREBP activity impairs insulin secretion and promotes lipid accumulation, exacerbating disease progression. SREBP-2 is critical for cholesterol metabolism and is linked to atherosclerosis. This review explores the therapeutic potential of targeting SREBPs. Compounds such as betulin, fatostatin, xanthohumol, vitamin D derivatives, and BF175 can modulate SREBP activity, reduce lipid accumulation, and improve metabolic outcomes in experimental models. Clarifying SREBP regulatory mechanisms across tissues, advancing small-molecule modulators, and applying gene-editing technologies such as CRISPR-Cas9 may enable more personalized therapeutic strategies. Integrating lifestyle interventions with pharmacological treatments may offer a comprehensive approach to improving therapeutic outcomes in metabolic diseases.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"65-73"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Metabolic Syndrome on Cataracts: A Systematic Review and Meta-Analysis.","authors":"Pawaris Tirakunwichcha, Noppachai Siranart, Somkiat Phutinart, Patavee Pajareya, Pannathorn Nakaphan, Chanissara Winson, Gavin W Roddy","doi":"10.1177/15578518251407586","DOIUrl":"https://doi.org/10.1177/15578518251407586","url":null,"abstract":"<p><p>Cataracts are the leading cause of blindness worldwide. Obesity, a key component of metabolic syndrome (MetS), may represent a modifiable risk factor for cataracts. However, the evidence regarding the association between MetS or its components and cataracts remains controversial. Therefore, our meta-analysis aims to clarify the relationship between MetS or its components and cataracts. A search was conducted until February 2024 via the MEDLINE, EMBASE, and Cochrane databases. The primary endpoint included the association between MetS or its components, including body mass index (BMI), diabetes mellitus (DM), hypertension (HT), and dyslipidemia (DLP), and cataracts. Secondary endpoints included the association between levels of blood pressure, blood sugar, and lipid profiles and cataracts. A total of 27 studies were included with a total of 1,010,014 patients (134,498 with cataracts and 875,516 without cataracts). Of these, there were 2 prospective cohort studies, 6 case-control studies, and 19 cross-sectional studies. The prevalence of cataracts was 13.3%. MetS was significantly associated with cataracts with an odds ratio (OR) of 1.60 (95% confidence interval [CI]: 1.44-1.77, <i>I</i>² = 93%). Among MetS components, high BMI and being diagnosed with DM, HT, and DLP were associated with cataracts with ORs of 1.45 (95% CI: 1.33-1.58, <i>I</i>² = 80%), 1.77 (95% CI: 1.69-1.85, <i>I</i>² = 51%), 1.23 (95% CI: 1.19-1.28, <i>I</i>² = 62%), and 1.38 (95% CI: 1.30-1.46, <i>I</i>² = 0%). Among the metabolic parameters, high total cholesterol, high triglycerides, low high-density lipoprotein cholesterol, and high low-density lipoprotein cholesterol were associated with cataracts with ORs of 1.25 (95% CI: 1.04-1.49, <i>I</i>² = 48%), 1.05 (95% CI: 1.04-1.06, <i>I</i>² = 68%), 1.07 (95% CI: 1.01-1.13, <i>I</i>² = 0%), and 1.30 (95% CI: 1.10-1.53, <i>I</i>² = 71%), respectively. MetS, obesity, DM, HT, and DLP are associated with cataracts. Prevention or treatment of MetS or its components likely represent a modifiable risk factor in cataract development.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":"24 2","pages":"57-64"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple Screening Strategy for Metabolic Dysfunction-Associated Steatotic Liver Disease in General Health Checkups.","authors":"Masahito Katahira, Shin-Ichi Shirokami, Satoko Ono, Shigeaki Moriura","doi":"10.1177/15578518251408508","DOIUrl":"https://doi.org/10.1177/15578518251408508","url":null,"abstract":"<p><strong>Objective: </strong>The recent redefinition of nonalcoholic fatty liver disease (NAFLD) as metabolic dysfunction-associated steatotic liver disease (MASLD) has emphasized the need for effective noninvasive diagnostic tools besides imaging. In this study, we developed a scoring system based on demographic and biochemical parameters for estimating steatotic liver disease (SLD) and compared its diagnostic performance with existing indices, including the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and NAFLD ridge score.</p><p><strong>Methods: </strong>Data from 21,056 individuals who underwent abdominal ultrasonography (US) and laboratory tests at a health screening center between 2017 and 2019 were retrospectively analyzed. A multivariate logistic regression model was used to identify the predictors of SLD, which resulted in the development of a novel scoring system. Receiver operating characteristic (ROC) curve analysis was performed to identify the optimal cutoff and to assess the comparative performance.</p><p><strong>Results: </strong>The score was comprised of six variables, including age, body mass index, high-density lipoprotein cholesterol, hemoglobin A1c, alanine aminotransferase, and albumin. It exhibited a higher area under the ROC curve compared with FLI, HSI, and the NAFLD ridge score. It also showed stronger concordance with ultrasonographic diagnosis, particularly among individuals meeting the cardiometabolic risk criteria for MASLD.</p><p><strong>Conclusions: </strong>This novel scoring system provides an accurate, useful tool for estimating SLD and may enhance MASLD detection when used in conjunction with US.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":"24 2","pages":"74-80"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Novel Inflammatory Indices and Metabolic Syndrome in Children and Adolescents with Obesity.","authors":"Muammer Büyükinan, Sadiye Sert","doi":"10.1177/15578518251405811","DOIUrl":"10.1177/15578518251405811","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the predictive value of complete blood count-derived inflammatory indices for metabolic syndrome (MetS) in children and adolescents with obesity.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from January to March 2025. Participants aged 5-17.9 years with obesity were classified into MetS and non-MetS groups according to the International Diabetes Federation pediatric criteria. Participants were further stratified by pubertal stage into prepubertal, pubertal, and postpubertal groups.</p><p><strong>Results: </strong>A total of 343 subjects with obesity (median age: 13.3 years; interquartile range: 4.74) were studied. MetS was diagnosed in 97 individuals (28.2%). Those with MetS had significantly higher body mass index (BMI), waist circumference, hip circumference, waist-to-height ratio, blood pressure, triglycerides, fasting plasma glucose, insulin levels, and Homeostasis Model Assessment of Insulin Resistance, and lower high-density lipoprotein cholesterol (HDL-C) compared with participants without MetS. Notably, inflammatory markers, including the neutrophil-to-HDL-C ratio, lymphocyte-to-HDL-C ratio, monocyte-to-HDL-C ratio, and platelet-to-HDL-C ratio (PHR), were also elevated in the MetS group. Correlation analyses revealed significant associations between these indices and various cardiometabolic parameters, including insulin resistance markers. Logistic regression analysis identified BMI and PHR as the most robust independent predictors of MetS. Additionally, stage-specific cutoff values for these markers were established according to pubertal development.</p><p><strong>Conclusions: </strong>The study shows that certain novel inflammatory indices are elevated in children with MetS and are significantly correlated with key cardiometabolic risk factors. These results suggest that such markers could serve as practical tools for early detection of cardiometabolic risk in youth with obesity.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"81-94"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing Cut-Off Points for Lipid Profile-Derived Markers to Diagnose Prehypertension in Young Adults.","authors":"Abraham Cardenas-Juarez, Mariana Haydee García-Hernández, Flor Itzel Lira-Hernandez, Edgar Eduardo Lara-Ramirez, Bruno Rivas-Santiago, Juan Manuel Vargas-Morales, Diana Patricia Portales-Pérez","doi":"10.1177/15578518251405802","DOIUrl":"10.1177/15578518251405802","url":null,"abstract":"<p><strong>Introduction: </strong>Prehypertension (pre-HTN) affects between 25% and 50% of the adult population worldwide and constitutes a significant risk factor for the development of cardiovascular diseases and chronic kidney disease. Although it is not considered a disease, its identification is crucial as it reflects a state of alert to identify individuals at high risk of developing cardiovascular disease. However, the difficulties associated with its diagnosis limit its use in preventive medicine. In this context, the present study aims to analyze the diagnostic utility of markers derived from the lipid profile (TyG index and the ratios triglycerides (TG)/high-density lipoprotein-cholesterol (HDL-c), total cholesterol (TC)/HDL-c, low-density lipoprotein cholesterol (LDL-c)/HDL-c, non-HDL-c/HDL-c, and fasting blood glucose (FBG)/HDL-c) in determining pre-HTN.</p><p><strong>Methods: </strong>A retrospective study was designed that included the participation of 668 young adults. A logistic regression model was used to examine the associations between the different markers and pre-HTN. The cut-off points of the markers were determined by receiver operating characteristic curve analysis and the Youden index.</p><p><strong>Results: </strong>A positive and significant association was observed between all markers with the presence of pre-HTN. The cut-off values for the markers that best predicted pre-HTN status were TG/HDL-c ≥2.055 (sensitivity = 62.28%, specificity = 87.03%); TC/HDL-c ≥3.466 (sensitivity = 60.48%, specificity = 91.82%); non-HDL-c/HDL-c ≥2.466 (sensitivity = 60.48%, specificity = 91.82%); and FBG/HDL-c ≥1.726 (sensitivity = 68.26%, specificity = 73.25%).</p><p><strong>Conclusions: </strong>Our study demonstrated the diagnostic relevance of the different markers for the detection of pre-HTN, suggesting that these markers may be useful in clinical practice for the timely and accurate diagnosis of pre-HTN.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"95-102"},"PeriodicalIF":1.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}