Metabolic syndrome and related disorders最新文献

{"title":"Adverse Health Outcomes Associated with Hypoglycemia Following Bariatric Surgery.","authors":"Yang Yu, Qianheng Ma, Adnin Zaman, Susan Groth","doi":"10.1089/met.2025.0010","DOIUrl":"10.1089/met.2025.0010","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Hypoglycemia is prevalent among patients postbariatric surgery, but its clinical implications remain unclear. The purpose of this study was to examine the longitudinal associations of hypoglycemia (<i>i.e.,</i> occurrence in the past 3 months, frequency in the past 7 days, number of severe episodes in the past 3 months, and symptoms) with depressive symptoms, quality of life (QoL), work productivity, and weight loss over an 84-month follow-up period after bariatric surgery. <b><i>Methods:</i></b> This secondary analysis used data from the Longitudinal Assessment of Bariatric Surgery-2 study. Hypoglycemia, depressive symptoms, QoL, and work productivity were self-reported. Weight was primarily based on objective measures. Linear mixed modeling with time-lagged techniques was used for analysis, adjusting for potential covariates such as age and gender. <b><i>Results:</i></b> Across the 84-month follow-up, 20%-30% of participants (<i>N</i> = 552) reported experiencing hypoglycemia in the past 3 months. Hypoglycemia occurrence was positively associated with depressive symptoms [β = 2.4; 95% confidence interval (CI): 1.7, 3.0] and negatively associated with physical (β = -4.2; 95% CI: -5.1, -3.3) and mental QoL (β = -3.4; 95% CI: -4.4, -2.4). These associations became stronger with increased frequency of hypoglycemia, a higher number of severe episodes, and the presence of symptoms. Additionally, hypoglycemia occurrence was associated with several domains of work productivity, including presenteeism (β = 5.8; 95% CI: 3.4, 8.2), work productivity loss (β = 5.6; 95% CI: 2.6, 8.6), and activity impairment (β = 8.8; 95% CI: 6.0, 11.6), with the strength of these associations increasing with greater hypoglycemic frequency. <b><i>Conclusions:</i></b> This study highlights the critical role of hypoglycemia in patients' physical and psychosocial well-being postbariatric surgery. Future studies employing more rigorous measures of hypoglycemia and expanded outcomes (<i>e.g.</i> cognitive function) are needed to fully understand its clinical relevance.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"244-252"},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Metabolic Syndrome and Combinations of Its Components: Findings from the Mexican National Health and Nutrition Survey, 2021.","authors":"Ismael Campos-Nonato, Maria Ramírez-Villalobos, Eric Monterrubio-Flores, Kenny Mendoza-Herrera, Carlos Aguilar-Salinas, Andrea Pedroza-Tobías, Barquera Simón","doi":"10.1089/met.2024.0179","DOIUrl":"10.1089/met.2024.0179","url":null,"abstract":"<p><p><b><i>Background:</i></b> Metabolic syndrome (MetS) is a clinical construct that conglomerates risk factors interconnected with cardiovascular diseases and type 2 diabetes. More than a thousand million individuals in the world were diagnosed with MetS in 2018. <b><i>Objective:</i></b> Our objective was to examine the prevalence of MetS and its components among Mexican adults. <b><i>Methods:</i></b> Data from 1733 adults aged ≥20 years who participated in the Mexican National Health and Nutrition Survey 2021. Sociodemographic, and clinical factors were gathered and analyzed. To define MetS, we used the harmonized diagnosis criteria. <b><i>Results:</i></b> The prevalence of MetS in Mexican adults was 45.3% (43.7% in men and 46.8% in women). This was mainly driven by increased abdominal obesity (AO) 79.8% and dyslipidemia (low high-density lipoprotein [HDL]-cholesterol and hypertriglyceridemia) 77.1%. The proportion of subjects with a least one MetS component was 90.5% and with any combination of two components was 25.2% and for three was 28.9%. The most frequent combination of MetS components was the cluster of AO, low HDL-cholesterol, and hypertriglyceridemia (15.6%). <b><i>Conclusions:</i></b> A high prevalence of MetS was registered in Mexico in 2021. Women and adults aged 40 years or older were the groups with the highest prevalence of MetS and its components. The health system in Mexico must promote strategies for the prevention and control of MetS and its components in adults.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"193-204"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Skeletal Muscle Mass with Habitual Exercise, Mealtime and Sleep in Middle-Aged Men: Cross-Sectional Study.","authors":"Yumi Masuda, Noriaki Kishimoto, Emiko Kuroda, Tamae Ogata, Shohei Misaki, Yuri Chimura, Masahiro Kikuchi, Chizumi Yamada, Akira Kubo, Yasuhiro Nishizaki","doi":"10.1089/met.2024.0195","DOIUrl":"10.1089/met.2024.0195","url":null,"abstract":"<p><p><b><i>Objective:</i></b> To investigate the cross-sectional association between skeletal muscle mass and lifestyles including exercise, mealtime, and sleep habits in adult men aged under 64. <b><i>Materials and Methods:</i></b> A total of 101 Japanese men aged under 64 who underwent \"Anti-aging Health Checkups\" were enrolled in the study. Cross-sectional analyses were conducted using the subjects' data such as body mass index, skeletal muscle mass index (SMI), and self-reported lifestyle information. The physical activity (PA) value of habitual exercise per week (metabolic equivalent hr/week) was categorized into three groups. Mealtime combination of breakfast and dinner time was categorized into five groups. A multiple regression analysis demonstrated how each PA group has an association with SMI. Moreover, an analysis of covariance was performed to investigate the association between \"mealtime combined with PA\" and SMI levels by comparison and to investigate the association between \"sleep duration or satisfaction combined with PA\" and SMI levels, respectively. <b><i>Results:</i></b> The subjects with \"breakfast before 8 a.m.\" had a significant positive association between SMI and PA levels; in addition, among the subjects from the \"dinner before 8 p.m.\" group, as the PA level was higher, the SMI level increased. Consequently, the SMI level increased as the PA level was higher among the subjects who had \"breakfast before 8 a.m. and dinner before 8 p.m.\" Furthermore, sufficient sleep such as more than 6 hr and satisfied sleep had positive associations with SMI as PA levels increased. <b><i>Conclusion:</i></b> These findings suggest a potential benefit of habitual exercise with breakfast before 8 a.m., dinner before 8 p.m., and sufficient sleep for maintaining skeletal muscle mass among middle-aged men.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"217-226"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Podocyte-Specific Protein Expression in Urine Exosome Acts as a Marker for Renal Injury in Post-COVID State.","authors":"Seshagiri Rao Nandula, Beda Brichacek, Sabyasachi Sen","doi":"10.1089/met.2024.0199","DOIUrl":"10.1089/met.2024.0199","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) has been associated with the development of COVID-19. COVID-19 may cause endothelial cell dysfunction (ECD), which can lead to cardiometabolic diseases and podocytopathy. In this study, we explored whether presence of hyperglycemia predisposes to SARS-CoV-2 infection, <i>in vitro</i>, and whether COVID-19 can put an individual at a higher risk of persistent renal damage in the long-term following acute COVID infection. To estimate renal damage, we evaluated albuminuria and podocytopathy. Podocytopathy was estimated by measuring podocyte-specific protein levels in urine-derived exosomes from patients who were admitted with acute COVID-19 at 10 days, 6 months, and 12 months post-acute SARS-CoV-2 infection. <b><i>Methods:</i></b> Blood and urine samples from patients with SARS-CoV-2 post-infection were procured from the George Washington University COVID repository. Peripheral blood mononuclear cells and urine exosomes were isolated. Podocyte-specific proteins Podocalyxin (PODXL) and Nephrin (NEPH) were identified from urine exosomes. <b><i>Results:</i></b> Urine exosomal podocalyxin levels were significantly high at 10 week (<i>n</i> = 18; <i>P</i> = 0.001), 6 month (<i>n</i> = 25; <i>P</i> = 0.003) and 12 month (<i>n</i> = 14; <i>P</i> = 0.0001) time points. Nephrin levels were also noted to be high at 10 week (<i>n</i> = 18; <i>P</i> = 0.001) and 12 month (<i>n</i> = 14; <i>P</i> = 0.007) time points, compared with urine samples obtained from type 2 diabetes subjects who never had COVID-19. Though urinary podocyte-specific proteins were high, compared to control, there were no significant differences noted on urine albumin:creatinine ratios (UACR) between the groups. <b><i>Conclusion:</i></b> Persistent high levels of podocyte-specific proteins noted in urinary exosomes even at 12 months post-Covid may lead to the development of chronic kidney disease.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"205-210"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithm to Identify Type 2 Diabetes Using Electronic Health Record and Self-Reported Data.","authors":"Ben T Varghese, Marlene E Girardo, Ruchi Gupta, Karen M Fischer, Madison Duellman, Michelle M Mielke, Aoife M Egan, Janet E Olson, Adrian Vella, Kent R Bailey, Sagar B Dugani","doi":"10.1089/met.2024.0133","DOIUrl":"10.1089/met.2024.0133","url":null,"abstract":"<p><p><b><i>Aims:</i></b> Identifying participants with type 2 diabetes (T2D) based only on electronic health record (EHR) or self-reported data has limited accuracy. Therefore, the objective of the study was to develop an algorithm using EHR and self-reported data to identify participants with and without T2D. <b><i>Methods:</i></b> We included participants enrolled in the Mayo Clinic Biobank. At enrollment, participants completed a baseline questionnaire on health conditions, including T2D, and provided access to their EHR data. T2D status was based on self-report and EHR data (International Classification of Diseases codes, hemoglobin A1c [HbA1c], plasma glucose, and glucose-regulating medications) within 5 years prior to and 2 months after enrollment. Participants who self-reported T2D but lacked corroborating EHR data were categorized separately (\"only self-reported T2D\"). After identifying participants with T2D, we identified participants without T2D based on normal HbA1c and plasma glucose. Participants who self-reported the absence of T2D but lacked corroborating EHR data were categorized separately (\"only self-reported no T2D\"). Using manual chart reviews (gold standard), we calculated the positive and negative predictive values (NPV) to identify T2D. <b><i>Results:</i></b> Of 57,000 participants, the algorithm classified participants as having T2D (<i>n</i> = 6,238), no T2D (<i>n</i> = 38,883), \"only self-reported T2D\" (<i>n</i> = 757), and \"only self-reported no-T2D\" (<i>n</i> = 9,759). The algorithm had a high positive predictive value (96.0% [91.5%-98.5%]), NPV (100% [98.0%-100%]), and accuracy (99.5% [98.3%-99.8%]). Participant age (median [range]) ranged from 52 (18-98) years (only self-reported T2D) to 67 (19-99) years (T2D) (<i>P</i> < 0.0001), and the proportion of women ranged from 45.3% (T2D) to 69.6% (only self-reported no T2D) (<i>P</i> < 0.0001). Most participants were of the White race (84.0%-92.7%) and non-Hispanic ethnicity (97.6%-98.6%). <b><i>Conclusions:</i></b> In this study, we developed an algorithm to accurately identify participants with and without T2D, which may be generalizable to cohorts with linked EHR data.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"186-192"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Household Food Insecurity and Metabolic Syndrome in Adults: A Meta-Analysis.","authors":"Taiana Lemos Camargo, Viviane Locatelli Rupolo, Mileni Vanti Beretta, Anderson Garcez","doi":"10.1089/met.2024.0194","DOIUrl":"10.1089/met.2024.0194","url":null,"abstract":"<p><p><b><i>Background:</i></b> Household food insecurity (HFI) refers to the lack of access to safe and nutritious food, and this condition may be associated with the occurrence of metabolic syndrome (MetS). Thus, this study aimed to conduct a quantitative synthesis (meta-analysis) to summarize the evidence from epidemiological studies on the association between HFI and MetS. <b><i>Methods:</i></b> A systematic search was conducted in the PubMed, Embase, Web of Science, and Latin American and Caribbean Health Sciences Information Center databases to retrieve epidemiological studies published until October 2023. The entire process of selection, data extraction, and assessment of article quality was independently performed by two reviewers. The quality of the studies was evaluated using the criteria proposed by the National Institutes of Health instrument. The random-effects model was used to report the quantitative synthesis of combined data. The <i>Q</i>-test and <i>I</i>² index were used to assess heterogeneity. Egger's and Begg's tests were employed to evaluate publication bias. <b><i>Results:</i></b> A total of 10 articles meeting the eligibility criteria were selected and included in this meta-analysis. High heterogeneity was observed among the studies (<i>I</i>² > 70), along with a low risk of publication bias. Considering all ten included studies, no statistically significant association was found between HFI and MetS (odds ratio = 1.17; 95% confidence interval: 0.89-1.55; <i>I</i>² = 79.9%). <b><i>Conclusions:</i></b> The findings of this meta-analysis did not reveal a statistically significant association between HFI and MetS, indicating the need for further studies aimed at exploring and expanding the scientific evidence on this relationship.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"175-185"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Laboratory-Measured Euthyroid Hashimoto's Thyroiditis on Reproductive Hormone Profile in Women with Obesity.","authors":"Feray Akbas, Zeynep Banu Teke, Vahit Can Cavdar, Hasan Zerdali","doi":"10.1089/met.2024.0181","DOIUrl":"10.1089/met.2024.0181","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Hashimoto's thyroiditis is a common endocrinological disorder that often coexists with obesity. Thyroid hormones interact with the regulation of sex steroids, and thyroid autoimmunity has a negative impact on female fertility. There are studies showing when euthyroid state is achieved with hormone replacement therapy (HRT), the reproductive hormone profile is improved but they usually compare the reproductive hormones before and after HRT in the same individuals. Studies comparing patients with Hashimoto's thyroiditis in an euthyroid state receiving HRT with individuals having normal thyroid function are limited. Here, it was aimed to search the impact of euthyroid Hashimoto's thyroiditis on reproductive hormone profile in women living with obesity. <b><i>Materials and Methods:</i></b> Sixty-one randomly selected female patients with Hashimoto's thyroiditis were included as the case group and 60 patients without Hashimoto's thyroiditis were included as the control group, from our obesity center. The case group included patients who had menstrual cycles and were euthyroid under l-thyroxine treatment for at least 6 months. Data on weight, height, body mass index (BMI), waist circumference (WC), free thyroxine (fT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibody (anti-TPO), cortisol, insulin, prolactin (PRL), follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E₂), progesterone (prog), testosterone (T), and dehydroepiandrosterone sulfate (DHEAS) levels, l-thyroxine treatment dosage (for case group), and accompanying diseases were recorded. The results were evaluated using SPSS. <b><i>Results:</i></b> A total of 121 patients were included in the study. Mean age was 41.8 ± 8.5 years in case and 38.6 ± 8.9 years in control group. There was no significant difference in weight, height, BMI, WC, or accompanying diseases between Hashimoto's thyroiditis and control group. fT4, anti-TPO, cortisol levels were higher in Hashimoto's thyroiditis group when compared with control group, but there was no significant difference for TSH, insulin, FSH, LH, E₂, prog, T, DHEAS, or PRL. <b><i>Conclusion:</i></b> In women living with obesity, it is important to screen for Hashimoto's thyroiditis and achieve euthyroidism through effective LT4 treatment to promote a healthy reproductive system and improve fertility rates.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"211-216"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipid Accumulation Product Outperforms BMI and Waist Circumference in Metabolic Disorders.","authors":"Doha Elsayed, Mohammed Al-Kuwari, Janatul Naeim, Ali Al-Marri, Noof Al-Thani, Haya Al-Mohannadi, Haya Al-Suliati, Amna Al-Ali, Suhail A Doi","doi":"10.1089/met.2024.0198","DOIUrl":"10.1089/met.2024.0198","url":null,"abstract":"<p><p><b><i>Background and Objective:</i></b> Obesity is a global health issue intricately linked to metabolic syndrome (MetS), insulin resistance, and dyslipidemia. Anthropometric indices, particularly those measuring central obesity, have emerged as more reliable predictors of these metabolic disorders than general obesity indices such as body mass index (BMI). However, the relative predictive power of these indices remains debated, particularly across sexes. This study aimed to evaluate the discriminative performance of various anthropometric measures, including lipid accumulation product (LAP), BMI, waist circumference (WC), and visceral adiposity index (VAI), in predicting insulin sensitivity, β-cell function, MetS, and dyslipidemia using National Health and Nutritional Evaluation Survey III (NHANES III) data. <b><i>Methods:</i></b> A cross-sectional analysis of 3,706 adults from the NHANES III database was conducted. Anthropometric indices were compared against insulin sensitivity Homeostasis Model Assessment (HOMA)-S, β-cell function (HOMA-B), metabolic syndrome (MetS) status, and dyslipidemia. Receiver-operating characteristic (ROC) curves and linear regression models were used to identify thresholds for predicting metabolic abnormalities. <b><i>Results:</i></b> LAP emerged as the most discriminative index across all outcomes, outperforming BMI and WC, particularly in predicting insulin sensitivity and β-cell function in males. In females, BMI was superior in predicting β-cell function. VAI demonstrated the strongest association with dyslipidemia but was less effective in predicting insulin resistance. <b><i>Conclusion:</i></b> LAP significantly outperforms conventional anthropometric indices in identifying insulin resistance and MetS, highlighting its potential as a screening tool for cardiometabolic risk. Gender differences in the predictive abilities of these measures suggest that BMI may retain value in assessing β-cell function in females. VAI should be considered when screening for dyslipidemia but is less effective for insulin resistance.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"166-174"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Dietary Vitamin C Intake with the Risk of Metabolic Syndrome Among Adults: NHANES 2007-2018.","authors":"Xinyi Yu, Jian Zhu, Zhaonv Xu","doi":"10.1089/met.2024.0149","DOIUrl":"10.1089/met.2024.0149","url":null,"abstract":"<p><p><b><i>Objectives:</i></b> There has been discussion over the association between vitamin C intake and the risk of metabolic syndrome (MetS). This study examined the relationship between dietary vitamin C intake and the risk of MetS in a sizable adult American population. <b><i>Methods:</i></b> We examined the relationship between dietary vitamin C intake and the risk of MetS in 12,943 persons from the 2007 to 2018 National Health and Nutrition Examination Survey (NHANES). This association was then evaluated using logistic regression and restricted cubic spline models. Sex and age-based subgroup analyses were carried out. <b><i>Results:</i></b> According to the results of the multiple regression model, the risk of MetS was inversely correlated with dietary vitamin C intake, vitamin C intake derived from fruits and vegetables. The adjusted results (odds ratios with 95% confidence intervals) for the highest versus lowest tertile were 0.80 (0.68-0.93), 0.86 (0.75-0.98), and 0.80 (0.69-0.93). Subgroup analyses further showed that the negative correlation of dietary vitamin C intake with the risk of MetS was particularly pronounced among females, those in the 20-39 age group, and those in the ≥60 age group. The dose-response relationship's findings indicated that vitamin C from diet and fruits had a nonlinear correlation with the risk of MetS, whereas vitamin C from vegetables had a linear correlation. <b><i>Conclusions:</i></b> The risk of MetS in adult Americans was found to be negatively correlated with dietary vitamin C intake, particularly from fruits and vegetables.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"146-154"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confusion Concerning the Calculation of the Triglyceride-Glucose Index: An Urgent Need for Clarity.","authors":"Ishwarlal Jialal","doi":"10.1089/met.2024.0193","DOIUrl":"10.1089/met.2024.0193","url":null,"abstract":"","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"135-136"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}