Metabolic syndrome and related disorders最新文献

{"title":"Uric Acid and Grip Strength as Predictors of Mortality in Older Adults: A Sex-Stratified Analysis.","authors":"Neslihan Doğan, Sibel Akın, Gökmen Zararsız, Serra İlayda Yerlitaş Taştan","doi":"10.1177/15578518261488223","DOIUrl":"https://doi.org/10.1177/15578518261488223","url":null,"abstract":"<p><strong>Background and aim: </strong>Sarcopenia and hyperuricemia correlate with negative outcomes in older adults, including increased mortality. While diminished muscle strength predicts functional deterioration and mortality, elevated serum uric acid's prognostic value remains controversial. This study investigated individual and combined effects of reduced handgrip strength and hyperuricemia on all-cause mortality, focusing on sex-specific differences.</p><p><strong>Methods and results: </strong>This retrospective cohort study evaluated 910 individuals aged ≥60 years between 2020 and 2024 at a university hospital. Participants with confounding conditions or interfering medications were excluded. Uric acid (UA) was quantified enzymatically and classified into quartiles. Sarcopenia was defined using EWGSOP2 criteria, including handgrip strength and skeletal muscle mass index from bioelectrical impedance analysis. Cox regression and Kaplan-Meier analyses assessed mortality risk. The mean age was 71 years, with 66.9% of participants being female. Reduced handgrip strength and elevated UA levels were correlated with detrimental metabolic indicators. Univariate analysis indicated that both low handgrip strength (hazard ratio [HR]: 1.91, 95% confidence interval [CI]: 1.15-3.18) and the highest quartile of UA levels (HR: 1.86, 95% CI: 1.13-3.08) were significant predictors of mortality. Nevertheless, these correlations diminished following multivariable correction. Sex-stratified studies indicated that hyperuricemia persisted as an independent predictor of mortality in females (HR: 3.08, 95% CI: 1.31-7.26, <i>P</i> = 0.010).</p><p><strong>Conclusions: </strong>Both diminished grip strength and elevated UA levels are associated with increased mortality in older adults, particularly among females. Routine incorporation of sex-specific metabolic and physical performance assessments may enhance risk stratification strategies in geriatric populations.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261488223"},"PeriodicalIF":1.6,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patatin-Like Phospholipase Domain-Containing Protein 3 rs2896019 and MASLD Susceptibility and Severity in Adults: A Systematic Review and Meta-Analysis of Case-Control Studies.","authors":"Wei-Yue Lim, Rosmawati Mohamed, Yuh-Fen Pung, Hak-Keith Leung, Rong-Xiang Ng, Shamsul Mohd Zain","doi":"10.1177/15578518261443934","DOIUrl":"10.1177/15578518261443934","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of global liver morbidity. Genetic variants, particularly in the patatin-like phospholipase domain-containing 3 (<i>PNPLA3</i>) gene, are critical determinants of metabolic traits and disease progression. This study presents the first meta-analysis to clarify the association between the <i>PNPLA3</i> rs2896019 polymorphism and MASLD susceptibility and severity. We systematically searched PubMed, Embase, Web of Science, and Google Scholar for relevant articles published up to February 12, 2026. Data were extracted, and summary estimates of the association between <i>PNPLA3</i> rs2896019 and MASLD were assessed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the effect. Ten eligible case-control cohorts involving 15,028 participants (3118 cases and 11,910 controls) were included. Our results demonstrated that the G allele is significantly associated with a 51% increased risk of MASLD (OR: 1.5, CI: 1.23-1.85, <i>P</i> < 0.0001). A clear gene-dose effect was observed, with risks escalating in the homozygous model (OR: 2.32, 95% CI: 1.53-3.53, <i>P</i> < 0.0001). Subgroup analysis revealed that diagnostic modality was the primary source of heterogeneity, whereby restricting the analysis to biopsy-proven cohorts eliminated heterogeneity (<i>I² =</i> 0%) and strengthened the association (OR = 1.91). Furthermore, the G allele significantly increased the risk of severe MASLD/MASH (OR = 2.06) compared to mild steatosis (OR = 1.40). In conclusion, the <i>PNPLA3</i> rs2896019 G allele is a robust, dose-dependent risk factor for both the development and severe progression of MASLD.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"285-293"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can the Diagnosis of Metabolic Syndrome and the Severity of the Disease Be Determined with the Help of Inflammatory Biomarkers?","authors":"Hilal Bektaş Uysal, Hüseyin Bayğın, Elif Duygu Topan, Mustafa Yılmaz","doi":"10.1177/15578518261443921","DOIUrl":"10.1177/15578518261443921","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic syndrome (MetS) is a growing public health problem characterized by clustering of cardiometabolic risk factors and a chronic low-grade inflammatory state. Biomarkers such as Fetuin-A, YKL-40, and high-sensitivity C-reactive protein (hsCRP) have been implicated in insulin resistance, obesity, and atherosclerosis. Identifying accessible and cost-effective biomarkers that reflect the presence and severity of MetS may provide clinically relevant insight into metabolic burden. Therefore, this study aimed to evaluate whether inflammatory biomarkers are associated with the presence and dynamic severity of MetS.</p><p><strong>Methods: </strong>Forty-seven patients diagnosed with MetS according to National Cholesterol Education Program Adult Treatment Panel III criteria (≥3 components) and 23 healthy controls were included. Serum hsCRP, Fetuin-A, and YKL-40 levels were measured at baseline and after a 3-month follow-up. No pharmacological treatment was initiated; participants received standardized lifestyle modification advice. Associations between biomarker levels and MetS severity scores (range 3-5) were assessed using correlation analyses.</p><p><strong>Results: </strong>Baseline serum Fetuin-A, YKL-40, and hsCRP levels were significantly higher in patients with MetS compared to controls (all <i>P</i> < 0.001). During follow-up, changes in MetS severity were positively correlated with changes in hsCRP (r = 0.844, <i>P</i> < 0.001), Fetuin-A (r = 0.918, <i>P</i> < 0.001), and YKL-40 (r = 0.913, <i>P</i> < 0.001). Sensitivity analysis using Kendall's tau-b confirmed robust monotonic associations (τ = 0.716-0.808, all <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>Fetuin-A and YKL-40 levels are strongly associated with both the presence and short-term changes in MetS severity. hsCRP appears to reflect longitudinal changes in metabolic burden. These findings suggest that selected inflammatory biomarkers may provide additional insight into the inflammatory and metabolic dynamics of MetS.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"311-317"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147699047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Associations of Android and Gynoid Adiposity with Prediabetes Among U.S. Adults: A Cross-Sectional Analysis of National Health and Nutrition Examination Survey 2011-2016.","authors":"Zihao Shi, Qiao Xu, Renjie Yin, Qunyan Zhou, Chunhua Wu","doi":"10.1177/15578518261446293","DOIUrl":"10.1177/15578518261446293","url":null,"abstract":"<p><strong>Objective: </strong>To investigate sex-specific associations between depot-specific adipose tissue distribution and prediabetes among U.S. adults.</p><p><strong>Methods: </strong>This cross-sectional analysis included 2993 adults from the 2011-2016 National Health and Nutrition Examination Survey. Android and gynoid fat percentages were measured using dual-energy X-ray absorptiometry. Sex-stratified multivariable logistic regression models were employed to assess these associations, adjusting for demographic, lifestyle, and metabolic covariates.</p><p><strong>Results: </strong>Individuals with prediabetes had significantly higher android and gynoid fat percentages than normoglycemic controls in both sexes. After full adjustment, higher android fat was consistently associated with increased odds of prediabetes in both men [odds ratio (OR) = 1.044, 95% confidence interval (CI): 1.013-1.077] and women (OR = 1.052, 95% CI: 1.023-1.083). In contrast, higher gynoid fat was associated with reduced odds of prediabetes in women only (OR = 0.940, 95% CI: 0.910-0.972), with no significant association observed in men (OR = 0.965, 95% CI: 0.930-1.001).</p><p><strong>Conclusions: </strong>The association between regional adiposity and prediabetes is fundamentally modified by sex. While android fat is a uniform risk factor, gynoid fat appears to be protective, specifically in women. These findings underscore the necessity of sex-specific assessment of body fat distribution for early cardiometabolic risk stratification.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"326-334"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancies Affected by Diabetes in Teenagers and Emerging Adults: A Population-Based Study.","authors":"Hannah E Christie, Anaelle Zimmowitch, Sneha Mohan, Leidy Plaza-Enriquez, Karina A Pone, Kylie Cooper, Adrian Vella, Ana L Creo, Aoife M Egan","doi":"10.1177/15578518261445043","DOIUrl":"10.1177/15578518261445043","url":null,"abstract":"<p><strong>Background: </strong>Pregnancy in teenagers and emerging adults is associated with an increased risk of adverse outcomes. Similarly, pregnancies complicated by pregestational and gestational diabetes mellitus (GDM) carry a higher risk of complications. However, limited data exist on the intersection of these two high-risk conditions. Our objective was to establish the prevalence of teenage and emerging adult pregnancies complicated by diabetes in a population-based cohort and compare outcomes to pregnancies uncomplicated by diabetes, noting a background prevalence of GDM of 8.1% and pregestational diabetes of 1.2% across all age groups in the United States.</p><p><strong>Methods: </strong>This is a retrospective cohort study conducted in Olmsted County, Minnesota, USA. It includes female residents aged ≤21 years with a pregnancy ICD-10 code between January 1, 2013, and December 31, 2022. The main outcome measures assessed include maternal characteristics and maternal and fetal pregnancy outcomes.</p><p><strong>Results: </strong>A total of 1491 pregnancies in 1379 individuals were identified and included. In total, 68 (4.6%) pregnancies were complicated by diabetes: 51 (3.4%) with GDM and 17 (1.1%) with pregestational diabetes. In this study, pregnancies with diabetes had higher rates of adverse outcomes including cesarean delivery (GDM 29.4% vs. pregestational 60.0% vs. no diabetes 17.0%, <i>P</i> < 0.001), preeclampsia (GDM 15.7% vs. pregestational 40.0% vs. no diabetes 7.3%, <i>P</i> < 0.001), large-for-gestational-age neonates (GDM 13.7% vs. pre-existing 50.0% vs. no diabetes 5.8%, <i>P</i> < 0.001), and neonatal hypoglycemia (GDM 42.6% vs. pregestational 60.0% vs. no diabetes 13.3%, <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>The prevalence of pregestational diabetes in our teenage and emerging adult population is similar to that of the general pregnancy population; however, the prevalence of GDM is significantly lower. Overall, diabetes in teenage pregnancy is associated with an elevated risk of adverse maternal and neonatal outcomes. Future research should evaluate interventions aimed at reducing adverse pregnancy outcomes in this vulnerable population.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"304-310"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual and Neurological Outcomes Following Glucagon-Like Peptide-1 Receptor Agonist Therapy and Bariatric Surgery in Idiopathic Intracranial Hypertension: A Network Meta-Analysis.","authors":"Somkiat Phutinart, Noppachai Siranart, Patavee Pajareya, Watsapon Chuanchai, Abhishet Varama, Prakit Anukoolwittaya, Sekh Thanprasertsuk, Gavin W Roddy","doi":"10.1177/15578518261442833","DOIUrl":"10.1177/15578518261442833","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) is commonly linked to obesity. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and bariatric surgery may improve outcomes beyond conventional therapy, but comparative evidence is limited.</p><p><strong>Methods: </strong>We systematically searched MEDLINE, EMBASE, and Cochrane from inception until June 2025. Eligible randomized and observational studies compared GLP-1RAs or bariatric surgery (each plus conventional care) against conventional management. Primary outcomes were the change in papilledema, visual acuity, and visual field. Secondary outcomes included body mass index (BMI), retinal nerve fiber layer (RNFL) thickness, monthly headache days, and risks of papilledema, visual disturbance, and headache. Pairwise random-effects meta-analyses and frequentist network meta-analysis (<i>P</i>-scores) were performed.</p><p><strong>Results: </strong>Out of 429 records, 8 studies were included. Versus conventional therapy, GLP-1RAs reduced BMI (mean difference -1.55 kg/m²; 95% confidence interval [CI]: -2.13 to -0.97) and lowered risks of papilledema (relative risk [RR]: 0.47; 95% CI: 0.34-0.65), visual disturbance (RR: 0.48; 95% CI: 0.24-0.98), and headache (RR: 0.78; 95% CI: 0.69-0.88). Changes in papilledema severity and RNFL thickness were not different; visual acuity favored GLP-1RAs at the end of follow-up, whereas visual field values were worse at some time points. In indirect comparisons with bariatric surgery, no significant differences were detected across outcomes.</p><p><strong>Conclusions: </strong>Adjunctive GLP-1RA therapy may be associated with weight loss and improved clinical/ophthalmic outcomes in IIH relative to conventional care, with a signal for worse visual fields at certain time points. Indirect comparisons suggest comparable efficacy to bariatric surgery. High-quality randomized trials are needed to define comparative effectiveness, safety, and optimal use.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"294-303"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Proenkephalin A as a Marker of Renal Dysfunction and Glycemic Status in Diabetic Nephropathy.","authors":"Feride Sevilmiş, Hanife Usta Atmaca, Çiğdem Usul Afşar, Hatice Özkul, Zahide Adiyaman, Mahmut Başar Aykent, Özlem Yilmaz","doi":"10.1177/15578518261444701","DOIUrl":"10.1177/15578518261444701","url":null,"abstract":"<p><strong>Introduction: </strong>Traditional biomarkers like creatinine and estimated glomerular filtration rate (eGFR) often fail to detect early diabetic nephropathy. Proenkephalin A (PENK-A), a stable, kidney-specific peptide, has emerged as a potential alternative biomarker. This study aimed to evaluate serum PENK-A levels in diabetic nephropathy and their association with renal and clinical parameters.</p><p><strong>Methods: </strong>In this prospective cross-sectional study, PENK-A levels were compared between patients with type 2 diabetes and healthy controls. Biochemical variables were assessed, and receiver operating characteristic (ROC) analysis was used to determine diagnostic performance. Binary logistic regression was conducted to identify independent predictors of elevated PENK-A levels.</p><p><strong>Results: </strong>A total of 120 participants (90 patients, 30 controls) were included. PENK-A levels were significantly higher in patients and correlated with lower eGFR, higher urea, and microalbuminuria. At a cut-off value of 2.25 pmol/L, PENK-A demonstrated moderate diagnostic accuracy (AUC = 0.702, <i>p</i> = 0.001), with high specificity (83.3%) and positive predictive value (90.6%). Logistic regression revealed an independent inverse association between PENK-A and HbA1c, while eGFR showed a borderline relationship.</p><p><strong>Conclusion: </strong>Serum PENK-A may serve as a supportive biomarker for renal dysfunction in diabetic nephropathy. Its relationship with HbA1c suggests possible links to metabolic stress. PENK-A could complement traditional markers, particularly in early detection or high-risk patients. Further longitudinal studies are warranted to confirm its prognostic value.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"318-325"},"PeriodicalIF":1.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Cardiac Autonomic Function Directly in GLP-1 Receptor Agonist Users: Heart Rate Variability Beyond Composite Allostatic Load.","authors":"Ogulcan Ozdemir","doi":"10.1177/15578518261481089","DOIUrl":"https://doi.org/10.1177/15578518261481089","url":null,"abstract":"","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"15578518261481089"},"PeriodicalIF":1.6,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Cognitive Function and Micronutrient Levels in Non-Geriatric Patients with Type 2 Diabetes Mellitus.","authors":"Emre Cem Gokce, Feray Akbas, Tugce Acar","doi":"10.1177/15578518261454615","DOIUrl":"10.1177/15578518261454615","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM) is a globally growing chronic disease and is associated with numerous complications. In recent years, its potential impact on cognitive functions has gained increasing attention. This study was conducted to investigate the relationship between cognitive performance and micronutrient status in non-geriatric individuals with type 2 DM (T2DM).</p><p><strong>Material and methods: </strong>This case-control study included 120 patients with T2DM aged 18-65 years. Patients with cognitive impairment constituted the case group, while age-matched patients without cognitive impairment served as controls, based on Montreal Cognitive Assessment scores. Individuals with malabsorption syndromes, severe acute or chronic illnesses, prior gastrointestinal surgery, dementia, Parkinson's disease, cerebrovascular events, psychiatric disorders, use of cognition-affecting medications, or micronutrient supplementation were excluded. Fasting blood glucose (FBG), HbA1c, renal and liver function tests, total protein, albumin, iron, zinc, magnesium, calcium, vitamin B12, folate, and vitamins A, C, D, and E were measured and compared between groups.</p><p><strong>Results: </strong>75 females and 45 males, a total of 120 patients were included in the study. The mean age was 53.0 ± 8.4 years. Cognitive dysfunction was present in 50% of the patients. There were no statistically significant differences in the levels of FBG, HbA1c, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein, folic acid, vitamin A, vitamin C, vitamin E according to age, gender, and cognitive dysfunction variables. Albumin, iron, zinc, magnesium, calcium, vitamin B12, vitamin D levels were significantly lower in the group with cognitive dysfunction than in the group without cognitive dysfunction. Albumin, iron, zinc, magnesium, calcium, vitamin B12, vitamin D levels in univariate model and iron, magnesium, calcium, vitamin B12 levels in multivariate model were effective in differentiating patients with and without cognitive dysfunction.</p><p><strong>Conclusion: </strong>This study shows that there is a significant relationship between cognitive functions and micronutrient levels in non-geriatric patients with DM. Screening of micronutrient levels and appropriate replacement of deficiencies during diabetes management is important for the protection and improvement of cognitive functions.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"250-257"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148032564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociation Between Hepatic Steatosis and Paraspinal Myosteatosis on Quantitative MRI.","authors":"Betul Akdal Dolek, Eda Sener, Berkan Alcin","doi":"10.1177/15578518261436372","DOIUrl":"10.1177/15578518261436372","url":null,"abstract":"<p><strong>Background: </strong>Hepatic steatosis and skeletal muscle fat infiltration represent key features of metabolic dysfunction, yet their interrelationship remains poorly defined. Paraspinal muscles are routinely visualized during abdominal MRI, offering an accessible site for quantifying myosteatosis using proton density fat fraction (PDFF).</p><p><strong>Objectives: </strong>To identify metabolic determinants of hepatic and paraspinal muscle PDFF and assess whether paraspinal myosteatosis provides independent diagnostic value for diabetes mellitus.</p><p><strong>Methods: </strong>In this retrospective study, 266 adults who underwent abdominal MRI with quantitative fat mapping were evaluated. Hepatic and paraspinal PDFF were measured using MRI-PDFF, and metabolic associations were analyzed using correlation, regression, and logistic models. ROC curves assessed whether paraspinal PDFF improved diabetes discrimination beyond age, sex, body mass index (BMI), and hepatic PDFF.</p><p><strong>Results: </strong>Hepatic PDFF correlated strongly with BMI (<i>r</i> = 0.46) and ALT (<i>r</i> = 0.29), while showing no association with paraspinal PDFF (<i>r</i> = 0.01). Paraspinal PDFF was higher in diabetes (14.0% vs. 10.6%) but was not an independent predictor after adjusting for age, sex, BMI, and hepatic PDFF. Adding hepatic PDFF minimally improved diabetes prediction (AUC = 0.794→0.799), and paraspinal PDFF offered no additional improvement. An exploratory threshold of 11.8% paraspinal PDFF yielded moderate sensitivity (63%) and specificity (70%).</p><p><strong>Conclusions: </strong>Hepatic steatosis and paraspinal myosteatosis are metabolically distinct ectopic fat depots. Although paraspinal fat is elevated in diabetes, it does not enhance metabolic risk prediction beyond BMI. These findings support organ-specific lipid pathways and highlight the need for longitudinal and volumetric analyses to clarify their independent clinical roles.</p>","PeriodicalId":18405,"journal":{"name":"Metabolic syndrome and related disorders","volume":" ","pages":"243-249"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}