Medical Journal of the Islamic Republic of Iran最新文献

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Creatine Kinase as a Predictor of Disease Severity in Children with COVID-19. 肌酸激酶作为COVID-19儿童疾病严重程度的预测因子
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.20
Alireza Nateghian, Marzieh Nojomi, Mahshid Roohravan Benis, Tayebeh Heidarpour
{"title":"Creatine Kinase as a Predictor of Disease Severity in Children with COVID-19.","authors":"Alireza Nateghian, Marzieh Nojomi, Mahshid Roohravan Benis, Tayebeh Heidarpour","doi":"10.47176/mjiri.39.20","DOIUrl":"10.47176/mjiri.39.20","url":null,"abstract":"<p><strong>Background: </strong>The majority of children with COVID-19 infection experience asymptomatic or mild disease, but some of them are at risk of developing severe illness. Determination of predictors of severe disease can help to prevent this form of disease in children. The aim of the current study was to determine the predictors of disease severity of COVID-19 infection based on laboratory markers and underlying conditions in children.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Iran from May 2021 to March 2022. Thirty hundred and seventeen children under 18 years old with positive tests or pulmonary manifestations of COVID-19 referred to a teaching hospital in Tehran were included in the study. Demographic, laboratory, and clinical parameters of included children were measured. The participants were classified into three severity groups based on a severity-scoring protocol. Data was analyzed using SPSS software with chi-square, analysis of variance (ANOVA) tests, and linear generalized model. Statistical significance was considered at 0.05.</p><p><strong>Results: </strong>Among 317 children, 186 patients (58.7%) were male. The mean age of the participants was 4.75 ± 4.47 years old. Examination of clinical factors showed cough (64%), Malaise (57.7%), and Tachypnea (35.3%) were the most frequent findings among the subjects. Employing the severity scoring protocol, most patients (69.1%) were classified into the mild group. There was a significant relationship between the severity of COVID-19 and the level of Hemoglobin, Aspartate Transaminase (AST), Alanine Transaminase (ALT), C-reactive protein (CRP), Lactate Dehydrogenase (LDH), Creatine Kinase (CK), D-dimer, Ferritin, and Fibrinogen (<i>P</i><0.001). Creatine Kinase was found to be a predictor of COVID-19 severity in adjusted model. All underlying conditions, except asthma, were significantly associated with disease severity.</p><p><strong>Conclusion: </strong>In our study, it was determined that CK could be considered a predictor of the severity of COVID-19 in children. These results suggest that integrating CK assessment into routine clinical protocols may aid healthcare providers in timely risk stratification and personalized patient care approaches.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"20"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Intraoperative Dexmedetomidine Infusion on Postoperative Delirium Prevention in Intensive Care Unit Patients after Esophagectomy: A Randomized Double-Blind Clinical Trial. 术中输注右美托咪定对重症监护病房患者食管切除术后谵妄预防的影响:一项随机双盲临床试验。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-02-03 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.19
Hassan Mohammadipour Anvari, Hossein Shiri, Saeid Charsouei, Nima Ashrafi, Mansour Rezaei
{"title":"The Impact of Intraoperative Dexmedetomidine Infusion on Postoperative Delirium Prevention in Intensive Care Unit Patients after Esophagectomy: A Randomized Double-Blind Clinical Trial.","authors":"Hassan Mohammadipour Anvari, Hossein Shiri, Saeid Charsouei, Nima Ashrafi, Mansour Rezaei","doi":"10.47176/mjiri.39.19","DOIUrl":"10.47176/mjiri.39.19","url":null,"abstract":"<p><strong>Background: </strong>Delirium is a significant issue for esophagectomy patients, with dexmedetomidine (Dex) showing promise in alleviating this burden. A randomized trial on Dex's role in post-esophagectomy delirium can enhance care strategies and patient outcomes.</p><p><strong>Methods: </strong>This randomized, double-blind clinical trial, conducted at Imam Reza Hospital, Tabriz University of Medical Sciences, in Iran in 2022, involved 60 esophagectomy patients. The intervention group received Dex infusion (0.5 μg/kg/h), while the control group received normal saline. Postoperatively, patients received analgesia and were monitored for delirium incidence over 3 days in the intensive care unit (ICU) using the Confusion Assessment Method. This study utilized an independent-sample t test, the Mann-Whitney U test, the χ2 test, and the Kaplan-Meier survival analysis with a log-rank test for data comparisons.</p><p><strong>Results: </strong>Delirium in the ICU over 3 days after surgery was significantly lower in the intervention group (10%, n=3) compared with the control group (20%, n=6) (relative risk, 0.62 [95% CI, 0.42-0.98]; <i>P</i>=0.036). On the first day, no delirium cases occurred in the intervention group, contrasting with 2 cases in the control group (<i>P</i>=0.014). Similarly, on the second day, one case was observed in the intervention group versus 2 in the control group (<i>P</i>=0.042). On the third day, 2 cases were recorded in the intervention group versus 3 in the control group (<i>P</i>=0.031).</p><p><strong>Conclusion: </strong>The significant reduction in delirium occurrence observed in patients receiving intraoperative Dex infusion highlights its potential as a preventive strategy for postoperative delirium in ICU patients after esophagectomy.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the Gap: Scenario Planning for Science and Technology in Breast Cancer. 弥合差距:乳腺癌科学和技术的情景规划。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-02-01 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.18
Homa Arshadi, Mostafa Hosseini Golkar, Zohreh Zahedi, Maryam Ashrafi, Maryam Okhovati
{"title":"Bridging the Gap: Scenario Planning for Science and Technology in Breast Cancer.","authors":"Homa Arshadi, Mostafa Hosseini Golkar, Zohreh Zahedi, Maryam Ashrafi, Maryam Okhovati","doi":"10.47176/mjiri.39.18","DOIUrl":"10.47176/mjiri.39.18","url":null,"abstract":"<p><strong>Background: </strong>The convergence of scientific research and technological breakthroughs is critical to societal health. However, both academic literature and patents can grow at separate rates, leading to gaps in fields like breast cancer. This study aims to identify and bridge the gap between science and technology in breast cancer research through scenario planning.</p><p><strong>Methods: </strong>This research is a foresight study conducted using the scenario technique method. A total of 191,871 papers and 9085 patents on breast cancer, published between 2012 and 2021, were analyzed using data from the Web of Science Core Collection and PATSTAT databases. Text mining was conducted using the Latent Dirichlet Allocation (LDA) topic modeling technique with Python libraries to identify subject clusters and areas of asynchrony. The scenario technique was then developed, aimed at bridging the gap between science and technology.</p><p><strong>Results: </strong>Our findings revealed that scientific output in breast cancer has greatly surpassed technical advancements, indicating gaps in several key domains. Scientific papers in our dataset, mostly concentrated on the complexities of breast cancer-including genetic mutations, hormone receptors, dietary factors, and environmental influences-whereas the analyzed patents frequently addressed lesser-known areas such as herbal medicine, medical devices, protective clothing, and micro ribonucleic acid therapies. To fill these gaps, 4 scenarios were created and, some effective actions for each scenario were recommended.</p><p><strong>Conclusion: </strong>Different priorities emerged across the 16 proposed actions for the 3 specific scenarios-excluding the favorable scenario. In all scenarios, enhancing stakeholder ties, establishing cooperative networks, and developing collaborative incentive systems were identified as key strategies for diminishing the gap between science and technology in breast cancer.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"18"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-Effectiveness Analysis of Mechanical and Pharmaceutical Methods of Labor Induction in Pregnant Women in Iran. 伊朗孕妇机械引产与药物引产的成本-效果分析
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-29 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.17
Ameneh Ameri, Zahra JafariAzar, Majid Annabi, Majid Davari
{"title":"Cost-Effectiveness Analysis of Mechanical and Pharmaceutical Methods of Labor Induction in Pregnant Women in Iran.","authors":"Ameneh Ameri, Zahra JafariAzar, Majid Annabi, Majid Davari","doi":"10.47176/mjiri.39.17","DOIUrl":"10.47176/mjiri.39.17","url":null,"abstract":"<p><strong>Background: </strong>Prescribing medication, employing mechanical interventions, and utilizing complementary methods are common practices for inducing labor. This study aimed to evaluate the cost-effectiveness of various labor induction methods in Iran.</p><p><strong>Methods: </strong>A comprehensive economic evaluation was conducted through cost-effectiveness analysis from the perspective of Iran's health system. This study assessed misoprostol, oxytocin, and the use of a catheter. A decision analysis model, specifically a decision tree, was developed to facilitate this cost-effectiveness analysis. Data on cost variables were sourced from patient bills, medical records, treatment guidelines, government tariffs, and official drug prices. The primary outcome measured was quality-adjusted life years (QALYs), analyzed via the incremental cost-effectiveness ratio (ICER). Both deterministic and probabilistic sensitivity analyses were conducted to address the uncertainty in model parameters. Tree Age 2020 software was utilized for analyzing various stages.</p><p><strong>Results: </strong>The catheter intervention was less costly 75,565,520 Rials(1,171 US$), with greater effectiveness, (0.628) compared with the other methods. The calculations of the net monetary benefit (NMB) for the strategies demonstrated that the catheter intervention, with a value of 364,374,089 Rials (5,646 US$), represented the highest monetary value in this comparison. Conversely, probabilistic sensitivity analysis, employing Monte Carlo simulation, demonstrated that in 1000 iterations, the catheter treatment method emerged as the optimal intervention with an 87% probability, while misoprostol was optimal with a 5% probability.</p><p><strong>Conclusion: </strong>Our economic evaluation revealed that the mechanical catheter method emerged as the dominant and cost-effective strategy compared with other methods.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Herbal Bioactive Compounds on the Angiogenic Factors and Modulation of Inflammatory Mediators in the Patients with the Deep Second-Degree Burn: A Single-Blinded, Randomized Clinical Trial. 中药生物活性化合物对深二度烧伤患者血管生成因子和炎症介质调节的影响:一项单盲随机临床试验
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-28 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.16
Mahdi Heydari, Seyyed Mohsen Seyyedkazemi, Mohammad Taghi Joghataei, Fereshteh Mehraein Ghomi, Hoorieh Mohammadi Kenari, Nader Sadigh, Auob Rustamzadeh, Mehrdad Bakhtiari, Hamidreza Alizadeh-Otaghvar
{"title":"Effect of Herbal Bioactive Compounds on the Angiogenic Factors and Modulation of Inflammatory Mediators in the Patients with the Deep Second-Degree Burn: A Single-Blinded, Randomized Clinical Trial.","authors":"Mahdi Heydari, Seyyed Mohsen Seyyedkazemi, Mohammad Taghi Joghataei, Fereshteh Mehraein Ghomi, Hoorieh Mohammadi Kenari, Nader Sadigh, Auob Rustamzadeh, Mehrdad Bakhtiari, Hamidreza Alizadeh-Otaghvar","doi":"10.47176/mjiri.39.16","DOIUrl":"10.47176/mjiri.39.16","url":null,"abstract":"<p><strong>Background: </strong>Inflammation is the first response to tissue damage. A hematoma occurs when blood leaves the damaged vessels, and platelets play an important role in this process. This study aimed to investigate the effect of herbal bioactive compounds on the angiogenic factors and modulation of inflammatory mediators in deep second-degree burn patients.</p><p><strong>Methods: </strong>In a randomized clinical trial, 54 patients were divided into two groups :Swalin ointment (n=31) and silver sulfadiazine (SSD) (n=23). Ointments were administered every other day for 28 days. The concentration of compounds in ointment oils was measured using the GC-MS technique. Serum levels of TNF-α and IL-6 were measured on days 3, 7, and 14, and tissue levels of VEGF, FGF, and PDGF variables were measured on day 14 by ELISA method. Student t-test was used to compare the mean in 2 groups, depending on the type of normal/abnormal distribution. The chi-square test was also used to check the relationship between qualitative variables.</p><p><strong>Results: </strong>The most common compounds in Swalin ointment were Linoleic acid (41.37%), Elaidic acid (37.45%), and Palmitic acid (9.45%), respectively. The tissue level of VEGF, FGF, and PDGF on the 14th day was higher in the Swalin group compared to the SSD group (<i>P</i><0.001). The serum level of IL-6 and TNF-α in both groups increased until day 7, but gradually decreased on day 14, which was significant in the Swalin group. IL-6 serum level was significant in the Swalin group (<i>P</i><0.001). The serum level of TNF-α was also significant in the Swalin group (<i>P</i><0.001).</p><p><strong>Conclusion: </strong>The present study showed that Swalin ointment, due to the presence of a wide range of fatty acids, especially linoleic acid, leads to the modulation of systemic tissue inflammation. The ingredients of the ointment, especially hemp and sesame oil, increase the tissue level of angiogenic factors and accelerate remodeling and wound healing.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"16"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological Basis for the Formation of Suicidal Behavior: A Review. 自杀行为形成的生物学基础:综述。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-27 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.15
Roza Tatayeva, Yerbol Nurkatov, Lyailya Akbayeva, Oralbek Ilderbayev, Akmaral Makhanova, Ainash Suleimenova
{"title":"Biological Basis for the Formation of Suicidal Behavior: A Review.","authors":"Roza Tatayeva, Yerbol Nurkatov, Lyailya Akbayeva, Oralbek Ilderbayev, Akmaral Makhanova, Ainash Suleimenova","doi":"10.47176/mjiri.39.15","DOIUrl":"10.47176/mjiri.39.15","url":null,"abstract":"<p><strong>Background: </strong>The article addresses one of the pivotal issues in the formation of suicidal behavior, namely the function of central and peripheral neurotransmitter systems and the mechanisms of neuroendocrine regulation. This article presents the relationship between alterations in lipid metabolism and suicidal behavior, as well as candidate genes of the serotonergic system involved in suicidal behavior.</p><p><strong>Methods: </strong>The present study is a review of a number of published completed papers by systematically searching original articles in English in the following electronic databases: PubMed, SCOPUS, Mendeley, Google Scholar, and ScienceDirect between 2013 and 2023.</p><p><strong>Results: </strong>A total of 126 sources were used in the scientific literature review, covering findings from a range of disciplines, including biology, neurochemistry, anatomy, neurohormones, and serotonergic system candidate genes relevant to suicidal behavior.</p><p><strong>Conclusion: </strong>The identification of neurobiological indicators of suicidality is of significant importance for the understanding of the pathophysiology of suicidality and for the search for peripheral markers that could be utilized to clarify risk, prediction, and, ideally, suicide prevention. The findings of this review underscore the intricate biological underpinnings of suicidal behavior, underscoring that suicidality is not merely a psychological or social phenomenon but rather a complex and deeply rooted system of neurobiological processes. The review suggests that biological markers should be integrated with existing psychological assessments to create a multidimensional profile of suicide risk.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"15"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Telepractice Voice Training on the Voice Quality oF Theater Actors with Voice Complaints. 远程语音训练对有语音抱怨的戏剧演员语音质量的影响。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-22 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.14
Ali Arabi, Maryam Tarameshlu, Roozbeh Behroozmand, Hamide Ghaemi, Leila Ghelichi
{"title":"The Effect of Telepractice Voice Training on the Voice Quality oF Theater Actors with Voice Complaints.","authors":"Ali Arabi, Maryam Tarameshlu, Roozbeh Behroozmand, Hamide Ghaemi, Leila Ghelichi","doi":"10.47176/mjiri.39.14","DOIUrl":"10.47176/mjiri.39.14","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding the application of telepractice voice training in theater actors is inconclusive. Our study aimed to investigate changes in acoustic parameters, auditory-perceptual characteristics, and self-reported voice symptoms of theater actors with voice complaints undergoing telepractice voice training.</p><p><strong>Methods: </strong>Nine theater actors with voice complaints participated in this single-group intervention. In this pre-post study, we observed changes in the participants' voice quality. The participants received twelve online voice training sessions over six weeks. An auditory-perceptual evaluation was performed using the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) profile to analyze the voice, while acoustic parameters were extracted from the recordings using Praat software. In addition, the Vocal Tract Discomfort Scale (VTDS) was administered as a self-report questionnaire. Outcome variables were measured pre-, post, and four weeks after the end of the training. The variables were then subjected to variance analysis with repeated measurements.</p><p><strong>Results: </strong>Voice training resulted in significant changes in acoustic parameters, such as jitter and HNR. Additionally, over time, significant improvements were observed in auditory-perceptual characteristics, including overall severity, roughness, breathiness, and strain.</p><p><strong>Conclusion: </strong>Telepractice voice training has the potential to enhance the voice quality of actors who experience voice complaints. However, more specific measures are necessary to fully understand the effectiveness of telepractice voice interventions compared with traditional face-to-face sessions.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Consensus Report on Management of Type 2 Diabetes Mellitus in Iran. 伊朗2型糖尿病管理的共识报告。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.13
Alireza Esteghamati, Mojtaba Malek, Farhad Hosseinpanah Ghasabeh, Farzad Hadaegh, Mohammad Afkhami-Ardekani, Hamid Reza Aghai Meybodi, Mohammad Hossein Dabbaghmanesh, Fatemeh Ghaemi, Seyed Adel Jahed, Saeed Kalbasi, Mojtaba Mehrdad, Zohreh Mousavi, Mitra Niafar, Hassan Rezvanian, Mojgan Sanjari, Amir Ziaee, Mohammad E Khamseh
{"title":"A Consensus Report on Management of Type 2 Diabetes Mellitus in Iran.","authors":"Alireza Esteghamati, Mojtaba Malek, Farhad Hosseinpanah Ghasabeh, Farzad Hadaegh, Mohammad Afkhami-Ardekani, Hamid Reza Aghai Meybodi, Mohammad Hossein Dabbaghmanesh, Fatemeh Ghaemi, Seyed Adel Jahed, Saeed Kalbasi, Mojtaba Mehrdad, Zohreh Mousavi, Mitra Niafar, Hassan Rezvanian, Mojgan Sanjari, Amir Ziaee, Mohammad E Khamseh","doi":"10.47176/mjiri.39.13","DOIUrl":"10.47176/mjiri.39.13","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is one of the most serious public health problems all over the world. Development of local consensus on management of T2DM, providing clinicians, researchers, and policymakers with updated and valid evidence in consideration of practical issues, is crucial. Therefore, we aimed to develop a consensus report on management of T2DM in Iran.</p><p><strong>Methods: </strong>A task force group comprised of experts in diabetes management reviewed published literature. The task force members reached the majority agreement on all recommendations after participating in several group meeting discussions.</p><p><strong>Results: </strong>The consensus provided recommendations on diverse aspects on management of people with T2DM in Iran. The recommendations covered the following topics: first-line treatment, diabetes management in people with obesity, combination therapy in people with T2DM, injectable therapy, and non-alcoholic fatty liver in people with T2DM.</p><p><strong>Conclusion: </strong>Considering evidence-based guidelines, the task force group developed a consensus to address important clinical issues in the management of people with T2DM in Iran.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Karydakis Flap as a Simple Surgical Method in the Treatment of Pilonidal Disease V.S Open Surgery with Average 30-month-follow up: A Clinical Trial. 核达基皮瓣作为一种简单的手术方法治疗毛鞘疾病vs开放手术,平均随访30个月:临床试验。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.12
Maryam Sarkardeh, Amin Dalili, Saeed Akhlaghi, Alireza Rezapanah, Peyman Saberian, Morteza Tavasolizadeh
{"title":"Karydakis Flap as a Simple Surgical Method in the Treatment of Pilonidal Disease V.S Open Surgery with Average 30-month-follow up: A Clinical Trial.","authors":"Maryam Sarkardeh, Amin Dalili, Saeed Akhlaghi, Alireza Rezapanah, Peyman Saberian, Morteza Tavasolizadeh","doi":"10.47176/mjiri.39.12","DOIUrl":"10.47176/mjiri.39.12","url":null,"abstract":"<p><strong>Background: </strong>Two common types of treatment for pilonidal disease include open and closed surgery. Closed surgery can be done with a Karydakis flap. The aim of this study was to compare the outcomes of pilonidal sinus management between Karydakis flap and open surgery.</p><p><strong>Methods: </strong>This clinical trial was conducted on patients diagnosed with pilonidal sinus referred to the surgical clinics of Imam Reza Hospital in Mashhad from 2021 to 2022. Patients were nonrandomly divided into closed and open surgical treatment groups. Demographic information was collected from patients' medical records, the severity of the disease was obtained from operation notes, and time to recovery and time to return to work was obtained during follow-up visits. Pain intensity was collected on the first, tenth, and one month after surgery. To describe the data, the number and percentage for qualitative variables and mean± standard deviation for quantitative variables have been used. Normality of variables investigated by Shapiro-Wilk test. A comparison of quantitative variables was done with an independent sample t-test. The comparison of pain changes within each group was done using Friedman's test. A comparison of qualitative variables in two groups was done with the Chi-Square test. The significance level of the tests is 5%, and the software used is SPSS25.</p><p><strong>Results: </strong>Sixty patients (43 men and 17 women) with a mean age of 23.90 ± 6.57 years were included. The frequency of wound paresthesia (<i>P</i>=0.023), and recovery delay (<i>P</i><0.001) was lower in closed surgery compared to the open surgery group, and the frequency of discharge and superficial SSI (Surgical Site Infection) was higher in closed surgery (<i>P</i>=0.038). Pain severity decreased during the study (<i>P</i>=0.029) among the closed surgery group.</p><p><strong>Conclusion: </strong>Closed surgical treatment was associated with shorter hospitalization time and return to work time than open surgery. Therefore, Karydakis flap can be a simple and acceptable method for the treatment of pilonidal sinus.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scrutiny of Iran Undergraduate Medical Education Program Accreditation: Post-accreditation Monitoring Challenges. 伊朗本科医学教育项目认证的审查:认证后的监测挑战。
Medical Journal of the Islamic Republic of Iran Pub Date : 2025-01-18 eCollection Date: 2025-01-01 DOI: 10.47176/mjiri.39.11
Babak Sabet, Mahdi Aghabagheri, Abtin Heidarzadeh, Ebrahim Kalantar, Marzieh Nojomi
{"title":"Scrutiny of Iran Undergraduate Medical Education Program Accreditation: Post-accreditation Monitoring Challenges.","authors":"Babak Sabet, Mahdi Aghabagheri, Abtin Heidarzadeh, Ebrahim Kalantar, Marzieh Nojomi","doi":"10.47176/mjiri.39.11","DOIUrl":"10.47176/mjiri.39.11","url":null,"abstract":"<p><p>Considering all medical schools in the nation and the preparation of the third round, which will begin in the coming months, a review of the accreditation of undergraduate medical education programs in Iran has identified both opportunities and threats with regard to the 2 previous rounds. The prediction of the third round will not result in quality assurance or improvement for medical schools if the aforementioned opportunities and threats are not carefully examined. This is due in part to a misinterpretation of the nature of accreditation, which is an expertise model, where expertise is the matter of competence, competency, knowledge, skills, and attitude that must be examined in compliance with the well-organized criteria.</p>","PeriodicalId":18361,"journal":{"name":"Medical Journal of the Islamic Republic of Iran","volume":"39 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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