The journal of medical investigation : JMI最新文献_第8页

Surgical Treatment of Lumbar Herniated Nucleus Pulposus Combined with Residual Bony Fragment of Apophyseal Ring Fracture in High-Level Athletes : A Report of Two Cases. 高水平运动员腰椎间盘髓核突出合并棘环骨折残余骨碎片的手术治疗:附2例报告。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.358

Yuto Sugimine, Kentaro Sakaeda, Kazuta Yamashita, H. Manabe, K. Sugiura, Fumio Hayashi, Y. Ishihama, Y. Takata, T. Sakai, Toru Maeda, T. Tateishi, K. Sairyo

{"title":"Surgical Treatment of Lumbar Herniated Nucleus Pulposus Combined with Residual Bony Fragment of Apophyseal Ring Fracture in High-Level Athletes : A Report of Two Cases.","authors":"Yuto Sugimine, Kentaro Sakaeda, Kazuta Yamashita, H. Manabe, K. Sugiura, Fumio Hayashi, Y. Ishihama, Y. Takata, T. Sakai, Toru Maeda, T. Tateishi, K. Sairyo","doi":"10.2152/jmi.66.358","DOIUrl":"https://doi.org/10.2152/jmi.66.358","url":null,"abstract":"In this paper, we present 2 cases of herniated nucleus pulposus (HNP) combined with the residual bony fragment of apophyseal ring fracture. HNP typically exists at the narrow lateral recess formed by the bony fragment, and so it has been reported that symptoms may persist. Case 1 was a 22-year-old man, a high-level javelin thrower and Paralympic athlete. He had a history of persistent pain for 4 years due to HNP, and so we performed surgical removal. Case 2 was a 23-year-old male professional baseball player. He was referred to us only 17 days after the onset of pain and presented with muscle weakness, a feature which may prolong the clinical course in addition other features such as pain. Thus, we performed a comparatively quick intervention of surgical removal. In both cases, we had excellent clinical outcomes and better function and performance. In conclusion, in cases with HNP and apophyseal ring separation, surgical intervention in the comparatively early phase can be recommended, particularly if the patients desire quick return to their original level of activity. J. Med. Invest. 66 : 358-361, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124758528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Visualization of Lumbar Artery Variations by Contrast-Enhanced Multi-detector Row Computed Tomography. 对比增强多检测器行计算机断层扫描显示腰动脉病变。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.45

S. Iwamoto, S. Takao, M. Harada

{"title":"Visualization of Lumbar Artery Variations by Contrast-Enhanced Multi-detector Row Computed Tomography.","authors":"S. Iwamoto, S. Takao, M. Harada","doi":"10.2152/jmi.63.45","DOIUrl":"https://doi.org/10.2152/jmi.63.45","url":null,"abstract":"PURPOSE\u0000This study was designed to identify the anatomical variations of lumbar arteries on contrast-enhanced multi-detector row computed tomography (MDCT).\u0000\u0000\u0000MATERIALS AND METHODS\u0000Consecutive 100 colon cancer patients underwent preoperative 3-dimensional navigation studies, which include CT colonography (CTC) and CT angiography (CTA) for evaluation of anatomical relationship between the colon cancer and mesenteric vasculatures. After exclusion of inappropriate cases, 84 cases (33 women and 51 men; mean age, 64 years) were finally analyzed. The visualization of lumbar arteries from the CTA was scored based on the agreement of two radiology specialists. Also the presence or absence of left and right common trunk of each lumbar artery was evaluated.\u0000\u0000\u0000RESULTS\u0000Visualization scores on both sides of L1 were significantly lower than those of L2-L4. No significant difference could be found on visualization of L1 lumbar arteries between the young and the elderly group. The common trunk tended to be in the lower lumbar levels (L1 in 2.4%, L2 in 9.5%, L3 in 11%, and L4 in 23%).\u0000\u0000\u0000CONCLUSION\u0000The development and variation of lumbar arteries can be evaluated with CTA. Furthermore, CTA can provide sufficient anatomical information on variations of the lumbar arteries prior to surgery or catheterization.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123366267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Japanese elderly individuals wish for enteral tube feeding more strongly for their parents than for themselves. 日本老年人对肠内管喂养的愿望比自己更强烈。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.258

Harutaka Yamaguchi, K. Sato, Keisuke Kawahito, Akiko Miyatake, Keisuke Kondo, Keisuke Inaba, Kaori Inaba, Shingo Kawaminami, R. Tabata, Shino Yuasa, Yoshihiro Okura, A. Tuchiya, Yoshihiro Suzuki, Kenji Tani

{"title":"Japanese elderly individuals wish for enteral tube feeding more strongly for their parents than for themselves.","authors":"Harutaka Yamaguchi, K. Sato, Keisuke Kawahito, Akiko Miyatake, Keisuke Kondo, Keisuke Inaba, Kaori Inaba, Shingo Kawaminami, R. Tabata, Shino Yuasa, Yoshihiro Okura, A. Tuchiya, Yoshihiro Suzuki, Kenji Tani","doi":"10.2152/jmi.66.258","DOIUrl":"https://doi.org/10.2152/jmi.66.258","url":null,"abstract":"[Introduction] The purpose of this study was to investigate the differences in the preference of enteral tube feeding between elderly inhabitants of Mugi town, Tokushima Prefecture, Japan, and their parents in various physical conditions. [Methods] This population-based questionnaire survey studied 300 randomly selected participants aged 65-80 years. Respondents were to consider a situation where eating was difficult, and were questioned on their desire for tube feeding, using a visual analogue scale (VAS) ranging from \"do not want tube feeding (0)\" to \"want tube feeding (100).\" [Results] Valid responses of 103 (34.4%) participants were analyzed. Under conditions of being \"healthy,\" \"bedridden,\" \"with dementia,\" and \"bedridden and with dementia,\" the median (IQR) of the VAS values for the desire for tube feeding were 31.8 (3.3 to 83.8), 19.3 (2.4 to 52.3), 5.2 (0.7 to 18.9), 4.0 (0.3 to 15.2) for respondents and 55.2 (11.6 to 92.2), 48.7 (5.5 to 85.5), 9.0 (1.2 to 46.8), 5.1 (0.1 to 36.5) for parents, respectively. The VAS values for the parents were significantly higher (p=0.001, 0.002, 0.001, and 0.01, respectively for the four conditions described) for the same items. [Conclusion] Surrogate decisions made by family members often differ from what the patients would have desired. J. Med. Invest. 66 : 258-263, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127791603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow Cytometric Evaluation of Surface CD56 Expression on Activated Natural Killer Cells as Functional Marker. 流式细胞术评价活化自然杀伤细胞表面CD56作为功能标记的表达。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.199

Wataru Oboshi, Kensaku Aki, T. Tada, Toru Watanabe, Nobuyasu Yukimasa, Ichiro Ueno, Ken Saito, Eiji Hosoi

{"title":"Flow Cytometric Evaluation of Surface CD56 Expression on Activated Natural Killer Cells as Functional Marker.","authors":"Wataru Oboshi, Kensaku Aki, T. Tada, Toru Watanabe, Nobuyasu Yukimasa, Ichiro Ueno, Ken Saito, Eiji Hosoi","doi":"10.2152/jmi.63.199","DOIUrl":"https://doi.org/10.2152/jmi.63.199","url":null,"abstract":"Surface CD56 is the most important cell marker for defining NK cells. However, the relationship between the expression of surface CD56 and NK cell activity has not yet been elucidated in detail. Thirteen healthy volunteers were enrolled in the present study. Peripheral blood mononuclear cells (PBMCs) were stimulated with rIL-2 or rIL-12 (1, 10, 100 U/mL) for 18 h at 37°C. After incubation, surface CD56 expression on NK cells was evaluated using a flow cytometric analysis. A colorimetric-based lactate dehydrogenase (LDH) assay was used for experiments on cytotoxicity. IFN-γ mRNA gene expression was quantified by real-time PCR. The expression level of surface CD56 on NK cells, cytotoxicity, and IFN-γ mRNA gene expression were significantly increased by the rIL-2 and rIL-12 stimulations. In addition, a positive correlation was found between surface CD56 expression and cytotoxic activity or IFN-γ mRNA gene expression. We revealed that the quantification of surface CD56 expression was applicable to the evaluation of cytotoxicity and IFN-γ production in activated NK cells. These results suggest that the measurement of surface CD56 expression represent an easy and rapidly reproducible technique to evaluate the activated state of NK cells and monitor NK cell activity in immunotherapy. J. Med. Invest. 63: 199-203, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117088567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Metastatic tumor to the orbital cavity from a primary carcinoma of the uterine cervix : a case report. 原发性子宫颈癌转移至眶腔1例报告。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.355

Hiroshi Kagusa, Y. Mizobuchi, Kohei Nakajima, Toshitaka Fujihara, Y. Bando, Y. Takagi

引用次数: 1

The intestinal microbiota and its role in human health and disease. 肠道菌群及其在人类健康和疾病中的作用。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.27

K. Kataoka

引用次数: 103

Reduction mammaplasty and mastopexy for the contralateral breast after reconstruction surgery following cancer resection: A report of 3 cases. 对侧乳房肿瘤切除术后重建术后缩乳及乳房切除术3例报告。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.281

Keisuke Kashiwagi, Yoshiro Abe, Soshi Ishida, K. Mineda, Yutaro Yamashita, Y. Fukunaga, S. Yoshimoto, Ryosuke Yamato, Tatsuya Tsuda, I. Hashimoto

{"title":"Reduction mammaplasty and mastopexy for the contralateral breast after reconstruction surgery following cancer resection: A report of 3 cases.","authors":"Keisuke Kashiwagi, Yoshiro Abe, Soshi Ishida, K. Mineda, Yutaro Yamashita, Y. Fukunaga, S. Yoshimoto, Ryosuke Yamato, Tatsuya Tsuda, I. Hashimoto","doi":"10.2152/jmi.63.281","DOIUrl":"https://doi.org/10.2152/jmi.63.281","url":null,"abstract":"BACKGROUND\u0000Breast reconstruction generally involves autologous tissue transplantation and placement of a mammary prosthesis. When the patient's breasts are extremely large and ptotic, breast reconstruction often results in significantly asymmetrical appearance. However, a good aesthetic outcome after reconstruction surgery following cancer resection is an important quality-of-life factor. We evaluated the efficacy of touch-up surgery, either reduction mammaplasty or mastopexy, performed on the contralateral breast for symmetrization.\u0000\u0000\u0000METHODS\u0000Reduction mammaplasty was performed on the contralateral breast in 2 patients and mastopexy was performed on the contralateral breast in 1 patient after reconstruction surgery following cancer resection, between 2008 and 2014. We reviewed each patient's medical record for general clinical information and for the methods of breast cancer resection and breast reconstruction used, wait time between breast cancer resection and touch-up surgery, preservation of the sensitivity of the nipple-areola complex after the touch-up surgery, and aesthetic outcome (based on visual analog scale score).\u0000\u0000\u0000RESULTS\u0000Wait times in the 3 cases were 4, 9, and 18 months. Nipple-areolar sensitivity was well preserved in all 3 cases. Aesthetic outcomes were judged \"excellent\" or \"very good.\"\u0000\u0000\u0000CONCLUSION\u0000Revision surgery on the contralateral breast 4 to 18 months after breast reconstruction substantially improves the aesthetic outcome. J. Med. Invest. 63: 281-285, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125877790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Additional effects of simultaneous treatment with C14-Cblin and celastrol on the clinorotation-induced rat L6 myotube atrophy. C14-Cblin和celastrol同时治疗对倾斜诱导的大鼠L6肌管萎缩的影响。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.127

Kanako Kitahata, Takayuki Uchida, Runa Taniguchi, A. Kato, Kosuke Sugiura, Iori Sakakibara, M. Oarada, T. Fukawa, Park Junsoo, Cho Inho, T. Nikawa

{"title":"Additional effects of simultaneous treatment with C14-Cblin and celastrol on the clinorotation-induced rat L6 myotube atrophy.","authors":"Kanako Kitahata, Takayuki Uchida, Runa Taniguchi, A. Kato, Kosuke Sugiura, Iori Sakakibara, M. Oarada, T. Fukawa, Park Junsoo, Cho Inho, T. Nikawa","doi":"10.2152/jmi.69.127","DOIUrl":"https://doi.org/10.2152/jmi.69.127","url":null,"abstract":"Two novel reagents, N-myristoylated Cbl-b inhibitory peptide (C14-Cblin) and celastrol, a quinone methide triterpene, are reported to be effective in preventing myotube atrophy. The combined effects of C14-Cblin and celastrol on rat L6 myotubes atrophy induced by 3D-clinorotation, a simulated microgravity model, was investigated in the present study. We first examined their effects on expression in atrogenes. Increase in MAFbx1/atrogin-1 and MuRF-1 by 3D-clinorotation was significantly suppressed by treatment with C14-Cblin or celastrol, but there was no additive effect of simultaneous treatment. However, celastrol significantly suppressed the upregulation of Cbl-b and HSP70 by 3D-clinorotation. Whereas 3D-clinorotation decreased the protein level of IRS-1 in L6 myotubes, C14-Cblin and celastrol inhibited the degradation of IRS-1. C14-Cblin and celastrol promoted the phosphorylation of FOXO3a even in microgravity condition. Simultaneous administration of C14-Cblin and celastrol had shown little additive effect in reversing the impairment of IGF-1 signaling by 3D-clinorotation. While 3D-clinorotation-induced marked oxidative stress in L6 myotubes, celastrol suppressed 3D-clinorotation-induced ROS production. Finally, the C14-Cblin and celastrol-treated groups were inhibited decrease in L6 myotube diameter and increased the protein content of slow-twitch MyHC cultured under 3D-clinorotation. The simultaneous treatment of C14-Cblin and celastrol additively prevented 3D-clinorotation-induced myotube atrophy than single treatment. J. Med. Invest. 69 : 127-134, February, 2022.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134257083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Improvement of acceptability in patients undergoing esophagogastroduodenoscopy using auditory and visual stimulation. 听觉和视觉刺激下食管胃十二指肠镜检查患者可接受性的提高。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.8

M. Sogabe, Yumiko Izaki, T. Okahisa, T. Takayama

引用次数: 0

Translational and Randomized Study of 5-HT3 Receptor Antagonists for Evaluation of Chemotherapy-induced Nausea and Vomiting Related Biomarkers. 5-HT3受体拮抗剂评估化疗诱导的恶心和呕吐相关生物标志物的转化和随机研究

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.269

Y. Tsubata, Mika Nakao, Yoshihiro Amano, T. Hotta, M. Hamaguchi, T. Okimoto, K. Miura, Shunichi Hamaguchi, T. Kuraki, M. Itakura, T. Isobe

引用次数: 2