The journal of medical investigation : JMI最新文献_第7页

Short-term pre-operative systemic administration with low-dose of steroid does not make a false-negative diagnosis of definite eosinophilic chronic rhinosinusitis after endoscopic sinus surgery. 短期术前系统管理低剂量类固醇不能假阴性诊断明确嗜酸性慢性鼻窦炎内镜鼻窦手术后。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.233

Chisa Fujimoto, K. Tamura, Shizuka Takaishi, Ikuji Kawata, Y. Kitamura, N. Takeda

{"title":"Short-term pre-operative systemic administration with low-dose of steroid does not make a false-negative diagnosis of definite eosinophilic chronic rhinosinusitis after endoscopic sinus surgery.","authors":"Chisa Fujimoto, K. Tamura, Shizuka Takaishi, Ikuji Kawata, Y. Kitamura, N. Takeda","doi":"10.2152/jmi.66.233","DOIUrl":"https://doi.org/10.2152/jmi.66.233","url":null,"abstract":"According to JESREC criteria, definite eosinophilic chronic rhinosinusitis (ECRS) is postoperatively diagnosed based on over 70 eosinophils in high power magnification fields of the resected nasal polyps in patients with probable ECRS. Preoperative systemic administration with steroid is a standard practice, because it reduced intraoperative bleeding during endoscopic sinus surgery (ESS) in patients with ECRS. However, it was recently reported that systemic administration with steroid decreased the number of eosinophils in the nasal polyps, leading to a false negative diagnosis of definite ECRS. To overcome the risk, we have adopted short-term pre-operative systemic administration with low-dose of steroid and examined if our steroid administration makes a false-negative diagnosis. We performed a retrospective chart review of 42 patients with probable ECRS. Eleven patients were administered with 0.5 mg of bethametasone for 7 days before ESS, and other 31 patients were not administered. The average number of eosinophils in nasal polyps in patients who were administered with steroid was 188 ± 167, which was not different from 199 ± 149 in the patients who were not administered. These findings suggest that short-term preoperative administration with low-dose of steroid has few risk of a false-negative diagnosis of definite ECRS. J. Med. Invest. 66 : 233-236, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123963617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Postmortem Diagnosis of Anorexia Nervosa: An Endocrinological and Immunohistochemical Approach. 神经性厌食症的死后诊断:内分泌学和免疫组织化学方法。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.305

A. Ishigami, I. Tokunaga, A. Nishimura, S. Kubo

{"title":"Postmortem Diagnosis of Anorexia Nervosa: An Endocrinological and Immunohistochemical Approach.","authors":"A. Ishigami, I. Tokunaga, A. Nishimura, S. Kubo","doi":"10.2152/jmi.63.305","DOIUrl":"https://doi.org/10.2152/jmi.63.305","url":null,"abstract":"A female in her 30s was found dead after a fire. She was severely emaciated and had been diagnosed with anorexia nervosa (AN) about 5 years ago, but had not been treated recently. Therefore, we investigated not only her cause of death but also her condition of AN. Some of her organs weighed less than normal although no clear lesions were observed. In the pituitary gland, the number of follicle-stimulating hormone-immunopositive cells was markedly decreased although a normal number of thyroid-stimulating hormone-positive cells were detected. A histological examination of the ovary suggested that she had been suffering from amenorrhea. The thyroid gland was atrophic, and marked variations in follicle size were observed. Because we could not obtain enough volume of her blood for endocrinological examinations, we tried to investigate her endocrinological condition by immunohistochemistry. Immunohistochemical staining detected decreased triiodothyronine immunoreactivity and normal thyroxine immunoreactivity. The adrenal glands were also atrophic. Based on these findings, it was considered that she had been suffering from AN at the time of her death. The autopsy and other findings revealed that she had died of burning with carbon monoxide intoxication. J. Med. Invest. 63: 305-309, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127114158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis. 在日本，30%的乳腺导管原位癌为极低级别ER(+)/HER2(-)型，无粉刺坏死。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.192

M. Kanematsu, M. Morimoto, Masako Takahashi, Junko Honda, Y. Bando, T. Moriya, Y. Tadokoro, M. Nakagawa, H. Takechi, Takahiro Yoshida, H. Toba, Mitsuteru Yoshida, Aiichirou Kajikawa, A. Tangoku, I. Imoto, M. Sasa

{"title":"Thirty percent of ductal carcinoma in situ of the breast in Japan is extremely low-grade ER(+)/HER2(-) type without comedo necrosis.","authors":"M. Kanematsu, M. Morimoto, Masako Takahashi, Junko Honda, Y. Bando, T. Moriya, Y. Tadokoro, M. Nakagawa, H. Takechi, Takahiro Yoshida, H. Toba, Mitsuteru Yoshida, Aiichirou Kajikawa, A. Tangoku, I. Imoto, M. Sasa","doi":"10.2152/jmi.63.192","DOIUrl":"https://doi.org/10.2152/jmi.63.192","url":null,"abstract":"Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis. Results The Ki67 index correlated significantly with NG, both with/without comedo necrosis, and reliably evaluated the grade of malignancy. The index for ER(+)/HER2(-) (n=117, 69.2%) was 7.45±7.10, which was significantly lower than for each of the other types. The index was 5.71±6.94 for ER(+)/HER2(-) without comedo necrosis (n=52, 30.8%), which was significantly lower than with comedo necrosis. This was considered LGD, characterized by absence of microcalcification in MMG and either presence of a solid mass or cystic lesion or absence of hypoechoic areas in ultrasound. Conclusion In Japan, ER(+)/HER2(-) without comedo necrosis accounts for about 30% of DCIS and is LGD. This may be being overdiagnosed. J. Med. Invest. 63: 192-198, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126381654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Minimally invasive cervical micro-endoscopic foraminotomy for C6 radiculopathy with overlooked scapular winging - A case report. 微创颈椎微内窥镜椎间孔切开术治疗C6神经根病伴肩胛翼忽视1例。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.340

Y. Ishihama, Fumitake Tezuka, H. Manabe, Kazuta Yamashita, Y. Takata, T. Sakai, T. Chikawa, K. Sairyo

引用次数: 1

Accumulation and washout of 99mTc-sestamibi in osteoarthritic subchondral bone may indicate increased osteoclastic activity accompanying microfractures: a case study. 骨关节炎软骨下骨中99mTc-sestamibi的积累和消失可能表明伴随微骨折的破骨细胞活性增加。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.127

Ryo Tanaka, Masato Ebine

引用次数: 1

Efficacy of erlotinib and imatinib in a patient with a rectal gastrointestinal stromal tumor and synchronous pulmonary adenocarcinoma: A case report. 厄洛替尼和伊马替尼治疗直肠胃肠道间质瘤合并同步肺腺癌1例疗效观察

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.144

T. Miyoshi, Riho Mori, Sachiko Amano, H. Sumitomo, M. Aoyama, Seiya Inoue, Naoki Hino, D. Wada

引用次数: 5

Change in the activity of trunk and lower limb muscles during 2000-m rowing. 2000米赛艇运动中躯干和下肢肌肉活动的变化。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.45

Tomoki Oshikawa, Norifumi Takaki, Koji Nakamura, Ren Kubota, Gen Adachi, Hiroshi Akuzawa, Chie Sekine, K. Kaneoka

{"title":"Change in the activity of trunk and lower limb muscles during 2000-m rowing.","authors":"Tomoki Oshikawa, Norifumi Takaki, Koji Nakamura, Ren Kubota, Gen Adachi, Hiroshi Akuzawa, Chie Sekine, K. Kaneoka","doi":"10.2152/jmi.69.45","DOIUrl":"https://doi.org/10.2152/jmi.69.45","url":null,"abstract":"This study aimed to clarify the changes in the activity of the trunk and lower limb muscles during 2000-m rowing. Ten male rowers performed a 2000-m race simulation on a rowing ergometer. Electromyography results of the abdominal muscles, back muscles, gluteus maximus (GMax), biceps femoris (BF), and rectus femoris (RF) were recorded. The electromyographic activity during the three strokes after the start (initial stage), at 1000m (middle stage), and before the end (final stage) were analyzed. From the handle position, the rowing motion was divided into five phases (early-drive, middle-drive, late-drive, early-recovery, and late-recovery). The peak activities of the abdominal muscles, back muscles, GMax, and BF in each stroke of the rowing motion were delayed at the middle and final stages compared to the initial stage (P<0.05). The peak activity of the RF was observed in the late-drive phase at the initial stage, whereas a high RF activity was observed in the middle-drive phase at the middle and final stages (P<0.05). Considering the results of the activity of the back muscles and RF, RF muscular endurance enhancement may lead to a decrease in the load on the back muscles and help prevent muscular low back pain in rowers. J. Med. Invest. 69 : 45-50, February, 2022.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115261223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Which muscle shows fasciculations by ultrasound in patients with ALS? 肌萎缩侧索硬化症患者的超声检查显示哪块肌肉有束状肌?

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.49

N. Takamatsu, H. Nodera, A. Mori, Keiko Maruyama-Saladini, Y. Osaki, Y. Shimatani, M. Oda, Y. Izumi, R. Kaji

{"title":"Which muscle shows fasciculations by ultrasound in patients with ALS?","authors":"N. Takamatsu, H. Nodera, A. Mori, Keiko Maruyama-Saladini, Y. Osaki, Y. Shimatani, M. Oda, Y. Izumi, R. Kaji","doi":"10.2152/jmi.63.49","DOIUrl":"https://doi.org/10.2152/jmi.63.49","url":null,"abstract":"The purpose of the present study was to elucidate the relative frequencies of fasciculations assessed by sonography in a large number of muscles in patients with amyotrophic lateral sclerosis (ALS). The patients diagnosed as having ALS were retrospectively assessed by muscle sonography. The frequencies of having fasciculations were compared among the 15 muscles and the subtypes according to the initially affected body region. Overall, approximately half of the muscles had fasciculations (48.8%), in the average of 11.4 muscles per patient. The frequency of fasciculations tended to be lower in the patients with longer disease durations upon testing. Biceps brachii had the highest frequency, followed by extensor digitorum communis, whereas sternocleidomastoid and rectus abdominis had the lowest frequencies. The frequencies of fasciculations were similar among the clinical subtypes. In conclusion, in patients with ALS, fasciculations were detected most frequently in proximal arm muscles by sonography, whereas truncal muscles had lower frequencies. Fasciculations tended to be less evident in the advanced disease stage, possibly reflecting muscle degeneration. Appropriate selection of muscles to observe fasciculations is important for diagnosis of ALS.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132652896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Anesthesia for a long-term anorexic patient with end-stage liver cirrhosis : A Case Report. 麻醉治疗长期厌食症合并终末期肝硬化1例。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.337

Kayo Hirose, M. Ogura, Yoshitsugu Yamada

引用次数: 1

Predictability of Pressure Ulcers Based on Operation Duration, Transfer Activity, and Body Mass Index Through the Use of an Alternating Decision Tree. 通过交替决策树的使用，基于手术时间、转移活动和体重指数的压疮的可预测性。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.248

Yoko Setoguchi, A. A. Ghaibeh, Kazue Mitani, Yoshiro Abe, I. Hashimoto, Hiroki Moriguchi

{"title":"Predictability of Pressure Ulcers Based on Operation Duration, Transfer Activity, and Body Mass Index Through the Use of an Alternating Decision Tree.","authors":"Yoko Setoguchi, A. A. Ghaibeh, Kazue Mitani, Yoshiro Abe, I. Hashimoto, Hiroki Moriguchi","doi":"10.2152/jmi.63.248","DOIUrl":"https://doi.org/10.2152/jmi.63.248","url":null,"abstract":"OBJECTIVE\u0000To develop a prediction model for pressure ulcer cases that continue to occur at an acute care hospital with a low occurrence rate of pressure ulcers.\u0000\u0000\u0000METHODS\u0000Analyzing data were collected from patients hospitalized at Tokushima University Hospital during 2012 using an alternating decision tree (ADT) data mining method.\u0000\u0000\u0000RESULTS\u0000The ADT-based analysis revealed transfer activity, operation time, and low body mass index (BMI) as important factors for predicting pressure ulcer development.\u0000\u0000\u0000DISCUSSION\u0000Among the factors identified, only \"transfer activity\" can be modified by nursing intervention. While shear force and friction are known to lead to pressure ulcers, transfer activity has not been identified as such. Our results suggest that transfer activities creating shear force and friction correlate with pressure ulcer development. The ADT algorithm was effective in determining prediction factors, especially for highly imbalanced data. Our three stumps ADT yielded accuracy, sensitivity, and specificity values of 72.1%±3.7%, 79.3%±18.1%, and 72.1%±3.8%, respectively.\u0000\u0000\u0000CONCLUSION\u0000Transfer activity, identified as an interventional factor, can be modified through nursing interventions to prevent pressure ulcer formation. The ADT method was effective in identifying factors within largely imbalanced data. J. Med. Invest. 63: 248-255, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117200331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18