Translational and Randomized Study of 5-HT3 Receptor Antagonists for Evaluation of Chemotherapy-induced Nausea and Vomiting Related Biomarkers.

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI:10.2152/jmi.66.269

Y. Tsubata, Mika Nakao, Yoshihiro Amano, T. Hotta, M. Hamaguchi, T. Okimoto, K. Miura, Shunichi Hamaguchi, T. Kuraki, M. Itakura, T. Isobe

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引用次数: 2

Abstract

Purpose We assessed the efficacy of palonosetron (PAL) in comparison to granisetron (GRA) for the treatment of CINV using the self-assessment questionnaires. In addition, we analyzed the serum levels of emetic various biomarkers. Methods We conducted a randomized study of 70 patients naïve to chemotherapy. The primary endpoint was the late phase score on the MAT questionnaire. The plasma concentrations of the biomarkers were measured on days 1 and 3. Results There were no statistical differences in the scores on the questionnaires, but the mean values in response to PAL were higher than those in response to GRA. The value of ghrelin on day 1 was significantly higher for GRA than for PAL. Conclusions For the primary endpoint, the score of the late phase on the MAT questionnaire was not statistically different between the PAL and GRA treatment groups. Further studies are needed to clarify the role of ghrelin for the treatment of CINV. J. Med. Invest. 66 : 269-274, August, 2019.

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5-HT3受体拮抗剂评估化疗诱导的恶心和呕吐相关生物标志物的转化和随机研究

目的采用自评问卷的方法，比较帕洛诺司琼(PAL)与格拉司琼(GRA)治疗CINV的疗效。此外，我们分析了催吐的各种生物标志物的血清水平。方法对70例naïve化疗患者进行随机研究。主要终点是MAT问卷的晚期评分。在第1天和第3天测量生物标志物的血浆浓度。结果两组问卷得分差异无统计学意义，但PAL应答的平均值高于GRA应答的平均值。GRA组第1天的ghrelin值明显高于PAL组。结论对于主要终点，PAL组和GRA组在MAT问卷上的晚期评分无统计学差异。需要进一步的研究来阐明胃饥饿素在治疗CINV中的作用。[j] .中国医学工程学报，2016,31(2):369 - 374。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The journal of medical investigation : JMI

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