The journal of medical investigation : JMI最新文献_第9页

Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells. 富丝氨酸/精氨酸剪接因子7调控p21依赖性结肠癌细胞生长阻滞。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.219

Saki Saijo, Y. Kuwano, K. Masuda, Tatsuya Nishikawa, K. Rokutan, K. Nishida

{"title":"Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells.","authors":"Saki Saijo, Y. Kuwano, K. Masuda, Tatsuya Nishikawa, K. Rokutan, K. Nishida","doi":"10.2152/jmi.63.219","DOIUrl":"https://doi.org/10.2152/jmi.63.219","url":null,"abstract":"Serine/arginine-rich splicing factors (SRSFs) play wide-ranging roles in gene expression through post-transcriptional regulation as well as pre-mRNA splicing. SRSF7 was highly expressed in colon cancer tissues, and its knockdown inhibited cell growth in colon cancer cells (HCT116) in association with altered expression of 4,499 genes. The Ingenuity Pathway Analysis revealed that cell cycle-related canonical pathways were ranked as the highly enriched category in the affected genes. Western blotting confirmed that p21, a master regulator in cell cycle, was increased without any induction of p53 in SRSF7 knockdown cells. Furthermore, cyclin-dependent kinase 2 and retinoblastoma protein were remained in the hypophosphorylated state. In addition, the SRSF7 knockdown-induced cell growth inhibition was observed in p53-null HCT116 cells, suggesting that p53-independent pathways were involved in the SRSF7 knockdown-induced cell growth inhibition. The reduction of SRSF7 stabilized cyclin-dependent kinase inhibitor 1A (CDKN1A) mRNA without any activation of the CDKN1A promoter. Interestingly, SRSF7 knockdown also blocked p21 degradation. These results suggest that the reduction of SRSF7 post-transcriptionally regulates p21 induction at the multistep processes. Thus, the present findings disclose a novel, important role of SRSF7 in cell proliferation through regulating p21 levels. J. Med. Invest. 63: 219-226, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121515426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Clinical impact of noncontrast percutaneous coronary intervention in patients with acute coronary syndrome. 非对比经皮冠状动脉介入治疗急性冠状动脉综合征的临床影响。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.69.57

S. Higuchi, Y. Kabeya, Yoshio Nishina, Yusuke Miura, S. Shibata, Noritaka Hata, Tomoya Suda, K. Hirabuki, Hiroshi Hasegawa, H. Yoshino, T. Matsuda

{"title":"Clinical impact of noncontrast percutaneous coronary intervention in patients with acute coronary syndrome.","authors":"S. Higuchi, Y. Kabeya, Yoshio Nishina, Yusuke Miura, S. Shibata, Noritaka Hata, Tomoya Suda, K. Hirabuki, Hiroshi Hasegawa, H. Yoshino, T. Matsuda","doi":"10.2152/jmi.69.57","DOIUrl":"https://doi.org/10.2152/jmi.69.57","url":null,"abstract":"PURPOSE\u0000Contrast-induced acute kidney injury (CI-AKI) is one of the common serious complications of percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). This study aimed to assess the significance of noncontrast strategy in the setting of ACS.\u0000\u0000\u0000METHODS\u0000CI-AKI was defined as an increase in serum creatinine of ?0.5 mg/dL or ?1.25 times from the baseline. One-year worsening renal function (WRF) was defined as an increase of ?0.3mg/dL in serum creatinine from the baseline after PCI.\u0000\u0000\u0000RESULTS\u0000Of 250 ACS patients, 81 were treated with noncontrast PCI. The average doses of contrast medium in the noncontrast and conventional groups were 17 (9?22) ml and 150 (120?200) ml, respectively. CI-AKI was observed in 4 patients (5%) in the noncontrast group and 29 patients (17%) in the conventional group. Noncontrast PCI was associated with a lower incidence of CI-AKI (adjusted odds ratio, 0.26;95% confidence interval [CI], 0.08?0.82). The bootstrap method and inverse probability weighting led to similar results. CI-AKI was associated with a higher incidence of 1-year WRF (adjusted hazard ratio, 2.30;95% CI, 1.12?4.69), while noncontrast PCI was not.\u0000\u0000\u0000CONCLUSIONS\u0000Noncontrast PCI was associated with the lower incidence of CI-AKI in ACS patients. J. Med. Invest. 69 : 57-64, February, 2022.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122676858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons. 虚拟三维图像分析在实习外科医生腹腔镜胃切除术中的应用。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.280

M. Nishi, K. Yoshikawa, Jun Higashijima, T. Tokunaga, C. Takasu, H. Kashihara, D. Ishikawa, M. Shimada

{"title":"Utility of virtual three-dimensional image analysis for laparoscopic gastrectomy conducted by trainee surgeons.","authors":"M. Nishi, K. Yoshikawa, Jun Higashijima, T. Tokunaga, C. Takasu, H. Kashihara, D. Ishikawa, M. Shimada","doi":"10.2152/jmi.66.280","DOIUrl":"https://doi.org/10.2152/jmi.66.280","url":null,"abstract":"Purpose The aim of this study was to investigate the utility the three-dimensional (3D) imaging for laparoscopic gastrectomy performed by trainee surgeons. Methods 3D-reconstruction was performed using multi-detector computed tomography (MDCT) and SYNAPSE VINCENT software. Trainee surgeons made 3D-imaging and checked the anatomical structure. Thirty-three patients who underwent laparoscopic gastrectomy (LG) for gastric cancer were examined. Trainees performed 19 LG, while specialists performed 14 LG. The vascular pattern and the surgical outcomes were evaluated. Result 3D imaging depicted the correct positional relationship between the gastric vasculatures and the organs. Regarding vascular pattern detected by 3D imaging, the origins of the infrapyloric artery were the right gastroepiploic artery in 12 cases (36%), the gastroduodenal artery in eight cases (24%), the bifurcation of the right gastroepiploic artery and gastroduodenal artery in seven cases (21%), and not detected in one case (3%). The types of confluence of the infrapyloric vein were the right gastroepiploic vein in 16 cases (48%), the anterior superior pancreatoduodenal vein in 10 cases (30%), and not detected in seven cases (21%). Surgical outcomes were not different between trainee group using intraoperative 3D image with the specialist in instruction group without the intraoperative 3D image. Conclusions Preoperative 3D imaging might contribute to successful and safe LG by trainee surgeons. J. Med. Invest. 66 : 280-284, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121682636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Osteolytic primary bone lymphoma in the multiple bones. 多发骨的溶解性原发性骨淋巴瘤。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.347

S. Yagi, R. Zheng, S. Nishiyama, Y. Kawabata, T. Ise, K. Sugiura, Haruhiko Yoshinari, Toshihiko Nishisho, Y. Bando, K. Kagawa, D. Fukuda, Tomohiro Soga, Y. Saijo, K. Kusunose, K. Yamaguchi, H. Yamada, T. Soeki, T. Wakatsuki, S. Kawahito, M. Akaike, M. Sata

引用次数: 2

Cervical root sonography to differentiate multifocal motor neuropathy from ALS. 颈根超声鉴别多灶性运动神经病变与渐冻症。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.104

H. Nodera, Y. Izumi, N. Takamatsu, R. Kaji

引用次数: 15

Recent great impact by an Isotope Separator On-Line (ISOL) in nuclear and radiochemistry. 近年来同位素在线分离器(ISOL)对核化学和放射化学的重大影响。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.19

M. Sakama

引用次数: 0

Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus. UVA照射与抗生素联合治疗对副溶血性弧菌有较好的杀菌效果。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.63

Yanfei Hou, Mutsumi Nakahashi, K. Mawatari, T. Shimohata, Takashi Uebanso, Yumi Harada, Akari Tsunedomi, T. Emoto, M. Akutagawa, Y. Kinouchi, A. Takahashi

引用次数: 0

Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury. FK506对肝缺血再灌注损伤保护作用的实验研究。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.63.262

T. Sawada, Katsuhiko Inoue, D. Tanabe, S. Kawamoto, Tatsuya Tsuji, S. Tashiro

{"title":"Experimental Studies on Protective Effects of FK506 Against Hepatic Ischemia-Reperfusion Injury.","authors":"T. Sawada, Katsuhiko Inoue, D. Tanabe, S. Kawamoto, Tatsuya Tsuji, S. Tashiro","doi":"10.2152/jmi.63.262","DOIUrl":"https://doi.org/10.2152/jmi.63.262","url":null,"abstract":"Purposes; FK506 (strong immunosuppressive agent) was investigated experimentally whether to protect the hepatic IRI. Methods; Warm ischemic experiment using pigs and rats were performed and examined whether FK506 is effective. Results; The results obtained are as follows. 1. Warm ischemia allowed time of the pigs without FK506 was 150 minutes, but as for that of FK506 group, the extension of 30 minutes was got in 180 minutes. 2. Biliary excretion rate of BSP after reperfusion were better in the group of 180 minutes ischemia with FK506 than in without FK506 group. 3. Chemiluminescence intensity in the peripheral neutrophils and adhered and infiltrated leukocytes in the liver were suppressed markedly by FK506. 4. The vascular endothelium with the scanning electron microscope was relatively preserved in the FK506 group comparing to the placebo group on 30 minutes after reperfusion. 5. Stress gastric ulcer was controlled and myeloperoxidase activity in the gastric mucosa was suppressed by FK506. Conclusion; Based on the results of theses experiments, it was suggested that FK506 has a protective effect on IRI by suppressing: the impairment of sinusoidal endothelial cells; the activation of KCs; the disturbance of micro-circulation; oxidative stress; inflammation; and the accumulation of leukocytes. J. Med. Invest. 63: 262-269, August, 2016.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"47 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129794920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Postoperative nausea and vomiting following lower limb surgery :a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia. 下肢手术后恶心呕吐:单次关节内注射麻醉与连续硬膜外麻醉的比较。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.303

Yuta Uemura, Y. Sakai, Y. Tsutsumi, N. Kakuta, Chiaki Murakami, S. Satomi, Takuro Oyama, N. Ohshita, Tomoya Takasago, Daisuke Hamada, K. Sairyo, Katsuya Tanaka

{"title":"Postoperative nausea and vomiting following lower limb surgery :a comparison between single-injection intraarticular anesthesia and continuous epidural anesthesia.","authors":"Yuta Uemura, Y. Sakai, Y. Tsutsumi, N. Kakuta, Chiaki Murakami, S. Satomi, Takuro Oyama, N. Ohshita, Tomoya Takasago, Daisuke Hamada, K. Sairyo, Katsuya Tanaka","doi":"10.2152/jmi.66.303","DOIUrl":"https://doi.org/10.2152/jmi.66.303","url":null,"abstract":"Study Objective : the incidence of postoperative nausea and vomiting (PONV) following single-injection intraarticular anesthesia was compared to that following continuous epidural anesthesia. Design : Prospective, double-blind, randomized study. Setting : University-affiliated teaching hospital. Patients : Forty-eight patients finally participated in this study, and each group contained twenty-four patients. Interventions : Patients scheduled to undergo lower limb surgery under general anesthesia were randomly allocated into two groups, to receive either single-injection intraarticular or continuous epidural anesthesia for postoperative analgesia. Measurements : The incidence and severity of PONV, complete response rates (i.e., no vomiting or rescue antiemetic use), and pain scores were recorded 2, 24, and 48 h postoperatively. Main results : No significant differences between groups were observed in the incidence and severity of PONV, rescue antiemetic use, or complete response rate at any of the time points, but only the use of rescue analgesics was significantly less in continuous epidural anesthesia group during the 2-24h postoperative period (P=0.04). Conclusion : While the use of single-injection intraarticular anesthesia following lower limb surgery did not prevent PONV more than continuous epidural anesthesia in this study, the intraarticular technique still provides greater simplicity, safety, and cost-effectiveness. J. Med. Invest. 66 : 303-307, August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130051474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Assessing the oral health of in-patients with diabetes using a clinical version of the Diabetes Oral Health Assessment Tool© and its association with dental examinations. 使用糖尿病口腔健康评估工具©的临床版本评估住院糖尿病患者的口腔健康及其与牙科检查的关联。

The journal of medical investigation : JMI Pub Date : 1900-01-01 DOI: 10.2152/jmi.66.328

Y. Kuwamura, E. Sakamoto, Masuko Sumikawa, M. Matsuhisa, D. Hinode, H. Uemura, S. Kishida

{"title":"Assessing the oral health of in-patients with diabetes using a clinical version of the Diabetes Oral Health Assessment Tool© and its association with dental examinations.","authors":"Y. Kuwamura, E. Sakamoto, Masuko Sumikawa, M. Matsuhisa, D. Hinode, H. Uemura, S. Kishida","doi":"10.2152/jmi.66.328","DOIUrl":"https://doi.org/10.2152/jmi.66.328","url":null,"abstract":"Aims : To compare assessment of the oral health conditions and behaviors of in-patients with diabetes using a clinical version of the Diabetes Oral Health Assessment Tool (C-DiOHAT©) with dental examinations. Methods : A cross-sectional design was used. A nurse assessed 60 in-patients using the C-DiOHAT© (a formatted questionnaire to assess four factors of patients' oral health conditions and behaviors : oral health conditions, oral hygiene behaviors, sharing health information among patients and dental/medical professionals, and perception and knowledge of oral health) while a dentist examined their oral health conditions. Results : \"Use of supplementary tools (e.g., interdental brush, dental floss)\" in the item of C-DiOHAT© was significantly associated with dental examination of \"the number of present teeth\" and \"no recommendation of further dental visit\". \"Symptoms of gingival swelling\" in the item of C-DiOHAT© was also significantly associated with \"recommendation of dental visit\". \"Knowledge of a relationship between periodontal disease and systemic disease including diabetes\" was significantly associated with Community Periodontal Index. Conclusions : These results suggest that nurses should prioritize these assessment items to most quickly acquire useful information about patients' oral health. It is important to encourage nurses to be interested in patients' oral health by such small pile of clue. J. Med. Invest. 66 : 328-336 August, 2019.","PeriodicalId":183570,"journal":{"name":"The journal of medical investigation : JMI","volume":"62 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132602892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5