Medical Molecular Morphology最新文献_第2页

Mixed hepatocellular carcinoma and high-grade neuroendocrine neoplasm with ambiguous histopathological features: a case report. 组织病理学特征模糊的混合型肝细胞癌和高级别神经内分泌肿瘤：一份病例报告。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-08-23 DOI: 10.1007/s00795-024-00396-x

Kentaro Tsuji, Makoto Abe, Saho Wakamatsu, Sayuri Hoshi, Nobuo Hoshi, Chisato Takagi, Noriyoshi Fukushima, Kaoru Hirabayashi

{"title":"Mixed hepatocellular carcinoma and high-grade neuroendocrine neoplasm with ambiguous histopathological features: a case report.","authors":"Kentaro Tsuji, Makoto Abe, Saho Wakamatsu, Sayuri Hoshi, Nobuo Hoshi, Chisato Takagi, Noriyoshi Fukushima, Kaoru Hirabayashi","doi":"10.1007/s00795-024-00396-x","DOIUrl":"10.1007/s00795-024-00396-x","url":null,"abstract":"Well-differentiated neuroendocrine tumor (NET) and poorly differentiated neuroendocrine carcinoma (NEC) are distinct entities with different biological behavior. However, difficult cases showing equivocal morphology have been reported in some organs. Herein, we report a case of primary hepatic neuroendocrine neoplasm (NEN) with ambiguous histopathological features admixed with conventional hepatocellular carcinoma (HCC). A 70-year-old man with untreated chronic hepatitis B underwent left medial sectionectomy because of two incidental liver masses. On pathological examination, one of the resected tumors had intermingling NEN and HCC components. The NEN component consisted of relatively uniform tumor cells proliferating in trabecular, cord-like, or solid patterns with peripheral nuclear palisading. The tumor cells were immunopositive for synaptophysin, chromogranin A, cluster of differentiation 56 (CD56), and focally hepatocyte paraffin 1. p53 showed wild-type expression. The Ki-67 labeling index was 27% at the hot spot. Eleven months after the surgery, he died of a cerebral hemorrhage without evidence of recurrent liver cancer. The intermediate degree of differentiation and the modest proliferative activity can challenge the distinction between NEC and NET G3. While the coexisting HCC indicates NEC rather than NET in a pathogenetic viewpoint, such ambiguous tumor may not be as aggressive as typical NECs.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"62-68"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral pemphigus vulgaris diagnostic characteristics and treatment: a systematic review. 口腔丘疹性荨麻疹的诊断特点和治疗：系统综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-12-16 DOI: 10.1007/s00795-024-00414-y

Solimar Ribeiro Carlete Filho, Luana Amorim Morais da Silva, Caio Rodrigues Maia, Paulo Roberto de Andrade Santos, Pollianna Muniz Alves, Pedro Paulo de Andrade Santos

{"title":"Oral pemphigus vulgaris diagnostic characteristics and treatment: a systematic review.","authors":"Solimar Ribeiro Carlete Filho, Luana Amorim Morais da Silva, Caio Rodrigues Maia, Paulo Roberto de Andrade Santos, Pollianna Muniz Alves, Pedro Paulo de Andrade Santos","doi":"10.1007/s00795-024-00414-y","DOIUrl":"10.1007/s00795-024-00414-y","url":null,"abstract":"Pemphigus vulgaris (PV) is a rare, potentially fatal, immune-mediated chronic disease characterized by the presence of bullous intraepithelial lesions on mucous membranes and skin. This study aimed to perform a systematic literature review covering PV clinical and histopathological aspects and treatment. The literature searches were carried out in the Pubmed, Periódicos Capes, Scopus, Science Direct, Web of Science and Scielo databases. Articles in English or Spanish published from 2000 to 2022 comprising case reports, case series and literature reviews with case report were included. After the analyses, 21 articles were selected. PV generally presents in the third to sixth decades of life and exhibits no gender predilection. The disease manifests itself clinically through irregular and painful blisters that rupture, resulting in erosion and ulceration areas. Histopathologically, the presence of an intraepithelial cleft located above the basal layer and acantholysis are observed. Standard treatment encompasses systemic and topical corticosteroids, with prednisolone being widely employed. Management consists of a remission induction phase and a maintenance phase. An early and accurate diagnosis is paramount to quickly initiate treatment, resulting in more favorable prognoses, as the choice of treatment and responses depend on the severity of the disease. Registered at the International Prospective Register of Systematic Reviews (PROSPERO): Number CRD42024497313.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"1-22"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal cord stimulation induces Neurotrophin-3 to improve diabetic foot disease. 脊髓刺激诱导神经营养素-3改善糖尿病足病。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-11-17 DOI: 10.1007/s00795-024-00410-2

Yi Liu, XuanPeng Li, HaiWen Xu, Ke Sun, Hui Jun Gong, Cheng Luo

{"title":"Spinal cord stimulation induces Neurotrophin-3 to improve diabetic foot disease.","authors":"Yi Liu, XuanPeng Li, HaiWen Xu, Ke Sun, Hui Jun Gong, Cheng Luo","doi":"10.1007/s00795-024-00410-2","DOIUrl":"10.1007/s00795-024-00410-2","url":null,"abstract":"Low-extremity ischemic disease is a common complication in diabetic patients, leading to reduced quality of life and potential amputation. This study investigated the therapeutic effect of spinal cord stimulation (SCS) on patients with diabetic foot disease and a rat model of diabetic foot injury. SCS was applied to patients with diabetic foot disease, with clinical assessments performed before and after therapy. Blood levels of NGF, BDNF, and NT-3 were determined by ELISA. A rat model of diabetic foot injury was established to validate NT-3's role in SCS therapy. SCS therapy improved the condition of patients with diabetic ischemic foot disease and promoted wound healing in the rat model. NT-3 levels significantly increased after SCS therapy in both patients and rats. Recombinant NT-3 administration improved wound healing and re-vascularization in the rat model, while NT-3 neutralization abrogated SCS's therapeutic effect. SCS improves the condition of patients with diabetic ischemic foot disease by inducing NT-3 production. Both SCS and NT-3 supplementation show therapeutic potential for ameliorating diabetic foot disease.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"43-52"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological aberration of corneal nerves in hyposecretory dry eye guinea pigs. 分泌不足性干眼症豚鼠角膜神经的形态畸变。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-11-14 DOI: 10.1007/s00795-024-00407-x

Takeshi Kiyoi, Qiang He, Li Liu, Shijie Zheng, Hitomi Nakazawa, Junsuke Uwada, Takayoshi Masuoka

{"title":"Morphological aberration of corneal nerves in hyposecretory dry eye guinea pigs.","authors":"Takeshi Kiyoi, Qiang He, Li Liu, Shijie Zheng, Hitomi Nakazawa, Junsuke Uwada, Takayoshi Masuoka","doi":"10.1007/s00795-024-00407-x","DOIUrl":"10.1007/s00795-024-00407-x","url":null,"abstract":"Dry eye, a common ocular surface disease associated with tear film instability and corneal impairment, is frequently accompanied by ocular discomfort and pain. Recent research has shown that corneal nerve dysfunction may play a role in certain pathologies of dry eye; however, the details remain unclear. To clarify the aberration in corneal nerves underlying sensory abnormalities, in addition to corneal impairment in dry eye, we examined the morphological alterations of nerve fibers in the corneas excised from guinea pigs with dry eye, where the lacrimal glands were surgically excised. Guinea pigs with dry eye exhibited reduced tear volume, increased spontaneous blink frequency, and corneal epithelial damage. Simultaneously, the subbasal nerve plexus in the cornea visualized using an anti-tubulin βIII antibody partially outgrew and became convoluted. The morphology of peptidergic nerves containing calcitonin gene-related peptide, which may function as a polymodal nociceptor, was also altered. These results indicate that guinea pigs with excised lacrimal glands can serve as useful tools for investigating the neuronal mechanisms underlying corneal pathology in dry eyes. Additionally, chronic tear deficiency may considerably alter nerve structure, including peptidergic nerves in the cornea, accompanied by epithelial damage and increased blink frequency.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"34-42"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Additional report: recurrence of intraductal papilloma with atypical ductal hyperplasia as solid papillary carcinoma. 附加报告：导管内乳头状瘤合并不典型导管增生复发为实性乳头状癌。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-12-22 DOI: 10.1007/s00795-024-00415-x

Yutaro Mihara, Ryuji Takahashi, Shinji Mizuochi, Rin Yamaguchi, Jun Akiba

引用次数: 0

Hepatic adenosquamous carcinoma with sarcomatous transformation: a case report and review of the literature. 肝腺鳞癌伴肉瘤变：病例报告和文献综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-10-07 DOI: 10.1007/s00795-024-00406-y

Quynh Thi Nguyen, Hiep Canh Nguyen, Kenta Takahashi, Kaori Yoshimura, Hiroko Ikeda, Kazuto Kozaka, Zihan Li, Dong Thanh Le, Rui Yang, Shintaro Yagi, Kenichi Harada

{"title":"Hepatic adenosquamous carcinoma with sarcomatous transformation: a case report and review of the literature.","authors":"Quynh Thi Nguyen, Hiep Canh Nguyen, Kenta Takahashi, Kaori Yoshimura, Hiroko Ikeda, Kazuto Kozaka, Zihan Li, Dong Thanh Le, Rui Yang, Shintaro Yagi, Kenichi Harada","doi":"10.1007/s00795-024-00406-y","DOIUrl":"10.1007/s00795-024-00406-y","url":null,"abstract":"Adenosquamous carcinoma (ASC) with the presence of a sarcomatous component is exceptionally uncommon in intrahepatic cholangiocarcinoma (iCCA). We report a case of hepatic ASC with rhabdoid transformation, one variation of sarcomatous change. A 72-year-old man was admitted to our hospital after being diagnosed with a 45 mm-diameter neoplastic lesion in the right hepatic duct on abdominal computed tomography. Laboratory findings showed increases in AST, ALT, ALP, gamma-GT, CA19-9 and DUPAN-II. The patient then underwent an extended right hepatectomy. Histopathologically, the tumor was composed of an ASC component within an abundant fibrous stroma and a sarcomatoid carcinoma component. By immunohistochemistry, keratin 7 and keratin 19 were expressed by all tumor cells. Expression of keratin 5/6, p40 and p63 was restricted to the squamous component. The sarcomatoid component was immunoreactive for vimentin with no loss of INI1 expression. This component also showed a loss of membranous E-cadherin expression and a reduction of membranous β-catenin expression. Staining for desmin, myoglobin and HepPar1 was negative in any tumor cells. The patient died of liver failure 3 months after surgery. This report aims to provide a better understanding of the clinicopathological characteristics and disease progression of the rare variants of iCCA to aid diagnosis and treatment.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"75-82"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary hepatic alpha-fetoprotein-producing neuroendocrine neoplasm harboring FGFR2 and TP53 mutations: a case report and literature review. 携带表皮生长因子受体2和TP53突变的原发性肝甲胎蛋白神经内分泌肿瘤：病例报告和文献综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-11-10 DOI: 10.1007/s00795-024-00408-w

Hirofumi Watanabe, Kodai Enda, Fumiyoshi Fujishima, Hidekazu Shirota, Masashi Ninomiya, Tetsuro Yamazaki, Hironobu Sasano, Takashi Suzuki

{"title":"Primary hepatic alpha-fetoprotein-producing neuroendocrine neoplasm harboring FGFR2 and TP53 mutations: a case report and literature review.","authors":"Hirofumi Watanabe, Kodai Enda, Fumiyoshi Fujishima, Hidekazu Shirota, Masashi Ninomiya, Tetsuro Yamazaki, Hironobu Sasano, Takashi Suzuki","doi":"10.1007/s00795-024-00408-w","DOIUrl":"10.1007/s00795-024-00408-w","url":null,"abstract":"This report presents a rare case of a 45-year-old man diagnosed with a primary hepatic alpha-fetoprotein-producing neuroendocrine neoplasm, a condition rarely reported in the literature. The patient presented with initial symptoms of back and epigastric pain, after which multiple liver lesions were discovered on contrast-enhanced computed tomography, suggesting intrahepatic cholangiocarcinoma. Histopathological and immunohistochemical analyses confirmed the diagnosis of alpha-fetoprotein-producing neuroendocrine neoplasm that was further supported by genetic testing, which revealed FGFR2 and TP53 mutations commonly encountered in intrahepatic cholangiocarcinoma. Despite receiving various chemotherapeutic regimens, the patient exhibited a progressive disease. This case underscores the importance of accurate differential diagnosis from hepatocellular carcinoma and intrahepatic cholangiocarcinoma due to differences in treatment approaches and prognoses and highlights the necessity for increased awareness of AFP-producing primary hepatic neuroendocrine neoplasms among clinicians and pathologists. It emphasizes the significance of comprehensive histopathological evaluation, immunohistochemical profiling, and genetic analysis for precise diagnosis and tailored therapeutic strategies. Further research is warranted to elucidate the molecular mechanisms underlying this rare liver tumor subtype and develop targeted treatments.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"83-86"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Element analysis applied to investigate acute kidney injury induced by red yeast rice supplement. 应用元素分析法研究红麴补充剂诱发的急性肾损伤。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-11-13 DOI: 10.1007/s00795-024-00411-1

Makoto Abe, Tadayuki Ogawa, Nobuyuki Magome, Yuko Ono, Akihiro Tojo

引用次数: 0

Is it really descemetocele? Morphology of extremely thin membrane that remained after severe corneal melting: a case report. 真的是角膜脱落症吗？严重角膜融化后残留的极薄膜的形态：病例报告。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-10-01 DOI: 10.1007/s00795-024-00405-z

Yasser Helmy Mohamed, Masafumi Uematsu, Mao Kusano, Takashi Kitaoka, Teruo Nishida

{"title":"Is it really descemetocele? Morphology of extremely thin membrane that remained after severe corneal melting: a case report.","authors":"Yasser Helmy Mohamed, Masafumi Uematsu, Mao Kusano, Takashi Kitaoka, Teruo Nishida","doi":"10.1007/s00795-024-00405-z","DOIUrl":"10.1007/s00795-024-00405-z","url":null,"abstract":"The aim of this study was to report transmission electron microscopic findings of a case with whole corneal descemetocele following infective corneal ulcer for the first time in literature. A 72-year-old male patient presented with infective corneal ulcer. After resolution of the infection, corneoscleral transplantation was performed. The excised very thin corneal membrane was processed for transmission electron microscopic examination. Transmission electron microscopic examination of the specimen revealed many layered structures that consisted of two different types of cells. The first type consisted of lighter staining polygonal cells, while the second consisted of elongated cells with relatively dense staining. All cells were connected with a large number of gap or adherens junctions with intercalation of the cell membranes of adjacent cells. A haphazard distribution of cytoplasmic microfilaments were also observed in all of the cell types. There was no evidence of the presence of endothelial cells throughout the specimen. There was also no evidence of Descemet membrane presence except for a small part adjacent to iris tissue that contained some melanosomes. Although we clinically diagnosed descemetocele, Descemet membrane was not present at the electron microscopic level, and thus, the expression \"descemetocele\" is inappropriate.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"69-74"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leucine drives LAT1-related SNAIL upregulation in glucose-starved pancreatic cancer cells. 亮氨酸驱动葡萄糖饥饿的胰腺癌细胞中与 LAT1 相关的 SNAIL 上调。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2025-03-01 Epub Date: 2024-09-06 DOI: 10.1007/s00795-024-00404-0

Hajime Masubuchi, Yasuko Imamura, Takumi Kawaguchi, Hironori Koga

{"title":"Leucine drives LAT1-related SNAIL upregulation in glucose-starved pancreatic cancer cells.","authors":"Hajime Masubuchi, Yasuko Imamura, Takumi Kawaguchi, Hironori Koga","doi":"10.1007/s00795-024-00404-0","DOIUrl":"10.1007/s00795-024-00404-0","url":null,"abstract":"Pancreatic cancer, a highly fibrotic and hypovascular tumor, is thought to have unique metabolic characteristics in surviving and proliferating in malnutritional microenvironments. In this study, we compared the differences in the ability of pancreatic cancer cells to adapt to glucose-free conditions with liver cancer cells, which are representative of hypervascular tumors. Three pancreatic cancer cells and two liver cancer cells were used to examine the transcriptional expression levels of molecules involved in intracellular amino acid uptake, epithelial-mesenchymal transition (EMT), and cancer stemness under glucose deprivation. The results showed that the proliferative activity of pancreatic cancer cells under glucose deprivation was significantly lower than that of liver cancer cells, but the expression levels of amino acid transporters were significantly higher. Among them, L-type amino acid transporter 1 (LAT1) upregulation was unique in concert with increased expression of the EMT regulator SNAIL and the cancer stemness marker doublecortin-like kinase 1. LAT1 knockdown canceled the upregulation of SNAIL in glucose-starved pancreatic cancer cells, suggesting a mechanistic link between the two molecules. When LAT1 was stimulated by its substrate leucine, the SNAIL expression was upregulated dose-dependently. Collectively, pancreatic cancer cells reprogrammed metabolism to adapt to energy crises involving leucine-induced SNAIL upregulation.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"23-33"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0