Medical Molecular Morphology最新文献_第2页

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-09-01 Epub Date: 2026-05-13 DOI: 10.1007/s00795-026-00463-5

Takao Senda, Nami O Yamada, Takanori Onouchi

引用次数: 0

Increased density of CD103-positive tissue-resident memory T cells predicts favorable response to immunotherapy in oral cancers. cd103阳性组织驻留记忆T细胞密度的增加预示着口腔癌免疫治疗的有利反应。

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-08-24 DOI: 10.1007/s00795-026-00473-3

Mayuko Yamashita, Hiromu Yano, Yoshihiro Komohara, Rin Yamada, Daiki Yoshii, Yukio Fujiwara, Yuki Seki, Masatoshi Hirayama, Kenta Kawahara, Akiyuki Hirosue, Ryoji Yoshida, Hideki Nakayama

{"title":"Increased density of CD103-positive tissue-resident memory T cells predicts favorable response to immunotherapy in oral cancers.","authors":"Mayuko Yamashita, Hiromu Yano, Yoshihiro Komohara, Rin Yamada, Daiki Yoshii, Yukio Fujiwara, Yuki Seki, Masatoshi Hirayama, Kenta Kawahara, Akiyuki Hirosue, Ryoji Yoshida, Hideki Nakayama","doi":"10.1007/s00795-026-00473-3","DOIUrl":"https://doi.org/10.1007/s00795-026-00473-3","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have become an important therapeutic option for oral cancers; however, reliable biomarkers predicting treatment efficacy remain limited. In this study, we investigated the association between intratumoral immune cell subsets, regional lymph node (RLN) immune status, and clinical responses to ICIs in patients with recurrent oral cancer. Pretreatment tumor tissues and RLNs were analyzed by immunohistochemistry to evaluate tumor-infiltrating lymphocytes, including CD8+, CD103+, CD3+, ICOS+, and CD163+ cells, as well as programmed death-ligand 1 (PD-L1) expression and CD169+ sinus macrophages. Treatment responses were assessed according to RECIST version 1.1. Responders to ICIs exhibited higher densities of CD8+ and CD103+ T cells compared with non-responders, whereas no significant associations were observed for CD3+, ICOS+, CD163+ cells, or PD-L1 expression. Elevated pretreatment serum C-reactive protein (CRP) levels were associated with poorer responses. CD169+ sinus macrophages in RLNs did not correlate significantly with treatment efficacy or T-cell infiltration. These findings suggest that intratumoral effector and tissue-resident memory-like T-cell infiltration, together with systemic inflammatory status, may influence ICI efficacy in recurrent oral cancer, and could improve patient stratification for immunotherapy.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid metabolic reprogramming in ovarian cancer: molecular mechanisms and therapeutic implications. 卵巢癌的脂质代谢重编程：分子机制和治疗意义。

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-08-23 DOI: 10.1007/s00795-026-00469-z

Naomi Nakayama, Daisaku Asai, Tomoka Ishibashi, Tsubasa Maejima, Kentaro Nakayama

引用次数: 0

Association of zinc transporter expression with clinicopathological features and prognosis in patients with breast cancer. 乳腺癌患者锌转运蛋白表达与临床病理特征及预后的关系

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-08-07 DOI: 10.1007/s00795-026-00472-4

Yukari Nagasaki, Tatsushi Shiomi, Fumiaki Sanuki, Yuka Mikami, Hirotake Nishimura, Takashi Akiyama, Tsunehisa Nomura, Naruto Taira, Takuya Moriya

{"title":"Association of zinc transporter expression with clinicopathological features and prognosis in patients with breast cancer.","authors":"Yukari Nagasaki, Tatsushi Shiomi, Fumiaki Sanuki, Yuka Mikami, Hirotake Nishimura, Takashi Akiyama, Tsunehisa Nomura, Naruto Taira, Takuya Moriya","doi":"10.1007/s00795-026-00472-4","DOIUrl":"https://doi.org/10.1007/s00795-026-00472-4","url":null,"abstract":"Zinc transporters, including ZIP6 (SLC39A6, also known as LIV-1) and ZIP10 (SLC39A10), are reportedly involved in breast cancer progression and metastasis. We aimed to clarify the association of the expression of zinc transporters with clinicopathological features and prognosis in breast cancer. We retrospectively included 200 patients who underwent surgery for invasive ductal carcinoma of the breast (invasive diameter ≥ 10 mm) at our institution between January 1, 2010 and June 30, 2023. Immunohistochemical staining for ZIP6 and ZIP10 was performed, and their expression levels were evaluated. Survival analyses were performed by stratifying patients into four groups based on combined ZIP6 and ZIP10 expression (high/low). We found that the expression levels of ZIP6 and ZIP10 showed a statistically significant positive correlation. Low ZIP6 expression was associated with aggressive clinicopathological features, including a higher Ki-67 labeling index, higher histological grade, and larger tumor size. Although survival differences did not reach statistical significance, combined evaluation of ZIP6 and ZIP10 expression revealed distinct survival tendencies among the expression groups. These findings suggest that combined assessment of ZIP6 and ZIP10 expression may provide additional prognostic information beyond ZIP6 expression alone. Future studies with larger cohorts and longer follow-up are warranted to validate these findings.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EWSR1-SMAD3-rearranged fibroblastic tumor: a case report with literature review. ewsr1 - smad3重排纤维母细胞瘤1例并文献复习。

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-07-27 DOI: 10.1007/s00795-026-00471-5

Guanghong Yang, Zhenwei Chen, Yuanli Zhong, Liqian Hu, Baizhou Li

{"title":"EWSR1-SMAD3-rearranged fibroblastic tumor: a case report with literature review.","authors":"Guanghong Yang, Zhenwei Chen, Yuanli Zhong, Liqian Hu, Baizhou Li","doi":"10.1007/s00795-026-00471-5","DOIUrl":"https://doi.org/10.1007/s00795-026-00471-5","url":null,"abstract":"This paper discusses an EWSR1-SMAD3-rearranged fibroblastic tumor (ESFT) occurring in the wrist of a 5-year-old child and summarizes its clinicopathological features, immunohistochemical phenotype, and molecular characteristics to improve the accuracy of clinical diagnosis. A retrospective analysis was performed on the clinical manifestations, histopathology, immunohistochemical phenotype, and molecular characteristics of a 5-year-old patient with recurrent ESFT. Additionally, this paper presents a literature review of relevant studies on ESFT. Among the 21 cases of ESFT, including the present case, the disease primarily affects young and middle-aged adult females, with most tumors measuring 1-2 cm in diameter. It preferentially occurs in the soft tissues of the distal extremities-particularly the foot-and exhibits low-grade invasiveness. Histomorphologically, the tumor is composed of uniform spindle-shaped fibroblasts arranged in fascicular and interlacing patterns, with no prominent nucleoli or mitotic figures. A zonation pattern, focal microcalcification, and interstitial myxoid change are observed in some cases. Immunohistochemistry reveals diffuse, strong ERG expression in tumor cells; FISH molecular detection shows EWSR1 break-apart; and NGS results confirm EWSR1-SMAD3 rearrangement. ESFT is a benign neoplasm with a risk of local recurrence. It exhibits complex histomorphological features but demonstrates diffuse, strong immunoreactivity for ERG on immunohistochemistry and harbors characteristic genetic alterations.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The emerging role of neutrophil extracellular traps in liver diseases: a narrative review. 中性粒细胞胞外陷阱在肝脏疾病中的新作用：叙述性回顾。

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-07-24 DOI: 10.1007/s00795-026-00470-6

Lanbao Ye, Yan Chen, Zefeng Liu, Junfeng Ye, Wengang Chai

{"title":"The emerging role of neutrophil extracellular traps in liver diseases: a narrative review.","authors":"Lanbao Ye, Yan Chen, Zefeng Liu, Junfeng Ye, Wengang Chai","doi":"10.1007/s00795-026-00470-6","DOIUrl":"https://doi.org/10.1007/s00795-026-00470-6","url":null,"abstract":"Neutrophil extracellular traps (NETs) are web-like chromatin structures released by neutrophils that play dual roles in host defense and tissue injury. In liver diseases, NETs have emerged as key pathogenic mediators. This narrative review synthesizes current evidence on the involvement of NETs in alcohol-associated liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), viral hepatitis, hepatic ischemia-reperfusion injury (HIRI), hepatocellular carcinoma (HCC), and intrahepatic cholangiocarcinoma (iCCA). Mechanistically, NETs amplify sterile inflammation, promote hepatocyte death, activate hepatic stellate cells to drive fibrosis. NETs also promote malignant transformation, sustain an aggressive phenotype, attenuate immunotherapy responses, mediate resistance to targeted therapies, and contribute to poor prognosis in primary liver cancers. Preclinical studies targeting NET formation or degrading existing NETs have shown therapeutic benefits across these liver diseases. Despite promising results, clinical translation remains limited, with challenges including a lack of standardized biomarkers, optimal timing of intervention, and the need for liver-specific delivery. This review highlights NETs as a druggable target in liver diseases, and underscores future directions toward biomarker development and targeted therapies.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphatic system in the liver: a new frontier in liver physiology and oncology. 肝脏淋巴系统：肝脏生理学和肿瘤学的新前沿。

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-06-21 DOI: 10.1007/s00795-026-00468-0

Reiichiro Kondo, Rio Sonoda, Jun Akiba

引用次数: 0

Scavenger receptor class B type I (SR-BI) as a potential therapeutic target in multiple myeloma. 清道夫受体B类I型（SR-BI）作为多发性骨髓瘤的潜在治疗靶点。

IF 1.1 4区医学

Medical Molecular Morphology Pub Date : 2026-06-10 DOI: 10.1007/s00795-026-00466-2

Yoshihiko Kondo, Hiromu Yano, Yukio Fujiwara, Daisuke Niino, Yawara Kawano, Jun-Ichirou Yasunaga, Masahiro Yamamoto, Yoshihiro Komohara

{"title":"Scavenger receptor class B type I (SR-BI) as a potential therapeutic target in multiple myeloma.","authors":"Yoshihiko Kondo, Hiromu Yano, Yukio Fujiwara, Daisuke Niino, Yawara Kawano, Jun-Ichirou Yasunaga, Masahiro Yamamoto, Yoshihiro Komohara","doi":"10.1007/s00795-026-00466-2","DOIUrl":"https://doi.org/10.1007/s00795-026-00466-2","url":null,"abstract":"Multiple myeloma (MM) is a malignant plasma cell neoplasm characterized by marked biological heterogeneity and complex metabolic reprogramming. Although dysregulated lipid metabolism has been implicated in MM, its morphological correlations and clinical significance remain unclear. The present study evaluated cytoplasmic vacuoles in peripheral blood smears and analyzed their associations with the prognosis and stage of MM. Additionally, lipid droplet formation and the expression of key cholesterol regulatory molecules among MM cell lines were examined via molecular and biochemical approaches. Intracytoplasmic vacuoles were more frequently observed at advanced Revised International Staging System stages of MM, although no significant difference in overall survival was observed. MM cell lines exhibited prominent lipid droplet accumulation and upregulated acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) and scavenger receptor class B type I (SR-BI) expression. The pharmacological inhibition of SR-BI suppressed MM cell proliferation and induced apoptotic cell death, whereas the inhibition of ACAT-1 had only a modest effect. Ultrastructural analysis revealed marked cytoplasmic vacuolization following SR-BI inhibition. These findings indicate that altered cholesterol metabolism is closely associated with cytoplasmic vacuolization in MM cells, suggesting that SR-BI plays a critical role in MM cell survival. Therefore, targeting the cholesterol trafficking pathways may represent a potential therapeutic strategy in MM.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

G protein-coupled receptor 56-mediated lung metastasis mechanisms in osteosarcoma LM8 cells. G蛋白偶联受体56介导的骨肉瘤LM8细胞肺转移机制

IF 1.1 4区医学

Medical Molecular Morphology Pub Date : 2026-06-10 DOI: 10.1007/s00795-026-00467-1

Nobuyoshi Suzuki, Erika Hayakawa, Hiroshi Nishiura, Wenting Chen, Mai Imasaka, Michihiko Sugimoto, Toshiya Tachibana, Masaki Ohmuraya

{"title":"G protein-coupled receptor 56-mediated lung metastasis mechanisms in osteosarcoma LM8 cells.","authors":"Nobuyoshi Suzuki, Erika Hayakawa, Hiroshi Nishiura, Wenting Chen, Mai Imasaka, Michihiko Sugimoto, Toshiya Tachibana, Masaki Ohmuraya","doi":"10.1007/s00795-026-00467-1","DOIUrl":"https://doi.org/10.1007/s00795-026-00467-1","url":null,"abstract":"Osteosarcoma has a poor prognosis and frequently metastasizes to the lungs. This study examined the role of transglutaminase 2 (TGM2), a ligand for adhesion G protein-coupled receptor 56 (GPR56), in lung metastasis of LM8 mouse osteosarcoma cells. Gβγ‑dependent ERK signaling mediated by GPR56 and the adhesion of GPR56-expressing LM8MOCK cells and GPR56‑deficient LM8LOW cells were analyzed using siRNA, western blotting, and cell staining. TGM2 and Ki67 expression in metastatic lung lesions was assessed by transplantation and immunohistochemistry. TGM2 enhanced endogenous ERK signaling in LM8MOCK cells. In the absence of TGM2, ERK signaling increased in LM8LOW cells but remained unchanged in LM8HIGH cells compared with LM8MOCK cells. In the presence of TGM2, ERK activity in LM8LOW cells resembled LM8MOCK, whereas it was decreased in LM8HIGH cells. LM8LOW cells showed reduced adhesion, whereas LM8HIGH cells did not differ from LM8MOCK cells. Proliferation did not differ between LM8LOW cells and LM8HIGH cells. TGM2 was co‑expressed in CD31 + endothelial cells, and Ki67‑positive LM8 cells were observed along bronchi. These findings suggest that GPR56 promotes lung metastasis through TGM2‑mediated adhesion to pulmonary endothelial cells and enhanced ERK‑dependent proliferative signaling.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic mutations in primary and metastatic tumors of a rare mixed neuroendocrine carcinoma and high-grade serous ovarian cancer. 原发性和转移性肿瘤基因突变的罕见混合神经内分泌癌和高级别浆液性卵巢癌。

IF 1.4 4区医学

Medical Molecular Morphology Pub Date : 2026-06-01 Epub Date: 2026-02-07 DOI: 10.1007/s00795-025-00453-z

Qiqi Wang, Fenghui Zhao, Shoufeng Chang, Fenglei Liu, Wei Cai, Yamei Dang

引用次数: 0