Medical Molecular Morphology最新文献_第2页

Element analysis applied to investigate acute kidney injury induced by red yeast rice supplement. 应用元素分析法研究红麴补充剂诱发的急性肾损伤。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-11-13 DOI: 10.1007/s00795-024-00411-1

Makoto Abe, Tadayuki Ogawa, Nobuyuki Magome, Yuko Ono, Akihiro Tojo

引用次数: 0

Coexistence of complete intestinal tract, prostatic tissue, prostatic urethra and bladder structure in ovarian mature cystic teratoma: a case report. 卵巢成熟囊性畸胎瘤中同时存在完整的肠道、前列腺组织、前列腺尿道和膀胱结构：一份病例报告。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-11-11 DOI: 10.1007/s00795-024-00409-9

Kaho Ito, Kohei Nakamura, Takeshi Kajihara, Yu Shinozaki, Johji Imura, Hiroshi Sakuma

引用次数: 0

Primary hepatic alpha-fetoprotein-producing neuroendocrine neoplasm harboring FGFR2 and TP53 mutations: a case report and literature review. 携带表皮生长因子受体2和TP53突变的原发性肝甲胎蛋白神经内分泌肿瘤：病例报告和文献综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-11-10 DOI: 10.1007/s00795-024-00408-w

Hirofumi Watanabe, Kodai Enda, Fumiyoshi Fujishima, Hidekazu Shirota, Masashi Ninomiya, Tetsuro Yamazaki, Hironobu Sasano, Takashi Suzuki

{"title":"Primary hepatic alpha-fetoprotein-producing neuroendocrine neoplasm harboring FGFR2 and TP53 mutations: a case report and literature review.","authors":"Hirofumi Watanabe, Kodai Enda, Fumiyoshi Fujishima, Hidekazu Shirota, Masashi Ninomiya, Tetsuro Yamazaki, Hironobu Sasano, Takashi Suzuki","doi":"10.1007/s00795-024-00408-w","DOIUrl":"https://doi.org/10.1007/s00795-024-00408-w","url":null,"abstract":"This report presents a rare case of a 45-year-old man diagnosed with a primary hepatic alpha-fetoprotein-producing neuroendocrine neoplasm, a condition rarely reported in the literature. The patient presented with initial symptoms of back and epigastric pain, after which multiple liver lesions were discovered on contrast-enhanced computed tomography, suggesting intrahepatic cholangiocarcinoma. Histopathological and immunohistochemical analyses confirmed the diagnosis of alpha-fetoprotein-producing neuroendocrine neoplasm that was further supported by genetic testing, which revealed FGFR2 and TP53 mutations commonly encountered in intrahepatic cholangiocarcinoma. Despite receiving various chemotherapeutic regimens, the patient exhibited a progressive disease. This case underscores the importance of accurate differential diagnosis from hepatocellular carcinoma and intrahepatic cholangiocarcinoma due to differences in treatment approaches and prognoses and highlights the necessity for increased awareness of AFP-producing primary hepatic neuroendocrine neoplasms among clinicians and pathologists. It emphasizes the significance of comprehensive histopathological evaluation, immunohistochemical profiling, and genetic analysis for precise diagnosis and tailored therapeutic strategies. Further research is warranted to elucidate the molecular mechanisms underlying this rare liver tumor subtype and develop targeted treatments.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic adenosquamous carcinoma with sarcomatous transformation: a case report and review of the literature. 肝腺鳞癌伴肉瘤变：病例报告和文献综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-10-07 DOI: 10.1007/s00795-024-00406-y

Quynh Thi Nguyen, Hiep Canh Nguyen, Kenta Takahashi, Kaori Yoshimura, Hiroko Ikeda, Kazuto Kozaka, Zihan Li, Dong Thanh Le, Rui Yang, Shintaro Yagi, Kenichi Harada

{"title":"Hepatic adenosquamous carcinoma with sarcomatous transformation: a case report and review of the literature.","authors":"Quynh Thi Nguyen, Hiep Canh Nguyen, Kenta Takahashi, Kaori Yoshimura, Hiroko Ikeda, Kazuto Kozaka, Zihan Li, Dong Thanh Le, Rui Yang, Shintaro Yagi, Kenichi Harada","doi":"10.1007/s00795-024-00406-y","DOIUrl":"https://doi.org/10.1007/s00795-024-00406-y","url":null,"abstract":"Adenosquamous carcinoma (ASC) with the presence of a sarcomatous component is exceptionally uncommon in intrahepatic cholangiocarcinoma (iCCA). We report a case of hepatic ASC with rhabdoid transformation, one variation of sarcomatous change. A 72-year-old man was admitted to our hospital after being diagnosed with a 45 mm-diameter neoplastic lesion in the right hepatic duct on abdominal computed tomography. Laboratory findings showed increases in AST, ALT, ALP, gamma-GT, CA19-9 and DUPAN-II. The patient then underwent an extended right hepatectomy. Histopathologically, the tumor was composed of an ASC component within an abundant fibrous stroma and a sarcomatoid carcinoma component. By immunohistochemistry, keratin 7 and keratin 19 were expressed by all tumor cells. Expression of keratin 5/6, p40 and p63 was restricted to the squamous component. The sarcomatoid component was immunoreactive for vimentin with no loss of INI1 expression. This component also showed a loss of membranous E-cadherin expression and a reduction of membranous β-catenin expression. Staining for desmin, myoglobin and HepPar1 was negative in any tumor cells. The patient died of liver failure 3 months after surgery. This report aims to provide a better understanding of the clinicopathological characteristics and disease progression of the rare variants of iCCA to aid diagnosis and treatment.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is it really descemetocele? Morphology of extremely thin membrane that remained after severe corneal melting: a case report. 真的是角膜脱落症吗？严重角膜融化后残留的极薄膜的形态：病例报告。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-10-01 DOI: 10.1007/s00795-024-00405-z

Yasser Helmy Mohamed, Masafumi Uematsu, Mao Kusano, Takashi Kitaoka, Teruo Nishida

{"title":"Is it really descemetocele? Morphology of extremely thin membrane that remained after severe corneal melting: a case report.","authors":"Yasser Helmy Mohamed, Masafumi Uematsu, Mao Kusano, Takashi Kitaoka, Teruo Nishida","doi":"10.1007/s00795-024-00405-z","DOIUrl":"https://doi.org/10.1007/s00795-024-00405-z","url":null,"abstract":"The aim of this study was to report transmission electron microscopic findings of a case with whole corneal descemetocele following infective corneal ulcer for the first time in literature. A 72-year-old male patient presented with infective corneal ulcer. After resolution of the infection, corneoscleral transplantation was performed. The excised very thin corneal membrane was processed for transmission electron microscopic examination. Transmission electron microscopic examination of the specimen revealed many layered structures that consisted of two different types of cells. The first type consisted of lighter staining polygonal cells, while the second consisted of elongated cells with relatively dense staining. All cells were connected with a large number of gap or adherens junctions with intercalation of the cell membranes of adjacent cells. A haphazard distribution of cytoplasmic microfilaments were also observed in all of the cell types. There was no evidence of the presence of endothelial cells throughout the specimen. There was also no evidence of Descemet membrane presence except for a small part adjacent to iris tissue that contained some melanosomes. Although we clinically diagnosed descemetocele, Descemet membrane was not present at the electron microscopic level, and thus, the expression \"descemetocele\" is inappropriate.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leucine drives LAT1-related SNAIL upregulation in glucose-starved pancreatic cancer cells. 亮氨酸驱动葡萄糖饥饿的胰腺癌细胞中与 LAT1 相关的 SNAIL 上调。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-09-06 DOI: 10.1007/s00795-024-00404-0

Hajime Masubuchi, Yasuko Imamura, Takumi Kawaguchi, Hironori Koga

{"title":"Leucine drives LAT1-related SNAIL upregulation in glucose-starved pancreatic cancer cells.","authors":"Hajime Masubuchi, Yasuko Imamura, Takumi Kawaguchi, Hironori Koga","doi":"10.1007/s00795-024-00404-0","DOIUrl":"https://doi.org/10.1007/s00795-024-00404-0","url":null,"abstract":"Pancreatic cancer, a highly fibrotic and hypovascular tumor, is thought to have unique metabolic characteristics in surviving and proliferating in malnutritional microenvironments. In this study, we compared the differences in the ability of pancreatic cancer cells to adapt to glucose-free conditions with liver cancer cells, which are representative of hypervascular tumors. Three pancreatic cancer cells and two liver cancer cells were used to examine the transcriptional expression levels of molecules involved in intracellular amino acid uptake, epithelial-mesenchymal transition (EMT), and cancer stemness under glucose deprivation. The results showed that the proliferative activity of pancreatic cancer cells under glucose deprivation was significantly lower than that of liver cancer cells, but the expression levels of amino acid transporters were significantly higher. Among them, L-type amino acid transporter 1 (LAT1) upregulation was unique in concert with increased expression of the EMT regulator SNAIL and the cancer stemness marker doublecortin-like kinase 1. LAT1 knockdown canceled the upregulation of SNAIL in glucose-starved pancreatic cancer cells, suggesting a mechanistic link between the two molecules. When LAT1 was stimulated by its substrate leucine, the SNAIL expression was upregulated dose-dependently. Collectively, pancreatic cancer cells reprogrammed metabolism to adapt to energy crises involving leucine-induced SNAIL upregulation.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NF1 mutation and TUBB3 amplification in gastric histiocytic sarcoma: a case report and literature review. 胃组织细胞肉瘤中的NF1突变和TUBB3扩增：病例报告和文献综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1007/s00795-024-00393-0

Yi Yang, Wei Fan, Xiaoping Liu, Qiongrong Chen

{"title":"NF1 mutation and TUBB3 amplification in gastric histiocytic sarcoma: a case report and literature review.","authors":"Yi Yang, Wei Fan, Xiaoping Liu, Qiongrong Chen","doi":"10.1007/s00795-024-00393-0","DOIUrl":"10.1007/s00795-024-00393-0","url":null,"abstract":"Histiocytic sarcoma is a rare neoplasm of mature histiocytes with an aggressive clinical course and poor response to treatment. Primary gastric histiocytic sarcoma is rarer and just reported sporadically.Histiocytic sarcoma is a rare neoplasm of mature histiocytes with an aggressive clinical course and poor response to treatment. Primary gastric histiocytic sarcoma is rarer and just reported sporadically. A case of a 71-year-old female admitted with a one-year history of upper abdominal pain exacerbated after meals. After CT scans revealed a bulged mass at the lesser curvature of the gastric body, the patient underwent endoscopic submucosal dissection. Microscopically, non-cohesive neoplastic cells diffusely infiltrated lamina propria and submucosa, and diffusely expressed LCA, CD4, CD163, CD68 (KP1), Cyclin D1, Lysozyme, and Vimentin. PD-L1 (22CS) expression evaluated as CPS 60. The final pathological diagnosis was gastric histiocytic sarcoma. Subsequently, next-generation sequencing identified a nonsense mutation in exon 21 of NF1 gene [c.2446C > T (p.R816*)] and the TUBB3 gene amplification (copy number: 4.55). The patient refused further treatment and died of the tumor half a year later. This case broadens the spectrum of differential diagnosis of gastric cancer and emphasizes the value of immunohistochemical and molecular tests in the accurate diagnosis of histiocytic sarcoma. Furthermore, we performed literature review of 11 cases of gastric histiocytic sarcoma so as to strengthen the understanding of the clinicopathologic features, treatment, and prognosis.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"244-251"},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary hepatobiliary mucoepidermoid carcinoma: a case report and review of literature. 原发性肝胆粘液表皮样癌：病例报告和文献综述。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-09-01 Epub Date: 2024-06-21 DOI: 10.1007/s00795-024-00390-3

Zihan Li, Hiep Nguyen Canh, Khuyen Nguyen Thi, Kenta Takahashi, Quynh Nguyen Thi, Dong Le Thanh, Rui Yang, Yasunori Sato, Kenichi Harada

{"title":"Primary hepatobiliary mucoepidermoid carcinoma: a case report and review of literature.","authors":"Zihan Li, Hiep Nguyen Canh, Khuyen Nguyen Thi, Kenta Takahashi, Quynh Nguyen Thi, Dong Le Thanh, Rui Yang, Yasunori Sato, Kenichi Harada","doi":"10.1007/s00795-024-00390-3","DOIUrl":"10.1007/s00795-024-00390-3","url":null,"abstract":"Hepatobiliary mucoepidermoid carcinoma is a rare malignant tumor comprising mucous, intermediate, and epidermoid cells. Herein, we presented a case of primary liver mucoepidermoid carcinoma preoperatively misdiagnosed as conventional intrahepatic cholangiocarcinoma. A 67-year-old male was admitted to our hospital. Preoperative laboratory tests showed increased aspartate transaminase, alanine transaminase, and carbohydrate antigen 19-9. Abdominal Computer Tomography revealed a 4.8 × 4.9 cm liver mass in segment VI. A preliminary diagnosis of intrahepatic cholangiocarcinoma was made, with undergoing partial hepatectomy. However, on histopathology, the tumor comprised a mixture of epidermoid, mucous, and intermediate cells with diffuse infiltrating at the tumor margin. On special stains, mucous and intermedia cells were positive for mucicarmine and Alcian blue, whereas epidermoid cells were positive for Keratin 5/6 and p63. Intermediate cells are also positive for p63. All tumor cells were positive for Keratin 7. The Ki-67 index was 35%. The final diagnosis was primary hepatic mucoepidermoid carcinoma. Although rare, hepatic mucoepidermoid carcinoma should be considered in the intrahepatic cholangiocarcinoma differential diagnosis. We reviewed previous studies and found that hepatobiliary mucoepidermoid carcinoma is more likely to originate from the biliary tract adjacent to the tumor.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"233-243"},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver fibrosis analysis using digital pathology. 利用数字病理学进行肝纤维化分析。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI: 10.1007/s00795-024-00395-y

Hisamitsu Miyaaki, Satoshi Miuma, Masanori Fukusima, Ryu Sasaki, Masafumi Haraguchi, Yasuhiko Nakao, Yuko Akazawa, Kazuhiko Nakao

引用次数: 0

P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer. 参与 SLUG 相关 EMT 的 P4HA2 预测了 KRAS 阳性结直肠癌患者的不良预后。

IF 1.2 4区医学

Medical Molecular Morphology Pub Date : 2024-09-01 Epub Date: 2024-03-24 DOI: 10.1007/s00795-024-00385-0

Heba El-Deek Mohammed El-Deek, Maha Salah El-Naggar, Aiat Morsy Mohamed Morsy, Mayada Fawzy Sedik, Heba Ahmed Osman, Asmaa M Ahmed

{"title":"P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer.","authors":"Heba El-Deek Mohammed El-Deek, Maha Salah El-Naggar, Aiat Morsy Mohamed Morsy, Mayada Fawzy Sedik, Heba Ahmed Osman, Asmaa M Ahmed","doi":"10.1007/s00795-024-00385-0","DOIUrl":"10.1007/s00795-024-00385-0","url":null,"abstract":"This study aimed to examine the immunohistochemical expression of epithelial-mesenchymal transition biomarkers: P4HA2 and SLUG in colorectal carcinoma (CRC) specimens, then to assess their relation to clinicopathological features including KRAS mutations and patients' survival, and finally to study the correlation between them in CRC. The result of this study showed that SLUG and P4HA2 were significantly higher in association with adverse prognostic factors: presence of lympho-vascular invasion, perineural invasion, higher tumor budding, tumor stage, presence of lymph node metastasis, and presence of distant metastasis. CRC specimens with KRAS mutation were associated with significant higher SLUG and P4HA2 expression. High expression of both SLUG and P4HA2 was significantly unfavorable prognostic indicator as regards overall survival (OS) and disease-free survival (DFS). In KRAS mutated cases, high P4HA2 expression was the only significant poor prognostic indicator as regarding DFS. In conclusions, our data highlight that both SLUG and P4HA2 expression may serve as potentially important poor prognostic biomarkers in CRC and targeting these molecules may be providing a novel therapeutic strategy. In KRAS mutation group, high P4HA2 expression is the only independent prognostic factor for tumor recurrence, so it can be suggested to be a novel target for therapy.","PeriodicalId":18338,"journal":{"name":"Medical Molecular Morphology","volume":" ","pages":"167-176"},"PeriodicalIF":1.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11343967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0