The cross-talk between NRF2 and apoptosis in cancer.

IF 1.2 4区医学 Q3 PATHOLOGY

Medical Molecular Morphology Pub Date : 2025-03-24 DOI:10.1007/s00795-025-00434-2

Elmira Aboutalebi Vand Beilankouhi, Bahareh Yousefi, Niloofar Sadat Hadian, Reza Safaralizadeh, Mohammad Valilo

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引用次数: 0

Abstract

Cancer is one of the common diseases that affects people in the society, the prevalence of which has decreased somewhat in recent years. Various genetic and environmental factors play a role in the development and progression of cancer. NRF2 is a transcriptional regulator that controls the expression of antioxidant response element-related genes. It plays an important role in regulating the physiological and pathophysiological consequences of oxidant exposure. NRF2 is also responsible for regulating the expression of various cellular protective genes. NRF2 activity is regulated at multiple levels including protein stability, transcription, and post-transcription. The Keap1-Cul3-Rbx1 axis is the most prominent regulator of NRF2 activity. Apoptosis is a type of programmed cell death that is initiated by two intrinsic and extrinsic pathways. Caspases play a major role in this cell death pathway. Apoptosis pathway is related to many cells signaling pathways that are interconnected. Disruption in one pathway affects the other pathway. One of these signaling pathways is the NRF2 pathway, which is associated with apoptosis, which are interconnected and play an important role in disease prevention or progression. Therefore, in this study, we decided to investigate the relationship between NRF2 and apoptosis in cancer.

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NRF2与肿瘤细胞凋亡的交互作用。

癌症是社会上影响人们的常见疾病之一，近年来发病率有所下降。各种遗传和环境因素在癌症的发生和发展中起作用。NRF2是一种转录调节因子，控制抗氧化反应元件相关基因的表达。它在调节氧化暴露的生理和病理生理后果中起着重要作用。NRF2还负责调节各种细胞保护基因的表达。NRF2活性在多个水平上受到调节，包括蛋白质稳定性、转录和转录后。Keap1-Cul3-Rbx1轴是NRF2活性最显著的调节因子。细胞凋亡是一种程序性细胞死亡，由两种内在和外在途径引发。半胱天冬酶在这一细胞死亡途径中起主要作用。凋亡通路与许多相互关联的细胞信号通路有关。一个通路的中断会影响另一个通路。其中一个信号通路是与细胞凋亡相关的NRF2通路，它们相互关联，在疾病的预防或进展中起重要作用。因此，在本研究中，我们决定研究NRF2与肿瘤细胞凋亡的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Molecular Morphology 医学-病理学

CiteScore

2.90

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Medical Molecular Morphology is an international forum for researchers in both basic and clinical medicine to present and discuss new research on the structural mechanisms and the processes of health and disease at the molecular level. The structures of molecules, organelles, cells, tissues, and organs determine their normal function. Disease is thus best understood in terms of structural changes in these different levels of biological organization, especially in molecules and molecular interactions as well as the cellular localization of chemical components. Medical Molecular Morphology welcomes articles on basic or clinical research in the fields of cell biology, molecular biology, and medical, veterinary, and dental sciences using techniques for structural research such as electron microscopy, confocal laser scanning microscopy, enzyme histochemistry, immunohistochemistry, radioautography, X-ray microanalysis, and in situ hybridization. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.