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Conversion of p-coumaric acid to caffeic acid and of p-hydroxyphenylacetic acid to 3,4-dihydroxyphenylacetic acid by Alnus rubra. 红桤木对香豆酸转化为咖啡酸和对羟基苯基乙酸转化为3,4-二羟基苯基乙酸。
Lloydia Pub Date : 1977-05-01
C Y Li
{"title":"Conversion of p-coumaric acid to caffeic acid and of p-hydroxyphenylacetic acid to 3,4-dihydroxyphenylacetic acid by Alnus rubra.","authors":"C Y Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"298-30"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a). 天然抗肿瘤药物的微生物转化。黑坎宁哈默氏菌(Cunninghamella blackesleana, ATCC 8688a) N-(2)-no -d-粉防己碱的形成。
Lloydia Pub Date : 1977-05-01
P J Davis, D R Wiese, J P Rosazza
{"title":"Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a).","authors":"P J Davis,&nbsp;D R Wiese,&nbsp;J P Rosazza","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"239-46"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolites of aspergilli. III. The isolation of citrinin, dihydrocitrinone and sclerin from aspergilus carneus. 曲霉的代谢物。3柠檬酸苷、二氢柠檬酸苷和硬化苷的分离。
Lloydia Pub Date : 1977-05-01
M M Chien, P L Schiff, D J Slatkin, J E Knapp
{"title":"Metabolites of aspergilli. III. The isolation of citrinin, dihydrocitrinone and sclerin from aspergilus carneus.","authors":"M M Chien,&nbsp;P L Schiff,&nbsp;D J Slatkin,&nbsp;J E Knapp","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"301-2"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and characterization of (+)-cannabitriol and (-)-10-ethoxy-9-hydroxy-delta 6a[10a]-tetrahydrocannabinol: two new cannabinoids from Cannabis sativa L. extract. 大麻提取物中(+)-大麻二醇和(-)-10-乙氧基-9-羟基- δ 6a[10a]-四氢大麻酚的分离与表征
Lloydia Pub Date : 1977-05-01
M A Elsohly, F S El-Feraly, C E Turner
{"title":"Isolation and characterization of (+)-cannabitriol and (-)-10-ethoxy-9-hydroxy-delta 6a[10a]-tetrahydrocannabinol: two new cannabinoids from Cannabis sativa L. extract.","authors":"M A Elsohly,&nbsp;F S El-Feraly,&nbsp;C E Turner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"275-80"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antineoplastic agents. 51. The yellow jacket Vespula pensylvanica. 抗肿瘤的代理。51. 黄色夹克的宾夕法尼亚蕨。
Lloydia Pub Date : 1977-05-01
G R Pettit, R M Blazer, D A Reierson
{"title":"Antineoplastic agents. 51. The yellow jacket Vespula pensylvanica.","authors":"G R Pettit,&nbsp;R M Blazer,&nbsp;D A Reierson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An ethyl alcohol extract of the yellow jacket Vespula pensylvanica Saussure was found to inhibit growth of the murine P388 lymphocytic leukemia cell line. Separation of a ligroin fraction guided by bioassay led to characterization of the cytotoxic constituents as oleic acid (1a) and palmitoleic acid (1b). Evidence was also found for the presence of palmitic acid and the sterols sitosterol, campesterol and cholesterol.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"247-52"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suitability of antidigoxin antiserum for digoxin in plant extracts. 地高辛抗血清对地高辛植物提取物的适用性。
Lloydia Pub Date : 1977-05-01
S L Nickel, E J Staba
{"title":"Suitability of antidigoxin antiserum for digoxin in plant extracts.","authors":"S L Nickel,&nbsp;E J Staba","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Antiserum specificity for digoxin was demonstrated by means of three tests: cross-reactivities test, dilutions test and thin-layer chromatography test. The cross-reactivities test examined quantitatively the cross-reactivities with specific compounds and provided an explanation for the basis of the dilutions test. The dilutions test was used to demonstrate the suitability or unsuitability of the antiserum for use in the radioimmunoassay of digoxin in a crude biological sample. The tlc test examined for antiserum cross-reactivity with digoxin and related compounds in a crude extract.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"231-5"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11763727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaloids of thalictrum. XX. Isolation, identification and structural elucidation of the alkaloids of the root of Thalictrum longistylum. 海芋生物碱。XX。长茎锥根生物碱的分离、鉴定及结构分析。
Lloydia Pub Date : 1977-05-01
W N Wu, J L Beal, R P Leu, R W Doskotch
{"title":"Alkaloids of thalictrum. XX. Isolation, identification and structural elucidation of the alkaloids of the root of Thalictrum longistylum.","authors":"W N Wu,&nbsp;J L Beal,&nbsp;R P Leu,&nbsp;R W Doskotch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study of the alkaloids of the roots of Thalictrum longistylum DC. resulted in the isolation of 12 alkaloids plus an artifact, 8-trichloromethyldihydroberberine. The 12 alkaloids were berberine, columbamine, jatrorrhizine, magnoflorine, methothalistyline, N-desmethylthalistyline, oxyberberine, palmatine, thalibrine, thalifendine, thaliglucinone, and thalistyline. Of these alkaloids, methothalistyline, N-desmethylthalistyline, and thalistyline are new compounds and with thaliglucinone possess hypotensive activity in dogs and rabbits. Methothalistyline, N-demethylthalistyline, thalistyline, and thalibrine were found to be active against Staphylococcus aureus and Mycobacterium smegmatis with with thalistyline being most active (50 microgram/ml).</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"281-9"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The succulent Euphorbias of Nigeria. II. aliphatic diterpene esters of the latices of E. poisonii Pax. and E. unispina N.E. Br. 尼日利亚多汁的大戟。二、博氏乳杆菌（E.poisonii Pax）胶乳的脂族二萜酯。和E.unispina N.E.Br。
Lloydia Pub Date : 1977-05-01
R J Schmidt, F J Evans
{"title":"The succulent Euphorbias of Nigeria. II. aliphatic diterpene esters of the latices of E. poisonii Pax. and E. unispina N.E. Br.","authors":"R J Schmidt,&nbsp;F J Evans","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Methanol-preserved latices of E. poisonii and E. unispina were examined for irritant principles. Six esters of the parent diterpene 12-deoxyphorbol were identified by spectroscopic and chemical methods. Three were the aliphatic esters 12-deoxyphorbol-13-(2-methyl-butyrate), 12-deoxyphorbol-13-angelate and 12-deoxyphorbol-13-isobutyrate, and a further three compounds were the 20-acetyl equivalents. Isobutyrate esters were absent from the latex of E. unispina, an observation of possible value in the identification of these two similar species.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"225-9"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cesalin--an anti-neoplastic protein. 凯撒林——一种抗肿瘤蛋白。
Lloydia Pub Date : 1977-05-01
R Montgomery, F Yamauchi
{"title":"Cesalin--an anti-neoplastic protein.","authors":"R Montgomery,&nbsp;F Yamauchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An anti-neoplastic protein was isolated from the endosperm of the seeds of Caesalpinia gilliesii by extraction with water, dialysis and precipitation by ammonium sulfate or acidification. The precipitated protein mixture was separated by column chromatography into three principal proteins, one of which, termed cesalin, inhibited the growth of Walker 256 carcinosarcoma. There is an associated carbohydrate with the cesalin that can be largely removed by chromatography on hydroxyl apatite; the remaining carbohydrate (about 0.3%) is a hexosan. Cesalin, molecular weight 110,000, migrates as a single component by polyacrylamide gel electrophoresis at pH 8.3, but in a denaturing system containing sodium dodecyl sulfate three bands were observed. The correspond to protein sub-units of approximately 30,000 daltons. Anti-tumor tests in rats showed 70-80% inhibition of Walker 256 growth at a dose of 80 microgram/kg/day of cesalin.</p>","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"269-74"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12079642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacologically active substances from the sea, II. Various cardiovascular activities found in the extracts of marine organisms. 海洋药理活性物质2。在海洋生物的提取物中发现了各种心血管活动。
Lloydia Pub Date : 1977-05-01
P N Kaul, S K Kulkarni
{"title":"Pharmacologically active substances from the sea, II. Various cardiovascular activities found in the extracts of marine organisms.","authors":"P N Kaul,&nbsp;S K Kulkarni","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"253-68"},"PeriodicalIF":0.0,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11243549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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