天然抗肿瘤药物的微生物转化。黑坎宁哈默氏菌(Cunninghamella blackesleana, ATCC 8688a) N-(2)-no -d-粉防己碱的形成。

Lloydia Pub Date : 1977-05-01

P J Davis, D R Wiese, J P Rosazza

{"title":"天然抗肿瘤药物的微生物转化。黑坎宁哈默氏菌(Cunninghamella blackesleana, ATCC 8688a) N-(2)-no -d-粉防己碱的形成。","authors":"P J Davis, D R Wiese, J P Rosazza","doi":"","DOIUrl":null,"url":null,"abstract":"Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.","PeriodicalId":18256,"journal":{"name":"Lloydia","volume":"40 3","pages":"239-46"},"PeriodicalIF":0.0000,"publicationDate":"1977-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a).\",\"authors\":\"P J Davis, D R Wiese, J P Rosazza\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.\",\"PeriodicalId\":18256,\"journal\":{\"name\":\"Lloydia\",\"volume\":\"40 3\",\"pages\":\"239-46\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1977-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lloydia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lloydia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

用抗肿瘤生物碱d-粉防己碱进行了微生物转化实验。该生物碱被黑坎宁哈默菌ATCC 8688a选择性地在N-(2)位去甲基化。该生物转化反应具有高度选择性，且不会产生复杂的副产物。使用氯甲酸甲酯进行生物碱的n -去甲基化不具有区域特异性。筛选微生物产生d-粉防己碱代谢物的能力的程序进行了评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Microbial transformations of natural antitumor agents. IV. Formation of N-(2)-nor-d-tetrandrine by Cunninghamella blakesleeana (ATCC 8688a).

Microbial transformation experiments have been conducted with the antitumor alkaloid, d-tetrandrine. The alkaloid is selectively demethylated at the N-(2)-position by Cunninghamella blakesleeana ATCC 8688a. The biotransformation reaction is highly selective and uncomplicated by side-product formation. N-demethylation of the alkaloid using methylchloroformate is not regio-specific. Procedures used in screening microorganisms for their abilities to yield metabolites of d-tetrandrine are evaluated.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Lloydia

自引率

0.00%

发文量