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[When the tumor talks to the bone marrow: a new dimension of immunosuppression]. [当肿瘤与骨髓对话：免疫抑制的新维度]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026044
Pauline Hamon
{"title":"[When the tumor talks to the bone marrow: a new dimension of immunosuppression].","authors":"Pauline Hamon","doi":"10.1051/medsci/2026044","DOIUrl":"https://doi.org/10.1051/medsci/2026044","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"325-327"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New candidate genes for prostate cancer germline testing in men of African ancestry]. [非洲裔男性前列腺癌生殖系检测的新候选基因]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026048
Olivier Cussenot, Géraldine Cancel-Tassin
{"title":"[New candidate genes for prostate cancer germline testing in men of African ancestry].","authors":"Olivier Cussenot, Géraldine Cancel-Tassin","doi":"10.1051/medsci/2026048","DOIUrl":"https://doi.org/10.1051/medsci/2026048","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"337-339"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Astrocytes and sleep: from genes to networks]. [星形胶质细胞与睡眠：从基因到网络]
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026054
Armelle Rancillac
{"title":"[Astrocytes and sleep: from genes to networks].","authors":"Armelle Rancillac","doi":"10.1051/medsci/2026054","DOIUrl":"10.1051/medsci/2026054","url":null,"abstract":"<p><p>Astrocytes are glial cells of the central nervous system that play key roles in regulating synaptic activity and sleep. Recent advances in genetic engineering, neuroimaging, and molecular biology have provided new insights into astrocytic functions. This review highlights the various mechanisms through which astrocytes regulate sleep, including transcriptomic and morphological changes, as well as gliotransmission. A better understanding of these astrocyte-dependent processes in sleep physiology will refine current models of sleep regulation and may open new avenues for sleep-targeted therapies.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"355-364"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comment to: House of cards?] [评论：《纸牌屋》？］
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026084
{"title":"[Comment to: House of cards?]","authors":"","doi":"10.1051/medsci/2026084","DOIUrl":"https://doi.org/10.1051/medsci/2026084","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"397"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The interkinetic envelope: a discovery that challenges our knowledge of oocyte meiosis]. [相互作用包膜：一个挑战我们对卵母细胞减数分裂知识的发现]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026046
Layla El Mossadeq, Julien Dumont
{"title":"[The interkinetic envelope: a discovery that challenges our knowledge of oocyte meiosis].","authors":"Layla El Mossadeq, Julien Dumont","doi":"10.1051/medsci/2026046","DOIUrl":"https://doi.org/10.1051/medsci/2026046","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"331-334"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clonal trajectories of post-transplant hematopoiesis]. 移植后造血的克隆轨迹。
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026056
Laurence Guyonneau-Harmand, Thierry Jaffredo
{"title":"[Clonal trajectories of post-transplant hematopoiesis].","authors":"Laurence Guyonneau-Harmand, Thierry Jaffredo","doi":"10.1051/medsci/2026056","DOIUrl":"10.1051/medsci/2026056","url":null,"abstract":"<p><p>Hematopoiesis relies on self-renewing hematopoietic stem and more committed progenitor cells (HSPCs), which occurs in specialized niches. Their transplantation can effectively treat malignant blood disorders and genetic diseases, thanks to advances in HLA typing, cell sources, and conditioning regimens. Clonal tracing reveals a biphasic pattern of hematopoietic reconstitution following transplantation, with initial contribution from short-term progenitors followed by long-term multi-potent hematopoietic stem cells (HSCs). Reconstituted hematopoiesis remains polyclonal, and is influenced by donor age, pathological context, and genetic history. Transplantation does not increase the mutational burden but induces clonal selection, leading to reduced clonal diversity, especially with HSPC from older donors. These results validate HSPC-based gene therapy and open new prospects for optimizing donor selection, conditioning regimens, and personalized patient care.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"373-381"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Humanin: a mitochondria-hidden peptide serving inflammation resolution]. Humanin：一种线粒体隐藏肽，用于解决炎症。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026049
Mélissa Maraux, Philippe Saas, Thomas Cherrier
{"title":"[Humanin: a mitochondria-hidden peptide serving inflammation resolution].","authors":"Mélissa Maraux, Philippe Saas, Thomas Cherrier","doi":"10.1051/medsci/2026049","DOIUrl":"https://doi.org/10.1051/medsci/2026049","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"340-343"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Telomere]. (端粒)。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026059
Anna Salvetti
{"title":"[Telomere].","authors":"Anna Salvetti","doi":"10.1051/medsci/2026059","DOIUrl":"https://doi.org/10.1051/medsci/2026059","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"389"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A "prion mechanism" involved in the progression of Parkinson's disease: towards innovative therapeutic approaches?] 参与帕金森病进展的“朊病毒机制”：迈向创新治疗方法？］
IF 0.5 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026058
Thierry Baron
{"title":"[A \"prion mechanism\" involved in the progression of Parkinson's disease: towards innovative therapeutic approaches?]","authors":"Thierry Baron","doi":"10.1051/medsci/2026058","DOIUrl":"10.1051/medsci/2026058","url":null,"abstract":"<p><p>Knowledge demonstrating the involvement of protein misfolding propagation mechanisms in the progression of Parkinson's disease opens up new therapeutic prospects. This article illustrates this possibility through two recent major publications. The first study focuses on a new receptor (FAM171A2) for abnormally folded α-synuclein protein, which could be blocked to limit the propagation of the pathological protein from cell to cell. The second study highlights that the unstructured ends of this protein have variable positions that may influence its pathogenicity and ability to spread. Modifying this positioning through the action of a substance, such as an antibody, could be an approach to slowing the progression of the disease.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"385-388"},"PeriodicalIF":0.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[HIV-1 translational inventory reveals about a hundred of alternative ORFs and new antigens]. [HIV-1翻译清单揭示了大约100种替代orf和新的抗原]。
IF 0.4 4区 医学
M S-medecine Sciences Pub Date : 2026-04-01 Epub Date: 2026-04-24 DOI: 10.1051/medsci/2026051
Arnaud Moris, Emiliano Ricci, Olivier Namy
{"title":"[HIV-1 translational inventory reveals about a hundred of alternative ORFs and new antigens].","authors":"Arnaud Moris, Emiliano Ricci, Olivier Namy","doi":"10.1051/medsci/2026051","DOIUrl":"https://doi.org/10.1051/medsci/2026051","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"42 4","pages":"346-349"},"PeriodicalIF":0.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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