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[Preparedness and response to pandemic at risk of demobilization]. [防备和应对面临遣散风险的大流行病]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024173
Alix Zuinghedau, Michel Kazatchkine
{"title":"[Preparedness and response to pandemic at risk of demobilization].","authors":"Alix Zuinghedau, Michel Kazatchkine","doi":"10.1051/medsci/2024173","DOIUrl":"https://doi.org/10.1051/medsci/2024173","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"805-806"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[AI-based discovery of broadly neutralizing antibodies against HIV-1]. [基于人工智能发现针对 HIV-1 的广泛中和抗体]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024144
Mathilde Foglierini, Laurent Perez
{"title":"[AI-based discovery of broadly neutralizing antibodies against HIV-1].","authors":"Mathilde Foglierini, Laurent Perez","doi":"10.1051/medsci/2024144","DOIUrl":"https://doi.org/10.1051/medsci/2024144","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"819-821"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Arthrogryposis Multiplex Congenita in pediatric age: Correlation between Muscle MRI and functional assessment]. [先天性多关节炎：肌肉磁共振成像与功能评估之间的相关性]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024131
Alicia Milot, Mariya Raikova, Claire Huzar, Véronique Thellier, Nicolas Hergibo, Marjolaine Gauthier, Gipsy Billy-Lopez, Chantal Durand, Frédérique Nugues, Véronique Bourg, Klaus Dieterich
{"title":"[Arthrogryposis Multiplex Congenita in pediatric age: Correlation between Muscle MRI and functional assessment].","authors":"Alicia Milot, Mariya Raikova, Claire Huzar, Véronique Thellier, Nicolas Hergibo, Marjolaine Gauthier, Gipsy Billy-Lopez, Chantal Durand, Frédérique Nugues, Véronique Bourg, Klaus Dieterich","doi":"10.1051/medsci/2024131","DOIUrl":"10.1051/medsci/2024131","url":null,"abstract":"<p><p>Arthrogryposis multiplex congenita (AMC) is a group of diseases with joint limitations at two or more distinct joint levels at birth. Joint limitations are not progressive, but the functional consequences have a lifelong impact on patients. In this article we will present the results of our study aimed at evaluating the correlation between muscle fat infiltration on MRI and activity deficiencies and limitations in children with AMC. Our study is one of the first in a pediatric population to establish the link between muscle imaging and functional aspects of AMC.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"26-29"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of the Advanced practice nurse (APN) in the follow-up of respiratory failure in neuromuscular patient]. [高级实践护士（APN）在神经肌肉患者呼吸衰竭随访中的作用]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024136
Raja Kraiem
{"title":"[Role of the Advanced practice nurse (APN) in the follow-up of respiratory failure in neuromuscular patient].","authors":"Raja Kraiem","doi":"10.1051/medsci/2024136","DOIUrl":"10.1051/medsci/2024136","url":null,"abstract":"<p><p>This study, which focuses on the follow-up of respiratory failure in neuromuscular patients, highlights the need to improve the supply of care and to compensate for gaps in care. Advanced practice nurses (APNs) as part of a multidisciplinary approach, could be the missing link. Improving the management of neuromuscular disorders is a key concern for the Filnemus neuromuscular rare disease network, the reference centers and the AFM-Téléthon. This is also where the need for an APN specialized in neuromuscular disorders is being discussed, and which could meet needs that are not covered, or are insufficiently covered, in the healthcare pathway.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"9-11"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Semaphorin-3A signaling decreases the porosity of sinusoidal endothelial cells in steatotic liver diseases]. [Semaphorin-3A信号降低了脂肪肝患者窦状内皮细胞的孔隙率】。］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024142
Nadia Ciriaci, Pierre-Emmanuel Rautou, Johanne Poisson
{"title":"[Semaphorin-3A signaling decreases the porosity of sinusoidal endothelial cells in steatotic liver diseases].","authors":"Nadia Ciriaci, Pierre-Emmanuel Rautou, Johanne Poisson","doi":"10.1051/medsci/2024142","DOIUrl":"https://doi.org/10.1051/medsci/2024142","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"812-815"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New-generation editing]. [新一代编辑］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024149
Bertrand Jordan
{"title":"[New-generation editing].","authors":"Bertrand Jordan","doi":"10.1051/medsci/2024149","DOIUrl":"10.1051/medsci/2024149","url":null,"abstract":"<p><p>Recent work on bacterial insertion sequences reveals that some of them use an RNA sequence (called Bridge RNA or Seek RNA) to define both donor and target DNA specificity. This opens the way to easy insertion of kilobase DNA sequences at pre-defined sites in the genome, announcing a host of new possibilities. The system still needs a lot of tweaking, as it has only been demonstrated in bacteria, but it holds great promise for genome editing and engineering.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"869-871"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transcription factors NEUROD1 and NEUROD4 in the migration of gonadotrope cells during pituitary embryogenesis]. [转录因子 NEUROD1 和 NEUROD4 在垂体胚胎发育过程中促性腺激素细胞迁移中的作用］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024141
Charles Le Ciclé, Vincent Pacini, Nicolas Rama, Servane Tauszig-Delamasure, Éloïse Airaud, Florence Petit, Simon de Beco, Joëlle Cohen-Tannoudji, David L'Hôte
{"title":"[Transcription factors NEUROD1 and NEUROD4 in the migration of gonadotrope cells during pituitary embryogenesis].","authors":"Charles Le Ciclé, Vincent Pacini, Nicolas Rama, Servane Tauszig-Delamasure, Éloïse Airaud, Florence Petit, Simon de Beco, Joëlle Cohen-Tannoudji, David L'Hôte","doi":"10.1051/medsci/2024141","DOIUrl":"https://doi.org/10.1051/medsci/2024141","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"810-812"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Muscle stem cells and metabolism in Duchenne muscular dystrophy, focus on AMPK]. [杜氏肌肉萎缩症的肌肉干细胞和新陈代谢，聚焦 AMPK】。］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024133
Audrey Saugues, Anita Kneppers, Rémi Mounier
{"title":"[Muscle stem cells and metabolism in Duchenne muscular dystrophy, focus on AMPK].","authors":"Audrey Saugues, Anita Kneppers, Rémi Mounier","doi":"10.1051/medsci/2024133","DOIUrl":"https://doi.org/10.1051/medsci/2024133","url":null,"abstract":"<p><p>Through their myogenic activity, adult muscle stem cells (MuSCs) are crucial for the regeneration of striated skeletal muscle. Once activated, they proliferate, differentiate and then fuse to repair or form new muscle fibers (myofibers). Their progression through myogenesis requires a complex regulation involving multiple players such as metabolism, in particular via AMPK. This protein kinase regulates the self-renewal and myonuclear accretion of MuSCs after acute skeletal muscle injury or skeletal muscle contraction. However, in a context of dystrophy such as Duchenne muscular dystrophy (DMD), the regenerative capacity of MuSCs is reduced, presumably due to an increase of the proliferation that is detrimental to differentiation. We are interested here in the potential of metabolism to regulate the myogenic activity of MuSCs in DMD via AMPK.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"60-63"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of the transcription factor PAX3 during myogenesis: from the embryo to the adult stage]. [转录因子 PAX3 在肌肉生成过程中的作用：从胚胎到成体阶段】。］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-11-18 DOI: 10.1051/medsci/2024139
Virginia Zoglio, Joana Esteves de Lima, Frédéric Relaix
{"title":"[Role of the transcription factor PAX3 during myogenesis: from the embryo to the adult stage].","authors":"Virginia Zoglio, Joana Esteves de Lima, Frédéric Relaix","doi":"10.1051/medsci/2024139","DOIUrl":"10.1051/medsci/2024139","url":null,"abstract":"<p><p>PAX3 plays a crucial role in embryonic myogenesis, controlling the specification, migration, proliferation, and differentiation of muscle progenitor cells to ensure normal skeletal muscle development in the embryo. However, PAX3 potential role in a context of muscle homeostasis and regeneration remains poorly investigated. The adult muscle stem cells, known as satellite cells (SCs) exhibit heterogeneity in Pax3 expression in various muscles throughout the body and display a bimodal response to environmental stress exposure. To explore the role of PAX3 in the context of tissue damage, we performed regeneration studies, which unveiled a functional heterogeneity of the SCs populations depending on Pax3 expression. Together, this project aims to decipher cell-type specific dysregulations linked to tissue damage and identify PAX3 downstream gene regulatory networks that can lead to specific SC behavior, thus potentially providing novel strategies for muscle disease preventive therapies.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 Hors série n° 1 ","pages":"56-59"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[From the discovery of incretin hormones to GIP / GLP-1 / glucagon double and triple agonists]. [从发现增量素激素到 GIP / GLP-1 / 胰高血糖素双重和三重激动剂]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2024-11-01 Epub Date: 2024-12-10 DOI: 10.1051/medsci/2024153
Franck Phan, Romane Bertrand, Chloé Amouyal, Fabrizio Andreelli
{"title":"[From the discovery of incretin hormones to GIP / GLP-1 / glucagon double and triple agonists].","authors":"Franck Phan, Romane Bertrand, Chloé Amouyal, Fabrizio Andreelli","doi":"10.1051/medsci/2024153","DOIUrl":"https://doi.org/10.1051/medsci/2024153","url":null,"abstract":"<p><p>The concept of treating diabetes with gut hormones was proposed in the early days of endocrinology (1902), but was not put into practice until the early 2000s. The discovery of the incretin effect (potentiation of insulin secretion when glucose is taken orally compared to intravenously) led to the discovery of the two main gut hormones responsible for this effect: GIP and GLP-1. The reduction of the incretin effect is directly involved in the pathogenesis of type 2 diabetes, which has led to the development of a series of innovative therapies such as GLP-1 analogues, GLP-1 receptor agonists, GIP/GLP-1 co-agonists and GIP/GLP-1/glucagon tri-agonists. These therapies, with their potent hypoglycaemic and weight-lowering effects, promote optimal control of excess weight and hyperglycaemia, avoiding the escalation of treatment that was once considered inevitable.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"40 11","pages":"837-847"},"PeriodicalIF":0.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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