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[New insights of vitamin D-based therapy for prostate cancer]. [基于维生素d的前列腺癌治疗的新见解]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1051/medsci/2025011
Kateryna Len-Tayon, Daniel Metzger, Gilles Laverny
{"title":"[New insights of vitamin D-based therapy for prostate cancer].","authors":"Kateryna Len-Tayon, Daniel Metzger, Gilles Laverny","doi":"10.1051/medsci/2025011","DOIUrl":"10.1051/medsci/2025011","url":null,"abstract":"<p><p>Prostate cancer is the third leading cause of cancer-related death among men in developed countries. Hormone and chemotherapy are the standard of care for advanced prostate cancer, but most patients develop resistance. Therefore, new therapeutic strategies are needed to improve the clinical management of prostate cancer. Low circulating levels of the secosteroid hormone vitamin D, and reduced expression of its receptor in prostate epithelial cells correlate with prostate cancer severity. However, the mechanisms underlying the anticancer effects of vitamin D are poorly understood. Our recent work demonstrates the therapeutic effects of a vitamin D analog on the tumor microenvironment in Pten<sup>(i)pe-/-</sup> mice, a mouse model of prostate cancer. In addition, we have shown that the combination of a vitamin D analog with the chemotherapeutic agent docetaxel, overcomes chemoresistance in primary prostate cancer spheroids, and in xenografts derived from a patient with prostate cancer resistant to docetaxel and to androgen deprivation. Therefore, therapeutic strategies based on the use of vitamin D analogs represent new avenues for advanced prostate cancer.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 2","pages":"154-159"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nobel Prize in physiology or medicine 2024: Victor Ambros and Gary Ruvkun - The discovery of microRNAs, revealing a New World in genetics]. [2024年诺贝尔生理学或医学奖：Victor Ambros和Gary Ruvkun -发现microrna，揭示遗传学的新世界]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1051/medsci/2025012
Pauline De Sousa, Hervé Seitz
{"title":"[Nobel Prize in physiology or medicine 2024: Victor Ambros and Gary Ruvkun - The discovery of microRNAs, revealing a New World in genetics].","authors":"Pauline De Sousa, Hervé Seitz","doi":"10.1051/medsci/2025012","DOIUrl":"10.1051/medsci/2025012","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 2","pages":"180-185"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Stark regional differences in excess mortality during the Covid-19 pandemic in Europe in 2020 and 2021]. [2020年和2021年欧洲Covid-19大流行期间死亡率过高的明显区域差异]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1051/medsci/2025001
Florian Bonnet, Carlo-Giovanni Camarda
{"title":"[Stark regional differences in excess mortality during the Covid-19 pandemic in Europe in 2020 and 2021].","authors":"Florian Bonnet, Carlo-Giovanni Camarda","doi":"10.1051/medsci/2025001","DOIUrl":"https://doi.org/10.1051/medsci/2025001","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 2","pages":"113-116"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gut microbiome, a new tool for Alzheimer diagnosis]. [肠道微生物组，阿尔茨海默病诊断的新工具]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1051/medsci/2025019
Louison Girodon, Perrine Hauet
{"title":"[Gut microbiome, a new tool for Alzheimer diagnosis].","authors":"Louison Girodon, Perrine Hauet","doi":"10.1051/medsci/2025019","DOIUrl":"https://doi.org/10.1051/medsci/2025019","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 2","pages":"195-197"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
["Mitochondrial medicine" in the light of the fourth national plan for rare diseases (PNMR4): The example of the MITOMICS project]. [根据第四个国家罕见病计划（PNMR4）的“线粒体医学”：以MITOMICS项目为例]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1051/medsci/2025016
Clémence Guillermain, Stéphane Tirard, Sylvie Bannwarth, Vincent Procaccio
{"title":"[\"Mitochondrial medicine\" in the light of the fourth national plan for rare diseases (PNMR4): The example of the MITOMICS project].","authors":"Clémence Guillermain, Stéphane Tirard, Sylvie Bannwarth, Vincent Procaccio","doi":"10.1051/medsci/2025016","DOIUrl":"10.1051/medsci/2025016","url":null,"abstract":"<p><p>The aim of the MITOMICS project is to establish a clinical database of patients diagnosed with mitochondrial diseases, combined with a « multiomics » integrated approach in order to gain a better understanding of the molecular mechanisms underlying these diseases, and ultimately, to offer better patient care. The MITOMICS project thus contributes to the consolidation of a French \"mitochondrial medicine\", a notion that deserves to be examined. With the upcoming launch of the fourth national plan for rare diseases, it is an example of the study and management of rare and ultrarare diseases in France. This article traces the emergence of mitochondrial medicine since the early 1960s. It presents its main characteristics (genocentrism, strong techno-dependence), as well as its major technical and theoretical limitations, with a view to developing personalized mitochondrial medicine for the years to come.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 2","pages":"173-179"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Scientific misconduct: The temptation of academic fake money]. [科学不端行为：学术假币的诱惑]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-02-01 Epub Date: 2025-03-03 DOI: 10.1051/medsci/2024154
Jacques Haiech
{"title":"[Scientific misconduct: The temptation of academic fake money].","authors":"Jacques Haiech","doi":"10.1051/medsci/2024154","DOIUrl":"https://doi.org/10.1051/medsci/2024154","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 2","pages":"111-112"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Women and biomedical research: is the glass ceiling finally cracking?] 女性和生物医学研究：玻璃天花板终于破裂了吗？］
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1051/medsci/2024208
Anna Salvetti
{"title":"[Women and biomedical research: is the glass ceiling finally cracking?]","authors":"Anna Salvetti","doi":"10.1051/medsci/2024208","DOIUrl":"https://doi.org/10.1051/medsci/2024208","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 1","pages":"7-8"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A CRISPR/Cas approach to β-haemoglobinopathies]. [CRISPR/Cas方法治疗β-血红蛋白病]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1051/medsci/2024191
Megane Brusson, Annarita Miccio
{"title":"[A CRISPR/Cas approach to β-haemoglobinopathies].","authors":"Megane Brusson, Annarita Miccio","doi":"10.1051/medsci/2024191","DOIUrl":"10.1051/medsci/2024191","url":null,"abstract":"<p><p>Beta-haemoglobinopathies are severe genetic anemias caused by mutations that affect adult haemoglobin production. Many therapeutic approaches aim to reactivate the expression of the fetal hemoglobin genes. To this end, the CRISPR/Cas9 system has recently been used to genetically modify patients' hematopoietic stem/progenitor cells ex vivo and reactivate fetal hemoglobin expression in their erythroid progeny. More than 70 patients with severe β-thalassemia and sickle cell disease have been treated with the Casgevy® therapy. Most have achieved a significant improvement of clinical phenotype, with high editing efficiency in hematopoietic cells associated with normal or near normal hemoglobin levels. While the long-term safety and efficacy of this powerful approach still need to be evaluated, new strategies are being developed to further improve therapeutic outcomes, reduce potential genotoxicity and lower the costs of therapy.</p>","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 1","pages":"33-39"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Overlooked facts about excretion]. [关于排泄的被忽视的事实]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1051/medsci/2024195
Marc-André Selosse
{"title":"[Overlooked facts about excretion].","authors":"Marc-André Selosse","doi":"10.1051/medsci/2024195","DOIUrl":"https://doi.org/10.1051/medsci/2024195","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 1","pages":"69-71"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Transcutaneous auricular neurostimulation: a promising alternative for opioid withdrawal in neonates]. [经皮耳神经刺激：新生儿阿片类药物戒断的有希望的替代方法]。
IF 0.6 4区 医学
M S-medecine Sciences Pub Date : 2025-01-01 Epub Date: 2025-01-31 DOI: 10.1051/medsci/2024200
Souheïla Ammari, Ronald Mendoza, Eurydice Papias, Lucie Romero, Alexia Telesco, Théo Vassiliou, Émeline Verna, Caroline Costedoat
{"title":"[Transcutaneous auricular neurostimulation: a promising alternative for opioid withdrawal in neonates].","authors":"Souheïla Ammari, Ronald Mendoza, Eurydice Papias, Lucie Romero, Alexia Telesco, Théo Vassiliou, Émeline Verna, Caroline Costedoat","doi":"10.1051/medsci/2024200","DOIUrl":"https://doi.org/10.1051/medsci/2024200","url":null,"abstract":"","PeriodicalId":18205,"journal":{"name":"M S-medecine Sciences","volume":"41 1","pages":"93-96"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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