Lymphatic research and biology最新文献_第6页

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2025-01-24 DOI: 10.1089/lrb.2024.0095

引用次数: 0

Evaluation of Respiratory Function, Respiratory Muscle Strength, Physical Activity, and Functionality in Patients with Lower Extremity Lymphedema. 下肢淋巴水肿患者呼吸功能、呼吸肌力量、体力活动和功能的评价。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-26 DOI: 10.1089/lrb.2023.0079

Zehra Demir, Gamze Aydin

{"title":"Evaluation of Respiratory Function, Respiratory Muscle Strength, Physical Activity, and Functionality in Patients with Lower Extremity Lymphedema.","authors":"Zehra Demir, Gamze Aydin","doi":"10.1089/lrb.2023.0079","DOIUrl":"10.1089/lrb.2023.0079","url":null,"abstract":"Background: Lymphedema is a chronic, progressive condition that has major physical and psychological consequences. It was aimed to examine the respiratory functions, respiratory muscle strength, physical activity level, and functionality of patients with lower extremity lymphedema and to compare them with healthy controls. Methods and Results: A total of 82 individuals (29.3% male, 70.7% female, with a mean age of 49.89 ± 15.07 years) with lower extremity lymphedema (Group 1) and healthy individuals (Group 2) were included. Respiratory functions of the participants were evaluated by spirometry, respiratory muscle strength by maximum oral pressure measurements, physical activity levels using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), functionality by Lower Extremity Functional Scale (LEFS) and Timed Up and Go test (TUG test). All respiratory function test measurements were lower in mean Group 1 than in Group 2 (p < 0.05). While inspiratory muscle strength did not differ between the groups (p > 0.05), expiratory muscle strength was lower in Group 1 than Group 2 (p < 0.05). Although spent time and energy for sitting were higher in Group 1 (p < 0.05), IPAQ vigorous-, moderate-, and light-intensity physical activity (MET-min/week) and IPAQ-total score did not differ between groups (p > 0.05). In Group 1, mean of LEFS score was lower and TUG test (seconds) in Group 1 was longer compared to Group 2 (p < 0.05). Conclusions: Respiratory functions, expiratory muscle strength, and functionality in patients with lower extremity lymphedema were adversely affected; however, inspiratory muscle strength and physical activity levels were similar to those of healthy controls.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"17-22"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Tissue Dielectric Constant Values in Tumor Bearing and Healthy Breasts. 评估肿瘤和健康乳房组织介电常数值。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-12-10 DOI: 10.1089/lrb.2023.0061

Harvey N Mayrovitz, Mary Beth Tomaselli

{"title":"Assessing Tissue Dielectric Constant Values in Tumor Bearing and Healthy Breasts.","authors":"Harvey N Mayrovitz, Mary Beth Tomaselli","doi":"10.1089/lrb.2023.0061","DOIUrl":"10.1089/lrb.2023.0061","url":null,"abstract":"Background: This study aimed to investigate, characterize, and provide quantitative reference data on tissue dielectric constant (TDC) values of female breasts when measurements were made to 5 mm depths and determine the utility of these measurements to differentiate between benign and malignant breast tumors. Methods and Results: Breast TDC was measured bilaterally in 82 women just prior to an ultrasound-guided diagnostic biopsy of one tumor in one breast. TDC was measured in triplicate over the tumor and the contralateral healthy breast. Considering all paired breasts, the average TDC (mean ± SD) for healthy breasts was less than for tumor-bearing breasts (26.7 ± 4.5 vs. 29.9 ± 8.5, p = 0.0003). Conclusions: Breast TDC values measured to 5 mm in 82 healthy nonedematous breasts provide a two-SD threshold reference value of 35.7. This represents a TDC value above which the presence of breast edema/lymphedema may be indicated based on the two-SD threshold criterion. For unilateral cases, an interbreast TDC ratio exceeding 1.275 may be considered a breast edema/lymphedema indicator also based on the two SD criteria used. These thresholds may have utility for early detection and to track breast edema/lymphedema changes. A comparison of these TDC values obtained from benign versus malignant tumors indicates no statistically significant difference between them. However, interbreast TDC ratios were statistically higher for breasts with malignant versus benign tumors. However, the large overlap of the ratio values renders this method of discrimination between benign vs. malignant tumors inadequate based on the present findings.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"23-30"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower Extremity Lymphedema: The Effect upon Gait and Function. 下肢淋巴水肿：对步态和功能的影响。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI: 10.1089/lrb.2025.12125

Stanley G Rockson

引用次数: 0

A Method to Improve the Accuracy for the Comparison of Consecutively Determined Upper Limb Cross-Sectional Area Profiles of Test Subjects: Impact on (Segmental) Limb Volume and Local Limb Circumference. 提高连续测定的测试对象上肢横截面积剖面图比较精度的方法：对（节段）肢体体积和局部肢体周长的影响。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-02-01 Epub Date: 2024-10-29 DOI: 10.1089/lrb.2024.0024

Frans Houwen, Johannes Stemkens, Don van Sonsbeek, Robby van Sonsbeek, René van der Hulst, Herman van Langen

{"title":"A Method to Improve the Accuracy for the Comparison of Consecutively Determined Upper Limb Cross-Sectional Area Profiles of Test Subjects: Impact on (Segmental) Limb Volume and Local Limb Circumference.","authors":"Frans Houwen, Johannes Stemkens, Don van Sonsbeek, Robby van Sonsbeek, René van der Hulst, Herman van Langen","doi":"10.1089/lrb.2024.0024","DOIUrl":"10.1089/lrb.2024.0024","url":null,"abstract":"Background: Chronic edema management depends on measuring small volume changes over time. Therefore, a highly sensitive, accurate, and reliable technique is needed to objectively judge sequential measurements. Methods and Results: The prototype of the Peracutus Aqua Meth (PAM), a new volumetric measuring device, was used in an experimental study. Thirty-nine healthy test subjects were measured three times. The measuring principle of the PAM is based on obtaining a profile of cross-sectional areas along the length of an object or limb. Besides total arm volumes, the volume of any chosen segment can be determined. The utmost tip of the middle finger appeared to be an unreliable reference point. Instead, the concept of \"hand median\" was introduced to align and compare profiles of cross-sectional areas of sequential measurements. Using the hand median strongly improved the measuring accuracy, rendering standard deviation values of 0.4%-1.3% for (segmental) volume determination. Conclusions: Measurements with the PAM show that accurate local/segmental volume determination of a limb is possible. Standard deviations of less than 1.3% are easily obtained for cross-sectional area and volume determination.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"46-53"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Matters. 研究很重要。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-01-22 DOI: 10.1089/lrb.2024.0108

引用次数: 0

Effect of Complex Decongestive Therapy Program on Volume and Functioning in Breast Cancer-Related Lymphedema: Global Effect and Predicting Factors. 复合减充血疗法对乳腺癌相关性淋巴水肿患者体积和功能的影响：整体效果与预测因素

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1089/lrb.2024.0013

Tri Tinh Vo, Paul Bayens, Chloé Meseeuw, Jacqueline Frippiat, Maxime Regnier, Alexis Lheureux, Thierry Deltombe

{"title":"Effect of Complex Decongestive Therapy Program on Volume and Functioning in Breast Cancer-Related Lymphedema: Global Effect and Predicting Factors.","authors":"Tri Tinh Vo, Paul Bayens, Chloé Meseeuw, Jacqueline Frippiat, Maxime Regnier, Alexis Lheureux, Thierry Deltombe","doi":"10.1089/lrb.2024.0013","DOIUrl":"10.1089/lrb.2024.0013","url":null,"abstract":"Background: The aim of this prospective study was to investigate the effect of a first and repeated complex decongestive therapy (CDT) program on volume and functioning in patients with unilateral breast cancer-related lymphedema (BCRL) and to identify whether the volume before treatment and/or the number of previous treatment influence outcomes. Methods and Results: In total, 100 and 42 patients with BCRL treated by 499 CDT (6 hours a day during 5 consecutive days) between April 2018 and December 2021 were included. Patients were assessed using volume including percentage of excess volume and percentage reduction in excess volume and lymph-International Classification of Functioning-UL questionnaire. After CDT, a significant reduction in BCRL volume (50%) and improvement in functioning (30%) were observed. The volume reduction was greater when the BCRL volume before treatment was low (10%-20%) and when CDT was performed for the first time. The functioning improvement was identical whatever the volume is before treatment and the number of previous CDT. Conclusion: A greater volume reduction after CDT was obtained in BCRL with low volume before treatment and after the first CDT. Such findings support the need for early intensive BCRL treatment to control volume and improve functioning.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"271-277"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Short-Term Educational Hospitalization with Multidisciplinary Approach for Lymphedema on Limb Circumference and Quality of Life. 采用多学科方法短期住院治疗淋巴水肿对肢体周长和生活质量的影响

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-12-01 Epub Date: 2024-10-22 DOI: 10.1089/lrb.2024.0052

Daisuke Atomura, Junichiro Inoue, Maho Okumura Pt, Shunsuke Sakakibara

{"title":"Effects of Short-Term Educational Hospitalization with Multidisciplinary Approach for Lymphedema on Limb Circumference and Quality of Life.","authors":"Daisuke Atomura, Junichiro Inoue, Maho Okumura Pt, Shunsuke Sakakibara","doi":"10.1089/lrb.2024.0052","DOIUrl":"10.1089/lrb.2024.0052","url":null,"abstract":"Background: Lymphedema is an intractable disease requiring lifelong treatment. Daily self-care by the patient is essential; however, establishing care is often difficult. Our hospital offers a short-term educational hospitalization program that involves intensive, multidisciplinary intervention to develop self-care. This study aimed to evaluate the effectiveness of this program. Methods and Results: Among the patients diagnosed with primary or secondary lymphedema who underwent educational hospitalization, 31 cases (33 limbs) were included in this study. The upper extremity lymphedema (UEL) index and lower extremity lymphedema (LEL) index were used for objective evaluation, and the Lymphedema Quality of Life Questionnaire was used for subjective evaluation. The therapeutic effects of educational hospitalization were examined before admission, at discharge, and at 6 months postdischarge. The UEL/LEL index significantly decreased for both the upper and lower limbs after educational hospitalization. In addition, the UEL/LEL index change rate from prehospitalization to 6 months postdischarge was compared between the continued and discontinued exercise groups; the former index showed significantly more improvement than the latter. Comparing the quality of life (QOL) assessments pre- and posthospitalization, statistically significant improvements were observed in all categories, including function, appearance, symptoms, and psychological state. Conclusions: Short-term educational hospitalization led to a sustained reduction in the circumference of lymphedema-affected limbs and an improvement in the QOL. The multidisciplinary approach resulted in improved self-efficacy and established daily self-care.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"285-290"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Physical Therapy Techniques Slow Down the Progression of Lipedema? 物理治疗技术能延缓脂肪性水肿的发展吗？

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-12-01 Epub Date: 2024-10-09 DOI: 10.1089/lrb.2024.0065

Murat Esmer, Franz Josef Schingale

{"title":"Can Physical Therapy Techniques Slow Down the Progression of Lipedema?","authors":"Murat Esmer, Franz Josef Schingale","doi":"10.1089/lrb.2024.0065","DOIUrl":"10.1089/lrb.2024.0065","url":null,"abstract":"Background: Lipedema is a disease characterized by an increase in extracellular fluid. In these patients, the increase in the amount of extracellular fluid may accelerate the progression of the disease. The aim of this study is to examine the effect of complex decongestive therapy (CDT) on intracellular/extracellular fluid balance. Methods and Results: Twenty-two female patients diagnosed with lipedema by a specialist lymphologist were included in the study. Patients were subjected to complex decongestive therapy and pneumatic compression therapy 6 days a week for 1 month. Extracellular and intracellular fluid volumes were assessed using bioimpedance spectroscopy before and after the treatment. A decrease in intracellular (p = 0.010) and extracellular (p = 0.002) fluid volumes was observed after the treatment. Conclusion: There is no completely curative treatment method for lipedema. Current treatments aim to slow down the progression of the disease. CDT is considered effective in reducing intracellular and extracellular fluid volume in lipedema patients. Therefore, it is thought to be effective in slowing down the progression of the disease.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"267-270"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chylous Reflux in Pediatric Primary Lymphedema of the Lower Limbs and Genitalia: A Retrospective Study of 167 Patients. 小儿下肢和生殖器原发性淋巴水肿的乳糜反流：167例患者的回顾性研究。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-12-01 Epub Date: 2024-10-21 DOI: 10.1089/lrb.2024.0044

Zhong Liu, Song Xia, Wenbin Shen, Yuguang Sun, Jianfeng Xin, Kun Chang, Yan Zhu, Chen Liang, Xin Liu, Ran An, Chenxiao Zhou, Zimin Zhao, Peilin Li

{"title":"Chylous Reflux in Pediatric Primary Lymphedema of the Lower Limbs and Genitalia: A Retrospective Study of 167 Patients.","authors":"Zhong Liu, Song Xia, Wenbin Shen, Yuguang Sun, Jianfeng Xin, Kun Chang, Yan Zhu, Chen Liang, Xin Liu, Ran An, Chenxiao Zhou, Zimin Zhao, Peilin Li","doi":"10.1089/lrb.2024.0044","DOIUrl":"10.1089/lrb.2024.0044","url":null,"abstract":"Background: Chylous reflux (CR) in primary lymphedema (PL) of the lower extremities is rare and requires particular diagnostic procedures. This study aimed to determine clinical and lymphoscintigraphic traits for efficient screening. Methods and Results: Pediatric patients with PL of lower extremities treated in our institution between January 2020 and December 2023 were reviewed. The medical history, lymphoscintigraphy, non-contrast MR lymphography, and direct lymphangiography were analyzed. Lymphoscintigraphic visual patterns were classified to detect CR. Patients with CR showed significantly higher proportions of childhood symptom onset (65.63% vs. 25.19%, p < 0.01), genital lymphedema (62.50% vs. 19.26%, p < 0.01), and proximal-to-distal swelling (31.25% vs. 8.89%, p < 0.01). Eight patients without skin lesions had milk discharge after acupuncture or skin breakdown. Pattern 4 shows diffused dermal backflow of the leg and an absence of superficial lymphatic drainage, or normal initial cephalad flow with subsequent reflux of tracer into the affected limb. CR showed significantly higher percentages of pattern 4 (87.50% vs. 12.59%, p < 0.01), normal/widened iliac lymphatics (78.13% vs. 11.11%, p < 0.01), and thigh/calf outlining (87.50% vs. 29.63%, p < 0.01). Genital swelling preceding limb swelling and genital radioactivity were more common in the CR group. Conclusions: CR tends to occur in childhood initially, begin centrally and progress distally, and involve genitals prior to lower extremities. Milk discharge after acupuncture or skin breakdown is important for screening CR without chylous vesicles. The patterns with typical \"profiling of the leg\" and normal or widened iliac lymphatic trunks strongly correlate with CR. Genital lymphedema with increased radioactivity indicates CR.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"278-284"},"PeriodicalIF":1.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0