Lymphatic research and biology最新文献

Children and Young People with Lymphedema: The Education Need of Health Care Professionals. 儿童和青少年淋巴水肿：卫生保健专业人员的教育需求。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-05-19 DOI: 10.1089/lrb.2024.0043

Rhian Noble-Jones, Melanie Thomas

{"title":"Children and Young People with Lymphedema: The Education Need of Health Care Professionals.","authors":"Rhian Noble-Jones, Melanie Thomas","doi":"10.1089/lrb.2024.0043","DOIUrl":"https://doi.org/10.1089/lrb.2024.0043","url":null,"abstract":"Introduction: The education need of health care professionals (HCP) to provide good quality care to children and young people with lymphedema (CYPwL) was unknown. While understanding of pediatric lymphedema grows, families still report delays in accessing appropriate treatment and HCP have reported being ill-prepared. Methods: A questionnaire was designed by phased process of literature search, focus group, and online consensus with international experts. The online survey, available in six languages, was distributed to HCP working with CYPwL by professional groups. Results: Questionnaires were received from 507 responders from 33 countries. Specific education on the treatment of CYPwL is needed, even when HCP are adult lymphedema trained according to 80% of respondents. Greatest consensus on best practice was that a multidisciplinary team (MDT) with specialist knowledge is required to treat CYPwL, but almost one in five HCP working with CYPwL have no, or rare, access to such a team. Reducing infections and adapting compression/treatment for age and development were deemed most essential. A variety of learning resources are needed including films, videos, and webinars from clinical experts. Discussion and Conclusion: This is the first international survey of the education need of HCP regarding CYPwL which include pathology, treatment, psychosocial care, and education of other professionals. Uppermost was knowing how to reduce infections and adapt compression and other treatments for age and development. Access to an experienced MDT was considered essential to support good clinical decision-making. Multimodal approaches are needed to address identified education need. Further research in individual countries and professions is recommended.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis. 翻译活性增强与皮肤利什曼病淋巴内皮细胞活化有关。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-25 DOI: 10.1089/lrb.2024.0080

Lucy Fry, Hayden Roys, Anne Bowlin, Gopinath Venugopal, Jordan T Bird, Alexx Weaver, Stephanie D Byrum, Tiffany Weinkopff

{"title":"Enhanced Translational Activity Is Linked to Lymphatic Endothelial Cell Activation in Cutaneous Leishmaniasis.","authors":"Lucy Fry, Hayden Roys, Anne Bowlin, Gopinath Venugopal, Jordan T Bird, Alexx Weaver, Stephanie D Byrum, Tiffany Weinkopff","doi":"10.1089/lrb.2024.0080","DOIUrl":"https://doi.org/10.1089/lrb.2024.0080","url":null,"abstract":"Introduction: Cutaneous leishmaniasis (CL) is a significant public health problem leading to permanently disfiguring skin lesions caused by Leishmania parasites. Lesion severity stems from an excessive host inflammatory response that prevents healing. Materials and Methods: Here, we characterized the transcriptional and translational responses of lymphatic endothelial cells (LECs) during murine CL using single-cell RNA sequencing data combined with flow cytometry and in vivo puromycin incorporation to assess translational activity. Results: We identified upregulation of antigen presentation pathways including MHC-I, MHC-II, and immunoproteasome transcripts in dermal LECs from Leishmania major-infected mice compared to naive controls. LECs also exhibited increased expression of guanylate binding proteins and interferon-inducible genes, indicative of immune activation. Moreover, our findings demonstrate that LECs in leishmanial lesions displayed heightened translational activity relative to LECs from uninflamed ears, and LEC translational activity was highest in activated LECs. Furthermore, LEC translational activity exceeded that of other cell types within the lesion microenvironment. Validating the transcriptomic data, LECs in lesions expressed elevated MHC-II and programmed death-ligand 1 (PDL-1), supporting their potential role in antigen presentation. Functional assays using DQ-ovalbumin confirmed that LECs from leishmanial lesions efficiently uptake and process antigens, highlighting their capability as antigen presenting cells in the inflamed dermal microenvironment. Conclusion: Overall, our study reveals the activation status of LECs in leishmanial lesions, shedding light on their potential role in shaping local immunity and inflammation in a variety of skin diseases.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-23 DOI: 10.1089/lrb.2025.0043

引用次数: 0

Relationship Between 25-Hydroxyvitamin D and Vitamin B12 Levels and Neuropathic Pain in Patients Diagnosed with Lipedema. 25-羟基维生素D和维生素B12水平与脂水肿患者神经性疼痛的关系

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-16 DOI: 10.1089/lrb.2024.0083

Gulcan Ozturk, Pinar Akpinar, Duygu Silte Karamanlioglu, Feyza Akan Begoğlu, Feyza Unlu Ozkan, Ilknur Aktas

{"title":"Relationship Between 25-Hydroxyvitamin D and Vitamin B12 Levels and Neuropathic Pain in Patients Diagnosed with Lipedema.","authors":"Gulcan Ozturk, Pinar Akpinar, Duygu Silte Karamanlioglu, Feyza Akan Begoğlu, Feyza Unlu Ozkan, Ilknur Aktas","doi":"10.1089/lrb.2024.0083","DOIUrl":"https://doi.org/10.1089/lrb.2024.0083","url":null,"abstract":"Background: Pain is a prevalent symptom in patients with lipedema predominantly impacting the lower extremities. This study aimed to evaluate the relationship between 25-hydroxyvitamin D [25(OH)D] and vitamin B12 levels and neuropathic pain (NP) in patients diagnosed with lipedema. Methods and Results: A total of 243 patients with lipedema who had 25(OH)D and B12 levels measured in the past 6 months were included in this study. Participants were divided into two groups: Group 1 (N = 78) with NP scores ≥13 and Group 2 (N = 165) with NP scores <13. The Turkish version of the painDETECT questionnaire was used to assess the patients' NP symptoms. Pain levels were measured using the Visual Analog Scale (VAS) and pain threshold through algometric measurement. Group 1 had significantly higher palpation and spontaneous VAS scores, and pain threshold through algometric measurements than Group 2 (p < 0.05). No statistically significant difference was found between the groups regarding vitamin D levels being below 30 ng/mL or vitamin B12 levels being below 400 pg/mL (p > 0.05). Conclusions: No association was found between NP and 25(OH)D or B12 levels in patients with lipedema.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Precision of Bioimpedance Spectroscopic Analysis for Lymphedema and Lipedema Assessment. 提高生物阻抗光谱分析淋巴水肿和脂水肿评估的精度。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-14 DOI: 10.1089/lrb.2024.0086

Leigh C Ward, Katrina Gaitatzis, Belinda Thompson, Vincent Singh Paramanandam, Louise A Koelmeyer

{"title":"Improving Precision of Bioimpedance Spectroscopic Analysis for Lymphedema and Lipedema Assessment.","authors":"Leigh C Ward, Katrina Gaitatzis, Belinda Thompson, Vincent Singh Paramanandam, Louise A Koelmeyer","doi":"10.1089/lrb.2024.0086","DOIUrl":"https://doi.org/10.1089/lrb.2024.0086","url":null,"abstract":"Background: Bioimpedance spectroscopy (BIS) is commonly used for the detection and monitoring of lymphedema and potentially lipedema. BIS measures limb electrical resistance, which decreases with fluid accumulation in these conditions. R0, the index of extracellular fluid and lymph accumulation, is typically estimated using Cole modeling, but technical and biological factors can affect accuracy. Methods: Participants with clinically affirmed bilateral leg lymphedema, lipedema, self-ascribed swelling, and healthy controls were included in this study. Impedance measurements were taken using a stand-on BIS device, and R0 was estimated using both the Cole modeling method and a regression approach. Quality of data fitting was assessed visually and statistically. Results: Control participants were younger and lighter compared with the clinical groups. The regression method was able to analyze 100% of participant data, whereas the Cole method was successful in only 80%-88% of cases in the lymphedema and lipedema groups. Additionally, the regression approach provided better curve fitting accuracy for all participants. Conclusion: The regression method offers a robust alternative for estimating R0 values in BIS data, especially in lower limb assessments where data analysis is challenging. The small difference between methods in absolute R0 values (2.5%) has minimal practical implications, suggesting interchangeability in data analysis. The Cole method showed poorer performance, particularly in participants with lymphedema, possibly due to differences in water proportions and limb size. Overall, the regression method can be effectively used in clinical practice for estimating R0 values in BIS data, offering a more accurate and reliable approach than traditional Cole plotting methods.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Forearm Bandaging Technique, Muscle Contraction, and Additional Compression Pad Use on Sub-Bandage Pressure. 前臂包扎技术、肌肉收缩和附加压缩垫对绷带下压力的影响。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-10 DOI: 10.1089/lrb.2025.0026

Elif Sakizli Erdal, Miray Haspolat, Burak Erturk, Ilke Keser

{"title":"Effects of Forearm Bandaging Technique, Muscle Contraction, and Additional Compression Pad Use on Sub-Bandage Pressure.","authors":"Elif Sakizli Erdal, Miray Haspolat, Burak Erturk, Ilke Keser","doi":"10.1089/lrb.2025.0026","DOIUrl":"https://doi.org/10.1089/lrb.2025.0026","url":null,"abstract":"Background: This study aimed to evaluate the effects of forearm bandaging techniques, muscle contraction, and additional compression pad use on sub-bandage pressure. Methods and Results: Thirty-one individuals (26 females, 5 males) with no chronic or lymphatic-related conditions participated in the study. Sub-bandage pressure was measured using the Kikuhime device, with a standardized protocol applied to the wrist extensor muscle belly. Participants were evaluated under rest and wrist extension conditions using two bandaging techniques: spiral and figure-of-eight. Variations included single and double layers, 1/2 and 1/3 overlaps, and the presence or absence of additional compression pads. Certified physiotherapists trained performed all bandaging applications using short-stretch compression materials. The figure-of-eight wrapping technique consistently produced significantly higher sub-bandage pressures compared to the spiral technique in all conditions. Double bandaging generated 1.4 times more pressure than single-layer applications, while 1/3 overlap resulted in greater pressure than 1/2 overlap. The addition of compression pads increased resting pressure by approximately 5 mmHg, and wrist extension further augmented pressure by 4-8 mmHg. The highest pressures were observed with the figure-of-eight technique, double bandaging, and 1/3 overlap combined (p < 0.05). Conclusions: These findings highlight the critical role of forearm bandaging technique, layering, and additional materials in determining sub-bandage pressure.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated Measurement of Skin Thickness in Computed Tomography Images for Unilateral Lower Extremity Lymphedema. 单侧下肢淋巴水肿计算机断层扫描图像中皮肤厚度的自动测量。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-07 DOI: 10.1089/lrb.2024.0075

Yukihiro Nomura, Hiroki Naganishi, Yuma Ando, Shinsuke Akita, Nobuyuki Mitsukawa

{"title":"Automated Measurement of Skin Thickness in Computed Tomography Images for Unilateral Lower Extremity Lymphedema.","authors":"Yukihiro Nomura, Hiroki Naganishi, Yuma Ando, Shinsuke Akita, Nobuyuki Mitsukawa","doi":"10.1089/lrb.2024.0075","DOIUrl":"https://doi.org/10.1089/lrb.2024.0075","url":null,"abstract":"Background: Lower extremity lymphedema (LEL) is a common complication following gynecological cancer treatment, characterized by the accumulation of protein-rich fluid owing to lymphatic system insufficiency. This condition manifests as in skin thickening, soft tissue swelling, and other complications. Therefore, this study proposes an automatic method for measuring skin thickness in lower extremity computed tomography (CT) images and assessing its effectiveness in diagnosing LEL. Methods and Results: We selected 56 patients with unilateral LEL based on specific diagnostic criteria, including clinical evaluation, lymphoscintigraphy, indocyanine green lymphography, and a noncontrast CT scan, which included the entire lower extremities. The CT images had a pixel spacing ranging from 0.723 to 0.976 mm, with a slice thickness of 10.0 mm. Our skin thickness measurement method involves preprocessing, such as extracting the leg, bone, muscle, and subcutaneous fat regions, defining the target slice range, and measuring the skin thickness. The lower extremity was divided into eight subregions, and the skin thickness was measured across these subregions. The overall median skin thicknesses were 0.883 ± 0.201 and 1.536 ± 0.487 mm in normal and positive subregions, respectively. The classification of LEL was based on the Z-score calculated for each subregion, with the median skin thickness from normal legs serving as a reference. Our classification method demonstrated an overall accuracy of 0.839, sensitivity of 0.703, and specificity of 0.937. Conclusions: Our automated method for measuring skin thickness in CT images shows promise in diagnosing LEL, with high accuracy and specificity. This approach enables a comprehensive evaluation of the entire leg, potentially enhancing the diagnostic process for LEL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Ultrasonography to Detect Lymphatic Dysfunction. 使用超声波检测淋巴功能障碍。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-03-28 DOI: 10.1089/lrb.2025.0039

Stanley G Rockson

引用次数: 0

The Concept of Palliative Lymphaticovenular Anastomosis. 姑息性淋巴-小静脉吻合的概念。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-01-10 DOI: 10.1089/lrb.2024.0079

Kahori Tsukura, Satoshi Onoda, Toshihiko Satake, Erika Hamada

{"title":"The Concept of Palliative Lymphaticovenular Anastomosis.","authors":"Kahori Tsukura, Satoshi Onoda, Toshihiko Satake, Erika Hamada","doi":"10.1089/lrb.2024.0079","DOIUrl":"10.1089/lrb.2024.0079","url":null,"abstract":"Introduction: Lymphaticovenular anastomosis (LVA) is the first-line surgical treatment for lymphedema. The therapeutic effects of LVA, including edema reduction and cellulitis prevention, vary among patients. We examined cases of palliative LVA in patients with lymphedema who were in the terminal stage due to recurrence or distant metastasis of the primary disease, with a focus on the course and usefulness of palliative LVA. Methods and Results: A total of 13 palliative LVAs were performed in 12 patients undergoing palliative treatment. LVA was performed without interfering with chemotherapy or radiation. Data on site and stage of edema, compression treatment status, number of anastomoses, percentage change in circumferential diameter (the total circumference at six locations was compared), treatment efficacy, and patient prognosis were collected. Edema was present in the upper and lower extremities of 10 and 2 patients, respectively. The average postoperative decrease in circumferential diameter was 8.6%. Psychological evaluation was based on the self-reports of patients, and 11 out of 12 patients showed improvement in their mental state. Two patients died during the observation period due to deterioration in the underlying disease. Conclusion: We reported our experience with palliative LVA in patients with advanced malignancies. Many patients had favorable physical and psychological outcomes. Surgery can be performed safely with appropriate planning based on the condition of the patients. Palliative LVA may be a treatment option for patients with recurrent or distant metastases of the primary disease who are refractory to edema treatment.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"71-77"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphedema, Fatigue, and Quality of Life in Breast Cancer Survivors with Axillary Lymph Node Dissection. 腋窝淋巴结清扫后乳腺癌幸存者的淋巴水肿、疲劳和生活质量。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1089/lrb.2024.0047

Seyma Acikgoz Orhan, Esma Ozsaker

{"title":"Lymphedema, Fatigue, and Quality of Life in Breast Cancer Survivors with Axillary Lymph Node Dissection.","authors":"Seyma Acikgoz Orhan, Esma Ozsaker","doi":"10.1089/lrb.2024.0047","DOIUrl":"10.1089/lrb.2024.0047","url":null,"abstract":"Introduction: Health-related quality of life (QOL) has gained importance due to the increasing incidence of breast cancer and the survival rate of breast cancer patients. We aimed to investigate the relationship between lymphedema, fatigue, and QOL in breast cancer survivors with axillary lymph node dissection. Methods: A total of 122 female breast cancer survivors with axillary lymph node dissection who applied to the oncology center of a teaching and research hospital between April 1, 2022, and July 1, 2022, were included in the cross-sectional study. An individual identification form, the EQ-5D General Quality of Life Scale, and the Cancer Fatigue Scale were used to collect data. Mann-Whitney U test, Kruskal-Wallis H test, Bonferroni post hoc test, and Spearman's correlation were used to assess differences between the survivor groups. Results: The study found that 40.2% of breast cancer survivors experienced lymphedema. The mean scores on the EQ-5D index, Visual Analogue Scale (VAS), and Cancer Fatigue Scale were 0.27 ± 0.25, 71.12 ± 14.21, and 35.86 ± 6.98, respectively. The Cancer Fatigue Scale total score and the EQ-5D VAS showed a strong positive correlation (r = 0.630; p < 0.05). Conversely, the total Cancer Fatigue Scale and the EQ-5D VAS scores showed a significant negative correlation (r = -0.626; p < 0.05). Conclusions: The study found that almost half of the breast cancer survivors experienced lymphedema. They also had excellent general health, moderate fatigue, and a good overall QOL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":" ","pages":"107-114"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0