Lymphatic research and biology最新文献

A Method to Improve the Accuracy for the Comparison of Consecutively Determined Upper Limb Cross-Sectional Area Profiles of Test Subjects: Impact on (Segmental) Limb Volume and Local Limb Circumference. 提高连续测定的测试对象上肢横截面积剖面图比较精度的方法：对（节段）肢体体积和局部肢体周长的影响。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-29 DOI: 10.1089/lrb.2024.0024

Frans Houwen, Johannes Stemkens, Don van Sonsbeek, Robby van Sonsbeek, René van der Hulst, Herman van Langen

{"title":"A Method to Improve the Accuracy for the Comparison of Consecutively Determined Upper Limb Cross-Sectional Area Profiles of Test Subjects: Impact on (Segmental) Limb Volume and Local Limb Circumference.","authors":"Frans Houwen, Johannes Stemkens, Don van Sonsbeek, Robby van Sonsbeek, René van der Hulst, Herman van Langen","doi":"10.1089/lrb.2024.0024","DOIUrl":"10.1089/lrb.2024.0024","url":null,"abstract":"Background: Chronic edema management depends on measuring small volume changes over time. Therefore, a highly sensitive, accurate, and reliable technique is needed to objectively judge sequential measurements. Methods and Results: The prototype of the Peracutus Aqua Meth (PAM), a new volumetric measuring device, was used in an experimental study. Thirty-nine healthy test subjects were measured three times. The measuring principle of the PAM is based on obtaining a profile of cross-sectional areas along the length of an object or limb. Besides total arm volumes, the volume of any chosen segment can be determined. The utmost tip of the middle finger appeared to be an unreliable reference point. Instead, the concept of \"hand median\" was introduced to align and compare profiles of cross-sectional areas of sequential measurements. Using the hand median strongly improved the measuring accuracy, rendering standard deviation values of 0.4%-1.3% for (segmental) volume determination. Conclusions: Measurements with the PAM show that accurate local/segmental volume determination of a limb is possible. Standard deviations of less than 1.3% are easily obtained for cross-sectional area and volume determination.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of Lymphedema and Other Complications in Patients Operated on for Gynecological Cancer Including Utilization of Two Lymph Node Dissection Techniques. 妇科癌症手术患者淋巴水肿及其他并发症的发生率，包括两种淋巴结清扫技术的使用。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-28 DOI: 10.1089/lrb.2024.0084

Varol Gülseren, Mehmet Dolanbay, İsa Aykut Özdemir, Fulya Çağlı, Ertuğrul Şen, Bülent Özçelik, İbrahim Serdar Serin, Kemal Güngördük

{"title":"Incidence of Lymphedema and Other Complications in Patients Operated on for Gynecological Cancer Including Utilization of Two Lymph Node Dissection Techniques.","authors":"Varol Gülseren, Mehmet Dolanbay, İsa Aykut Özdemir, Fulya Çağlı, Ertuğrul Şen, Bülent Özçelik, İbrahim Serdar Serin, Kemal Güngördük","doi":"10.1089/lrb.2024.0084","DOIUrl":"https://doi.org/10.1089/lrb.2024.0084","url":null,"abstract":"Background: To assess the impact of the lymph node dissection (LND) technique on short- and long-term complications. This retrospective review included patients who underwent hysterectomy, oophorectomy, and pelvic ± para-aortic LND for gynecological malignancies (cervical, endometrial, and ovarian) from 2020 to 2022 in our Gynecological Oncology Surgery clinic. Methods and Results: Among 147 patients who underwent pelvic LND for gynecological malignancy, 48 had procedures involving scissors and 99 had procedures involving unipolar cautery. There was no significant difference in the numbers of extracted pelvic and para-aortic lymph nodes between groups. The extents of LND were comparable between the scissors and unipolar cautery groups (p = 0.945). The scissors group exhibited less fluid drainage between days 2 and 5 postoperatively (1300 [600-3100] vs 1800 [600-3400]; p = 0.038). In terms of primary early and late clinical outcomes, there were no significant differences in lymphocele (16.7% vs 15.2%; p = 0.494) and lymphedema (18.8% vs 17.2%; p = 0.491) rates between groups. Conclusions: After retroperitoneal LND for gynecological malignancy, early complications such as lymphocele and late complications such as lower extremity lymphedema did not significantly differ between procedures using cold scissors and procedures using unipolar cautery.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Short-Term Educational Hospitalization with Multidisciplinary Approach for Lymphedema on Limb Circumference and Quality of Life. 采用多学科方法短期住院治疗淋巴水肿对肢体周长和生活质量的影响

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-22 DOI: 10.1089/lrb.2024.0052

Daisuke Atomura, Junichiro Inoue, Maho Okumura Pt, Shunsuke Sakakibara

{"title":"Effects of Short-Term Educational Hospitalization with Multidisciplinary Approach for Lymphedema on Limb Circumference and Quality of Life.","authors":"Daisuke Atomura, Junichiro Inoue, Maho Okumura Pt, Shunsuke Sakakibara","doi":"10.1089/lrb.2024.0052","DOIUrl":"https://doi.org/10.1089/lrb.2024.0052","url":null,"abstract":"Background: Lymphedema is an intractable disease requiring lifelong treatment. Daily self-care by the patient is essential; however, establishing care is often difficult. Our hospital offers a short-term educational hospitalization program that involves intensive, multidisciplinary intervention to develop self-care. This study aimed to evaluate the effectiveness of this program. Methods and Results: Among the patients diagnosed with primary or secondary lymphedema who underwent educational hospitalization, 31 cases (33 limbs) were included in this study. The upper extremity lymphedema (UEL) index and lower extremity lymphedema (LEL) index were used for objective evaluation, and the Lymphedema Quality of Life Questionnaire was used for subjective evaluation. The therapeutic effects of educational hospitalization were examined before admission, at discharge, and at 6 months postdischarge. The UEL/LEL index significantly decreased for both the upper and lower limbs after educational hospitalization. In addition, the UEL/LEL index change rate from prehospitalization to 6 months postdischarge was compared between the continued and discontinued exercise groups; the former index showed significantly more improvement than the latter. Comparing the quality of life (QOL) assessments pre- and posthospitalization, statistically significant improvements were observed in all categories, including function, appearance, symptoms, and psychological state. Conclusions: Short-term educational hospitalization led to a sustained reduction in the circumference of lymphedema-affected limbs and an improvement in the QOL. The multidisciplinary approach resulted in improved self-efficacy and established daily self-care.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chylous Reflux in Pediatric Primary Lymphedema of the Lower Limbs and Genitalia: A Retrospective Study of 167 Patients. 小儿下肢和生殖器原发性淋巴水肿的乳糜反流：167例患者的回顾性研究。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-21 DOI: 10.1089/lrb.2024.0044

Zhong Liu, Song Xia, Wenbin Shen, Yuguang Sun, Jianfeng Xin, Kun Chang, Yan Zhu, Chen Liang, Xin Liu, Ran An, Chenxiao Zhou, Zimin Zhao, Peilin Li

{"title":"Chylous Reflux in Pediatric Primary Lymphedema of the Lower Limbs and Genitalia: A Retrospective Study of 167 Patients.","authors":"Zhong Liu, Song Xia, Wenbin Shen, Yuguang Sun, Jianfeng Xin, Kun Chang, Yan Zhu, Chen Liang, Xin Liu, Ran An, Chenxiao Zhou, Zimin Zhao, Peilin Li","doi":"10.1089/lrb.2024.0044","DOIUrl":"https://doi.org/10.1089/lrb.2024.0044","url":null,"abstract":"Background: Chylous reflux (CR) in primary lymphedema (PL) of the lower extremities is rare and requires particular diagnostic procedures. This study aimed to determine clinical and lymphoscintigraphic traits for efficient screening. Methods and Results: Pediatric patients with PL of lower extremities treated in our institution between January 2020 and December 2023 were reviewed. The medical history, lymphoscintigraphy, non-contrast MR lymphography, and direct lymphangiography were analyzed. Lymphoscintigraphic visual patterns were classified to detect CR. Patients with CR showed significantly higher proportions of childhood symptom onset (65.63% vs. 25.19%, p < 0.01), genital lymphedema (62.50% vs. 19.26%, p < 0.01), and proximal-to-distal swelling (31.25% vs. 8.89%, p < 0.01). Eight patients without skin lesions had milk discharge after acupuncture or skin breakdown. Pattern 4 shows diffused dermal backflow of the leg and an absence of superficial lymphatic drainage, or normal initial cephalad flow with subsequent reflux of tracer into the affected limb. CR showed significantly higher percentages of pattern 4 (87.50% vs. 12.59%, p < 0.01), normal/widened iliac lymphatics (78.13% vs. 11.11%, p < 0.01), and thigh/calf outlining (87.50% vs. 29.63%, p < 0.01). Genital swelling preceding limb swelling and genital radioactivity were more common in the CR group. Conclusions: CR tends to occur in childhood initially, begin centrally and progress distally, and involve genitals prior to lower extremities. Milk discharge after acupuncture or skin breakdown is important for screening CR without chylous vesicles. The patterns with typical \"profiling of the leg\" and normal or widened iliac lymphatic trunks strongly correlate with CR. Genital lymphedema with increased radioactivity indicates CR.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142469129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correspondence to the Article: "Proposed Framework for Research Case Definitions of Lipedema". 文章通讯："脂肪性水肿研究病例定义的拟议框架"。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-21 DOI: 10.1089/lrb.2024.0062

Robert J Damstra, Kristiana Gordon, Tobias Bertsch, Hakan Brorson, Denise Hardy, Guenther Klose, Kathleen Francis, Gabriele Erbacher, Ad Hendrickx, Christine Moffatt

引用次数: 0

Effect of Complex Decongestive Therapy Program on Volume and Functioning in Breast Cancer-Related Lymphedema: Global Effect and Predicting Factors. 复合减充血疗法对乳腺癌相关性淋巴水肿患者体积和功能的影响：整体效果与预测因素

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-11 DOI: 10.1089/lrb.2024.0013

Tri Tinh Vo, Paul Bayens, Chloé Meseeuw, Jacqueline Frippiat, Maxime Regnier, Alexis Lheureux, Thierry Deltombe

{"title":"Effect of Complex Decongestive Therapy Program on Volume and Functioning in Breast Cancer-Related Lymphedema: Global Effect and Predicting Factors.","authors":"Tri Tinh Vo, Paul Bayens, Chloé Meseeuw, Jacqueline Frippiat, Maxime Regnier, Alexis Lheureux, Thierry Deltombe","doi":"10.1089/lrb.2024.0013","DOIUrl":"https://doi.org/10.1089/lrb.2024.0013","url":null,"abstract":"Background: The aim of this prospective study was to investigate the effect of a first and repeated complex decongestive therapy (CDT) program on volume and functioning in patients with unilateral breast cancer-related lymphedema (BCRL) and to identify whether the volume before treatment and/or the number of previous treatment influence outcomes. Methods and Results: In total, 100 and 42 patients with BCRL treated by 499 CDT (6 hours a day during 5 consecutive days) between April 2018 and December 2021 were included. Patients were assessed using volume including percentage of excess volume and percentage reduction in excess volume and lymph-International Classification of Functioning-UL questionnaire. After CDT, a significant reduction in BCRL volume (50%) and improvement in functioning (30%) were observed. The volume reduction was greater when the BCRL volume before treatment was low (10%-20%) and when CDT was performed for the first time. The functioning improvement was identical whatever the volume is before treatment and the number of previous CDT. Conclusion: A greater volume reduction after CDT was obtained in BCRL with low volume before treatment and after the first CDT. Such findings support the need for early intensive BCRL treatment to control volume and improve functioning.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Physical Therapy Techniques Slow Down the Progression of Lipedema? 物理治疗技术能延缓脂肪性水肿的发展吗？

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-09 DOI: 10.1089/lrb.2024.0065

Murat Esmer, Franz Josef Schingale

{"title":"Can Physical Therapy Techniques Slow Down the Progression of Lipedema?","authors":"Murat Esmer, Franz Josef Schingale","doi":"10.1089/lrb.2024.0065","DOIUrl":"https://doi.org/10.1089/lrb.2024.0065","url":null,"abstract":"Background: Lipedema is a disease characterized by an increase in extracellular fluid. In these patients, the increase in the amount of extracellular fluid may accelerate the progression of the disease. The aim of this study is to examine the effect of complex decongestive therapy (CDT) on intracellular/extracellular fluid balance. Methods and Results: Twenty-two female patients diagnosed with lipedema by a specialist lymphologist were included in the study. Patients were subjected to complex decongestive therapy and pneumatic compression therapy 6 days a week for 1 month. Extracellular and intracellular fluid volumes were assessed using bioimpedance spectroscopy before and after the treatment. A decrease in intracellular (p = 0.010) and extracellular (p = 0.002) fluid volumes was observed after the treatment. Conclusion: There is no completely curative treatment method for lipedema. Current treatments aim to slow down the progression of the disease. CDT is considered effective in reducing intracellular and extracellular fluid volume in lipedema patients. Therefore, it is thought to be effective in slowing down the progression of the disease.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Matters. 研究事项。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 DOI: 10.1089/lrb.2024.0081

引用次数: 0

Effectiveness of Lymphovenular Anastomosis and Complex Decongestive Therapy for the Treatment of Lymphedema in Patients with Breast Cancer: A Systematic Review. 淋巴管吻合术和复合减充血疗法治疗乳腺癌患者淋巴水肿的效果：系统回顾

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1089/lrb.2024.0014

Alejandro Zapata-Ospina, Catalina Lopera-Muñetón, Silvia P Betancur-Bedoya, Isabel C Ángel-Bustos, María G Vásquez-Montoya

{"title":"Effectiveness of Lymphovenular Anastomosis and Complex Decongestive Therapy for the Treatment of Lymphedema in Patients with Breast Cancer: A Systematic Review.","authors":"Alejandro Zapata-Ospina, Catalina Lopera-Muñetón, Silvia P Betancur-Bedoya, Isabel C Ángel-Bustos, María G Vásquez-Montoya","doi":"10.1089/lrb.2024.0014","DOIUrl":"10.1089/lrb.2024.0014","url":null,"abstract":"Background: Lymphedema is a common breast cancer side effect, with an average incidence of 30%. The gold standard conservative treatment for lymphedema is complex decongestive therapy (CDT), which includes manual lymphatic drainage, compression therapy, skin care, and exercise. Lymphovenular anastomosis (LVA) is a microsurgical technique that intends to redirect excess lymphatic fluid to the venous circulation; this procedure is usually performed when conservative treatment fails. Therefore, the objective of this study is to evaluate the effectiveness of LVA and CDT for the treatment of breast cancer-related lymphedema (BCRL). Methods and Results: The search was performed in CENTRAL, MEDLINE, Embase, PsycINFO, SCOPUS, and LILACS. Inclusion criteria were (1) population: women with BCRL; (2) intervention: treated with LVA and CDT; and (3) outcome: primary outcome was lymphedema reduction. Secondary outcome was quality of life. Risk of bias and quality of study reporting were also assessed. The search found 3872 articles, with 5 articles meeting the PICO (population, intervention, comparison, outcomes) criteria, 4 pre-post studies, and one observational cohort study. The total sample included 2763 patients. Follow-up was variable. The follow-up varies from 7.8 to 120 months, with an average of 35 months. Lymphedema reduction was obtained in the five studies. Conclusion: The present systematic review suggests that for patients with lymphedema secondary to breast cancer, the combination of both treatments is effective in reducing the size of the limb and improving quality of life. Low-quality evidence was found for both limb circumference reduction and quality of life. Additional research effort is needed to reduce bias and improve the quality of evidence, in order to better inform clinical practice and enhance the care and well-being of patients with BCRL.","PeriodicalId":18168,"journal":{"name":"Lymphatic research and biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for Lymphatic Research and Biology. 罗莎琳德-富兰克林学会自豪地宣布 2023 年淋巴研究与生物学奖得主。

IF 1.6 4区医学

Lymphatic research and biology Pub Date : 2024-10-01 DOI: 10.1089/lrb.2024.56378.rfs2023

Christine Joy Moffatt

引用次数: 0