超声评估乳腺癌相关淋巴水肿的有效性。

IF 1.9 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Doyoung Yuk, Kyungmin Kim, Kyeong Eun Uhm
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引用次数: 0

摘要

背景:淋巴水肿是乳腺癌治疗的常见副作用,影响20%-40%的患者。超声评估测量结构变化以及皮肤和皮下组织厚度,以评估淋巴水肿的严重程度。本研究旨在探讨超声评估作为乳腺癌患者淋巴水肿结果测量的有效性。方法与结果:入选31例单侧乳腺癌相关淋巴水肿患者。在四个点测量手臂周长,作为手臂淋巴水肿的相对度量系数(RMCAL)。在上臂和前臂的四个点用超声测量皮肤和皮下组织的厚度,比较两边。根据Suehiro等人描述的方法评估皮下回声增强等级(SEG)和皮下无回声空间等级(SEFS)。淋巴显像评估腋窝淋巴结摄取和真皮回流。生活质量采用欧洲癌症研究和治疗组织生活质量问卷-乳腺癌模块23 (EORTC QLQ-BR23)进行评估。皮肤和皮下组织厚度、SEG和SEFS的增加比例与RMCAL值有良好的相关性。此外,根据淋巴显像上腋窝淋巴结摄取的异常,皮下组织的增加比例也有显著差异。然而,超声参数与EORTC QLQ-BR23的功能和症状量表无显著相关性。结论:超声参数与臂围有良好的相关性。此外,超声显示的皮下组织厚度与淋巴显像评估的淋巴功能显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Usefulness of Ultrasound Assessment of Breast Cancer-Related Lymphedema.

Background: Lymphedema, a common side effect of breast cancer treatments, affects 20%-40% of patients. Ultrasound evaluation measures structural change as well as skin and subcutaneous tissue thicknesses to assess lymphedema severity. This study aimed to investigate the usefulness of ultrasound evaluation as an outcome measure of lymphedema in patients with breast cancer. Methods and Results: Thirty-one patients with unilateral breast cancer-related lymphedema were enrolled. Arm circumferences were measured at four points, as the Relative Metric Coefficient of Arm Lymphedema (RMCAL). The thickness of the skin and subcutaneous tissue was measured using ultrasound at four points of the upper arm and forearm, comparing both sides. Subcutaneous echogenicity grade (SEG) and subcutaneous echo-free space (SEFS) grade were assessed following the method described by Suehiro et al. Lymphoscintigraphy evaluated axillary lymph node uptake and dermal backflow. Quality of life was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Breast Cancer Module 23 (EORTC QLQ-BR23). Increase ratios of skin and subcutaneous tissue thickness, SEG, and SEFS were well correlated with RMCAL value. Additionally, the increase ratio of subcutaneous tissue was significantly different according to the abnormality of axillary lymph node uptake on lymphoscintigraphy. However, ultrasound parameters did not significantly associate with functional and symptom scales of EORTC QLQ-BR23. Conclusions: Ultrasound parameters were well correlated with arm circumferences. Furthermore, subcutaneous tissue thickness on ultrasound was significantly related to lymphatic function assessed by lymphoscintigraphy.

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来源期刊
Lymphatic research and biology
Lymphatic research and biology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.10
自引率
7.10%
发文量
85
审稿时长
>12 weeks
期刊介绍: Lymphatic Research and Biology delivers the most current peer-reviewed advances and developments in lymphatic biology and pathology from the world’s leading biomedical investigators. The Journal provides original research from a broad range of investigative disciplines, including genetics, biochemistry and biophysics, cellular and molecular biology, physiology and pharmacology, anatomy, developmental biology, and pathology. Lymphatic Research and Biology coverage includes: -Vasculogenesis and angiogenesis -Genetics of lymphatic disorders -Human lymphatic disease, including lymphatic insufficiency and associated vascular anomalies -Physiology of intestinal fluid and protein balance -Immunosurveillance and immune cell trafficking -Tumor biology and metastasis -Pharmacology -Lymphatic imaging -Endothelial and smooth muscle cell biology -Inflammation, infection, and autoimmune disease
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